Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 23, 2023

The exogenous excitation requirement and electron-hole recombination are the key elements limiting application of catalytic therapies. Here a tumor microenvironment (TME)-specific self-triggered thermoelectric nanoheterojunction (Bi0.5Sb1.5Te3/CaO2 nanosheets, BST/CaO2 NSs) with self-built-in electric field facilitated charge separation is fabricated. Upon exposure to TME, CaO2 coating undergoes rapid hydrolysis, releasing Ca2+, H2O2, heat. resulting temperature difference on BST NSs initiates effect, driving reactive oxygen species production. H2O2 not only serves as substrate supplement for ROS generation but also dysregulates Ca2+ channels, preventing efflux. This further exacerbates calcium overload-mediated therapy. Additionally, promotes DC maturation antigen presentation, facilitating immunotherapy. It worth noting that NP hydrolyzes very slowly in normal cells, O2 without causing any adverse effects. Tumor-specific combined therapy, ion interference immunotherapy exhibit excellent antitumor performance female mice.

Language: Английский

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External physical field‐driven nanocatalytic cancer therapy

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Feb. 14, 2023

Abstract Recently, variable nanocatalysts have provided novel, highly selective, minimally invasive strategies driven by external physical fields for cancer therapy. In the catalytic reaction, less toxic or nontoxic substances can be in situ converted into agents suppression. this review, we systematically summarize therapy based on different types of fields, including light, ultrasound, electricity, temperature, X‐ray, magnetic field, and microwave. The properties, mechanisms, advantages corresponding are also introduced. Importantly, considering rapid development nanomedicine, research progress is discussed. Finally, remaining challenges outlooks that faced outlined. We believe emerging fields‐driven nanocatalytic will provide a new avenue treatment.

Language: Английский

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Self‐Driven Electricity Modulates d‐Band Electrons of Copper Single‐Atom Nanozyme for Boosting Cancer Therapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(48)

Published: July 21, 2023

Abstract Single‐atom nanozymes (SAzymes) are considered as the most promising candidates for natural enzymes due to their atomically dispersed active sites that closely resemble metal centers of counterparts. However, a significant challenge still exists improving catalytic activities, retarding practical applications. Herein, this article presents through application human self‐driven triboelectric device impose electrical stimulus, multiple enzyme‐like activities single‐atom copper nanozyme (Cu‐NC) remarkably improved, thereby boosting cancer cell oxidative damage and death realizing improved therapy. Under an stimulus with 20 V voltage, peroxidase, catalase, oxidase, glutathione oxidase like Cu‐NC all boost generation free radicals. Through calculation, work analyzes how modulates activity via decreasing adsorption energy H 2 O on Cu sites, increasing d xy orbital near Fermi level, shifting d‐band center Cu, facilitating reactions. This opens new perspectives nanoenzymes

Language: Английский

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The fundamentals and applications of piezoelectric materials for tumor therapy: recent advances and outlook

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(4), P. 1140 - 1184

Published: Jan. 1, 2023

Malignant tumors are one of the main diseases leading to death, and vigorous development nanotechnology has opened up new frontiers for antitumor therapy. Currently, researchers focused on solving biomedical challenges associated with traditional anti-tumor medical methods, promoting research nano-drug carriers nano-drugs, which brings great hope improving curative effect reducing toxic side effects. Among systems being investigated, piezoelectric nano biomaterials, including ferroelectrics, pyroelectric materials, have recently received extensive attention applications. By coupling force, light, magnetism or heat electricity, polarized charges generated in these materials microscopically, forming a piezo-potential establishing built-in electric field. Polarized can directly act tumor micro-environment also assist separation inhibit recombination based theory optoelectronic theory. Based this, convert various forms primary energy (such as light energy, mechanical thermal magnetic energy) from surrounding environment into secondary electrical chemical energy). Herein, we review basic principles ferroelectric nanomedicine. Then, summarize types reported date their wide applications treatment, imaging, device construction probe detection treatment fields. discuss relevant characteristics post-processing strategies biomaterials obtain maximum response. Finally, present key future prospects ferroelectric, nanomaterial-based nanoagents efficient harvesting conversion desirable therapeutic outcomes.

Language: Английский

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Enhanced Sonodynamic Cancer Therapy through Iron‐Doping and Oxygen‐Vacancy Engineering of Piezoelectric Bismuth Tungstate Nanosheets

Small, Journal Year: 2023, Volume and Issue: 19(24)

Published: March 15, 2023

Sonodynamic therapy (SDT) is regarded as a new-rising strategy for cancer treatment with low invasiveness and high tissue penetration, but the scarcity of high-efficiency sonosensitizers has seriously hindered its application. Herein, iron-doped oxygen-deficient bismuth tungstate nanosheets (BWO-Fe NSs) piezotronic effect are synthesized enhanced SDT. Due to existence oxygen defects introduced through Fe doping, bandgap BWO-Fe significantly narrowed so that can be more easily activated by exogenous ultrasound (US). The acting electron traps inhibit recombination US-induced electrons holes. More importantly, dynamically renewed piezoelectric potential facilitates migration holes opposite side causes energy band bending, which further promotes production reactive species. Furthermore, doping endows Fenton reactivity, converts hydrogen peroxide (H2 O2 ) in tumor microenvironment into hydroxyl radicals (•OH), thereby amplifying cellular oxidative damage enhancing Both vitro vivo experiments illustrate their cytotoxicity suppression rate against refractory breast mice. This work may provide an alternative develop SDT via metal ions.

Language: Английский

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A Light‐Triggered J‐Aggregation‐Regulated Therapy Conversion: from Photodynamic/Photothermal Therapy to Long‐Lasting Chemodynamic Therapy for Effective Tumor Ablation

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(23)

Published: April 5, 2024

Abstract Reactive oxygen species (ROS) have become an effective tool for tumor treatment. The combination of photodynamic therapy (PDT) and chemodynamic (CDT) takes advantage various ROS enhances therapeutic effects. However, the activation CDT usually occurs before PDT, which hinders sustained maintenance hydroxyl radicals (⋅OH) reduces treatment efficiency. Herein, we present a light‐triggered nano‐system based on molecular aggregation regulation converting cancer from PDT/photothermal (PTT) to long‐lasting CDT. ordered J‐aggregation properties cyanine moiety while simultaneously suppressing capabilities copper‐porphyrin moiety. Upon light irradiation, Cu‐PCy JNPs demonstrate strong photothermal Meanwhile, triggers rapid degradation backbone, leading destruction J‐aggregation. As result, is sequentially activated, generation ⋅OH observed up 48 hours, causing potent cellular oxidative stress apoptosis. Due their excellent accumulation, exhibit in vivo ablation through therapy. This work provides new approach effectively prolonging activity ROS‐based

Language: Английский

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Piezoelectric Biomaterials Inspired by Nature for Applications in Biomedicine and Nanotechnology

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 22, 2024

Bioelectricity provides electrostimulation to regulate cell/tissue behaviors and functions. In the human body, bioelectricity can be generated in electromechanically responsive tissues organs, as well biomolecular building blocks that exhibit piezoelectricity, with a phenomenon known piezoelectric effect. Inspired by natural bio-piezoelectric phenomenon, efforts have been devoted exploiting high-performance synthetic biomaterials, including molecular materials, polymeric ceramic composite materials. Notably, biomaterials polarize under mechanical strain generate electrical potentials, which used fabricate electronic devices. Herein, review article is proposed summarize design research progress of devices toward bionanotechnology. First, functions regulating electrophysiological activity from cellular tissue level are introduced. Next, recent advances structure-property relationship various provided detail. following part, applications engineering, drug delivery, biosensing, energy harvesting, catalysis systematically classified discussed. Finally, challenges future prospects presented. It believed this will provide inspiration for development innovative fields biomedicine nanotechnology.

Language: Английский

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Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(13), P. 8307 - 8472

Published: June 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Language: Английский

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A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Language: Английский

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Advanced nanozymes possess peroxidase-like catalytic activities in biomedical and antibacterial fields: review and progress

Nanoscale, Journal Year: 2024, Volume and Issue: 16(7), P. 3324 - 3346

Published: Jan. 1, 2024

POD nanozymes for bactericidal treatment.

Language: Английский

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