Multifunctional mesoporous silica nanoparticles for biomedical applications

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Language: Английский

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A Noble AuPtAg‐GOx Nanozyme for Synergistic Tumor Immunotherapy Induced by Starvation Therapy‐Augmented Mild Photothermal Therapy

Advanced Science, Journal Year: 2022, Volume and Issue: 9(31)

Published: Sept. 25, 2022

Abstract Notwithstanding immune checkpoint blocking (ICB) therapy has made eminent clinical breakthroughs, overcoming immunologically “cold” tumors remains challenging. Here, a cascade potentiated nanomodulator AuPtAg‐GOx is engineered for boosting responsiveness. Upon 1064 nm laser irradiation, AuPtAg‐mediated mild photothermal (PTT) activates cytotoxic T lymphocytes and reverses the immunogenic tumor microenvironment. Further, to amplify thermal sensitivity of cells, glucose oxidase (GOx) introduced suppress production heat shock proteins, thereby promoting therapy. Complementarily, AuPtAg nanozymes with catalase‐like activity can ameliorate hypoxia, significantly improving GOx activity. As result, combination self‐augmented ability PD‐L1 antibody further escalate antitumor efficacy. The AuPtAg‐GOx‐based synergistic starvation therapy, PTT, immunotherapy enhancement strategy be favorable tool effectively kill cancer cells.

Language: Английский

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Gas‐Mediated Tumor Energy Remodeling for Sensitizing Mild Photothermal Therapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(27)

Published: May 4, 2023

Abstract The metabolic reprogramming of tumors requires high levels adenosine triphosphate (ATP) to maintain therapeutic resistance, posing a major challenge for photothermal therapy (PTT). Although raising the temperature helps in tumor ablation, it frequently leads severe side effects. Therefore, improving response and promoting healing are critical considerations development PTT. Here, we proposed gas‐mediated energy remodeling strategy improve mild PTT efficacy while minimizing In proof‐of‐concept study, Food Drug Administration (FDA)‐approved drug‐based hydrogen sulfide (H 2 S) donor was developed provide sustained supply H S sites, serving as an adjuvant This approach proved be highly effective disrupting mitochondrial respiratory chain, inhibiting ATP generation, reducing overexpression heat shock protein 90 (HSP90), which ultimately amplified outcome. With ability reverse thermotolerance, this delivered greatly potent antitumor response, achieving complete ablation single treatment harm healthy tissues. Thus, holds great promise universal solution overcoming limitations may serve valuable paradigm future clinical translation nanoagents.

Language: Английский

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Defect-Rich Glassy IrTe₂ with Dual Enzyme-Mimic Activities for Sono-Photosynergistic-Enhanced Oncotherapy

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(7), P. 3952 - 3960

Published: Feb. 9, 2023

The complexity, diversity, and heterogeneity of malignant tumors pose a formidable challenge for antitumor therapy. To achieve the goal significantly enhancing effect, nanomedicine-based synergistic therapy is one important strategies. Herein, we innovatively report defect-rich glassy IrTe2 (G-IrTe2) with weak Ir–Te bond strength sonodynamic (SDT), chemodynamic (CDT), mild photothermal (PTT). G-IrTe2 sonosensitizer under ultrasound (US) stimuli exhibits excellent reactive oxygen species (ROS) production performance. Besides, catalase (CAT)-like activity can provide abundant to enhance SDT effect. Then, theoretical calculation verifies that US easily make irregular be broken in amorphous free electrons will released combine further form singlet (1O2). Meanwhile, peroxidase (POD)-like also catalyze endogenous H2O2 produce more ROS which conducive better tumor ablation. Furthermore, produced by sono-/chemodynamic processes cause mitochondrial dysfunction give rise heat shock protein (HSP) downregulated expression, maximizing efficiency PTT. Therefore, such rich defect could involved oncotherapy then effectively outstanding efficacy. This study provides new research idea expanding application inorganic nanomaterials promoting therapeutic effect tumors.

Language: Английский

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Bioactivable STING Nanoagonists to Synergize NIR‐II Mild Photothermal Therapy Primed Robust and Long‐Term Anticancer Immunity

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(48)

Published: Sept. 11, 2023

Pharmacological activation of the stimulator interferon genes (STING) pathway has become a promising strategy for cancer immunotherapy. However, insufficient tumorous accumulation, rapid clearance, and short duration drug efficacy in tumor microenvironment small structural STING agonists greatly compromise therapeutic efficacy. Herein, extracellular matrix (ECM) is presented anchoring agonist-based photoimmunothernostic nanomedicine (SAPTN) that can be activated by mild-temperature photothermal therapy (mild PTT) induced neutrophilic inflammation. The SAPTN owns second window near-infrared (NIR-II) photonics properties fitting NIR-II fluorescence photoacoustic imaging-guided therapy. aggregates targeting to ECM provide slow continuous release potent diABZIs. mild PTT long-lasting released synergistically prime systematic, robust, long-term anticancer immunity. In model, this approach leads complete eradication about 100% mice with orthotopic breast tumors, regained tumor-free survival at least 2 months. addition, immune-mediated abscopal effect shows inhibition distant solid growth intratumoral administration laser irradiation. Overall, represents generalized photoactivable immunity improved theranostics.

Language: Английский

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Pore Space Partition Approach of ZIF-8 for pH Responsive Codelivery of Ursolic Acid and 5-Fluorouracil

ACS Materials Letters, Journal Year: 2023, Volume and Issue: 5(2), P. 466 - 472

Published: Jan. 13, 2023

Metal–organic frameworks are smart carriers for controlled drug delivery due to large surface area and adjustable pore size. Current approaches can hardly utilize the space of MOFs thoroughly, greatly causing waste space. Here, Pore Space Partition (PSP) approach was employed achieve effective encapsulation pH-controlled codelivery two guest molecules. The ZIF-8 partitioned by molecule ursolic acid (UA), remaining filled with small 5-fluorouracil (5-FU), obtaining 5-FU&UA@ZIF-8 high loading capacity UA (12.80 wt %) 5-FU (11.20 %). Accompanied collapse in acidic surroundings, exhibited delivery. To our surprise, also showed pH responsive delivery, which did not exist before partition UA. Codelivery enable have good anticancer performance against 4T1 cells.

Language: Английский

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Smart Nanozymes for Cancer Therapy: The Next Frontier in Oncology

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(25)

Published: July 1, 2023

Nanomaterials that mimic the catalytic activity of natural enzymes in complex biological environment human body are called nanozymes. Recently, nanozyme systems have been reported with diagnostic, imaging, and/or therapeutic capabilities. Smart nanozymes strategically exploit tumor microenvironment (TME) by situ generation reactive species or modulation TME itself to result effective cancer therapy. This topical review focuses on such smart for diagnosis, and therapy modalities enhanced effects. The dominant factors guide rational design synthesis include an understanding dynamic TME, structure-activity relationships, surface chemistry imparting selectivity, site-specific therapy, stimulus-responsive activity. article presents a comprehensive analysis subject including diverse mechanisms different types systems, overview synergistic therapies. strategic application treatment can well be game changer future oncology. Moreover, recent developments may pave way deployment into other healthcare challenges, as genetic diseases, immune disorders, ageing.

Language: Английский

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Crucial Breakthrough of BODIPY‐Based NIR‐II Fluorescent Emitters for Advanced Biomedical Theranostics

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)

Published: March 29, 2024

Abstract Fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) has aroused immense attention for biomedical applications, offering exceptional advantages such as ultra‐low photon scattering and increased tissue penetration. Among NIR‐II‐emitted organic dyes, Boron dipyrromethene (BODIPY), emerged a noteworthy candidate. BODIPY, distinguished by its controllable molecular structure optical properties, outstanding fluorescence quantum yields, high molar absorption coefficients, remarkable chemical stability, undergone comprehensive investigation extensive exploration within realm of biological theranostics. This work aims to provide summary advancements development design strategies NIR‐II BODIPY fluorophores tailored advanced phototheranostics. Initially, elucidates several representative strategies, concluding electron‐programming strategy, extension conjugated backbone, J‐aggregation strategic establishment activatable fluorophores, which enhance skeletons. Subsequently, developments fluorescent BODIPY‐based nanoplatforms applications are intricately elaborated. In conclusion, this outlines future efforts directions refining meet evolving clinical demands. It is anticipated that contribution may feasible reference thereby advancing their potential practices.

Language: Английский

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Hierarchically Micro-, Meso-, and Macro-Porous MOF Nanosystems for Localized Cross-Scale Dual-Biomolecule Loading and Guest-Carrier Cooperative Anticancer Therapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(33), P. 21911 - 21924

Published: Aug. 5, 2024

Mass transfer of bulky molecules,

Language: Английский

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CeO₂ and Glucose Oxidase Co-Enriched Ti₃C₂T_x MXene for Hyperthermia-Augmented Nanocatalytic Cancer Therapy

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(8), P. 9968 - 9979

Published: Feb. 15, 2024

Foreseen as foundational in forthcoming oncology interventions are multimodal therapeutic systems. Nevertheless, the tumor microenvironment (TME), marked by heightened glucose levels, hypoxia, and scant concentrations of endogenous hydrogen peroxide could potentially impair their effectiveness. In this research, two-dimensional (2D) Ti3C2 MXene nanosheets engineered with CeO2 nanozymes oxidase (GOD), optimizing them for TME, specifically targeting cancer therapy. Following our design, nanozymes, embodying both peroxidase-like catalase-like characteristics, enable transformation H2O2 into hydroxyl radicals catalytic therapy while also producing oxygen to mitigate hypoxia. Concurrently, GOD metabolizes glucose, thereby augmenting levels disrupting intracellular energy supply. When subjected a near-infrared laser, 2D accomplishes photothermal (PTT) photodynamic (PDT), additionally amplifying cascade treatment via thermal enhancement. Empirical evidence demonstrates robust suppression vitro vivo CeO2/Ti3C2-PEG-GOD nanocomposite. Consequently, integrated approach, which combines PTT/PDT enzymatic catalysis, offer valuable blueprint development advanced therapies.

Language: Английский

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