Frontiers in Bioengineering and Biotechnology,
Journal Year:
2021,
Volume and Issue:
9
Published: Sept. 20, 2021
Wound
healing
is
a
common
physiological
process
which
consists
of
sequence
molecular
and
cellular
events
that
occur
following
the
onset
tissue
lesion
in
order
to
reconstitute
barrier
between
body
external
environment.
The
inherent
properties
hydrogels
allow
damaged
heal
by
supporting
hydrated
environment
has
long
been
explored
wound
management
aid
autolytic
debridement.
However,
chronic
non-healing
wounds
require
added
therapeutic
features
can
be
achieved
incorporation
biomolecules
cells
promote
faster
better
outcomes.
In
recent
decades,
numerous
have
developed
modified
match
time
scale
for
distinct
stages
healing.
This
review
will
discuss
effects
various
types
on
pathophysiology,
as
well
ideal
characteristics
healing,
crosslinking
mechanism,
fabrication
techniques
design
considerations
hydrogel
engineering.
Finally,
several
challenges
related
adopting
future
perspectives
are
discussed.
Clinical and Translational Medicine,
Journal Year:
2022,
Volume and Issue:
12(11)
Published: Nov. 1, 2022
Abstract
Hydrogels
are
promising
and
widely
utilized
in
the
biomedical
field.
In
recent
years,
anti‐inflammatory
function
of
hydrogel
dressings
has
been
significantly
improved,
addressing
many
clinical
challenges
presented
ongoing
endeavours
to
promote
wound
healing.
Wound
healing
is
a
cascaded
highly
complex
process,
especially
chronic
wounds,
such
as
diabetic
severe
burn
which
adverse
endogenous
or
exogenous
factors
can
interfere
with
inflammatory
regulation,
leading
disruption
process.
Although
insufficient
inflammation
uncommon,
excessive
infiltration
an
almost
universal
feature
impedes
histological
repair
predictable
biological
step
chronological
order.
Therefore,
resolving
essential.
past
5
extensive
research
conducted
on
address
healing,
specifically
by
efficiently
scavenging
free
radicals,
sequestering
chemokines
promoting
M
1
‐to‐M
2
polarization
macrophages,
thereby
regulating
this
study,
we
introduced
novel
demonstrated
innovative
methods
for
their
preparation
application
achieve
enhanced
addition,
summarize
most
important
properties
required
discuss
our
analysis
potential
yet
be
addressed.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
30, P. 129 - 141
Published: July 28, 2023
In
clinical
applications,
there
is
a
lack
of
wound
dressings
that
combine
efficient
resistance
to
drug-resistant
bacteria
with
good
self-healing
properties.
this
study,
series
adhesive
conductive
antibacterial
hydrogel
based
on
oxidized
sodium
alginate-grafted
dopamine/carboxymethyl
chitosan/Fe3+
(OSD/CMC/Fe
hydrogel)/polydopamine-encapsulated
poly(thiophene-3-acetic
acid)
(OSD/CMC/Fe/PA
hydrogel)
were
prepared
for
the
repair
infected
wound.
The
Schiff
base
and
Fe3+
coordination
bonds
structure
are
dynamic
can
be
repaired
automatically
after
network
disrupted.
Macroscopically,
exhibits
properties,
allowing
dressing
adapt
complex
surfaces.
OSD/CMC/Fe/PA
showed
conductivity
photothermal
properties
under
near-infrared
(NIR)
light
irradiation.
addition,
hydrogels
exhibit
tunable
rheological
suitable
mechanical
antioxidant
tissue
adhesion
hemostatic
Furthermore,
all
improved
healing
in
full-thickness
defect
skin
test
mice.
size
by
OSD/CMC/Fe/PA3
+
NIR
was
much
smaller
(12%)
than
control
group
treated
Tegaderm™
film
14
days.
conclusion,
have
high
efficiency,
conductivity,
great
biocompatibility,
hemostasis
making
them
promising
candidates
treatment
wounds.
Life,
Journal Year:
2021,
Volume and Issue:
11(10), P. 1016 - 1016
Published: Sept. 27, 2021
Wounds
have
become
one
of
the
causes
death
worldwide.
The
metabolic
disorder
wound
microenvironment
can
lead
to
a
series
serious
symptoms,
especially
chronic
wounds
that
bring
great
pain
patients,
and
there
is
currently
no
effective
widely
used
dressing.
Therefore,
it
important
develop
new
multifunctional
dressings.
Hydrogel
an
ideal
dressing
candidate
because
its
3D
structure,
good
permeability,
excellent
biocompatibility,
ability
provide
moist
environment
for
repair,
which
overcomes
shortcomings
traditional
This
article
first
briefly
introduces
skin
healing
process,
then
preparation
methods
hydrogel
dressings
characteristics
made
natural
biomaterials
synthetic
materials
are
introduced.
Finally,
development
prospects
challenges
discussed.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(22)
Published: May 21, 2022
Abstract
The
pH
value
in
the
wound
milieu
plays
a
key
role
cellular
processes
and
cell
cycle
involved
process
of
healing.
Here,
microfluidic
assembly
technique
is
employed
to
fabricate
micro‐gel
ensembles
that
can
precisely
tune
surface
accelerate
consist
poly
(hydroxypropyl
acrylate‐
co
‐acrylic
acid)‐magnesium
ions
(poly‐(HPA‐
‐AA)‐Mg
2+
)
gel
carboxymethyl
chitosan
(CMCS)
gel,
which
release
absorb
hydrogen
ion
(H
+
separately
at
different
stages
healing
response
evolution
microenvironment.
By
regulating
affect
proliferation
migration
on
activity
various
biological
factors
wound,
physiological
are
greatly
facilitated
results
much
accelerated
chronic
wound.
This
work
presents
an
effective
strategy
designing
materials
with
vast
potentials
for
management.
Macromolecular Bioscience,
Journal Year:
2022,
Volume and Issue:
22(7)
Published: April 7, 2022
Abstract
As
the
first
defensive
line
between
human
body
and
outside
world,
skin
is
vulnerable
to
damage
from
external
environment.
Skin
wounds
can
be
divided
into
acute
(mechanical
injuries,
chemical
surgical
wounds,
etc.)
chronic
(burns,
infections,
diabetes,
etc.).
In
order
manage
wound,
a
variety
of
wound
dressings
have
been
developed,
including
gauze,
films,
foams,
nanofibers,
hydrocolloids,
hydrogels.
Recently,
hydrogels
received
much
attention
because
their
natural
extracellular
matrix
(ECM)‐mimik
structure,
tunable
mechanical
properties,
facile
bioactive
substance
delivery
capability.
They
show
great
potential
application
in
repair.
This
paper
introduces
anatomy
function
skin,
process
healing
conventional
dressings,
then
composition
construction
methods
Next,
this
necessary
properties
repair
latest
research
progress
hydrogel
for
Finally,
future
development
goals
materials
field
are
proposed.
Biomacromolecules,
Journal Year:
2021,
Volume and Issue:
22(4), P. 1654 - 1663
Published: March 3, 2021
Hydrogels
as
a
wound
dressing,
integrated
with
ultrastretchability,
rapid
self-healing,
and
excellent
antimicrobial
activity,
are
in
high
demand,
particularly
for
joint
skin
healing.
Herein,
multifunctional
ductile
composite
hydrogel
was
developed
using
poly(vinyl
alcohol)
(PVA)-borax
gel
matrix
that
synergized
or
dual-reinforced
dopamine-grafted
oxidized
carboxymethyl
cellulose
(OCMC-DA)
nanofibers
(CNF).
Moreover,
neomycin
(NEO),
an
aminoglycoside
antibiotic
groups,
incorporated
into
the
network
both
antibacterial
agent
cross-linker.
The
dynamic
reversible
borate
ester
linkages
hydrogen
bonds
between
OCMC-DA,
PVA,
CNF,
along
cross-linking
imine
NEO
endowed
self-healing
ability
stretchability
(3300%).
as-reinforced
networks
enhanced
mechanical
properties
of
hydrogels
significantly.
More
remarkably,
improved
biodegradability
biocompatibility
is
pH-responsive
effective
against
broad
spectrum
bacteria,
which
attributed
to
controllable
release
steady
availability
on
location.
Overall,
reliable
holds
significant
promise
dressing
material
