Potential Active Marine Peptides as Anti-Aging Drugs or Drug Candidates

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(3), P. 144 - 144

Published: Feb. 23, 2023

Aging is an irreversible physiological process in the human body, and aging characteristics of body that accompany this also lead to many other chronic diseases, such as neurodegenerative diseases represented by Alzheimer’s disease Parkinson’s disease, cardiovascular hypertension, obesity, cancer, so on. The marine environment highly biodiverse, natural active products these organisms constitute a vast treasure trove drugs or drug candidates play essential role prevention treatment, peptide among them have received special attention because their unique chemical properties. Therefore, development compounds anti-aging emerging important research area. This review highlights currently available data on bioactive peptides with potential from 2000 2022 analyzing prevalent mechanisms, critical metabolic pathways well-established multi-omics characteristics, well grouping different biological species lines discussing modalities functional characteristics. Active promising topic explore develop candidates. We expect be instructive for future reveal new directions biopharmaceuticals.

Language: Английский

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Black Goji Berry (Lycium ruthenicum Murray): A Review of Its Pharmacological Activity

Nutrients, Journal Year: 2023, Volume and Issue: 15(19), P. 4181 - 4181

Published: Sept. 27, 2023

Lycium ruthenicum Murray (LRM; commonly known as black goji berry or wolfberry), a plant in the Solanaceae family, grows deserts of China’s Qinghai–Tibet plateau. LRM is widely consumed traditional Chinese medicine, and its fruits are frequently used herbal remedies to treat heart disease, fatigue, inflammation, other conditions. Many studies have reported that rich functional phytochemicals, such anthocyanins polysaccharides, has various pharmacological actions. This article reviews research on biological effects constituents fruits. properties, antioxidant, anti-inflammatory, anti-radiation, immune-enhancing, anti-tumor, protective effects. much promise dietary supplement for preventing many types chronic metabolic disease.

Language: Английский

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Lycium barbarum glycopetide prolong lifespan and alleviate Parkinson’s disease in Caenorhabditis elegans

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: July 4, 2023

Lycium barbarum glycopeptide (LbGp) is the main bioactive compound extracted from traditional Chinese medicine. L. berries and has been proven to have numerous health benefits, including antioxidative, anti-inflammatory, anticancer, cytoprotective activities. However, antiaging effect of LbGp remains unknown.The lifespan body movement C. elegans were used evaluate on span. The thrashing assay was determine role in Parkinson's disease. To investigate mechanisms LbGp-induced effects, we analyzed changes lifespan, movement, expression longevity-related genes a series worm mutants after treatment.We found that treatment prolonged span elegans. Mechanistically, could activate transcription factors DAF-16/FOXO, SKN-1/Nrf2, HSF-1, as well nuclear receptor DAF-12, thereby upregulating achieve extension. In addition, extension induced by partially depends mitochondrial function. Intriguingly, also ameliorated neurodegenerative diseases such disease DAF-16-, SKN-1-, HSF-1-dependent manner.Our work suggests might be viable candidate for prevention aging age-related diseases.

Language: Английский

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Polyphenols as Potential Geroprotectors

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: 40(7-9), P. 564 - 593

Published: Jan. 22, 2024

Significance: Currently, a large amount of evidence beneficial effects diets enriched with polyphenols on various aspects health has been accumulated. These phytochemicals have geroprotective potential slowing down the pathological processes associated aging and ensuring longevity. In this study, comprehensive analysis was conducted to determine adherence individual geroprotector criteria. Data from experimental models, clinical trials, epidemiological studies were analyzed. Recent Advances: Sixty-two described increase life span improve biomarkers in animal models. They act via evolutionarily conserved molecular mechanisms, including hormesis maintenance redox homeostasis, epigenetic regulation, response cellular damage, metabolic control, anti-inflammatory senolytic activity. Epidemiological suggest that certain for prevention treatment diseases, cancer, disorders, cardiovascular conditions humans. Critical Issues: Among reviewed phytochemicals, chlorogenic acid, quercetin, epicatechin, genistein, resveratrol, curcumin identified as compounds highest potential. However, there is lack unambiguous information effectiveness safety increasing span, preventing treating aging-associated diseases Future Directions: Further research needed fully understand considering their long-term consumption, modification bioavailability, complex interactions between different groups other well individuals status. Antioxid. Redox Signal. 40, 564–593. Color images are available online.

Language: Английский

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Establishing healthy longevity clinics in publicly funded hospitals

GeroScience, Journal Year: 2024, Volume and Issue: 46(5), P. 4217 - 4223

Published: March 21, 2024

Abstract Healthy longevity medicine integrates geroscience and other disciplines into clinical settings, aiming to optimize health throughout one’s lifespan. Multiple factors have led increased consumer engagement, with private clinics currently meeting the demand for guidance improve healthy longevity. The establishment of in publicly funded hospitals is a significant development, making longevity-focused healthcare more accessible. These rely on multidisciplinary teams physicians allied professionals. Diagnostics involve comprehensive evaluations medical history, physical examinations, various tests detect early signs age-related functional decline. Interventions encompass lifestyle modifications, supplements, repurposed drugs, social environmental interventions. Collaboration research institutions industry partners crucial advancing creating standardized protocols. In this article, we review process public ensure best possible care individuals pursuing

Language: Английский

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Methylated urolithin A, mitigates cognitive impairment by inhibiting NLRP3 inflammasome and ameliorating mitochondrial dysfunction in aging mice

Neuropharmacology, Journal Year: 2024, Volume and Issue: 252, P. 109950 - 109950

Published: April 16, 2024

Language: Английский

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The connection between aging, cellular senescence and gut microbiome alterations: A comprehensive review

Aging Cell, Journal Year: 2024, Volume and Issue: 23(10)

Published: Aug. 15, 2024

Abstract The intricate interplay between cellular senescence and alterations in the gut microbiome emerges as a pivotal axis aging process, increasingly recognized for its contribution to systemic inflammation, physiological decline, predisposition age‐associated diseases. Cellular senescence, characterized by cessation of cell division response various stressors, induces morphological functional changes within tissues. complexity heterogeneity senescent cells, alongside secretion senescence‐associated secretory phenotype, exacerbate process through pro‐inflammatory pathways influence microenvironment immune system. Concurrently, aging‐associated diversity composition contribute dysbiosis, further exacerbating inflammation undermining integrity bodily functions. This review encapsulates burgeoning research on reciprocal relationship highlighting their collective impact age‐related musculoskeletal diseases, including osteoporosis, sarcopenia, osteoarthritis. It also explores potential modulating targeting innovative strategies healthy mitigating progression aging‐related conditions. By exploring targeted interventions, development senotherapeutic drugs probiotic therapies, this aims shed light novel therapeutic avenues. These leverage connection advance interventions aimed at extending health span improving quality life older population.

Language: Английский

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Exploring human biology with N-of-1 clinical trials

Cambridge Prisms Precision Medicine, Journal Year: 2023, Volume and Issue: 1

Published: Jan. 1, 2023

Abstract Studies on humans that exploit contemporary data-intensive, high-throughput ‘omic’ assay technologies, such as genomics, transcriptomics, proteomics and metabolomics, have unequivocally revealed differ greatly at the molecular level. These differences, which are compounded by each individual’s distinct behavioral environmental exposures, impact individual responses to health interventions diet drugs. Questions about best way tailor individuals based their nuanced genomic, physiologic, behavioral, etc. profiles motivated current emphasis ‘precision’ medicine. This review’s purpose is describe how design execution of N-of-1 (or personalized) multivariate clinical trials can advance field. Such focus from a whole-person perspective, leverage emerging monitoring be used address most relevant questions in precision medicine era. includes validate biomarkers may indicate appropriate activity an intervention well identify likely beneficial for individual. We also argue aggregated ideal vehicles advancing biomedical translational science era since insights gained them not only shed light treat or prevent diseases generally, but provide insight into real-time care very who seeking attention concerns first place.

Language: Английский

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Intestinal stem cell aging at single‐cell resolution: Transcriptional perturbations alter cell developmental trajectory reversed by gerotherapeutics

Aging Cell, Journal Year: 2023, Volume and Issue: 22(5)

Published: March 2, 2023

Abstract The intestinal epithelium consists of cells derived from continuously cycling Lgr5 hi stem (Lgr5 ISCs) that mature developmentally in an ordered fashion as the progress along crypt‐luminal axis. Perturbed function ISCs with aging is documented, but consequent impact on overall mucosal homeostasis has not been defined. Using single‐cell RNA sequencing, progressive maturation progeny was dissected mouse intestine, which revealed transcriptional reprogramming retarded their progression Importantly, treatment metformin or rapamycin at a late stage lifespan reversed effects and subsequent progenitors. overlapped reversing changes profiles were also complementary, more efficient than correcting developmental trajectory. Therefore, our data identify novel daughter contributing to decline epithelial regeneration correction by geroprotectors.

Language: Английский

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Multi-layered effects of Panax notoginseng on immune system

Pharmacological Research, Journal Year: 2024, Volume and Issue: 204, P. 107203 - 107203

Published: May 6, 2024

Recent research has demonstrated the immunomodulatory potential of Panax notoginseng in treatment chronic inflammatory diseases and cerebral hemorrhage, suggesting its significance clinical practice. Nevertheless, complex immune activity various components hindered a comprehensive understanding immune-regulating properties notoginseng, impeding broader utilization. This review evaluates effect to types white blood cells, elucidates underlying mechanisms, compares effects different active fractions, aiming provide theory basis for future investigation.

Language: Английский

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