International Journal of Nursing Studies, Journal Year: 2024, Volume and Issue: 161, P. 104923 - 104923
Published: Oct. 3, 2024
Language: Английский
Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(9), P. 1603 - 1612
Published: Aug. 21, 2023
Abstract Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, long-term effects of adversity on structure association individual neurobiological heterogeneity with behavior have yet be elucidated. Here we estimated normative models structural development based a lifespan profile longitudinal at-risk cohort aged 25 years ( n = 169). This revealed widespread morphometric changes brain, partially adversity-specific features. pattern was replicated at age 33 114) independent sample 22 115). At level, greater volume contractions relative model were predictive future anxiety. We show stable signature that persists into adulthood emphasize importance considering individual-level rather than group-level predictions explain emerging psychopathology.
Language: Английский
Citations
36
Development and Psychopathology, Journal Year: 2023, Volume and Issue: 35(5), P. 2444 - 2463
Published: June 7, 2023
Abstract This study expanded the Benevolent Childhood Experiences scale (termed “BCEs-Original” scale) with 10 new multisystem items and identified a subset of “BCEs-Revised” that are systematically less commonly reported across samples. Total BCEs-Revised scores were tested against total BCEs-Original three dimensions childhood adversity (maltreatment, threat, deprivation) as predictors young adulthood mental health problems (depression, anxiety, PTSD symptoms). Hypotheses expected stronger inverse associations than all problems. Participants 1,746 U.S. adults ( M = 26.6 years, SD 4.7, range 19–35 years; 55.3% female, 42.4% male, 2.3% gender non-conforming; 67.0% White, 10.3% Asian, 8.6% Black, 8.4% Latine, 5.7% other) who completed 20-item BCEs well-validated instruments on adversities Compared to scores, significantly more strongly inversely associated outcomes. threat deprivation, maltreatment was symptoms. After controlling for current depression symptoms, interacted predict Maltreatment also influenced symptoms in person-oriented analyses. The has strong psychometric properties unique strengths research practice. Implications resilience discussed.
Language: Английский
Citations
31
Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 152, P. 105297 - 105297
Published: June 28, 2023
Language: Английский
Citations
20
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: June 30, 2023
Exposure to any number of stressors during the first 1000 days from conception age 2 years is important in shaping an individual’s life trajectory health and disease. Despite expanding range as well later-life phenotypes outcomes, underlying molecular mechanisms remain unclear. Our previous data strongly suggests that early-life exposure a stressor reduces capacity immune system generate subsequent generations naïve cells, while others have shown that, early stress impairs neuronal stem cells proliferate they age. This leads us “stem cell hypothesis” whereby adversity sensitive period acts through common mechanism all types by programming tissue resident progenitor cells. Furthermore, we review mechanistic differences observed fully differentiated suggest (ELA) may alter mitochondria consequently destiny these producing lifelong “supply” functionally altered
Language: Английский
Citations
17
Journal of Psychiatric Research, Journal Year: 2023, Volume and Issue: 169, P. 364 - 377
Published: Nov. 29, 2023
Language: Английский
Citations
17
Translational Psychiatry, Journal Year: 2022, Volume and Issue: 12(1)
Published: Oct. 4, 2022
Abstract Adverse childhood experiences have been consistently linked with physical and mental health disorders in adulthood that may be mediated, part, via the effects of such exposures on biological aging. Using recently developed “epigenetic clocks”, which provide an estimate age, several studies demonstrated a link between cumulative exposure to adversities accelerated epigenetic However, not all are equivalent less is known about how distinct dimensions adversity relate aging metrics. two measures exposure, we assess Maltreatment Household Dysfunction using “second-generation” clocks, GrimAge PhenoAge, cohort unmedicated somatically healthy adults moderate severe major depression ( n = 82). Our results demonstrate dimension associated age acceleration (EAA) PhenoAge but clock. This association was observed both Childhood Trauma questionnaire (CTQ; β 0.272, p 0.013 ) Experiences (ACEs) (β 0.307, 0.005 remained significant when adjusting for 0.322, 0.009 ). In contrast, deceleration −0.194, 0.083 achieved significance after −0.304, 0.022 study first investigate these among individuals Major Depressive Disorder suggests disease mechanisms.
Language: Английский
Citations
25
Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 350, P. 721 - 727
Published: Jan. 23, 2024
Language: Английский
Citations
6
The Lancet Psychiatry, Journal Year: 2024, Volume and Issue: 11(9), P. 720 - 730
Published: Aug. 13, 2024
Cognitive deficits might contribute to the elevated risk of life-course psychopathology observed in maltreated children. Leading theories about links between childhood maltreatment and cognitive focus on documented exposures (objective experience), but empirical research has largely relied retrospective self-reports these experiences (subjective two measures identify non-overlapping groups. We aimed test associations objective subjective with abilities within same individuals.
Language: Английский
Citations
6
Development and Psychopathology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 19
Published: Jan. 10, 2024
Abstract Childhood maltreatment (CM) is experienced by ∼40% of all children at major personal and societal costs. The divergent associations between emotional, physical, sexual abuse or neglect in childhood differences adult emotional functioning regulation were examined terms daily emotion intensity, variability, instability, inertia, diversity, reported over 30 days 290 Dutch aged 19-73. Participants described their abuse/neglect experiences retrospectively using the Trauma Questionnaire (CTQ). Dissecting CM effects on dynamics may inform theories ontogenesis emotions, neglect, to better understand (dys)functional development, prevent adverse sequelae. Structural equation models (SEM) showed that most types associated with specific patterns dynamics, only had no unique dynamic indices. Emotional was measures (i.e., less intense, variable, unstable, diverse emotions). Sexual increases physical decreases negative affect variability instability. Physical inertia but a small effect size. Social contact frequency did not mediate much relationship dynamics.
Language: Английский
Citations
5
Development and Psychopathology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 31
Published: April 8, 2024
Growing evidence supports the unique pathways by which threat and deprivation, two core dimensions of adversity, confer risk for youth psychopathology. However, extent to these differ in their direct associations with psychopathology remains unclear. The primary aim this preregistered meta-analysis was synthesize between threat, internalizing, externalizing, trauma-specific Because is proposed be directly linked socioemotional development, we hypothesized that magnitude would larger than those deprivation. We conducted a search peer-reviewed articles English using PubMed PsycINFO databases through August 2022. Studies assessed both deprivation used previously validated measures were included. One hundred twenty-seven included synthesis (
Language: Английский
Citations
5