Effects of a ketogenic diet in overweight women with polycystic ovary syndrome

Journal of Translational Medicine, Journal Year: 2020, Volume and Issue: 18(1)

Published: Feb. 27, 2020

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during reproductive age. It characterised clinically by oligo-ovulation or anovulation, hyper-androgenism, and presence of polycystic ovaries. associated with an increased prevalence metabolic syndrome, cardiovascular disease type 2 diabetes. The onset PCOS has been to several hereditary environmental factors, but insulin resistance plays a key pathogenetic role. We sought investigate effects ketogenic diet (KD) on childbearing age diagnosis PCOS.Fourteen overweight underwent Mediterranean phyoextracts (KEMEPHY) for 12 week. Changes body weight, mass index (BMI), fat (FBM), lean (LBM), visceral adipose tissue (VAT), insulin, glucose, HOMA-IR, total cholesterol, low density lipoprotein (LDL), high (HDL), triglycerides (TGs), free testosterone, luteinizing hormone (LH), follicle stimulating (FSH); dehydroepiandrosterone sulfate (DHEAs), estradiol, progesterone, sex binding globulin (SHBG) Ferriman Gallwey score were evaluated.After weeks, anthropometric composition measurements revealed significant reduction weight (- 9.43 kg), BMI 3.35), FBM (8.29 kg) VAT. There was significant, slightly decrease LBM. A glucose blood levels observed, together improvement HOMA-IR. triglycerides, cholesterol LDL observed along rise HDL levels. LH/FSH ratio, LH DHEAS also significantly reduced. Estradiol, progesterone SHBG increased. Score slightly, although not significantly, reduced.Our results suggest that KD may be considered as valuable non pharmacological treatment PCOS. Longer periods should tested verify effect dermatological aspects Trial registration Clinicaltrial.gov, NCT04163120, registrered 10 November 2019, retrospectively registered, https://clinicaltrials.gov.

Language: Английский

---

Efficacy and safety of very low calorie ketogenic diet (VLCKD) in patients with overweight and obesity: A systematic review and meta-analysis

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2019, Volume and Issue: 21(1), P. 5 - 16

Published: Nov. 9, 2019

Language: Английский

---

European Guidelines for Obesity Management in Adults with a Very Low-Calorie Ketogenic Diet: A Systematic Review and Meta-Analysis

Obesity Facts, Journal Year: 2021, Volume and Issue: 14(2), P. 222 - 245

Published: Jan. 1, 2021

<b><i>Background:</i></b> The very low-calorie ketogenic diet (VLCKD) has been recently proposed as an appealing nutritional strategy for obesity management. VLCKD is characterized by a low carbohydrate content (&#x3c;50 g/day), 1–1.5 g of protein/kg ideal body weight, 15–30 fat/day, and daily intake about 500–800 calories. <b><i>Objectives:</i></b> aim the current document to suggest common protocol summarize existing literature on its efficacy in weight management weight-related comorbidities, well possible side effects. <b><i>Methods:</i></b> This prepared adherence with Preferred Reporting Items Systematic Review Meta-Analyses (PRISMA) guidelines. Literature searches, study selection, methodology development, quality appraisal were performed independently 2 authors data collated means meta-analysis narrative synthesis. <b><i>Results:</i></b> Of 645 articles retrieved, 15 studies met inclusion criteria reviewed, revealing 4 main findings. First, was shown result significant loss short, intermediate, long terms improvement composition parameters glycemic lipid profiles. Second, when compared other interventions same duration, showed major effect reduction fat mass, waist circumference, total cholesterol triglyceridemia improved insulin resistance. Third, although also resulted glycemia, HbA1c, LDL cholesterol, these changes similar those obtained interventions. Finally, can be considered safe approach under health professional’s supervision since most effects are usually clinically mild easily manage recovery often spontaneous. <b><i>Conclusions:</i></b> recommended effective dietary treatment individuals after considering potential contra-indications keeping mind that any personalized. <b><i>Prospero Registry:</i></b> assessment composition, overweight obese subjects: (CRD42020205189).

Language: Английский

---

Very Low-Calorie Ketogenic Diet: A Safe and Effective Tool for Weight Loss in Patients with Obesity and Mild Kidney Failure

Nutrients, Journal Year: 2020, Volume and Issue: 12(2), P. 333 - 333

Published: Jan. 27, 2020

Very low-calorie ketogenic diets (VLCKD) are an effective and increasingly used tool for weight loss. Traditionally considered high protein, often looked at with concern by clinicians due to the potential harm they pose kidney function. We herein evaluated efficacy safety of a VLCKD in patients obesity mild failure. A prospective observational real-life study was conducted on ninety-two following approximately 3 months. Thirty-eight had failure fifty-four no renal condition were therefore designated as control. Anthropometric parameters, bioelectrical impedance biochemistry data collected before end dietary intervention. The average loss nearly 20% initial weight, significant reduction fat mass. report improvement metabolic parameters clinically relevant variation regarding liver Upon stratification based function, differences outcomes found. Interestingly, 27.7% reported normalization glomerular filtrate after conclude that, when under supervision healthcare professionals, is safe treatment obesity, including those affected

Language: Английский

---

The management of very low-calorie ketogenic diet in obesity outpatient clinic: a practical guide

Journal of Translational Medicine, Journal Year: 2019, Volume and Issue: 17(1)

Published: Oct. 29, 2019

The epidemic of obesity is growing steadily across the whole world. Obesity not only a merely aesthetic disease but "mother" most chronic diseases such as associated with range type 2 diabetes, cardiovascular disease, obstructive sleep apnea, and cancer. However, although there need to find strategy stop this times current nutritional strategies are effective in weight loss long term maintenance. Very low-calorie ketogenic diets (VLCKD) increasingly establishing successful pattern manage obesity; due rapid that gives rise positive psychological cycle which turn increases compliance diet. Another important key point VLCKD ability preserve fatty free mass known play role paramount importance glucose metabolism. Despite clinical evidence paucity data regarding its management. Therefore, we will provide useful guide be used by nutrition experts taking care subjects obesity. In particular, report recommendations on correct use therapeutic approach for management side effects.

Language: Английский

---

The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction

Journal of Endocrinological Investigation, Journal Year: 2023, Volume and Issue: 46(6), P. 1241 - 1274

Published: Jan. 25, 2023

Language: Английский

---

The Influence of Metabolic Factors and Diet on Fertility

Nutrients, Journal Year: 2023, Volume and Issue: 15(5), P. 1180 - 1180

Published: Feb. 27, 2023

Infertility is a disease globally affecting 20–30% of the reproductive age female population. However, in up to 50% on recorded cases, problems with infertility are ascribed men; therefore, it important popularize healthy eating also this group. During last decade, has been observed that society’s lifestyle changed drastically: reduced energy expenditure physical activity per day, increased consumption hypercaloric and high-glycemic-index foods high content trans fats, dietary fiber, which negatively affects fertility. Increasing evidence points link between diet It becoming clear well-planned nutrition can contribute effectiveness ART. The low-GI plant-based appears have positive effect, especially when based Mediterranean patterns: rich antioxidants, vegetable protein, MUFA fatty acids, omega-3, vitamins, minerals. Importantly, shown protect against chronic diseases associated oxidative stress, translates into pregnancy success. As seem be factors fertility, worth expanding knowledge regard among couples trying conceive child.

Language: Английский

---

Ketogenic nutritional therapy (KeNuT)—a multi-step dietary model with meal replacements for the management of obesity and its related metabolic disorders: a consensus statement from the working group of the Club of the Italian Society of Endocrinology (SIE)—diet therapies in endocrinology and metabolism

Journal of Endocrinological Investigation, Journal Year: 2024, Volume and Issue: 47(3), P. 487 - 500

Published: Jan. 18, 2024

Abstract Purpose The ketogenic nutritional therapy (KeNuT) is an effective dietary treatment for patients with obesity and obesity-related comorbidities, including type 2 diabetes, dyslipidaemia, hypertension, coronary artery disease, some of cancers. However, to date official document on the correct prescription diet, validated by authoritative societies in nutrition or endocrine sciences, missing. It important emphasize that requires proper medical supervision patient selection, due complex biochemical implications ketosis need a strict therapeutic compliance, experienced nutritionist personalization whole protocol. Methods This practical guide provides update main clinical indications contraindications meal replacements its mechanisms action. In addition, various phases protocol involving replacements, monitoring, management potential side effects, are also discussed. Conclusion will help healthcare provider acquire necessary skills provide comprehensive care overweight, diseases, using multistep treatment, recognized Club Italian Society Endocrinology (SIE)—Diet Therapies Metabolism.

Language: Английский

---

A New Nomenclature for the Very Low-Calorie Ketogenic Diet (VLCKD): Very Low-Energy Ketogenic Therapy (VLEKT). Ketodiets and Nutraceuticals Expert Panels: “KetoNut”, Italian Society of Nutraceuticals (SINut) and the Italian Association of Dietetics and Clinical Nutrition (ADI)

Current Nutrition Reports, Journal Year: 2024, Volume and Issue: 13(3), P. 552 - 556

Published: July 23, 2024

Abstract Purpose of Review In an attempt to clarify the most appropriate nomenclature for very low-calorie ketogenic diets (VLCKD), we propose change and acronym this medical nutrition therapy. The new definition proposed by "KetoNut" panel experts Italian Society Nutraceuticals (SINut) Association Dietetics Clinical Nutrition (ADI) is Very Low-Energy Ketogenic Therapy (VLEKT). Recent Findings last few years, different authors have focused on issue confusion in diets. detail, been differentiated VLCKD that provides < 800 kcal per day, which intended weight loss treatment obesity, a eucaloric diet, contains more calories from fat (predominantly unsaturated) with specific ratios, allow growth children while helping, at same time, establish epileptic seizure control. Summary recent attracted great interest their efficacy epilepsy other neurological diseases but also patients overweight obesity-related metabolic disorders. Nevertheless, although are dietary intervention designed induce nutritional ketosis, macronutrients’ composition called name. may result significant bias mistakes interpretation current scientific evidence. Graphical

Language: Английский

---

Nutritional Strategies for Battling Obesity-Linked Liver Disease: the Role of Medical Nutritional Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 11, 2025

This narrative review explores the role of Medical Nutritional Therapy (MNT) in managing Metabolic-Associated Steatotic Liver Disease (MASLD), previously known as nonalcoholic fatty liver disease. It aims to examine effectiveness specific nutritional strategies preventing and treating this obesity-linked Emerging evidence underscores benefits Mediterranean diet, low-carbohydrate diets, intermittent fasting reducing fat, improving insulin sensitivity, mitigating inflammation. Supplementing with vitamin E, omega-3 acids, silymarin can potentially reduce fibrosis promote health. MNT is a key intervention for MASLD management, emphasizing dietary patterns, caloric restriction, nutraceutical supplementation. Integrating these lifestyle modifications, including regular physical activity, offers comprehensive approach metabolic outcomes patients MASLD. Further research needed refine personalize therapeutic interventions.

Language: Английский

---