Tea and coffee polyphenols and their biological properties based on the latest in vitro investigations

Industrial Crops and Products, Journal Year: 2021, Volume and Issue: 175, P. 114265 - 114265

Published: Nov. 18, 2021

Tea and coffee contain numerous polyphenolic compounds that exhibit health-promoting properties for humans, including antioxidant neuroprotective properties, can also take part in the treatment of covid-19 improve fertility. This review, presents activity polyphenols found different types tea describes effects fermentation roasting on their polyphenol composition properties. Polyphenol oxidase is reduced process; therefore black contains significantly less compared to green white tea. Epigallocatechin-3-gallate - a from effectively has been shown inhibit SARS-CoV-2 as it blocked binding coronavirus 2 human angiotensin converting enzyme 2, decreased expression inflammatory factors blood, tumor necrosis factor-α interleukin-6, increased overall fertilization efficiency animals. Coffee process influences both content oxidative activity. The lowest levels active such caffeine, chlorogenic acid acids are identified roasted beans. On other hand, light show strongest cytotoxic potential thus greatest ability decrease apoptosis by stopping cell cycle S phase. Proteins, components milk, strongly bind/interact with phenolic (especially, CGAs) coffee, which may explain negative influence milk its have antiproliferative antiesterase activities, be important prevention cancer neurodegenerative disorders, respectively. In this biological polyphenols, observed mainly vitro studies described. Based these findings, future directions research works suggested.

Language: Английский

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Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview

Antioxidants, Journal Year: 2021, Volume and Issue: 10(4), P. 507 - 507

Published: March 24, 2021

Aging and, particularly, the onset of age-related diseases are associated with tissue dysfunction and macromolecular damage, some which can be attributed to accumulation oxidative damage. Recently, growing interest has emerged on beneficial effects plant-based diets for prevention chronic including obesity, diabetes, cardiovascular disease. Several studies collectively suggests that intake polyphenols their major food sources may exert improving insulin resistance related diabetes risk factors, such as inflammation stress. They most abundant antioxidants in diet, been a reduced aging humans. Polyphenolic shown effective at ameliorating several phenotypes, stress, inflammation, impaired proteostasis, cellular senescence, both vitro vivo. In this paper, these phytochemicals (either pure forms or polyphenolic-food) reviewed summarized according affected signaling pathways. Finally, effectiveness anti-aging preventive action nutritional interventions based rich polyphenolic food, Blue zones, discussed.

Language: Английский

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Resveratrol Improves Boar Sperm Quality via 5′AMP-Activated Protein Kinase Activation during Cryopreservation

Oxidative Medicine and Cellular Longevity, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 15

Published: Sept. 4, 2019

Mammalian sperm is highly susceptible to the reactive oxygen species (ROS) stress caused by biochemical and physical modifications during cryopreservation process. 5′AMP-activated protein kinase (AMPK) involved in regulating both cell metabolism cellular redox status. The aim of present study was investigate whether resveratrol protects boar against ROS via activation AMPK cryopreservation. Boar diluted with freezing medium supplemented at different concentrations (0, 25, 50, 75, 100, 125 μ M). It observed that addition 50 M significantly improved postthaw progressive motility, membrane integrity, acrosome mitochondrial activity, glutathione (GSH) level, activities enzymatic antioxidants (glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase), phosphorylation AMPK. Meanwhile, lipid peroxidation, levels, apoptosis were reduced presence resveratrol. Furthermore, when fresh incubated 30 Compound C (an inhibitor), effects partly counteracted C. These observations suggest promoting phosphorylation. In conclusion, extenders damage for decreasing production improving antioxidative defense system sperm. findings provide novel insights into understanding mechanisms on how protect quality contrary

Language: Английский

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Not every sperm is sacred; a perspective on male infertility

Molecular Human Reproduction, Journal Year: 2018, Volume and Issue: unknown

Published: March 13, 2018

This article is a personal perspective on male infertility, condition that not only extremely prevalent but also major reason for couples to resort ART. The introduction of ICSI as form facilitated fertilization had revolutionary impact our capacity treat cases infertility associated with severely compromised semen quality. However, the widespread use this technique thought pose risks in terms incidence miscarriage, health and wellbeing offspring perpetuation infertile phenotype into future generations. Furthermore, advent curtailed intellectual interest underlying aetiology or development non-invasive therapeutic strategies target patient rather than physical deployment his gametes. As consequence, progress elucidating pathological mechanisms responsible has been slow. Genetic and/or epigenetic defects are certainly involved many may involve mutations/splicing affecting integrity testicular RNA profile, well overall kinetics transcription process. In addition, spermatogenesis disrupted by variety factors (age, smoking, obesity) which influence fertility sperm DNA through creation oxidative stress. Determining relative contributions stress genetic/epigenetic mutations will be focus research important neglected area

Language: Английский

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A Comprehensive Insight on the Health Benefits and Phytoconstituents of Camellia sinensis and Recent Approaches for Its Quality Control

Antioxidants, Journal Year: 2019, Volume and Issue: 8(10), P. 455 - 455

Published: Oct. 6, 2019

Tea, Camellia sinensis, which belongs to the family Theaceae, is a shrub or evergreen tree up 16 m in height. Green tea very popular because of its marked health benefits comprising anticancer, anti-oxidant, and antimicrobial activities, as well effectiveness reducing body weight. Additionally, it was recognized by Chinese people an effective traditional drink required for prophylaxis against many ailments. This due complex chemical composition green tea, comprises different classes compounds, such polyphenols, alkaloids, proteins, minerals, vitamins, amino acids, others. The beneficial effects ultimately led great consumption increase liability be adulterated either low-quality non-green products with concomitant decrease activity. Thus, this review, selected highlight phytoconstituents, recent approaches quality-control monitoring that guarantee incorporation pharmaceutical industries. More research needed find out other more biological active constituents, simple cheap techniques quality assurance ascertain prevention adulteration.

Language: Английский

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Polyphenols in Farm Animals: Source of Reproductive Gain or Waste?

Antioxidants, Journal Year: 2020, Volume and Issue: 9(10), P. 1023 - 1023

Published: Oct. 21, 2020

Reproduction is a complex process that substantially affected by environmental cues, specifically feed/diet and its components. Farm animals as herbivorous are exposed to large amount of polyphenols present in their natural feeding system, alternative feed resources (shrubs, trees, agro-industrial byproducts), polyphenol-enriched additives. Such exposure has increased because the well-known antioxidant properties polyphenols. However, date, argumentation around impacts on reproductive events debatable. Accordingly, intensive inclusion diets breeding media for assisted techniques needs further investigation, avoiding any source waste achieving maximum benefits. This review illustrates recent findings connecting dietary consumption from different sources (conventional unconventional feeds) with performance farm animals, underpinned vitro studies this field. update will help formulating proper diets, optimizing introduction new plant species, additives improving function, possible wastes maximizing

Language: Английский

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Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review

Nutrients, Journal Year: 2018, Volume and Issue: 10(7), P. 834 - 834

Published: June 27, 2018

Sperm cells are highly sensitive to reactive oxygen species (ROS), which produced during cellular oxidation. In normal cell biology, ROS levels increase with a decreasing antioxidant response, resulting in oxidative stress threatens sperm biology. Oxidative has numerous effects, including increased apoptosis, reduced motion parameters, and integrity. this regard, green tea polyphenols (GrTPs) have been reported possess properties that may the quality of male female gametes, mostly via capability catechins reduce production. GrTPs improve major semen such as concentration, motility, morphology, DNA damage, fertility rate, gamete quality. These unique could reproductive health represent an important study area. This exploratory review discusses therapeutic effects against infertility, their possible mechanisms action, recommended supportive therapy for improving humans animals.

Language: Английский

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Preservation of boar semen: An update

Reproduction in Domestic Animals, Journal Year: 2018, Volume and Issue: 54(3), P. 423 - 434

Published: Dec. 8, 2018

Contents In the pork industry, artificial insemination and storage of boar semen in liquid at 17°C are routinely applied to optimize ejaculate bring about rapid genetic changes that reflected animal protein. Although results satisfactory, they below what occurs with natural mating. It is currently possible preserve slow freezing, since date there only one study on vitrification, negative applicable case implementing an intracytoplasmic sperm injection. both methods due sensitivity osmotic temperature changes, a loss quality initial sample; however, freezing has greater deleterious effects sample pregnancy rates number live births. Therefore, 1% all inseminations done frozen semen. The aim this review provide advances studies conducted preservation semen, delving more deeply into critical points each techniques presents, including bacterial contamination, extender components, temperature, ice nucleation, use additives extenders main quality.

Language: Английский

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Environment and Male Fertility: Effects of Benzo-α-Pyrene and Resveratrol on Human Sperm Function In Vitro

Journal of Clinical Medicine, Journal Year: 2019, Volume and Issue: 8(4), P. 561 - 561

Published: April 25, 2019

Lifestyle, cigarette smoking and environmental pollution have a negative impact on male fertility. Therefore, the aim of this study was to evaluate in-vitro effects benzo-α-pyrene (BaP) aryl hydrocarbon receptor (AHR) agonists motility bio-functional sperm parameters. We further assessed whether resveratrol (RES), an AHR antagonist antioxidant molecule, had any protective effect. To accomplish this, 30 normozoospermic, healthy, non-smoker men not exposed BaP were enrolled. Spermatozoa 15 incubated with increasing concentrations its effect establish dose response. Then, spermatozoa other (15 µM/mL), chosen according dose-response and/or RES antagonistic effects. The both substances evaluated after 3 h incubation total progressive following parameters by flow cytometry: Degree chromatin compactness, viability, phosphatidylserine externalization (PS), late apoptosis, mitochondrial membrane potential (MMP), DNA fragmentation, degree lipoperoxidation (LP), superoxide anion. Benzo-α-pyrene decreased motility, impaired increased anion levels. All these statistically significant at lowest concentration tested µM/mL) they confirmed 45 µM/mL. In turn, able counteract detrimental abnormal lipid peroxidation, superoxide. This showed that alters exerts BaP-induced damage.

Language: Английский

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Improving the quality of cryopreserved goat semen with a commercial bull extender supplemented with resveratrol

Animal Reproduction Science, Journal Year: 2019, Volume and Issue: 208, P. 106127 - 106127

Published: July 17, 2019

Language: Английский

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