Synergistic Effect of Ferroptosis‐Inducing Nanoparticles and X‐Ray Irradiation Combination Therapy

Small, Journal Year: 2024, Volume and Issue: 20(19)

Published: Jan. 26, 2024

Abstract Ferroptosis, characterized by the induction of cell death via lipid peroxidation, has been actively studied over last few years and shown potential to improve efficacy cancer nanomedicine in an iron‐dependent manner. Radiation therapy, a common treatment method, limitations as stand‐alone due radiation resistance safety it affects even normal tissues. Although ferroptosis‐inducing drugs help alleviate resistance, there are no safe that can be considered for clinical application still research stage. Here, effectiveness combined with radiotherapy Fe hyaluronic acid‐based nanoparticles (FHA‐NPs) directly induce ferroptosis, considering applications is reported. Through ferroptosis FHA‐NPs apoptosis X‐ray irradiation, therapeutic efficiency greatly improved both vitro vivo. In addition, Monte Carlo simulations performed assess physical interactions X‐rays iron‐oxide nanoparticle. The study provides deeper understanding synergistic effect irradiation combination therapy. Furthermore, serve valuable reference elucidating role mechanisms

Language: Английский

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Understanding the Novel Approach of Nanoferroptosis for Cancer Therapy

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 2, 2024

As a new form of regulated cell death, ferroptosis has unraveled the unsolicited theory intrinsic apoptosis resistance by cancer cells. The molecular mechanism depends on induction oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage structural integrity Due their high loading tunability, nanocarriers can escort delivery ferro-therapeutics desired site enhanced permeation or retention effect active targeting. This review shed light necessity iron in growth fascinating features regulating cycle metastasis. Additionally, we discussed ferroptosis-mediated therapy using nanoplatforms chemical basis overcoming barriers therapy.

Language: Английский

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Amorphous NiB@IrOx nanozymes trigger efficient apoptosis-ferroptosis hybrid therapy

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 155, P. 575 - 587

Published: Oct. 30, 2022

Language: Английский

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Mussel-inspired “plug-and-play” hydrogel glue for postoperative tumor recurrence and wound infection inhibition

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 650, P. 1907 - 1917

Published: July 25, 2023

Language: Английский

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Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy

Cancers, Journal Year: 2023, Volume and Issue: 15(20), P. 5043 - 5043

Published: Oct. 19, 2023

Ferroptosis is a programmed death mode that regulates redox homeostasis in cells, and recent studies suggest it promising of tumor cell death. regulated by iron metabolism, lipid intracellular reducing substances, which the mechanism basis its combination with photodynamic therapy (PDT). PDT generates reactive oxygen species (ROS) 1O2 through type I II photochemical reactions, subsequently induces ferroptosis Fenton reaction peroxidation membrane lipids. kills cells generating excessive cytotoxic ROS. Due to limited laser depth photosensitizer enrichment, systemic treatment effect not good. Combining can compensate for these shortcomings. Nanoparticles constructed photosensitizers agonists are widely used field therapy, their targeting biological safety be improved modification. These nanoparticles only directly kill but also further exert synergistic activating antitumor immunity, improving hypoxia microenvironment, inhibiting angiogenesis. Ferroptosis-agonist-induced chemotherapy PDT-induced ablation have good clinical application prospects. In this review, we summarize current research progress on how promote each other.

Language: Английский

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Defect engineering to tailor structure-activity relationship in biodegradable nanozymes for tumor therapy by dual-channel death strategies

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 557 - 571

Published: Feb. 3, 2024

Language: Английский

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Mn-phenolic networks as synergistic carrier for STING agonists in tumor immunotherapy

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101018 - 101018

Published: March 11, 2024

The cGAS-STING pathway holds tremendous potential as a regulator of immune responses, offering means to reshape the tumor microenvironment and enhance immunotherapy. Despite emergence STING agonists, their clinical viability is hampered by stability delivery challenges, well variations in expression within tumors. In this study, we present Mn-phenolic networks novel carrier for ADU-S100, hydrophilic agonist, aimed at bolstering These nanoparticles, termed TMA NMs, are synthesized through coordination tannic acid manganese ions, with surface modification involving bovine serum albumin colloidal stability. NMs exhibit pH/GSH-responsive disintegration properties, enabling precise drug release. This effectively addresses issues facilitates efficient intracellular delivery. Importantly, synergistically effects ADU-S100 concurrent release Mn2+, which serves sensitizer pathway, resulting significant activation. Upon systemic administration, these nanoparticles efficiently accumulate activation pathways not only induces immunogenic cell death (ICD) cells but also orchestrates remodeling immunosuppressive microenvironment. includes promotion cytokine release, dendritic maturation, T infiltration, leading pronounced suppression growth. Combining excellent biocompatibility biodegradability, Mn-based nanocarrier represents promising strategy enhancing immunotherapy pathway.

Language: Английский

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A novel oxidative stress- and ferroptosis-related gene prognostic signature for distinguishing cold and hot tumors in colorectal cancer

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 31, 2022

Oxidative stress and ferroptosis exhibit crosstalk in many types of human diseases, including malignant tumors. We aimed to develop an oxidative stress- ferroptosis-related gene (OFRG) prognostic signature predict the prognosis therapeutic response patients with colorectal cancer (CRC). Thirty-four insertion genes between stress-related were identified as OFRGs. then performed bioinformatics analysis expression profiles 34 OFRGs clinical information obtained from multiple datasets. Patients CRC divided into three OFRG clusters, differentially expressed (DEGs) clusters identified. correlated patient survival immune cell infiltration. Prognosis-related DEGs used calculate risk score, a was constructed according score. In this study, low-risk group had better prognosis, higher infiltration levels, responses fluorouracil-based chemotherapy checkpoint blockade therapy than high-risk patients; these results successfully validated independent Thus, could be defined hot tumors cold To further identify potential biomarkers for CRC, levels five adjacent normal tissues verified via vitro experiment. conclusion, we OFRG-related signature, which showed excellent performance predicting CRC. This help distinguish might helpful precise treatment protocols practice.

Language: Английский

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Self-amplified ROS production from fatty acid oxidation enhanced tumor immunotherapy by atorvastatin/PD-L1 siRNA lipopeptide nanoplexes

Biomaterials, Journal Year: 2022, Volume and Issue: 291, P. 121902 - 121902

Published: Nov. 3, 2022

Language: Английский

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Hyperthermia-triggered NO release based on Cu-doped polypyrrole for synergistic catalytic/gas cancer therapy

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 167, P. 463 - 472

Published: June 10, 2023

Language: Английский

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