Protein and Peptide‐Based Nanotechnology for Enhancing Stability, Bioactivity, and Delivery of Anthocyanins DOI Creative Commons
Lei Zhang, Liang Yao, Feng Zhao

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(25)

Published: Aug. 3, 2023

Anthocyanin, a unique natural polyphenol, is abundant in plants and widely utilized biomedicine, cosmetics, the food industry due to its excellent antioxidant, anticancer, antiaging, antimicrobial, anti-inflammatory properties. However, degradation of anthocyanin an extreme environment, such as alkali pH, high temperatures, metal ions, limits physiochemical stabilities bioavailabilities. Encapsulation combining with biomaterials could efficiently stabilize for protection. Promisingly, or artificially designed proteins peptides favorable stabilities, biocapacity, wide sources are potential candidates anthocyanin. This review focuses on recent progress, strategies, perspectives protein peptide functionalization delivery, i.e., formulation technologies, physicochemical stability enhancement, cellular uptake, bioavailabilities, biological activities development. Interestingly, simplicity diversity structure, interaction mechanisms between be illustrated. work sheds light mechanism protein/peptide-anthocyanin nanoparticle construction expands applications nutrition biomedicine.

Language: Английский

Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment DOI
Rui Liu, Cong Luo, Zhiqing Pang

et al.

Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 34(2), P. 107518 - 107518

Published: May 14, 2022

Language: Английский

Citations

343
(Macro)molecular self-assembly for hydrogel drug delivery DOI Creative Commons
Matthew J. Webber, E. Thomas Pashuck

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 172, P. 275 - 295

Published: Jan. 13, 2021

Language: Английский

Citations

141
Natural-Based Biomaterial for Skin Wound Healing (Gelatin vs. Collagen): Expert Review DOI Open Access
Ruth Naomi, Hasnah Bahari,

Pauzi Muhd Ridzuan

et al.

Polymers, Journal Year: 2021, Volume and Issue: 13(14), P. 2319 - 2319

Published: July 14, 2021

Collagen (Col) and gelatin are most extensively used in various fields, particularly pharmaceuticals therapeutics. Numerous researchers have proven that they highly biocompatible to human tissues, exhibit low antigenicity easy degrade. Despite their different sources both Col almost the same effects when it comes wound healing mechanisms. Considering this, bioactivity biological of been, being, constantly investigated through vitro vivo assays obtain maximum outcomes future. With regard nutritional values as protein, products exert possible activities on cells extracellular matrix (ECM). In addition, a vast number novel applications been discovered. This review compared terms structures, derivatives, physicochemical properties, results studies, roles current challenges healing. Thus, this provides insights latest discoveries

Language: Английский

Citations

135
Oral nanotherapeutics based on Antheraea pernyi silk fibroin for synergistic treatment of ulcerative colitis DOI

Ya Ma,

Lian Duan, Jianfeng Sun

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 282, P. 121410 - 121410

Published: Feb. 16, 2022

Language: Английский

Citations

84
Recent Advances in Poly(α-L-glutamic acid)-Based Nanomaterials for Drug Delivery DOI Creative Commons
Yu Zhang, Wenliang Song, Yiming Lu

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 12(5), P. 636 - 636

Published: April 25, 2022

Poly(α-L-glutamic acid) (PGA) is a class of synthetic polypeptides composed the monomeric unit α-L-glutamic acid. Owing to their biocompatibility, biodegradability, and non-immunogenicity, PGA-based nanomaterials have been elaborately designed for drug delivery systems. Relevant studies including latest research results on discussed in this work. The following related topics are summarized as: (1) brief description strategies PGAs; (2) an elaborated presentation evolving applications PGA areas delivery, rational design, precise fabrication, biological evaluation; (3) profound discussion further development delivery. In summary, unique structures superior properties enables represent as enormous potential biomaterials-related areas.

Language: Английский

Citations

77
Nanofibers: A current era in drug delivery system DOI Creative Commons
Abhijeet Hiwrale,

Swati Bharati,

Prashant Pingale

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(9), P. e18917 - e18917

Published: Aug. 9, 2023

Nanofibers have a large area of surface variable 3D topography, porosity, and adaptable functions. Several researchers are researching nanofiber technology as potential solution to the current problems in several fields. It manages cardiovascular disorders, infectious diseases, gastrointestinal tract-associated neurodegenerative pain treatment, contraception, wound healing. The nanofibers fabricated using various fabrication techniques, such electrospinning, phase separation, physical Fabrication, chemical fabrication. Depending on their intended use, manufactured variety polymers. comprises natural polymers, semi-synthetic synthetic metals, metal oxides, ceramics, carbon, nonporous materials, mesoporous hollow structures, core-shell biocomponents, multi-component materials. Nanofiber composites good alternative for targeted gene delivery, protein peptide growth factor delivery. Thus, huge drug which enables them be used applications can revolutionize these therapeutic areas. This review systematically studied nanofibers' history, advantages, disadvantages, types, polymers technology. Further, types preparation were summarised. Mainly article focuses method, i.e., electrospinning its types. Finally, discussed recent advancements nanofabrication

Language: Английский

Citations

64
Multifunctional Self-Assembled Peptide Hydrogels for Biomedical Applications DOI Open Access
Mahsa Sedighi, Neha Shrestha, Zahra Mahmoudi

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(5), P. 1160 - 1160

Published: Feb. 25, 2023

Self-assembly is a growth mechanism in nature to apply local interactions forming minimum energy structure. Currently, self-assembled materials are considered for biomedical applications due their pleasant features, including scalability, versatility, simplicity, and inexpensiveness. Self-assembled peptides can be applied design fabricate different structures, such as micelles, hydrogels, vesicles, by diverse physical between specific building blocks. Among them, bioactivity, biocompatibility, biodegradability of peptide hydrogels have introduced them versatile platforms applications, drug delivery, tissue engineering, biosensing, treating diseases. Moreover, capable mimicking the microenvironment natural tissues responding internal external stimuli triggered release. In current review, unique characteristics recent advances design, fabrication, well chemical, physical, biological properties presented. Additionally, developments these biomaterials discussed with particular focus on targeted delivery gene stem cell therapy, cancer therapy immune regulation, bioimaging, regenerative medicine.

Language: Английский

Citations

56
Polymeric nanoparticles (PNPs) for oral delivery of insulin DOI Creative Commons
Yunyun Wang, Hao Li, Aamir Rasool

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 3, 2024

Abstract Successful oral insulin administration can considerably enhance the quality of life (QOL) diabetes patients who must frequently take injections. Oral administration, on other hand, is seriously hampered by gastrointestinal enzymes, wide pH range, mucus and mucosal layers, which limit bioavailability to ≤ 2%. Therefore, a large number technological solutions have been proposed increase insulin, in polymeric nanoparticles (PNPs) are highly promising for delivery. The recently published research articles chosen this review based applications PNPs with strong future potential delivery, do not cover all related work. In review, we will summarize controlled release mechanisms latest delivery nanocarrier, challenges prospect. This serve as guide investigators wish engineer study systems. Graphical

Language: Английский

Citations

56
Protein‐based Nanoparticles: From Drug Delivery to Imaging, Nanocatalysis and Protein Therapy DOI Creative Commons

Jonas Kaltbeitzel,

Peter Wich

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(44)

Published: March 14, 2023

Proteins and enzymes are versatile biomaterials for a wide range of medical applications due to their high specificity receptors substrates, degradability, low toxicity, overall good biocompatibility. Protein nanoparticles formed by the arrangement several native or modified proteins into nanometer-sized assemblies. In this review, we will focus on artificial nanoparticle systems, where main structural element not just an encapsulated payload. While under natural conditions, only certain form defined aggregates nanoparticles, chemical modifications change in physical environment can further extend pool available building blocks. This allows assembly many globular even enzymes. These advances preparation methods led emergence new generations nanosystems that beyond transport vehicles diverse applications, from multifunctional drug delivery imaging, nanocatalysis protein therapy.

Language: Английский

Citations

50
Natural polymers in wound healing: From academic studies to commercial products DOI Open Access
Mohamadreza Tavakoli, Sheyda Labbaf, Marjan Mirhaj

et al.

Journal of Applied Polymer Science, Journal Year: 2023, Volume and Issue: 140(22)

Published: April 12, 2023

Abstract Natural biopolymers (carbohydrates and proteins) are the family of natural polymers that widely used in wound healing. This is due to their biocompatibility chemical structural similarity extracellular matrix (ECM). Wound healing a complex process requires multidisciplinary approach appropriate treatment product enable full recovery. Chronic nonhealing wounds significantly caused reduction. Currently, diabetic considered unmet clinical need new effective will benefit patients economy. research was aimed critically review both literature as well industrial products carbohydrates proteins dressing for wound. The outcome chitosan (CS), carbohydrate, has most application it readily available affordable, shown excellent antibacterial activity. Among proteins, keratin (Kr) can be an option with similar characteristics, however, Kr not yet found use when compared CS.

Language: Английский

Citations

47