Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(10), P. 1486 - 1498.e7

Published: Oct. 1, 2022

Language: Английский

---

Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial

Diabetologia, Journal Year: 2022, Volume and Issue: 65(10), P. 1710 - 1720

Published: July 24, 2022

Time-restricted eating (TRE) is suggested to improve metabolic health by limiting food intake a defined time window, thereby prolonging the overnight fast. This prolonged fast expected lead more pronounced depletion of hepatic glycogen stores and might insulin sensitivity due an increased need replenish nutrient storage. Previous studies showed beneficial effects 6-8 h TRE regimens in healthy, overweight adults under controlled conditions. However, on glucose homeostasis individuals with type 2 diabetes are unclear. Here, we extensively investigated levels diabetes.Fourteen (BMI 30.5±4.2 kg/m2, HbA1c 46.1±7.2 mmol/mol [6.4±0.7%]) participated 3 week (daily within 10 h) vs control (spreading over ≥14 regimen randomised, crossover trial design. The study was performed at Maastricht University, Netherlands. Eligibility criteria included diagnosis diabetes, intermediate chronotype absence medical conditions that could interfere execution and/or outcome. Randomisation study-independent investigator, ensuring equal amount participants started CON. Due nature study, neither volunteers nor investigators were blinded interventions. quality data checked without knowledge intervention allocation. Hepatic assessed 13C-MRS using hyperinsulinaemic-euglycaemic two-step clamp. Furthermore, 24 continuous monitoring devices. Secondary outcomes energy expenditure substrate oxidation, lipid content skeletal muscle mitochondrial capacity.Results depicted as mean ± SEM. similar between condition (0.15±0.01 0.15±0.01 AU, p=0.88). M value not significantly affected (19.6±1.8 17.7±1.8 μmol kg-1 min-1 control, respectively, p=0.10). peripheral also remained unaffected (p=0.67 p=0.25, respectively). Yet, insulin-induced non-oxidative disposal (non-oxidative 4.3±1.1 1.5±1.7 min-1, p=0.04). spent normoglycaemic range (15.1±0.8 12.2±1.1 per day, p=0.01), decreased fasting (7.6±0.4 8.6±0.4 mmol/l, p=0.03) (6.8±0.2 7.6±0.3 p<0.01). Energy unaffected; nevertheless, oxidation (260.2±7.6 277.8±10.7 g/day, No adverse events reported related interventions.We show feasible, safe effective means free-living diabetes. these changes accompanied or glycogen.ClinicalTrials.gov NCT03992248 FUNDING: ZonMW, 459001013.

Language: Английский

---

Timing of daily calorie loading affects appetite and hunger responses without changes in energy metabolism in healthy subjects with obesity

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(10), P. 1472 - 1485.e6

Published: Sept. 9, 2022

Language: Английский

---

Time-restricted eating: Watching the clock to treat obesity

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(2), P. 301 - 314

Published: Jan. 3, 2024

Language: Английский

---

Chrono‐nutrition: From molecular and neuronal mechanisms to human epidemiology and timed feeding patterns

Journal of Neurochemistry, Journal Year: 2020, Volume and Issue: 157(1), P. 53 - 72

Published: Nov. 22, 2020

Abstract The circadian timing system governs daily biological rhythms, synchronising physiology and behaviour to the temporal world. External time cues, including light‐dark cycle of food intake, provide signals for entrainment central, master clock in hypothalamic suprachiasmatic nuclei (SCN), metabolic rhythms peripheral tissues, respectively. Chrono‐nutrition is an emerging field building on relationship between eating patterns, health. Evidence from both animal human research demonstrates adverse consequences disruption. Conversely, a growing body evidence indicates that aligning intake periods day when processes are optimised nutrition may be effective improving Circadian glucose lipid homeostasis, insulin responsiveness sensitivity, energy expenditure, postprandial metabolism, favour patterns characterised by earlier distribution energy. This review details molecular basis clocks, regulation feeding behaviour, meal as entraining signal models. epidemiology humans examined, together with intervention studies investigating effects morning compared evening chrono‐nutrition interventions such time‐restricted feeding. have therapeutic application individuals at‐risk disease convey health benefits within general population. image

Language: Английский

---

Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms

Nutrients, Journal Year: 2020, Volume and Issue: 12(4), P. 1194 - 1194

Published: April 24, 2020

Genetic and pharmacological interventions have successfully extended healthspan lifespan in animals, but their genetic are not appropriate options for human applications intervention needs more solid clinical evidence. Consequently, dietary manipulations the only practical probable strategies to promote health longevity humans. Caloric restriction (CR), reduction of calorie intake a level that does compromise overall health, has been considered as being one most promising extend Although it is straightforward, continuous or food easy practice real lives Recently, fasting-related such intermittent fasting (IF) time-restricted feeding (TRF) emerged alternatives CR. Here, we review history CR animal models, discuss molecular mechanisms underlying these interventions, propose future directions can fill missing gaps current understanding interventions. appear by both partially overlapping common target rapamycin (TOR) pathway circadian clock, distinct independent remain be discovered. We systems approach combining global transcriptomic, metabolomic, proteomic analyses followed perturbation studies targeting multiple candidate pathways will allow us better understand how interact with each other longevity.

Language: Английский

---

Time-Restricted Eating as a Nutrition Strategy for Individuals with Type 2 Diabetes: A Feasibility Study

Nutrients, Journal Year: 2020, Volume and Issue: 12(11), P. 3228 - 3228

Published: Oct. 22, 2020

Individuals with type 2 diabetes (T2D) require a long-term dietary strategy for blood glucose management and may benefit from time-restricted eating (TRE, where the duration between first last energy intake is restricted to 8–10 h/day). We aimed determine feasibility of TRE individuals T2D. Participants T2D (HbA1c >6.5 <9%, window >12 h/day) were recruited pre-post, non-randomised intervention consisting 2-week Habitual period establish baseline intake, followed by 4-weeks during which they instructed limit all occasions 10:00 19:00 h on as many days each week possible. Recruitment, retention, acceptability, safety recorded throughout study indicators feasibility. Dietary glycaemic control, psychological well-being, cognitive outcomes, physiological measures explored secondary outcomes. From 594 interested persons, 27 eligible individuals, 24 participants enrolled 19 (mean ± SD; age: 50 9 years, BMI: 34 5 kg/m2, HbA1c: 7.6 1.1%) completed 6-week study. Overall daily did not change (~8400 kJ/d; 35% carbohydrate, 20% protein, 41% fat, 1% alcohol) periods (~8500 19% 42% alcohol). Compliance was 72 24% 28 (i.e., ~5 days/week), varied adherence (range: 4–100%). Comparisons adherent vs. non-adherent showed that 9-h reduced through lower absolute carbohydrate alcohol intakes. Overall, significantly improve control −0.2 0.4%; p = 0.053) or reduce body mass. impair variable effects function. described hunger, stressors, emotions main barriers adherence. demonstrate feasible achievable these adhere at least days/week. The degree strongly influenced intake. Future trials supporting incorporate in regular life overcome

Language: Английский

---

Associations of Meal Timing and Frequency with Obesity and Metabolic Syndrome among Korean Adults

Nutrients, Journal Year: 2019, Volume and Issue: 11(10), P. 2437 - 2437

Published: Oct. 13, 2019

Emerging studies indicate that meal timing is linked to cardiometabolic risks by deterioration of circadian rhythms, however limited evidence available in humans. This large-scale cross-sectional study explored the associations and frequency with obesity metabolic syndrome among Korean adults. Meal was defined as nightly fasting duration morning, evening, night eating, estimated number daily eating episodes using a single-day 24-hour dietary recall method. inversely associated prevalence abdominal obesity, elevated blood pressure, triglycerides men only. Independent episodes, morning lower (odds ratio (OR), 0.73; 95% confidence interval (CI), 0.57–0.93 for OR, 0.69; CI, 0.54–0.89 women) than no whereas 48% higher (OR, 1.48; 1.15–1.90) Longer less sleep were syndrome. These findings suggest overall patterns, including energy distribution across day, frequency, duration, rather alone, are related free-living

Language: Английский

---

Intermittent Fasting and Metabolic Health: From Religious Fast to Time‐Restricted Feeding

Obesity, Journal Year: 2020, Volume and Issue: 28(S1)

Published: July 1, 2020

Over the past 10 to 15 years, intermittent fasting has emerged as an unconventional approach reduce body weight and improve metabolic health beyond simple calorie restriction. In this review, we summarize findings related Ramadan Sunnah fasting. We then discuss role of caloric restriction not only intervention for control, but importantly, a strategy healthy aging longevity. Finally, review four most common (IF) strategies used date management cardiometabolic health. Weight loss is after IF does appear be different than daily when compared directly. may also provide additional benefit, such insulin sensitization, that independent from loss. While no specific regimen stands out superior at time, there indeed heterogeneity in responses these diets. This suggests one dietary ideally suited every individual. Future studies should consider tailoring prescriptions, including IF, based on advanced phenotyping genotyping prior diet initiation.

Language: Английский

---

Interconnections between circadian clocks and metabolism

Journal of Clinical Investigation, Journal Year: 2021, Volume and Issue: 131(15)

Published: Aug. 1, 2021

Circadian rhythms evolved through adaptation to daily light/dark changes in the environment; they are believed be regulated by core circadian clock interlocking feedback loop. Recent studies indicate that each component executes general and specific functions metabolism. Here, we review current understanding of role these genes regulation metabolism using various genetically modified animal models. Additionally, emerging evidence shows exposure environmental stimuli, such as artificial light, unbalanced diet, mistimed eating, exercise, remodels physiological processes causes metabolic disorders. This Review summarizes reciprocal between metabolism, highlights remaining gaps knowledge about examines potential applications human health disease.

Language: Английский

---