Near-infrared luminescence high-contrast in vivo biomedical imaging

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(1), P. 60 - 78

Published: Jan. 19, 2023

Language: Английский

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Multicharged cyclodextrin supramolecular assemblies

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(11), P. 4786 - 4827

Published: Jan. 1, 2022

Multicharged cyclodextrin (CD) supramolecular assemblies, including those based on positively/negatively charged modified mono-6-deoxy-CDs, per-6-deoxy-CDs, and random 2,3,6-deoxy-CDs, as well parent CDs binding guests, have been extensively applied in chemistry, materials science, medicine, biological catalysis, other fields. In this review, we primarily focus summarizing the recent advances encapsulating especially construction process of assemblies their applications. Compared with uncharged CDs, multicharged display remarkably high antiviral antibacterial activity efficient protein fibrosis inhibition. Meanwhile, can interact oppositely dyes, drugs, polymers, biomacromolecules to achieve effective encapsulation aggregation. Consequently, CD show great advantages improving drug-delivery efficiency, luminescence properties materials, molecular recognition imaging, toughness hydrogels, addition enabling multistimuli-responsive assemblies. These features are anticipated not only promote development CD-based chemistry but also contribute rapid exploitation these diverse interdisciplinary

Language: Английский

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Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(16), P. 5607 - 5651

Published: Jan. 1, 2023

Since their inception, rhodamine dyes have been extensively applied in biotechnology as fluorescent markers or for the detection of biomolecules owing to good optical physical properties. Accordingly, they emerged a powerful tool visualization living systems. In addition fluorescence bioimaging, molecular design derivatives with disease therapeutic functions (e.g., cancer and bacterial infection) has recently attracted increased research attention, which is significantly important construction libraries diagnostic integration. However, reviews focusing on integrated strategies dye-based diagnosis treatment wide application are extremely rare. this review, first, brief history development dyes, transformation from bioimaging therapy, concept optics-based integration its significance human presented. Next, systematic review several excellent rhodamine-based well treatment, Finally, challenges practical future outlook clinical translation also discussed.

Language: Английский

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Bioengineered nanogels for cancer immunotherapy

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(12), P. 5136 - 5174

Published: Jan. 1, 2022

Recent years have witnessed increasingly rapid advances in nanocarrier-based biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as multipurpose and constructed vectors formed via intramolecular cross-linking to generate drug delivery systems, which is attributed predominantly their satisfactory biocompatibility, bio-responsiveness, high stability, low toxicity. Recently, immunotherapy has experienced unprecedented growth become the preferred strategy cancer treatment, mainly involves mobilisation of immune system an enhanced anti-tumour immunity tumour microenvironment. Despite inspiring success, immunotherapeutic strategies are limited due response rates immune-related adverse events. Like other nanomedicines, nanogels comparably by lower focal enrichment upon introduction into organism injection. Because three-dimensional cross-linked aqueous materials that exhibit similar properties natural tissues structurally stable, they can comfortably cope with shear forces serum proteins bloodstream, longer circulation life increases chance nanogel accumulation tumour, conferring deep penetration. The large specific surface area reduce or eliminate off-target effects introducing stimuli-responsive functional groups, allowing multiple physical chemical modifications purposes improve targeting cell subpopulations organs, increasing bioavailability drug, a events on therapies. slow release reaching site facilitates long-term awakening host's system, ultimately achieving therapeutic effects. As effective candidate immunotherapy, nanogel-based been widely used. In this review, we summarize recent deliver immunomodulatory small molecule drugs, antibodies, genes cytokines, target antigen presenting cells, form vaccines, enable chimeric receptor (CAR)-T therapy. Future challenges well expected feasible prospects clinical also highlighted.

Language: Английский

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Activatable fluorescent probes for real-time imaging-guided tumor therapy

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 196, P. 114793 - 114793

Published: March 22, 2023

Language: Английский

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Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(13), P. 4392 - 4442

Published: Jan. 1, 2023

Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.

Language: Английский

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Activatable Multimodal Probes for In Vivo Imaging and Theranostics

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(50)

Published: Sept. 24, 2022

Abstract Multimodal imaging, which harnesses two or more imaging modalities to produce complementary anatomical and molecular information of a living subject, has become as powerful tool in both basic biomedical research clinical diagnosis. The progresses multimodal are paralleled by the advances probes, particularly activatable probes that can generate concurrent switches different modality signals upon interaction with target. These extremely promising for vivo imaging. In this Minireview, we summarize recent progress cancer theranostics, focusing on their design principle, signal activation mechanism applications. current challenges perspectives future developments also briefly discussed. We hope Minireview will provide inspiration other improving theranostics.

Language: Английский

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Controlled sequential in situ self-assembly and disassembly of a fluorogenic cisplatin prodrug for cancer theranostics

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Feb. 13, 2023

Temporal control of delivery and release drugs in tumors are important improving therapeutic outcomes to patients. Here, we report a sequential stimuli-triggered situ self-assembly disassembly strategy direct theranostic vivo. Using cisplatin as model anticancer drug, design stimuli-responsive small-molecule prodrug (P-CyPt), which undergoes extracellular alkaline phosphatase-triggered succeeding intracellular glutathione-triggered process, allowing enhance accumulation elicit burst tumor cells. Compared with cisplatin, P-CyPt greatly improves antitumor efficacy while mitigates off-target toxicity mice subcutaneous HeLa orthotopic HepG2 liver after systemic administration. Moreover, also produces activated near-infrared fluorescence (at 710 nm) dual photoacoustic imaging signals 700 750 nm), permitting high sensitivity spatial-resolution delineation foci real-time monitoring drug This leverages the advantages offered by those disassembly, may act general platform for prodrugs capable cancer theranostics. Manipulating molecular vivo permit temporal release. authors fluorogenic theranostics leveraging processes.

Language: Английский

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Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region

Chemical Reviews, Journal Year: 2023, Volume and Issue: 124(2), P. 554 - 628

Published: Nov. 22, 2023

In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. particular, luminescence in the tissue-transparent near-infrared (NIR, 700–1700 nm) region offers tremendous potential visualizing biological architectures pathophysiological events living subjects with deep tissue penetration high contrast owing to reduced light–tissue interactions of absorption, scattering, autofluorescence. The distinctive quantum effects nanocrystals been harnessed achieve exceptional photophysical properties, establishing them promising category luminescent probes. this comprehensive review, between light tissues, well advantages NIR imaging, are initially elaborated. Subsequently, we focus on achieving improved by optimizing performance nanocrystal fluorophores. ingenious design strategies probes discussed, along their respective biomedical applications versatile modalities. Finally, thought-provoking reflections challenges prospects future translation nanocrystal-based wisely provided.

Language: Английский

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Nanoprobe-based molecular imaging for tumor stratification

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(18), P. 6447 - 6496

Published: Jan. 1, 2023

This review highlights the use of nanoprobes to stratify various therapeutic modalities and provides an outlook on challenges future directions for patient stratification.

Language: Английский

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