Ultrasound Activated Nanobowls with Deep Penetration for Enhancing Sonodynamic Therapy of Orthotopic Liver Cancer DOI Creative Commons
Xiahui Lin, Shan Chen,

Yina Su

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(13)

Published: Jan. 21, 2024

Abstract Owing to the high penetration ability and safety of ultrasound (US) sonodynamic therapy (SDT), it has gained significant attention in tumor treatment. However, its therapeutic efficiency depends on performance sonosensitizers. The hypoxic microenvironment abnormal stromal matrix restrict full potential In this study, a US‐activated bowl‐shaped nanobomb (APBN) is designed as novel sonosensitizer enhance SDT effect through various means. This enhancement strategy combines three major characteristics: relieving hypoxia, amplifying bubble cavitation damage, US‐movement‐enhanced permeation. unique structure APBN provides more favorable attachment sites for generated oxygen gas bubbles. Thus, when catalase‐like catalyzes endogenous hydrogen peroxide produce oxygen, bubbles accumulate at groove, preventing dissipation increasing number nuclei improve acoustic effect. approach differs from traditional strategies because couples with reactive species generation damage rather than single action. Additionally, asymmetric generates driving force under US field, improving distribution sonosensitizers tumors. Using photoacoustic imaging dual localization, these can accuracy orthotopic liver treatment, which presents promising avenue treatment deep

Language: Английский

Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy DOI
Shuang Liang, Jianjun Yao, Dan Liu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: March 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Language: Английский

Citations

142

An acid-responsive MOF nanomedicine for augmented anti-tumor immunotherapy via a metal ion interference-mediated pyroptotic pathway DOI

Zhenzhen Feng,

Gui Chen,

Min Zhong

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 302, P. 122333 - 122333

Published: Sept. 16, 2023

Language: Английский

Citations

83

Reticular Chemistry‐Enabled Sonodynamic Activity of Covalent Organic Frameworks for Nanodynamic Cancer Therapy DOI

Yanqiu Duan,

Yang Yu, Peilai Liu

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(20)

Published: March 10, 2023

The development of covalent organic framework (COF) sonosensitizers with intrinsic sonodynamic effects is highly desirable. However, such COFs are generally constructed using small-molecule photosensitizers. Herein, we report that the reticular chemistry-based synthesis from two inert monomers yields a COF-based sonosensitizer (TPE-NN) inherent activity. Subsequently, nanoscale COF TPE-NN fabricated and embedded copper (Cu)-coordinated sites to obtain TPE-NN-Cu. Results show Cu coordination can enhance effect TPE-NN, whereas ultrasound (US) irradiation for therapy augment chemodynamic efficacy Consequently, TPE-NN-Cu upon US shows high-performance anticancer based on mutually reinforced sono-/chemo-nanodynamic therapy. This study reveals backbone-originated activity proposes paradigm nanodynamic

Language: Английский

Citations

59

Strategies to engineer various nanocarrier-based hybrid catalysts for enhanced chemodynamic cancer therapy DOI
Ji‐Na Hao,

Kaiming Ge,

Guoli Chen

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(22), P. 7707 - 7736

Published: Jan. 1, 2023

This review summarizes the strategies to engineer CDT nanocatalysts based on diverse nanocarriers, especially those with intrinsic therapeutic activities.

Language: Английский

Citations

54

Ultrasound-Based Micro-/Nanosystems for Biomedical Applications DOI
Hui Huang,

Yi Zheng,

Meiqi Chang

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(13), P. 8307 - 8472

Published: June 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Language: Английский

Citations

49

Metal‐based smart nanosystems in cancer immunotherapy DOI Creative Commons
Ying Luo,

Xiaojing He,

Qianying Du

et al.

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: March 22, 2024

Abstract Metals are an emerging topic in cancer immunotherapy that have shown great potential modulating immunity cycle and promoting antitumor by activating the intrinsic immunostimulatory mechanisms which been identified recent years. The main challenge of metal‐assisted lies fact free metals as ion forms easily cleared during circulation, even cause systemic metal toxicity due to off‐target effects. With rapid development nanomedicine, metal‐based smart nanosystems (MSNs) with unique controllable structure become one most promising delivery carriers solve issue, owing their various endogenous/external stimuli‐responsiveness release ions for metalloimmunotherapy. In this review, state‐of‐the‐art research progress metal‐related is comprehensively summarized. First, mainstream MSNs‐assisted will be delineated. immunological effects certain categorization MSNs different characters compositions then provided, followed representative exemplar applications treatment, synergistic combination immunotherapy. Finally, we conclude review a summary remaining challenges associated provide authors' perspective on further advances.

Language: Английский

Citations

31

Endogenous Nitric Oxide Releases In Situ for RNS/ROS Synergistic Cancer Therapy DOI

Zichuang Xu,

Qingzhi Luo,

Yaqian He

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(17)

Published: Jan. 2, 2024

Abstract Gas therapy, represented by nitric oxide (NO), has shown a powerful anti‐tumor effect. However, current NO therapy relies on precursors, which are often released prematurely during in vivo delivery, resulting poor targeting and obvious toxic side effects. Herein, core/shell‐structured nanocatalyst is designed prepared to catalyze the generation of tumor without introduction donor. In this system, C‐Z@CM coating octahedron Cu‐MOF with nano‐ZnO, camouflaging homologous cell membrane. After nanomedicine taken up cells, ZnO reacts situ endogenous S‐nitrosoglutathione (GSNO), highly expressed tumors, continuously stably generate NO. addition, dispersed copper ions acts as catalytic active centers Fenton‐like reaction, catalyzes H 2 O large number hydroxyl radicals ( • OH). Importantly, cascade reactive oxygen species (ROS) leads massive production more lethal nitrogen (RNS), further enhancing therapeutic Catalytic high concentrations tumor, combined ROS RNS, accompanied glutathione (GSH) depletion, achieving effective suppression.

Language: Английский

Citations

25

Multifunctional Porphyrin‐Based Sonosensitizers for Sonodynamic Therapy DOI
Jiajun Chen, Qi Zhou, Wenwu Cao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(40)

Published: July 3, 2024

Abstract Sonodynamic therapy (SDT), as a promising non‐invasive therapeutic modality combining ultrasound (US) and sonosensitizers to produce cytotoxic reactive oxygen species (ROS) for treating deep‐seated tumors, has received increasing attention in recent years. Porphyrins are multifunctional organic materials, which can be excited both by light US ROS possess various fascinating features, including controllable synthetic processes, excellent biodegradability, low cytotoxicity without or US. Nevertheless, their poor water solubility, skin‐photosensitive toxicity, insufficient target specificity hinder clinical applications sonosensitizer. Although the issue may improved using nanoparticle carriers, SDT efficacy enhanced with other modalities, such combination makes it more confusing about true mechanism of SDT. This review will focus on following points: 1) Why porphyrin‐based considered most sonosensitizer SDT? 2) Recent progress development sonosensitizers. 3) What new insight been gained years? 4) The trend designing efficient existing challenges. Finally, future perspective practical based discussed.

Language: Английский

Citations

21

Advancing nanotechnology for neoantigen-based cancer theranostics DOI Creative Commons
Jianhua Zou, Yu Zhang,

Yuanbo Pan

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(7), P. 3224 - 3252

Published: Jan. 1, 2024

Neoantigens play a pivotal role in the field of tumour therapy, encompassing stimulation anti-tumour immune response and enhancement targeting capability. Nonetheless, numerous factors directly influence effectiveness neoantigens bolstering responses, including neoantigen quantity specificity, uptake rates by antigen-presenting cells (APCs), residence duration within microenvironment (TME), their ability to facilitate maturation APCs for activation. Nanotechnology assumes significant several aspects, facilitating release, promoting delivery cells, augmenting dendritic shielding from protease degradation, optimizing interactions between system. Consequently, development nanotechnology synergistically enhances efficacy cancer theranostics. In this review, we provide an overview sources, mechanisms neoantigen-induced evolution precision neoantigen-based nanomedicine. This encompasses various therapeutic modalities, such as immunotherapy, phototherapy, radiotherapy, chemotherapy, chemodynamic other strategies tailored augment therapeutics. We also discuss current challenges prospects application nanomedicine, aiming expedite its clinical translation.

Language: Английский

Citations

19

Covalent organic framework nanomaterials: Syntheses, architectures, and applications DOI
Qing Li, Yuanyuan Zhu,

Tao Pan

et al.

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 339, P. 103427 - 103427

Published: Feb. 6, 2025

Language: Английский

Citations

4