Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(13)
Published: Jan. 21, 2024
Abstract
Owing
to
the
high
penetration
ability
and
safety
of
ultrasound
(US)
sonodynamic
therapy
(SDT),
it
has
gained
significant
attention
in
tumor
treatment.
However,
its
therapeutic
efficiency
depends
on
performance
sonosensitizers.
The
hypoxic
microenvironment
abnormal
stromal
matrix
restrict
full
potential
In
this
study,
a
US‐activated
bowl‐shaped
nanobomb
(APBN)
is
designed
as
novel
sonosensitizer
enhance
SDT
effect
through
various
means.
This
enhancement
strategy
combines
three
major
characteristics:
relieving
hypoxia,
amplifying
bubble
cavitation
damage,
US‐movement‐enhanced
permeation.
unique
structure
APBN
provides
more
favorable
attachment
sites
for
generated
oxygen
gas
bubbles.
Thus,
when
catalase‐like
catalyzes
endogenous
hydrogen
peroxide
produce
oxygen,
bubbles
accumulate
at
groove,
preventing
dissipation
increasing
number
nuclei
improve
acoustic
effect.
approach
differs
from
traditional
strategies
because
couples
with
reactive
species
generation
damage
rather
than
single
action.
Additionally,
asymmetric
generates
driving
force
under
US
field,
improving
distribution
sonosensitizers
tumors.
Using
photoacoustic
imaging
dual
localization,
these
can
accuracy
orthotopic
liver
treatment,
which
presents
promising
avenue
treatment
deep
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(33)
Published: March 7, 2023
Abstract
Immunotherapy
has
made
remarkable
strides
in
cancer
therapy
over
the
past
decade.
However,
such
emerging
still
suffers
from
low
response
rates
and
immune‐related
adverse
events.
Various
strategies
have
been
developed
to
overcome
these
serious
challenges.
Therein,
sonodynamic
(SDT),
as
a
non‐invasive
treatment,
received
ever‐increasing
attention
especially
treatment
of
deep‐seated
tumors.
Significantly,
SDT
can
effectively
induce
immunogenic
cell
death
trigger
systemic
anti‐tumor
immune
response,
termed
immunotherapy.
The
rapid
development
nanotechnology
revolutionized
effects
with
robust
induction.
As
result,
more
innovative
nanosonosensitizers
synergistic
modalities
are
established
superior
efficacy
safe
profile.
In
this
review,
recent
advances
immunotherapy
summarized
particular
emphasis
on
how
be
explored
harness
for
amplifying
response.
Moreover,
current
challenges
field
prospects
its
clinical
translation
also
presented.
It
is
anticipated
that
review
provide
rational
guidance
facilitate
nanomaterials‐assisted
immunotherapy,
helping
pave
way
next‐generation
eventually
achieve
durable
patients.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(20)
Published: March 10, 2023
The
development
of
covalent
organic
framework
(COF)
sonosensitizers
with
intrinsic
sonodynamic
effects
is
highly
desirable.
However,
such
COFs
are
generally
constructed
using
small-molecule
photosensitizers.
Herein,
we
report
that
the
reticular
chemistry-based
synthesis
from
two
inert
monomers
yields
a
COF-based
sonosensitizer
(TPE-NN)
inherent
activity.
Subsequently,
nanoscale
COF
TPE-NN
fabricated
and
embedded
copper
(Cu)-coordinated
sites
to
obtain
TPE-NN-Cu.
Results
show
Cu
coordination
can
enhance
effect
TPE-NN,
whereas
ultrasound
(US)
irradiation
for
therapy
augment
chemodynamic
efficacy
Consequently,
TPE-NN-Cu
upon
US
shows
high-performance
anticancer
based
on
mutually
reinforced
sono-/chemo-nanodynamic
therapy.
This
study
reveals
backbone-originated
activity
proposes
paradigm
nanodynamic
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(22), P. 7707 - 7736
Published: Jan. 1, 2023
This
review
summarizes
the
strategies
to
engineer
CDT
nanocatalysts
based
on
diverse
nanocarriers,
especially
those
with
intrinsic
therapeutic
activities.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(13), P. 8307 - 8472
Published: June 26, 2024
Due
to
the
intrinsic
non-invasive
nature,
cost-effectiveness,
high
safety,
and
real-time
capabilities,
besides
diagnostic
imaging,
ultrasound
as
a
typical
mechanical
wave
has
been
extensively
developed
physical
tool
for
versatile
biomedical
applications.
Especially,
prosperity
of
nanotechnology
nanomedicine
invigorates
landscape
ultrasound-based
medicine.
The
unprecedented
surge
in
research
enthusiasm
dedicated
efforts
have
led
mass
multifunctional
micro-/nanosystems
being
applied
biomedicine,
facilitating
precise
diagnosis,
effective
treatment,
personalized
theranostics.
deployment
applications
is
rooted
profound
understanding
relationship
among
composition,
structure,
property,
bioactivity,
application,
performance.
In
this
comprehensive
review,
we
elaborate
on
general
principles
regarding
design,
synthesis,
functionalization,
optimization
abundant
particular,
recent
advancements
imaging
are
meticulously
summarized.
Furthermore,
systematically
elucidate
state-of-the-art
studies
concerning
progress
therapeutic
targeting
various
pathological
abnormalities
including
cancer,
bacterial
infection,
brain
diseases,
cardiovascular
metabolic
diseases.
Finally,
conclude
provide
an
outlook
field
with
in-depth
discussion
challenges
faced
future
developments
further
extensive
clinical
translation
application.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(6)
Published: March 22, 2024
Abstract
Metals
are
an
emerging
topic
in
cancer
immunotherapy
that
have
shown
great
potential
modulating
immunity
cycle
and
promoting
antitumor
by
activating
the
intrinsic
immunostimulatory
mechanisms
which
been
identified
recent
years.
The
main
challenge
of
metal‐assisted
lies
fact
free
metals
as
ion
forms
easily
cleared
during
circulation,
even
cause
systemic
metal
toxicity
due
to
off‐target
effects.
With
rapid
development
nanomedicine,
metal‐based
smart
nanosystems
(MSNs)
with
unique
controllable
structure
become
one
most
promising
delivery
carriers
solve
issue,
owing
their
various
endogenous/external
stimuli‐responsiveness
release
ions
for
metalloimmunotherapy.
In
this
review,
state‐of‐the‐art
research
progress
metal‐related
is
comprehensively
summarized.
First,
mainstream
MSNs‐assisted
will
be
delineated.
immunological
effects
certain
categorization
MSNs
different
characters
compositions
then
provided,
followed
representative
exemplar
applications
treatment,
synergistic
combination
immunotherapy.
Finally,
we
conclude
review
a
summary
remaining
challenges
associated
provide
authors'
perspective
on
further
advances.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(17)
Published: Jan. 2, 2024
Abstract
Gas
therapy,
represented
by
nitric
oxide
(NO),
has
shown
a
powerful
anti‐tumor
effect.
However,
current
NO
therapy
relies
on
precursors,
which
are
often
released
prematurely
during
in
vivo
delivery,
resulting
poor
targeting
and
obvious
toxic
side
effects.
Herein,
core/shell‐structured
nanocatalyst
is
designed
prepared
to
catalyze
the
generation
of
tumor
without
introduction
donor.
In
this
system,
C‐Z@CM
coating
octahedron
Cu‐MOF
with
nano‐ZnO,
camouflaging
homologous
cell
membrane.
After
nanomedicine
taken
up
cells,
ZnO
reacts
situ
endogenous
S‐nitrosoglutathione
(GSNO),
highly
expressed
tumors,
continuously
stably
generate
NO.
addition,
dispersed
copper
ions
acts
as
catalytic
active
centers
Fenton‐like
reaction,
catalyzes
H
2
O
large
number
hydroxyl
radicals
(
•
OH).
Importantly,
cascade
reactive
oxygen
species
(ROS)
leads
massive
production
more
lethal
nitrogen
(RNS),
further
enhancing
therapeutic
Catalytic
high
concentrations
tumor,
combined
ROS
RNS,
accompanied
glutathione
(GSH)
depletion,
achieving
effective
suppression.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(40)
Published: July 3, 2024
Abstract
Sonodynamic
therapy
(SDT),
as
a
promising
non‐invasive
therapeutic
modality
combining
ultrasound
(US)
and
sonosensitizers
to
produce
cytotoxic
reactive
oxygen
species
(ROS)
for
treating
deep‐seated
tumors,
has
received
increasing
attention
in
recent
years.
Porphyrins
are
multifunctional
organic
materials,
which
can
be
excited
both
by
light
US
ROS
possess
various
fascinating
features,
including
controllable
synthetic
processes,
excellent
biodegradability,
low
cytotoxicity
without
or
US.
Nevertheless,
their
poor
water
solubility,
skin‐photosensitive
toxicity,
insufficient
target
specificity
hinder
clinical
applications
sonosensitizer.
Although
the
issue
may
improved
using
nanoparticle
carriers,
SDT
efficacy
enhanced
with
other
modalities,
such
combination
makes
it
more
confusing
about
true
mechanism
of
SDT.
This
review
will
focus
on
following
points:
1)
Why
porphyrin‐based
considered
most
sonosensitizer
SDT?
2)
Recent
progress
development
sonosensitizers.
3)
What
new
insight
been
gained
years?
4)
The
trend
designing
efficient
existing
challenges.
Finally,
future
perspective
practical
based
discussed.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(7), P. 3224 - 3252
Published: Jan. 1, 2024
Neoantigens
play
a
pivotal
role
in
the
field
of
tumour
therapy,
encompassing
stimulation
anti-tumour
immune
response
and
enhancement
targeting
capability.
Nonetheless,
numerous
factors
directly
influence
effectiveness
neoantigens
bolstering
responses,
including
neoantigen
quantity
specificity,
uptake
rates
by
antigen-presenting
cells
(APCs),
residence
duration
within
microenvironment
(TME),
their
ability
to
facilitate
maturation
APCs
for
activation.
Nanotechnology
assumes
significant
several
aspects,
facilitating
release,
promoting
delivery
cells,
augmenting
dendritic
shielding
from
protease
degradation,
optimizing
interactions
between
system.
Consequently,
development
nanotechnology
synergistically
enhances
efficacy
cancer
theranostics.
In
this
review,
we
provide
an
overview
sources,
mechanisms
neoantigen-induced
evolution
precision
neoantigen-based
nanomedicine.
This
encompasses
various
therapeutic
modalities,
such
as
immunotherapy,
phototherapy,
radiotherapy,
chemotherapy,
chemodynamic
other
strategies
tailored
augment
therapeutics.
We
also
discuss
current
challenges
prospects
application
nanomedicine,
aiming
expedite
its
clinical
translation.
