Advances in the Potential of Quinoline‐Derived Metal Complexes as Antimalarial Agents: A Review DOI Open Access
Carla Peron, Raoni S. B. Gonçalves, Sidnei Moura

et al.

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 11, 2025

ABSTRACT Quinolines obtained from native trees of South and Central America, the genus Cinchona , have been used since 17th century for treatment malaria. However, it was only in 1820 that quinine had its structure elucidated, subsequently, during 20th century, several synthetic derivatives were produced with superior activities. In parallel, search synthesis metal complex compounds malaria dates 1994, development ferroquine, an iron derived chloroquine, developed by Biot collaborators at Lille University. After, there are complexes synthesized various metals, such as ruthenium, gold, iridium, platinum, over last 30 years, which aims this review. This review identified 84 quinoline–metal reported across 25 studies, gold (Complex 63) showing significant potency against FcBI strain (IC 50 10 nM), outperforming chloroquine (CQ, indicating coordination enhances drug's action. The ruthenium 03) exhibited activity PFB but less effective than CQ 22.5 vs. 8.2 nM). Other complexes, Au(III) 61), Ir(I) 52), Ir(II) 50), also demonstrated promising results varying effectiveness different strains. Structural features, including linear geometry Au(I) square planar or piano stool geometries Ru(II) Ir play crucial roles influencing their biological activity. These findings highlight potential improving antimalarial efficacy.

Language: Английский

It Is Not All about the Ligands: Exploring the Hidden Potentials of tBu3P through Its Oxidative Addition Complex as the Precatalyst DOI

Yam N. Timsina,

Guolin Xu, Thomas J. Colacot

et al.

ACS Catalysis, Journal Year: 2023, Volume and Issue: 13(12), P. 8106 - 8118

Published: June 1, 2023

A series of oxidative addition complexes with a general formula (tBu3P)Pd(Ar)X, as class precatalysts, were synthesized for challenging Suzuki–Miyaura coupling involving partners, such (i) sensitive polyfluorinated arylboronic acids or their corresponding boronic esters, (ii) sterically hindered electrophiles, and (iii) nucleophiles. total 89 examples are reported, which 39 in the Supporting Information. These particular (tBu3P)Pd(4-CF3Ph)Br, demonstrated to be powerful catalytic systems cross reactions comparison situ created by mixing tBu3P ligand palladium precursor. The precatalysts also superior other monoligated systems, Buchwald's biaryl based G3 G4 palladacycles. In addition, (tBu3P)Pd(4-CF3Ph)Br precatalyst is highly effective second most popular reaction, namely Buchwald–Hartwig coupling. this study, electron-deficient amines coupled (hetero)aryl bromides chlorides 34 examples, 8 Interestingly, results obtained both C–C C–N couplings on par that "state-of-the-art" catalysts containing Ad3P Np3P ligands same similar substrates, suggesting it not all about ligands.

Language: Английский

Citations

14
Metal‐(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple‐Negative Breast Cancer DOI
Svetlana A. Katkova, Alexander S. Bunev, Rovshan Е. Gasanov

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(28)

Published: Feb. 16, 2024

Abstract Hydrolytically stable Pd II and Pt complexes supported by acyclic diaminocarbene ligands represent a novel class of structural organometallic anticancer agents exhibiting nanomolar antiproliferative activity in panel cancer cell lines (IC 50 0.07–0.81 μ M) up to 300‐fold selectivity for cells over normal primary fibroblasts. The lead drug candidate was 300 times more potent than cisplatin vitro showed higher efficacy reducing the growth aggressive MDA‐MB‐231 xenograft tumors mice.

Language: Английский

Citations

5
Design, structural characterization, DFT, molecular docking, and chemotherapeutic activity of novel platinum(II) and palladium(II) complexes derived from Metformin-based Schiff base DOI
Safaa Shawky Hassan,

Eman F. Mohamed,

Aml M. Saleh

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1315, P. 138830 - 138830

Published: June 4, 2024

Language: Английский

Citations

5
Antibody Drug Conjugates for Cancer Therapy: From Metallodrugs to Nature-Inspired Payloads DOI Open Access
Giovanni Tonon, Flavio Rizzolio, Fabiano Visentin

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8651 - 8651

Published: Aug. 8, 2024

This review highlights significant advancements in antibody–drug conjugates (ADCs) equipped with metal-based and nature-inspired payloads, focusing on synthetic strategies for antibody conjugation. Traditional methods such us maleimide succinimide conjugation classical condensation reactions are prevalent metallodrugs natural compounds. However, emerging non-conventional as photoconjugation gaining traction due to their milder conditions and, an aspect which minimizes side reactions, selective formation of ADC. The also summarizes the therapeutic diagnostic properties these ADCs, highlighting enhanced selectivity reduced effects cancer treatment compared non-conjugated payloads. ADCs combine specificity monoclonal antibodies cytotoxicity chemotherapy drugs, offering a targeted approach elimination cells while sparing healthy tissues. mechanism has demonstrated impressive clinical efficacy various malignancies. Key future include improved linker technology stability controlled release cytotoxic agents, incorporation novel, more potent, identification new cancer-specific antigens through genomic proteomic technologies. expected play crucial role combination therapies immune checkpoint inhibitors, CAR-T cells, small molecule leading durable potentially curative outcomes. Ongoing research trials expanding capabilities, paving way effective, safer, personalized treatments, positioning cornerstone modern medicine hope patients.

Language: Английский

Citations

5
Review about Powerful Combinations of Advanced and Hyphenated Sample Introduction Techniques with Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) for Elucidating Trace Element Species in Pathologic Conditions on a Molecular Level DOI Open Access
Bernhard Michalke

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(11), P. 6109 - 6109

Published: May 29, 2022

Element analysis in clinical or biological samples is important due to the essential role diagnostics, drug development, and drug-effect monitoring. Particularly, specific forms of element binding, actual redox state, their spatial distribution tissue single cells are interest medical research. This review summarized exciting combinations sophisticated sample delivery systems hyphenated inductively coupled plasma-mass spectrometry (ICP-MS), enabling a broadening information beyond well-established outstanding detection capability. Deeper insights into pathological disease processes intracellular active substances were provided, better understanding dynamics. Examples presented from elemental mapping tissue, cells, spheroids, also considering tagging. The use natural artificial tags for monitoring was shown. In context oxidative stress ferroptosis iron, speciation gained importance. Quantification methods Fe2+, Fe3+, ferritin-bound iron introduced. Wilson’s disease, free exchangeable copper play decisive roles; respective paragraph provided about Cu techniques, which provide fast reliable quantification. Finally, cell ICP-MS provides highly valuable on cell-to-cell variance, uptake metal-containing drugs, accumulation release single-cell level.

Language: Английский

Citations

22
Antiproliferative evaluation and supramolecular properties of a Pd(II) complex harvested from benzil bis(pyridyl hydrazone) ligand: Combined experimental and theoretical studies DOI
Suman Adhikari,

Afzal Hussain Sheikh,

Nabajyoti Baildya

et al.

Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 152, P. 110646 - 110646

Published: March 28, 2023

Language: Английский

Citations

13
Gold(I)‐N‐Heterocyclic Carbene Synthons in Organometallic Synthesis DOI
Thomas Scattolin, Giovanni Tonon, Eleonora Botter

et al.

Chemistry - A European Journal, Journal Year: 2023, Volume and Issue: 29(58)

Published: July 18, 2023

The prominent role of gold-N-heterocyclic carbene (NHC) complexes in numerous research areas such as homogeneous (photo)catalysis, medicinal chemistry and materials science has prompted organometallic chemists to design gold-based synthons that permit access target through simple synthetic steps under mild conditions. In this review, the main gold-NHC employed synthesis are discussed. Mechanistic aspects involved their reactivity well applications efficient pre-catalysts, antitumor agents and/or photo-emissive presented.

Language: Английский

Citations

12
The current status in computational exploration of Pt(iv) prodrug activation by reduction DOI Creative Commons
Fortuna Ponte, Stefano Scoditti, Gloria Mazzone

et al.

Physical Chemistry Chemical Physics, Journal Year: 2023, Volume and Issue: 25(23), P. 15586 - 15599

Published: Jan. 1, 2023

This perspective focuses on computational studies for the reduction mechanism of octahedral Pt IV complexes to afford active II species. All plausible pathways depending specific axial leaving ligands and reducing agents were addressed.

Language: Английский

Citations

11
Survey of Main Group Metals and Metalloids in Cancer Treatment DOI Creative Commons
Irena Kostova

Inorganics, Journal Year: 2024, Volume and Issue: 12(1), P. 29 - 29

Published: Jan. 12, 2024

Cancer is one of the leading causes human death among all major diseases. Metal-based complexes are considered as most promising vital part in existing arsenal cytotoxic candidates used cancer therapy and diagnostics. The efforts many scientific groups resulted development numerous metal-based compounds featuring different biologically active organic ligands order to modulate their bioactivity. Along with main representatives potential therapeutic agents, such Pt(II)/Pt(IV), Pd(II), Ru(II)/Ru(III), Ag(I), Au(I)/Au(III), Ti(IV), V(IV) Ga(III), other transition metal lanthanide possessing antiproliferative activity widely discussed literature. However, drugs remain outside scope this review. purpose current study review group metal- metalloid-based against common cell types, carcinomas (lung, liver, breast, kidney, gastric, colorectal, bladder, ovarian, cervical, prostate, etc.); sarcomas; blastomas; lymphomas; multiple myeloma; melanoma. Overcoming long disregard organometallic metals metalloids from groups, a growing number emerging anticancer agents remarkably prove field offers an extensive variety new options for design innovative unexplored chemopharmaceutics. Moreover, some these elements can exhibit entirely different, specific modes action biological targets. Obviously, exploitation distinct properties deserves more attention.

Language: Английский

Citations

4
Palladium(II)‐Imidoyl Complexes: A New Piece in the Puzzle of Organopalladium Anticancer Agents DOI
Enrica Bortolamiol,

Sofia Novaselich,

Chiara Tupini

et al.

European Journal of Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 27(8)

Published: Jan. 25, 2024

Abstract Our search of new organopalladium compounds able to promote an effective antiproliferative action towards ovarian cancer cells continues. In this paper we have examined for the first time anticancer activity palladium imidoyl complexes, which two different types phosphines been chosen as ancillary ligands: i) PTA and DAPTA take advantage from their solubility in aqueous environment, ii) dppf combining Pd‐imidoyl fragment with that, well‐known, ferrocene. The synthetic protocols well exhaustive characterisation complexes through spectroscopic diffractometric methods are described. vitro tests carried out assess cytotoxicity cell lines (one cisplatin sensitive other resistant) revealed interesting effect halide coordinated centre (halogen effect). Moreover, all shown same against cisplatin‐sensitive (A2780) cisplatin‐resistant (A2780 cis ) lines, suggesting a mode respect “classical” platinum‐based drugs. Finally, selection most active has selectivity cells.

Language: Английский

Citations

4