Nanoprobe-based molecular imaging for tumor stratification

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(18), P. 6447 - 6496

Published: Jan. 1, 2023

This review highlights the use of nanoprobes to stratify various therapeutic modalities and provides an outlook on challenges future directions for patient stratification.

Language: Английский

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Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(24), P. 13966 - 14037

Published: Nov. 22, 2023

Phosphorescence, characterized by luminescent lifetimes significantly longer than that of biological autofluorescence under ambient environment, is great value for biomedical applications. Academic evidence fluorescence imaging indicates virtually all metrics (sensitivity, resolution, and penetration depths) are improved when progressing into wavelength regions, especially the recently reported second near-infrared (NIR-II, 1000–1700 nm) window. Although emission probes does matter, it not clear whether guideline "the wavelength, better effect" still suitable developing phosphorescent probes. For tissue-specific bioimaging, long-lived probes, even if they emit visible phosphorescence, enable accurate visualization large deep tissues. studies dealing with bioimaging tiny architectures or dynamic physiopathological activities, prerequisite rigorous planning long-wavelength being aware cooperative contribution long wavelengths improving spatiotemporal depth, sensitivity bioimaging. In this Review, emerging molecular engineering methods room-temperature phosphorescence discussed through lens photophysical mechanisms. We highlight roles from to NIR-II windows toward bioapplications. To appreciate such advances, challenges prospects in rapidly growing described.

Language: Английский

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Photooxidation triggered ultralong afterglow in carbon nanodots

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 15, 2024

Abstract It remains a challenge to obtain biocompatible afterglow materials with long emission wavelengths, durable lifetimes, and good water solubility. Herein we develop photooxidation strategy construct near-infrared carbon nanodots an extra-long lifetime of up 5.9 h, comparable that the well-known rare-earth or organic long-persistent luminescent materials. Intriguingly, size-dependent evolution from 3.4 h has been observed systems in aqueous solution. With structural/ultrafast dynamics analysis density functional theory simulations, reveal persistent luminescence is activated by photooxidation-induced dioxetane intermediate, which can slowly release convert energy into luminous via steric hindrance effect nanoparticles. luminescence, tissue penetration depth 20 mm be achieved. Thanks high signal-to-background ratio, biological safety cancer-specific targeting ability nanodots, ultralong-afterglow guided surgery successfully performed on mice model remove tumor tissues accurately, demonstrating potential clinical applications. These results may facilitate development long-lasting for precision resection.

Language: Английский

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Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(13), P. 8307 - 8472

Published: June 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Language: Английский

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Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: March 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Language: Английский

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A Highly Bright Near‐Infrared Afterglow Luminophore for Activatable Ultrasensitive In Vivo Imaging

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 63(4)

Published: Nov. 29, 2023

Afterglow luminescence imaging probes, with long-lived emission after cessation of light excitation, have drawn increasing attention in biomedical field owing to their elimination autofluorescence. However, current afterglow agents always suffer from an unsatisfactory signal intensity and complex systems consisting multiple ingredients. To address these issues, this study reports a near-infrared (NIR) luminophore (TPP-DO) by chemical conjugation substrate photosensitizer acting as both initiator energy relay unit into single molecule, resulting intramolecular transfer process improve the brightness. The constructed TPP-DO NPs emit strong NIR up 10

Language: Английский

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Single‐Component Photochemical Afterglow Near‐Infrared Luminescent Nano‐Photosensitizers: Bioimaging and Photodynamic Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)

Published: Feb. 9, 2024

Long afterglow luminescence-guided photodynamic therapy (PDT) performs advantages of noninvasiveness, spatiotemporal controllability, and higher signal to noise ratio. Photochemical (PCA) system emitting in an aqueous environment is highly suitable for biomedical applications, but still faces the challenges poor tissue penetration depth responsive sensitivity. In this work, two novel compounds, Iso-TPA ABEI-TPA, are designed synthesized integrate PCA as a single component by coupling near-infrared (NIR) photosensitizers with singlet oxygen cache units, respectively. Both compounds emit NIR based on photochemical reaction. ABEI-TPA exhibits photoluminescence quantum efficiency nonconjugated linkage, while conjugated linkage possesses better reactive species generation achieve stronger effective PDT, which ascribed intramolecular charge transfer effect Iso-TPA. nanoparticles can long-lasting vivo bioimaging up 120 s imaging resolution outstanding PDT efficacy tumor, exhibiting promising potential therapy.

Language: Английский

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Artificial urinary biomarker probes for diagnosis

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(5), P. 425 - 441

Published: Feb. 28, 2024

Language: Английский

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Revolutionizing lymph node metastasis imaging: the role of drug delivery systems and future perspectives

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 29, 2024

Abstract The deployment of imaging examinations has evolved into a robust approach for the diagnosis lymph node metastasis (LNM). advancement technology, coupled with introduction innovative drugs, led to incorporation an increasingly diverse array techniques clinical practice. Nonetheless, conventional methods administering agents persist in presenting certain drawbacks and side effects. employment controlled drug delivery systems (DDSs) as conduit transporting offers promising solution ameliorate these limitations intrinsic metastatic (LN) imaging, thereby augmenting diagnostic precision. Within scope this review, we elucidate historical context LN encapsulate frequently employed DDSs conjunction variety techniques, specifically imaging. Moreover, engage discourse on conceptualization practical application fusing treatment by employing DDSs. Finally, venture prospective applications realm LNM share our perspective potential trajectory DDS development. Graphical

Language: Английский

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Imaging-guided companion diagnostics in radiotherapy by monitoring APE1 activity with afterglow and MRI imaging

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 27, 2024

Companion diagnostics using biomarkers have gained prominence in guiding radiotherapy. However, biopsy-based techniques fail to account for real-time variations target response and tumor heterogeneity. Herein, we design an activated afterglow/MRI probe as a companion tool dynamically assessing biomarker apurinic/apyrimidinic endonuclease 1(APE1) during radiotherapy vivo. We employ ultrabright afterglow nanoparticles ultrasmall FeMnOx dual contrast agents, significantly broadening signal change range enhancing the sensitivity of APE1 imaging (limit detection: 0.0092 U/mL 0.16 MRI). devise longitudinally transversely subtraction-enhanced (L&T-SEI) strategy markedly enhance MRI signal-to-noise ratio between normal tissue living female mice. The combined facilitate both anatomical functional activity. This enables correlation signals with expression, radiation dosage, intratumor ROS, DNA damage, enabling early prediction outcomes (as 3 h), preceding size reduction (6 days). By monitoring levels, this allows sensitive detection liver organ injury, outperforming histopathological analysis. Furthermore, evaluates expression radiation-induced abscopal effects provides insights into underlying mechanisms, supports development treatment protocols. are promising radiotherapy, but normally detect authors report

Language: Английский

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