Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment DOI
Min Zhang, Dandan Sun, Hui Huang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Language: Английский

In vivo synergistic tumor therapies based on copper sulfide photothermal therapeutic nanoplatforms DOI Creative Commons
Jingwen Ma, Na Li,

Jingjian Wang

et al.

Exploration, Journal Year: 2023, Volume and Issue: 3(5)

Published: June 24, 2023

Abstract Tumor cells may be eliminated by increasing their temperature. This is achieved via photothermal therapy (PTT) penetrating the tumor tissue with near‐infrared light and converting energy into heat using agents. Copper sulfide nanoparticles (CuS NPs) are commonly used as PTAs in PTT. In this review, we aimed to discuss synergism between PTT CuS NPs other therapies such chemotherapy, radiotherapy, dynamic (photodynamic, chemodynamic, sonodynamic therapy), immunotherapy, gene therapy, gas magnetic hyperthermia. Furthermore, summarized results obtained a combination of two treatments at least therapies, one included therapies. Finally, benefits drawbacks various therapeutic options state art CuS‐based provided future directions for

Language: Английский

Citations

81
Near-Infrared-II-Activatable Self-Assembled Manganese Porphyrin-Gold Heterostructures for Photoacoustic Imaging-Guided Sonodynamic-Augmented Photothermal/Photodynamic Therapy DOI

Peijing Xu,

Changchun Wen, Cunji Gao

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 18(1), P. 713 - 727

Published: Dec. 20, 2023

Porphyrins and their derivatives are widely used as photosensitizers sonosensitizers in tumor treatment. Nevertheless, poor water solubility low chemical stability reduce singlet oxygen (1O2) yield and, consequently, photodynamic therapy (PDT) sonodynamic (SDT) efficiency. Although strategies for porphyrin molecule assembly have been developed to augment 1O2 generation, there is scope further improving PDT SDT efficiencies. Herein, we synthesized ordered manganese (SM) nanoparticles with well-defined self-assembled metalloporphyrin networks that enabled efficient energy transfer enhanced photocatalytic sonocatalytic activity production. Subsequently, Au were grown situ on the SM surface by anchoring terminal alkynyl of form plasmonic SMA heterostructures, which showed excellent near-infrared-II (NIR-II) region absorption photothermal properties, facilitated electron–hole pair separation transfer. With modification hyaluronic acid (HA), SMAH heterostructure nanocomposites exhibited good actively targeted cancer cells. Under NIR-II light ultrasound (US) irradiation, generates hyperthermia, a large amount 1O2, inducing cell damage. Both vitro vivo studies confirmed effectively suppressed growth decreasing GSH levels SDT-augmented PDT/PTT. Moreover, utilizing strong window, can achieve photoacoustic imaging-guided combined This work provides paradigm enhancing metalloporphyrins improve synergistic therapeutic effect SDT/PDT/PTT.

Language: Английский

Citations

56
Drug-Free Antimicrobial Nanomotor for Precise Treatment of Multidrug-Resistant Bacterial Infections DOI

Luntao Liu,

Shuqin Li,

Kaiqiong Yang

et al.

Nano Letters, Journal Year: 2023, Volume and Issue: 23(9), P. 3929 - 3938

Published: April 27, 2023

Manufacturing heteronanostructures with specific physicochemical characteristics and tightly controllable designs is very appealing. Herein, we reported NIR-II light-driven dual plasmonic (AuNR-SiO2-Cu7S4) antimicrobial nanomotors an intended Janus configuration through the overgrowth of copper-rich Cu7S4 nanocrystals at only one high-curvature site Au nanorods (Au NRs). These were applied for photoacoustic imaging (PAI)-guided synergistic photothermal photocatalytic treatment bacterial infections. Both performance activity are dramatically improved owing to strong plasmon coupling between NRs component enhanced energy transfer. The motion behavior promotes transdermal penetration enhances matter–bacteria interaction. More importantly, directional navigation could be synchronously driven by light. marriage active antibacterial resulted in expected good effects abscess infection mouse model.

Language: Английский

Citations

44
Defect‐Engineering Bismuth‐Based Homologous Schottky Heterojunction for Metabolic Regulation‐Augmented Sonodynamic Tumor Therapy DOI
Xinyue Cao, Ying Wang, Xinran Song

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(25)

Published: March 16, 2023

Abstract Sonodynamic therapy demonstrates tremendous potential in biomedicine due to its non‐invasiveness, deep tissue penetration, and spatiotemporal controllability. However, the lack of favorable nanosonosensitizers with prominent reactive oxygen species generation capability green chemical constituents remains a significant challenge for broad biomedical applications. Herein, homologous bismuth‐based nanosonosensitizer (Bi‐HJ) is designed fabricated by direct defect engineering combinational tumor therapy. Specifically, self‐derived Schottky heterojunction vacancies are concurrently constructed Bi‐HJ, which prominently promotes separation ultrasound‐triggered electron–hole pairs improves charge utilization efficiency. With porous structure, Bi‐HJ loaded metabolic regulation drug atovaquone block mitochondrial respiration oxygen‐economized sonodynamic suppression. The strong near‐infrared absorption imparted allows implementation photothermal Accordingly, rationally combines two therapeutic modalities function, as well computed tomography imaging ability, thus achieving effective theranostics vitro vivo. Therefore, this study provides new insight into fabrication without introduction other synergistically enhanced

Language: Английский

Citations

43
Chitosan- and hyaluronic acid-based nanoarchitectures in phototherapy: Combination cancer chemotherapy, immunotherapy and gene therapy DOI
Zheng Wang,

Shuo Pang,

Xiaoli Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132579 - 132579

Published: May 23, 2024

Language: Английский

Citations

35
Ultrasound-Based Micro-/Nanosystems for Biomedical Applications DOI
Hui Huang,

Yi Zheng,

Meiqi Chang

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(13), P. 8307 - 8472

Published: June 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Language: Английский

Citations

33
A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains DOI
Wen Qin, Qiaoling Yang, Chunyan Zhu

et al.

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Language: Английский

Citations

28
Opsonization Inveigles Macrophages Engulfing Carrier‐Free Bilirubin/JPH203 Nanoparticles to Suppress Inflammation for Osteoarthritis Therapy DOI Creative Commons
Huirong Huang,

Shimin Zheng,

Jianing Wu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(22)

Published: April 9, 2024

Abstract Osteoarthritis (OA) is a chronic inflammatory disease characterized by cartilage destruction, synovitis, and osteophyte formation. Disease‐modifying treatments for OA are currently lacking. Because inflammation mediated an imbalance of M1/M2 macrophages in the synovial cavities contributes to progression, regulating M1 M2 polarization can be potential therapeutic strategy. Basing on inherent immune mechanism pathological environment OA, immunoglobulin G‐conjugated bilirubin/JPH203 self‐assembled nanoparticle (IgG/BRJ) developed, its evaluated. After intra‐articular administration, IgG conjugation facilitates recognition engulfment nanoparticles macrophages. The internalized disassemble response increased oxidative stress, released bilirubin (BR) JPH203 scavenge reactive oxygen species (ROS), inhibit nuclear factor kappa‐B pathway, suppress activated mammalian target rapamycin result repolarization enhance M2/M1 ratios. Suppression IgG/BRJ promotes protection repair rat model, thereby improving outcomes. This strategy opsonization involving engulf carrier‐free BR/JPH203 therapy holds great intervention treatment.

Language: Английский

Citations

20
Near‐Infrared Light‐Triggered MXene Nanocomposite for Tumor‐Specific Mild Photothermal‐Enhanced Chemodynamic Therapy DOI

Peizheng Xiong,

Xiaodan Wei, Li Zhou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 20, 2024

Abstract Mild photothermal therapy (PTT) is an emerging and elegant approach with minimal adverse effects, demonstrating itself as effective treatment for cancer. However, potential challenges may arise from the overexpression of heat shock protein 90 (HSP90) reliance on monotherapy. Here, a near‐infrared (NIR) light‐triggered MXene nanocomposite (FA@MXene/CuO 2 /GA) developed to synergistically combine mild PTT chemodynamic (CDT) remarkably tumor eradication without any notable tissue damage. Under irradiation NIR light, effectively enhances by suppressing HSP90 expression through release gambogic acid (GA) due excellent performance Ti 3 C nanosheets well tumor‐targeting ability biocompatibility surface‐modified FA‐PEG‐SH. The copper‐based catalyst CuO in this system releases Cu 2+ acid‐triggered manner within microenvironment, activating Fenton‐like reaction generate hydroxyl radicals, simultaneous production H O serves alleviate deficiency endogenous tumor. Overall, current work showcases remarkable synergistic anticancer effect CDT, also proposes new avenues research utilizing nanomaterials treatment.

Language: Английский

Citations

20
Advances in Atherosclerosis Theranostics Harnessing Iron Oxide‐Based Nanoparticles DOI Creative Commons
Shi Wang, Hongliang He, Yu Mao

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(17)

Published: Feb. 17, 2024

Abstract Atherosclerosis, a multifaceted chronic inflammatory disease, has profound impact on cardiovascular health. However, the critical limitations of atherosclerosis management include delayed detection advanced stages, intricate assessment plaque stability, and absence efficacious therapeutic strategies. Nanotheranostic based nanotechnology offers novel paradigm for addressing these challenges by amalgamating imaging capabilities with targeted interventions. Meanwhile, iron oxide nanoparticles have emerged as compelling candidates theranostic applications in due to their magnetic resonance capability biosafety. This review delineates current state prospects nanoparticle‐based nanotheranostics realm atherosclerosis, including pivotal aspects development, pertinent targeting strategies involved disease pathogenesis, diagnostic roles nanoparticles. Furthermore, this provides comprehensive overview nanomedicine approaches employing nanoparticles, encompassing chemical therapy, physical stimulation biological therapy. Finally, proposes discusses associated translating innovative into clinically viable anti‐atherosclerosis In conclusion, new insights future theranostic, showcasing remarkable potential oxide‐based versatile tools battle against atherosclerosis.

Language: Английский

Citations

17