Biochemistry (Moscow),
Journal Year:
2024,
Volume and Issue:
89(6), P. 1014 - 1023
Published: June 1, 2024
Damages
of
various
origin
accumulated
in
the
genomic
DNA
can
lead
to
breach
genome
stability,
and
are
considered
be
one
main
factors
involved
cellular
senescence.
repair
systems
mammalian
cells
ensure
effective
damage
removal
structure,
therefore,
activity
these
is
expected
correlated
with
high
maximum
lifespan
observed
long-lived
mammals.
This
review
discusses
current
results
studies
focused
on
determination
system
investigation
properties
its
key
regulatory
proteins
rodents
bats.
Based
works
discussed
review,
it
could
concluded
that
bats
general
demonstrate
efficiency
functioning
regulation
systems.
Nevertheless,
a
number
questions
around
study
remain
poorly
understood,
answers
which
open
up
new
avenues
for
further
research.
Molecular Metabolism,
Journal Year:
2023,
Volume and Issue:
74, P. 101755 - 101755
Published: June 16, 2023
Recently,
the
hallmarks
of
aging
were
updated
to
include
dysbiosis,
disabled
macroautophagy,
and
chronic
inflammation.
In
particular,
low-grade
inflammation
during
aging,
without
overt
infection,
is
defined
as
"inflammaging,"
which
associated
with
increased
morbidity
mortality
in
population.
Emerging
evidence
suggests
a
bidirectional
cyclical
relationship
between
development
age-related
conditions,
such
cardiovascular
diseases,
neurodegeneration,
cancer,
frailty.
How
crosstalk
other
underlies
biological
mechanisms
disease
thus
particular
interest
current
geroscience
research.
Cell Reports,
Journal Year:
2022,
Volume and Issue:
38(10), P. 110459 - 110459
Published: March 1, 2022
Biological
age
(BA)
has
been
proposed
to
evaluate
the
aging
status
instead
of
chronological
(CA).
Our
study
shows
evidence
that
there
might
be
multiple
"clocks"
within
whole-body
system:
systemic
drivers/clocks
overlaid
with
organ/tissue-specific
counterparts.
We
utilize
multi-omics
data,
including
clinical
tests,
immune
repertoire,
targeted
metabolomic
molecules,
gut
microbiomes,
physical
fitness
examinations,
and
facial
skin
estimate
BA
different
organs
(e.g.,
liver,
kidney)
systems
(immune
metabolic
system).
The
rates
organs/systems
are
diverse.
People's
patterns
different.
also
demonstrate
several
applications
in
two
independent
datasets.
Mortality
predictions
compared
among
organs'
dataset
United
States
National
Health
Nutrition
Examination
Survey.
Polygenic
risk
score
BAs
constructed
Chinese
Longitudinal
Healthy
Longevity
Survey
cohort
can
predict
possibility
becoming
centenarian.
Frontiers in Endocrinology,
Journal Year:
2022,
Volume and Issue:
13
Published: Aug. 19, 2022
Progressive
loss
of
physiological
integrity
and
accumulation
degenerative
changes
leading
to
functional
impairment
increased
susceptibility
diseases
are
the
main
features
aging.
The
ovary,
key
organ
that
maintains
female
reproductive
endocrine
function,
enters
aging
earlier
faster
than
other
organs
has
attracted
extensive
attention
from
society.
Ovarian
is
mainly
characterized
by
progressive
decline
in
number
quality
oocytes,
regulatory
mechanisms
which
have
yet
be
systematically
elucidated.
This
review
discusses
hallmarks
further
highlight
characteristics
ovarian
attempt
explore
its
clinical
symptoms
underlying
mechanisms.
Finally,
intervention
strategies
related
elaborated,
especially
potential
role
stem
cells
cryopreservation
embryos,
or
tissue
delay
Ageing Research Reviews,
Journal Year:
2023,
Volume and Issue:
89, P. 101985 - 101985
Published: June 15, 2023
Old
age
is
associated
with
a
greater
burden
of
disease,
including
neurodegenerative
disorders
such
as
Alzheimer's
disease
and
Parkinson's
well
other
chronic
diseases.
Coincidentally,
popular
lifestyle
interventions,
caloric
restriction,
intermittent
fasting,
regular
exercise,
in
addition
to
pharmacological
interventions
intended
protect
against
age-related
diseases,
induce
transcription
factor
EB
(TFEB)
autophagy.
In
this
review,
we
summarize
emerging
discoveries
that
point
TFEB
activity
affecting
the
hallmarks
aging,
inhibiting
DNA
damage
epigenetic
modifications,
inducing
autophagy
cell
clearance
promote
proteostasis,
regulating
mitochondrial
quality
control,
linking
nutrient-sensing
energy
metabolism,
pro-
anti-inflammatory
pathways,
senescence
promoting
regenerative
capacity.
Furthermore,
therapeutic
impact
activation
on
normal
aging
tissue-specific
development
assessed
contexts
neurodegeneration
neuroplasticity,
stem
differentiation,
immune
responses,
muscle
adaptation,
adipose
tissue
browning,
hepatic
functions,
bone
remodeling,
cancer.
Safe
effective
strategies
activating
hold
promise
strategy
for
multiple
age-associated
diseases
extending
lifespan.
Molecular Ecology,
Journal Year:
2021,
Volume and Issue:
31(23), P. 6040 - 6052
Published: Aug. 26, 2021
Abstract
It
is
well
known
that
oxidative
stress
a
major
cause
of
DNA
damage
and
telomere
attrition.
Most
endogenous
reactive
oxygen
species
(ROS)
are
produced
in
the
mitochondria,
producing
link
between
mitochondrial
function,
integrity
dynamics.
In
this
review
we
will
describe
how
ROS
production,
rates
to
telomeric
repair
dynamic
processes.
The
rate
production
depends
on
features
such
as
level
inner
membrane
uncoupling
proportion
time
ATP
actively
being
produced.
However,
efficiency
(the
ATP/O
ratio)
positively
related
so
leading
trade‐off
body's
energy
requirements
its
need
prevent
stress.
Telomeric
especially
vulnerable
due
high
guanine
content;
while
damaged
regions
possible
through
range
mechanisms,
these
can
result
more
rapid
shortening.
There
increasing
evidence
varies
over
with
environmental
context,
do
repair.
We
argue
dynamics
only
be
understood
by
appreciating
optimal
solution
energetic
protection
differ
individuals
change
time,
depending
resource
availability,
demands
life
history
strategy.
Nucleic Acids Research,
Journal Year:
2022,
Volume and Issue:
unknown
Published: Jan. 1, 2022
Aging
in
humans
is
intricately
linked
with
alterations
circadian
rhythms
concomitant
physiological
decline
and
stem
cell
exhaustion.
However,
whether
the
machinery
directly
regulates
aging,
especially
primates,
remains
poorly
understood.
In
this
study,
we
found
that
deficiency
of
BMAL1,
only
non-redundant
clock
component,
results
an
accelerated
aging
phenotype
both
human
cynomolgus
monkey
mesenchymal
progenitor
cells
(MPCs).
Unexpectedly,
was
mainly
attributed
to
a
transcription-independent
role
BMAL1
stabilizing
heterochromatin
thus
preventing
activation
LINE1-cGAS-STING
pathway.
senescent
primate
MPCs,
observed
decreased
capacity
bind
LINE1
synergistic
expression.
Likewise,
skin
muscle
tissues
from
BMAL1-deficient
monkey,
destabilized
aberrant
transcription.
Altogether,
these
findings
uncovered
noncanonical
inactivate
drives
cells.
Aging Cell,
Journal Year:
2022,
Volume and Issue:
21(9)
Published: Aug. 22, 2022
It
is
known
that
chondrocytes
from
joints
with
osteoarthritis
(OA)
exhibit
high
levels
of
DNA
damage,
but
the
degree
to
which
accumulate
damage
during
"normal
aging"
has
not
been
established.
The
goal
this
study
was
quantify
present
in
obtained
cadaveric
donors
a
wide
age
range,
and
compare
extent
OA
chondrocytes.
alkaline
comet
assay
used
measure
normal
cartilage
ankle
(talus)
knee
(femur)
donors,
as
well
at
time
total
replacement.
Chondrocytes
younger
(<45
years)
had
less
than
older
(>70
assessed
by
percentage
"tail".
In
between
50
60
years
old,
there
increased
compared
cadaveric.
Talar
23
ages
34
78
revealed
linear
increase
(R2
=
0.865,
p
<
0.0001).
A
"two-tailed"
demonstrate
most
accumulated
form
strand
breaks
opposed
alkali-labile
base
damage.
young
required
10
Gy
irradiation
recapitulate
donors.
Given
potential
for
contribute
chondrocyte
dysfunction
senescence,
supports
investigation
mechanisms
hypo-replicative
cell
types
