Preparation and evaluation of a polycaprolactone/chitosan/propolis fibrous nanocomposite scaffold as a tissue engineering skin substitute DOI Creative Commons
Seyedeh‐Sara Hashemi,

Ali Akbar Mohammadi,

Seyedeh-Somayeh Rajabi

et al.

Bioimpacts, Journal Year: 2023, Volume and Issue: 13(4), P. 275 - 287

Published: June 12, 2023

Recently, the application of nanofibrous mats for dressing skin wounds has received great attention. In this study, we aimed to fabricate and characterize an electrospun mat containing polycaprolactone (PCL), chitosan (CTS), propolis use as a tissue-engineered substitute.Raw was extracted, its phenolic flavonoid contents were measured. The physiochemical biological properties fabricated mats, including PCL, PCL/CTS, PCL/CTS/Propolis evaluated by scanning electron microscopy (SEM), atomic force (AFM), mechanical analysis, swelling degradation behaviors, contact angle measurement, cell attachment, DAPI staining, MTT assay. On other hand, drug release pattern from scaffold determined. A deep second-degree burn wound model induced in rats investigate healing using macroscopical histopathological evaluations.The results revealed that extract contained high amounts compounds. had suitable physicochemical properties. Uniform, bead-free, well-branched fibers observed SEM images mats. AFM analysis indicated addition CTS PCL elevated surface roughness. biocompatible. presence fibroblast cells on confirmed staining images. Also, sustainably released mat. animal study significantly improved healing.The can be applied substitute cutaneous wounds, such wounds.

Language: Английский

Antibacterial Properties of Propolis DOI Creative Commons

Izabela Przybyłek,

Tomasz M. Karpiński

Molecules, Journal Year: 2019, Volume and Issue: 24(11), P. 2047 - 2047

Published: May 29, 2019

Researchers are continuing to discover all the properties of propolis due its complex composition and associated broad spectrum activities. This review aims characterize latest scientific reports in field antibacterial activity this substance. The results studies on influence more than 600 bacterial strains were analyzed. greater against Gram-positive bacteria Gram-negative was confirmed. Moreover, antimicrobial from different regions world compared. As a result, high Middle East found relation both, (Staphylococcus aureus) (Escherichia coli) strains. Simultaneously, lowest demonstrated for samples Germany, Ireland Korea.

Language: Английский

Citations

557

Composition and functional properties of propolis (bee glue): A review DOI Creative Commons
Syed Ishtiaq Anjum, Amjad Ullah, Khalid Ali Khan

et al.

Saudi Journal of Biological Sciences, Journal Year: 2018, Volume and Issue: 26(7), P. 1695 - 1703

Published: Aug. 17, 2018

Propolis is a natural substance collected by honey bees from various plants such as, poplar, palm, pine, conifer secretions, gums, resins, mucilage and leaf buds. It brought very painstakingly to be used for sealing cracks crevices occurring in their hives. Originally, it as an antiseptic meant preventing bee-hive microbial infections along with decomposition of intruders. Additionally, propolis has been folk medicine centuries. The biological characteristics depend upon its chemical composition, plant sources, geographical zone seasons. More than 300 compounds have identified phenolic compounds, aromatic acids, essential oils, waxes amino acids. Many scientific articles are published every year different international journals, several groups researchers focused attention on the activity propolis.

Language: Английский

Citations

550

Active packaging films and edible coatings based on polyphenol‐rich propolis extract: A review DOI

Huimin Yong,

Jun Liu

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2021, Volume and Issue: 20(2), P. 2106 - 2145

Published: Jan. 23, 2021

Abstract The development of active packaging films and edible coatings based on biopolymers natural bioactive substances has received increasing attention in recent years. Propolis, also called bee glue, is a resin substance collected by worker‐bees from the mucilage, gum, several plants. In food industry, propolis commonly extracted solvents to afford polyphenol‐rich extract with potent antimicrobial antioxidant activities. prepared can be mixed biopolymers, plasticizers, emulsifiers, reinforcing agents develop coatings. functionality closely related type, harvesting method, geographic origin, extraction method conditions propolis, content composition polyphenolic compounds extract, presence other substances. Active impact physical, biochemical, sensory properties (e.g., fruits, vegetables, meat, fish) during storage. This review focuses advances extract. structural characterization, functionality, potential applications summarized.

Language: Английский

Citations

156

Tackling Antibiotic Resistance with Compounds of Natural Origin: A Comprehensive Review DOI Creative Commons
Francisco Javier Álvarez‐Martínez, Enrique Barrajón‐Catalán, Vicente Micol

et al.

Biomedicines, Journal Year: 2020, Volume and Issue: 8(10), P. 405 - 405

Published: Oct. 11, 2020

Drug-resistant bacteria pose a serious threat to human health worldwide. Current antibiotics are losing efficacy and new antimicrobial agents urgently needed. Living organisms an invaluable source of compounds. The activity the most representative natural products animal, bacterial, fungal plant origin reviewed in this paper. Their against drug-resistant bacteria, their mechanisms action, possible development resistance them, role current medicine future perspectives discussed. Electronic databases such as PubMed, Scopus ScienceDirect were used search scientific contributions until September 2020, using relevant keywords. Natural compounds heterogeneous origins have been shown possess capabilities, including antibiotic-resistant bacteria. commonly found action related protein biosynthesis alteration cell walls membranes. Various compounds, especially phytochemicals, synergistic capacity with antibiotics. There is little literature on specific New technologies -omics, network pharmacology informatics potential identify characterize future. This knowledge may be useful for therapeutic strategies.

Language: Английский

Citations

155

Natural Compounds for Wood Protection against Fungi—A Review DOI Creative Commons
Magdalena Broda

Molecules, Journal Year: 2020, Volume and Issue: 25(15), P. 3538 - 3538

Published: Aug. 2, 2020

Wood is a renewable, versatile material with multiple applications and the largest terrestrial pool of sequestered carbon. However, it susceptible to degradation, mainly caused by wood-decaying fungi. Since several traditional wood preservatives have been banned owing their detrimental effects on humans environment, extending lifespan products using new generation natural an imperative from perspectives human health environmental protection. Several compounds plant animal origin tested for fungicidal properties, including essential oils, tannins, extractives, alkaloids, propolis or chitosan; enormous potential in protection has shown. Although they are not free limitations, methods overcome drawbacks enhance bioactivity already exist, such as co-impregnation different polymers, cross-linkers, metal chelators antioxidants. The presence discrepancies between laboratory tests field performance, well legislation-related problems resulting lack standards defining quality performance protective formulations, however, create urgent need further thorough research arrangements. collaboration other industries interested utilisation active will reduce associated costs, thus, facilitate successful implementation alternative antifungal agents.

Language: Английский

Citations

146

Anticancer Activity of Propolis and Its Compounds DOI
Ewa Forma, Magdalena Bryś

Nutrients, Journal Year: 2021, Volume and Issue: 13(8), P. 2594 - 2594

Published: July 28, 2021

Propolis is a natural material that honey bees (Apis mellifera) produce from various botanical sources. The therapeutic activity of propolis, including antibacterial, antifungal, and anti-inflammatory effects, have been known since antiquity. Cancer one the major burdens disease worldwide, therefore, numerous studies are being conducted to develop new chemotherapeutic agents treatments for cancer. rich source biologically active compounds, which affect signaling pathways regulating crucial cellular processes. results latest research show propolis can inhibit proliferation, angiogenesis, metastasis cancer cells stimulate apoptosis. Moreover, it may influence tumor microenvironment multidrug resistance cancers. This review briefly summarizes molecular mechanisms anticancer its compounds highlights potential benefits reduce side effects chemotherapy radiotherapy.

Language: Английский

Citations

139

An in vitro and in vivo study of PCL/chitosan electrospun mat on polyurethane/propolis foam as a bilayer wound dressing DOI

Mohsen Shie Karizmeh,

Seyed Ali Poursamar, Amirhosein Kefayat

et al.

Biomaterials Advances, Journal Year: 2022, Volume and Issue: 135, P. 112667 - 112667

Published: Jan. 19, 2022

Language: Английский

Citations

77

The phytochemistry of the honeybee DOI
Vassya Bankova, Milena Popova, Boryana Trusheva

et al.

Phytochemistry, Journal Year: 2018, Volume and Issue: 155, P. 1 - 11

Published: July 24, 2018

Language: Английский

Citations

110

Evaluation of the antioxidant profile and cytotoxic activity of red propolis extracts from different regions of northeastern Brazil obtained by conventional and ultrasound-assisted extraction DOI Creative Commons

João Henrique de Oliveira Reis,

Gabriele de Abreu Barreto,

Jamile Costa Cerqueira

et al.

PLoS ONE, Journal Year: 2019, Volume and Issue: 14(7), P. e0219063 - e0219063

Published: July 5, 2019

Propolis is a complex mixture of resinous and balsamic material collected from the exudates plants, shoots, leaves by bees. This study evaluated red propolis extracts obtained conventional (ethanolic) extraction ultrasound-assisted six samples different regions northeastern Brazil. The total phenolic compounds flavonoids, in vitro antioxidant activity, concentration formononetin kaempferol cytotoxicity against four human tumor cell lines were determined for all twelve extracts. Significant variations levels investigated identified extracts, confirming that chemical composition varied according to sampling region. method used also influenced resulting compounds. highest interest activity exhibited state Alagoas. Formononetin samples. concentrations ultrasound, thus indicating greater selectivity this compound method. Regarding cytotoxic HCT-116 line, showed an inhibition than 90%, whereas HL-60 PC3 lines, minimum was 80%. In general, there no significant difference (p>0.05) antiproliferative potential when comparing methods. results Brazilian varies significantly depending on geographical origin influences are present propolis. However, regardless used, studied presented great biological high activity. Furthermore, can be efficiently applied obtain more quickly with biomarkers interest.

Language: Английский

Citations

96

Plants‐Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms DOI Creative Commons
Taiwo O. Elufioye,

Tomayo Ireti Berida,

Solomon Habtemariam

et al.

Evidence-based Complementary and Alternative Medicine, Journal Year: 2017, Volume and Issue: 2017(1)

Published: Jan. 1, 2017

Neuroprotection is the preservation of structure and function neurons from insults arising cellular injuries induced by a variety agents or neurodegenerative diseases (NDs). The various NDs including Alzheimer’s, Parkinson’s, Huntington’s as well amyotropic lateral sclerosis affect millions people around world with main risk factor being advancing age. Each these affects specific and/or regions in brain involves characteristic pathological molecular features. Hence, several vitro vivo study models to each disease have been employed aim understanding their underlying mechanisms identifying new therapeutic strategies. Of most prevalent drug development efforts past few decades, implicated accumulation protein‐based deposits, oxidative stress, neuroinflammation, certain neurotransmitter deficits such acetylcholine dopamine scrutinized great detail. In this review, we presented classical examples plant‐derived neuroprotective highlighting structural class action. Many natural products that shown efficacies appear be working through above‐mentioned key multiple

Language: Английский

Citations

89