Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Small, Journal Year: 2021, Volume and Issue: 18(6)

Published: Nov. 2, 2021

Abstract Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in tumor region, was first proposed by Bu, Shi, and co‐workers 2016. Recently, with rapid development of nanomaterials, CDT has attracted tremendous attention because its unique advantages: 1) It is tumor‐selective low side effects; 2) process does not depend on external field stimulation; 3) it can modulate hypoxic immunosuppressive microenvironment; 4) cost low. In addition Fe‐involved strategies, reaction‐mediated strategies have also been proposed, which are based many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, zinc. Moreover, combined therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, immunotherapy for achieving enhanced anticancer effects. Besides, there studies that extend application antibacterial field. This review introduces latest advancements nanomaterials‐involved from 2018 present proposes current limitations well future research directions related

Language: Английский

---

Advanced biotechnology-assisted precise sonodynamic therapy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(20), P. 11227 - 11248

Published: Jan. 1, 2021

Herein, we provide the enhancement of SDT effect through elaborate strategies including design and modification sonosensitizers, combination other therapy modalities, molecular imaging-guided for precise treatment.

Language: Английский

---

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(48)

Published: Sept. 27, 2021

Chemodynamic therapy (CDT) uses the tumor microenvironment-assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective treatment. However, limited efficiency restricts therapeutic efficacy of CDT. Recent years have witnessed impressive development various strategies increase reaction. The introduction these reinforcement can dramatically improve treatment CDT and further promote enhanced (ECDT)-based multimodal anticancer treatments. In this review, authors systematically introduce strategies, from their basic working principles, mechanisms representative clinical applications. Then, ECDT-based is discussed, including how integrate emerging accelerating therapy, as well synergistic ECDT other methods. Eventually, future direction challenges therapies are elaborated, highlighting key scientific problems unsolved technical bottlenecks facilitate translation.

Language: Английский

---

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(22)

Published: March 8, 2021

Abstract Triggered by the endogenous chemical energy in tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non‐exogenous stimulant therapeutic modality has received increasing attention recent years. The agents can convert internal hydrogen peroxide (H 2 O ) into lethal reactive oxygen species (ROS) hydroxyl radicals ( • OH) for oncotherapy. Compared with other modalities, CDT possesses many notable advantages, such tumor‐specific, highly selective, fewer systemic side effects, and no need external stimulation. Nevertheless, mild acid pH, low H content, overexpressed reducing substance TME severely suppressed efficiency. With rapid development of nanotechnology, some kinds nanomaterials have been utilized improved In particular, excellent photo‐, ultrasound‐, magnetic‐, stimuli‐response properties make it possible combination cancer shown superior anti‐cancer activity than monotherapies. Therefore, is necessary to summarize application nanomaterial‐based therapy. this review, various nanomaterials‐based nanoplatforms its combinational therapies are summarized discussed, aiming provide inspiration design better‐quality promote lay foundation future conversion clinical applications.

Language: Английский

---

2D Piezoelectric Bi₂MoO₆ Nanoribbons for GSH‐Enhanced Sonodynamic Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(51)

Published: Oct. 16, 2021

Abstract Reducing the scavenging capacity of reactive oxygen species (ROS) and elevating ROS production are two primary goals developing novel sonosensitizers for sonodynamic therapy (SDT). Hence, ultrathin 2D Bi 2 MoO 6 –poly(ethylene glycol) nanoribbons (BMO NRs) designed as piezoelectric glutathione (GSH)‐enhanced SDT. In cancer cells, BMO NRs can consume endogenous GSH to disrupt redox homeostasis, GSH‐activated (GBMO) exhibit an oxygen‐deficient structure, which promote separation electron–hole pairs, thereby enhancing efficiency in The GBMO piezoelectric, ultrasonic waves introduce mechanical strain nanoribbons, resulting polarization band tilting, thus accelerating toxic production. as‐synthesized enable excellent computed tomography imaging tumors significant tumor suppression vitro vivo. A sonosensitizer‐mediated two‐step enhancement SDT process, is activated by amplified exogenous ultrasound, proposed. This process not only provides new options improving but also broadens application materials

Language: Английский

---

Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 30, 2022

Theranostic sonosensitizers with combined sonodynamic and near infrared (NIR) imaging modes are required for guided therapy (SDT). It is challenging, however, to realize a single material that simultaneously endowed both NIR emitting activities. Herein, we report the design of class NIR-emitting from phosphorescent carbon dot (CD) narrow bandgap (1.62 eV) long-lived excited triplet states (11.4 μs), two which can enhance SDT as thermodynamically dynamically favorable factors under low-intensity ultrasound irradiation, respectively. The NIR-phosphorescent CDs identified bipolar quantum dots containing p- n-type surface functionalization regions drive spatial separation e--h+ pairs fast transfer reaction sites. Importantly, cancer-specific targeting high-level intratumor enrichment theranostic achieved by cancer cell membrane encapsulation precision complete eradication solid tumors injection irradiation. These results will open up promising approach engineer materials tumor therapy.

Language: Английский

---

Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: Jan. 12, 2023

Abstract Emerging piezocatalysts have demonstrated their remarkable application potential in diverse medical fields. In addition to ultrahigh catalytic activities, inherent and unique charge‐carrier‐releasing properties can be used initiate various redox reactions, displaying bright prospects for future applications. Triggered by mechanical energy, piezocatalytic materials release electrons/holes, catalyze reactions of substrates, or intervene biological processes promote the production effector molecules purposes, such as decontamination, sterilization, therapy. Such a piezocatalysis is termed medicine (PCM) herein. To pioneer novel technologies, especially therapeutic modalities, this review provides an overview state‐of‐the‐art research progress medicine. First, principle preparation methodologies piezoelectric are introduced. Then, comprehensive summary applications tumor treatment, antisepsis, organic degradation, tissue repair regeneration, biosensing provided. Finally, main challenges perspectives discussed proposed, expecting fuel development emerging scientific discipline.

Language: Английский

---

Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry

Chemical Science, Journal Year: 2021, Volume and Issue: 13(4), P. 863 - 889

Published: Nov. 29, 2021

Applying Fenton chemistry in the tumor microenvironment (TME) for cancer therapy is most significant feature of chemodynamic (CDT). Owing to mild acid and overexpressed H2O2 TME, more cytotoxic hydroxyl radicals (˙OH) are generated cells via Fenton-like reactions. Without external stimulus drug resistance generation, reactive oxygen species (ROS)-mediated CDT exhibits a specific desirable anticancer effect has been seen as promising strategy therapy. However, optimizing treatment efficiency TME still challenging because limited catalytic agents strong antioxidant capacity TME. Hence, scientists trying their best design fabricate many with excellent activity remodeling optimal CDT. In this perspective, latest progress discussed, some representative examples presented. Consequently, strategies further guided by provided. Most importantly, several feasible ways developing future offered reference.

Language: Английский

---

Single-Atom Catalysis for Efficient Sonodynamic Therapy of Methicillin-Resistant Staphylococcus aureus-Infected Osteomyelitis

ACS Nano, Journal Year: 2021, Volume and Issue: 15(6), P. 10628 - 10639

Published: June 4, 2021

Osteomyelitis, as a severe bone disease caused by bacterial infection, can result in lifelong disability or fatal sepsis. Considering that the infection is stubborn and deep-sited tissue, situ rapid treatments for osteomyelitis remain significant challenge. Herein, we prepare an ultrasound (US)-activated single-atom catalyst consists of Au nanorod (NRs)-actuated single-atom-doped porphyrin metal–organic framework (HNTM-Pt@Au) red cell membrane (RBC), which efficiently treat methicillin-resistant Staphylococcus aureus (MRSA)-infected under US. Besides outstanding performance field photocatalysis, find single atoms (such Pt, Au, Cu) also improve sonocatalytic ability sonosensitizer. Due to strong electron-trapping oxygen adsorption capacity, Pt atom endows RBC-HNTM-Pt@Au with excellent activity. It shows antibacterial efficiency 99.9% toward MRSA 15 min US irradiation. Meanwhile, be propelled directionally thus dynamically neutralize secreted toxins. The MRSA-infected rat tibia was successfully treated, negligible loss, reduced inflammation response, great biocompatibility. This work presents efficient sonodynamic therapy treatment deep tissue infections via multifunctional catalyst.

Language: Английский

---

Piezotronic Effect-Augmented Cu_2–xO–BaTiO₃ Sonosensitizers for Multifunctional Cancer Dynamic Therapy

ACS Nano, Journal Year: 2022, Volume and Issue: 16(6), P. 9304 - 9316

Published: June 14, 2022

Ultrasound (US)-triggered sonodynamic therapy (SDT) based on semiconductor nanomaterials has attracted considerable attention for cancer therapy. However, most inorganic sonosensitizers suffer from low efficiency due to the rapid recombination of electron-hole pairs. Herein, Cu2-xO-BaTiO3 piezoelectric heterostructure was fabricated as a sonosensitizer and chemodynamic agent, simultaneously, improving reactive oxygen species (ROS) generation therapeutic outcome. Under US irradiation, heterojunction with piezotronic effect exhibits high-performance singlet (1O2) hydroxyl radical (•OH) enhance SDT. Moreover, it possesses Fenton-like reaction activity convert endogenous H2O2 into •OH (CDT). The integration SDT CDT substantially boosts ROS cellular mitochondria damage, in vitro vivo results demonstrate high cytotoxicity tumor inhibition murine refractory breast cancer. This work realizes improvement using heterostructures effects.

Language: Английский

---