Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We? DOI Creative Commons

Lylian Ellen Militão dos Santos Xavier,

T. Reis,

Amylly Sanuelly da Paz Martins

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1369 - 1369

Published: Nov. 8, 2024

Inflammatory bowel diseases (IBD) pose a growing public health challenge with unclear etiology and limited efficacy of traditional pharmacological treatments. Alternative therapies, particularly antioxidants, have gained scientific interest. This systematic review analyzed studies from MEDLINE, Cochrane, Web Science, EMBASE, Scopus using keywords like “Inflammatory Bowel Diseases” “Antioxidants.” Initially, 925 publications were identified, after applying inclusion/exclusion criteria—covering July 2015 to June 2024 murine models or clinical trials in humans evaluating natural synthetic substances affecting oxidative stress markers—368 articles included. comprised 344 animal 24 human studies. The most investigated antioxidants polyphenols active compounds medicinal plants (n = 242; 70.3%). found strong link between inflammation IBD, especially on nuclear factor kappa B erythroid 2-related 2 pathways. However, it remains whether occurs first IBD. Lipid peroxidation was the studied damage, followed by DNA damage. Protein damage rarely investigated. relationship gut microbiota examined 103 Human markers scarce, reflecting major research gap IBD treatment. PROSPERO registration: CDR42022335357 CRD42022304540.

Language: Английский

Inhibition of inflammation by berberine: Molecular mechanism and network pharmacology analysis DOI
Kaijun Wang, Jie Yin, Jiayi Chen

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155258 - 155258

Published: Jan. 11, 2024

Language: Английский

Citations

46
Research progress on pharmacological effects and bioavailability of berberine DOI

Yulong Cui,

Quanying Zhou,

Min Jin

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(11), P. 8485 - 8514

Published: June 18, 2024

Language: Английский

Citations

10
Berberine: An inspiring resource for the treatment of colorectal diseases DOI Open Access
Fang Cao,

Weiyang Xia,

Shengcheng Dai

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 167, P. 115571 - 115571

Published: Sept. 25, 2023

Colorectal cancer is a prevalent malignant tumor with complex and diverse pathogenesis. In recent years, natural products have shown promising application prospects as sources of anticancer drugs. BBR, class benzoquinoline alkaloids extracted from various plants, widely used in disease treatments owing to its pharmacological activities, including antibacterial, anti-inflammatory, antioxidant, anticancer, anti-angiogenesis properties. Research has demonstrated that BBR exerts an anti-Salmonella -Escherichia coli infection effect, attenuating inflammatory reactions by inhibiting harmful bacteria. During the stage colorectal precancerous lesions, inhibits activity cell cyclin regulating PI3K/AKT, MAPK, Wnt signaling pathways, thereby decelerating cycle progression polyp or adenoma cells. Moreover, inhibitory effect on primarily occurs through regulation cycle, anti-angiogenesis, gut microbiota, antioxidant pathways. The specific involved pathways include MPK/ERK, NF-kB, EGFR encompassing Bcl-2 family proteins, vascular endothelial growth factor, superoxide dismutase. This study reviews summarizes, for first time, mechanisms action carcinogenesis process cancer, providing novel insights clinical intestinal diseases.

Language: Английский

Citations

18
Nrf2 activation by neferine mitigates microglial neuroinflammation after subarachnoid hemorrhage through inhibiting TAK1-NF-κB signaling DOI Creative Commons

Xiaotian Zhang,

Jun Li, Changchun Cao

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 130, P. 111693 - 111693

Published: March 1, 2024

Oxidative stress and neuroinflammation are two major causes leading to early brain injury after subarachnoid hemorrhage (SAH). Nuclear factor E2-related 2 (Nrf2) is a critical transcription that contributes antioxidant responses. Additionally, Nrf2 could inhibit transforming growth beta-activated kinase 1 (TAK1), which plays vital role in microglial activation-mediated neuroinflammation. Neferine (NE) exhibits considerable protective effects diverse disease models. However, the detailed effect mechanism of NE on SAH remain unknown. Our data showed treatment significantly reduced behavior cognitive impairment, edema period SAH. In addition, mitigated SAH-induced oxidative damage, neuroinflammation, neural death. Moreover, inhibited M1 polarization enhanced M2 phenotype microglia both vivo vitro. Further investigations revealed Nrf2-antioxidant response element (ARE) signaling pathway suppressed TAK1-NF-κB signaling. contrast, depletion by ML385 Nrf2-ARE signaling, induced activation, further promoted polarization. abated neuroprotective against Notably, LPS also aggravated activation reversed beneficial summary, provides protection inhibiting modulating through suppression.

Language: Английский

Citations

7
p-Hydroxy benzaldehyde, a phenolic compound from Nostoc commune, ameliorates DSS-induced colitis against oxidative stress via the Nrf2/HO-1/NQO-1/NF-κB/AP-1 pathway DOI Creative Commons
Meng Liu, Guoqiang Guan, Yuhui Wang

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 133, P. 155941 - 155941

Published: Aug. 6, 2024

Ulcerative colitis (UC), a chronic idiopathic inflammatory bowel disease (IBD), presents with limited current drug treatment options. Consequently, the search for safe and effective UC prevention is imperative. Our prior studies have demonstrated that phenolic compound p-Hydroxybenzaldehyde (HD) from Nostoc commune, effectively mitigates intestinal inflammation. However, mechanisms underlying HD's anti-inflammatory effects remain unclear.

Language: Английский

Citations

7
Extraction optimization and constituent analysis of total flavonoid from Hosta plantaginea (Lam.) Aschers flowers and its ameliorative effect on chronic prostatitis via inhibition of multiple inflammatory pathways in rats DOI
Li Yang, Fengxiang Zhang, Weiwei He

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 318, P. 116922 - 116922

Published: July 27, 2023

Language: Английский

Citations

15
Kuijieling decoction regulates the Treg/Th17 cell balance in ulcerative colitis through the RA/RARα signaling pathway DOI
Suting Xiao, Yizhen Yan,

Mingyin Shao

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 318, P. 116909 - 116909

Published: July 13, 2023

Language: Английский

Citations

14
Formononetin ameliorates dextran sulfate sodium-induced colitis via enhancing antioxidant capacity, promoting tight junction protein expression and reshaping M1/M2 macrophage polarization balance DOI

Qiuping Xiao,

Jiaqi Huang, Xiyan Zhu

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113174 - 113174

Published: Sept. 16, 2024

Language: Английский

Citations

5
Recent developments and new directions in the use of natural products for the treatment of inflammatory bowel disease DOI

Yaqian Feng,

Mengting Pan,

Ruiqiong Li

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155812 - 155812

Published: June 13, 2024

Language: Английский

Citations

4
Anti-Neuroinflammatory Effect of Ombuin from Rhamnus erythroxylon Pall. Leaves in LPS-Induced BV-2 Microglia by Targeting Src and Suppressing the PI3K-AKT/NF-κB Signaling Pathway DOI Open Access
Yanjie Bian, Nan Qiao,

Suyun Han

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8789 - 8789

Published: Aug. 13, 2024

The leaves of Rhamnus erythroxylon Pall. are widely used as tea substitutes in northwest China for their fragrant aroma, anti-irritability, and digestion-enhancing properties. Ombuin, a main flavonoid compound found the leaves, exhibited notable anti-inflammatory antioxidant effects. However, its potential role treating neuroinflammatory-related diseases remains unexplored. Thus, this study aims to evaluate anti-neuroinflammatory effects ombuin explore underlying molecular mechanisms. According our findings, dramatically reduced release interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), IL-1β, nitric oxide (NO), reactive oxygen species (ROS) lipopolysaccharide (LPS)-stimulated BV-2 microglia. Further analysis, including transcriptomics, network pharmacology, docking, cellular heat transfer assays, revealed that Src was direct target ombuin. Western blot analysis showed effectively suppressed phosphorylation inhibited downstream expressions p-PI3K p85, p-AKT1, p-IKKα/β, p-IκBα, nuclear factor κB (NF-κB). Meanwhile, repression significantly reversed activity Our results identified implied exerted an effect by inhibiting suppressing activation PI3K-AKT NF-κB pathways, which might provide alternative therapeutic strategy neurodegenerative diseases.

Language: Английский

Citations

4