Bright Bacterium for Hypoxia‐Tolerant Photodynamic Therapy Against Orthotopic Colon Tumors by an Interventional Method DOI
Daoming Zhu, Jing Zhang, Guanghong Luo

et al.

Advanced Science, Journal Year: 2021, Volume and Issue: 8(15)

Published: June 18, 2021

While promising, the efficacy of aggregation-induced emission (AIE)-based photodynamic therapy (PDT) is limited by several factors including depth laser penetration and intratumoral hypoxia. In present study, a novel bacteria-based AIEgen (TBP-2) hybrid system (AE) developed, that able to facilitate hypoxia-tolerant PDT treatment orthotopic colon tumors via an interventional method. For this approach, device initially designed, composed optical fiber endoscope, allowing for clear visualization position tumor within abdominal cavity. It then possible conduct successful hypoxic irradiation, as TBP-2 generate hydroxyl radicals (•OH) type I mechanism microenvironment. Moreover, approach proved significantly impair cancer growth overcame defects. This study first report involving such strategy knowledge, it has potential complement other modalities while also highlighting approaches design systems.

Language: Английский

Single‐Atom Pd Nanozyme for Ferroptosis‐Boosted Mild‐Temperature Photothermal Therapy DOI
Mengyu Chang,

Zhiyao Hou,

Man Wang

et al.

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(23), P. 12971 - 12979

Published: March 27, 2021

Abstract Photothermal therapy (PTT) is an extremely promising tumor therapeutic modality. However, excessive heat inevitably injures normal tissues near tumors, and the damage to cancer cells caused by mild hyperthermia easily repaired stress‐induced shock proteins (HSPs). Thus, maximizing PTT efficiency minimizing healthy simultaneously adopting appropriate temperatures imperative. Herein, innovative strategy reported: ferroptosis‐boosted based on a single‐atom nanozyme (SAzyme). The Pd SAzyme with atom‐economical utilization of catalytic centers exhibits peroxidase (POD) glutathione oxidase (GSHOx) mimicking activities, photothermal conversion performance, which can result in ferroptosis featuring up‐regulation lipid peroxides (LPO) reactive oxygen species (ROS). accumulation LPO ROS provides powerful approach for cleaving HSPs, enables SAzyme‐mediated mild‐temperature PTT.

Language: Английский

Citations

547

Solutions to the Drawbacks of Photothermal and Photodynamic Cancer Therapy DOI Creative Commons
Xiangyu Deng, Zengwu Shao,

Yanli Zhao

et al.

Advanced Science, Journal Year: 2021, Volume and Issue: 8(3)

Published: Jan. 5, 2021

Phototherapy such as photothermal therapy and photodynamic in cancer treatment has been developed quickly over the past few years for its noninvasive nature high efficiency. However, there are still many drawbacks phototherapy that prevent it from clinical applications. Thus, scientists have designed different systems to overcome issues associated with phototherapy, including enhancing targeting ability of low-temperature therapy, replacing near-infrared light other excitation sources, so on. This article discusses problems shortcomings encountered development highlights possible solutions address them may become a useful approach practice. aims give brief summary about current research advancements provides quick guideline toward future developments field.

Language: Английский

Citations

465

Inorganic nanomaterials with rapid clearance for biomedical applications DOI
Xianwen Wang, Xiaoyan Zhong, Jianxiang Li

et al.

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8669 - 8742

Published: Jan. 1, 2021

Inorganic nanomaterials that have inherently exceptional physicochemical properties (e.g., catalytic, optical, thermal, electrical, or magnetic performance) can provide desirable functionality drug delivery, diagnostics, imaging, therapy) considerable potential for application in the field of biomedicine. However, toxicity be caused by long-term, non-specific accumulation these inorganic healthy tissues, preventing their large-scale clinical utilization. Over past several decades, emergence biodegradable and clearable has offered to prevent such long-term toxicity. In addition, a comprehensive understanding design metabolic pathways within body is essential enabling expansion theranostic applications various diseases advancing trials. Thus, it critical importance develop biomedical applications. This review systematically summarizes recent progress nanomaterials, particularly cancer theranostics other disease therapies. The future prospects opportunities this rapidly growing are also discussed. We believe timely will stimulate guide additional in-depth studies area nanomedicine, as rapid vivo clearance degradation likely prerequisite translation with unique functionality.

Language: Английский

Citations

373

Colorectal Tumor Microenvironment‐Activated Bio‐Decomposable and Metabolizable Cu2O@CaCO3 Nanocomposites for Synergistic Oncotherapy DOI
Mengyu Chang,

Zhiyao Hou,

Dayong Jin

et al.

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(43)

Published: Sept. 18, 2020

Abstract Rational design of tumor microenvironment (TME)‐activated nanocomposites provides an innovative strategy to construct responsive oncotherapy. In colorectal cancer (CRC), the specific physiological features are overexpressed endogenous H 2 S and slightly acidic microenvironment. Here, a core–shell Cu O@CaCO 3 nanostructure for CRC “turn‐on” therapy is reported. With CaCO pH decomposition O sulfuration, can be triggered “on” into therapeutic mode by TME. When shell decomposes releases calcium in TME, loss protection from exposes core sulfuretted form metabolizable 31 16 nanocrystals that gain remarkably strong near‐infrared absorption. After modifying hyaluronic acid, achieve synergistic CRC‐targeted TME‐triggered photothermal/photodynamic/chemodynamic/calcium‐overload‐mediated therapy. Moreover, it found generation hyperthermia oxidative stress efficiently reprogram macrophages M2 phenotype M1 initiate vaccine‐like immune effect after primary removal, which further induces immune‐favorable TME intense responses anti‐CD47 antibody simultaneously inhibit distant metastasis recurrence immunotherapy.

Language: Английский

Citations

207

NIR‐II Responsive Inorganic 2D Nanomaterials for Cancer Photothermal Therapy: Recent Advances and Future Challenges DOI

Dong An,

Jianye Fu, Bin Zhang

et al.

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(32)

Published: June 10, 2021

Abstract Non‐invasive cancer photothermal therapy (PTT) is a promising replacement for traditional treatments. The second near‐infrared region induced PTT (NIR‐II PTT, 1000–1500 nm) with less energy dissipation has been developed deeper‐seated tumor treatment in recent years compared the first light (750–1000 nm). In addition, use of emerging inorganic 2D nanomaterials as agents (PTAs) further enhanced efficiency due to their intrinsic properties. NIR‐II stimulated becoming hot topic both academic and clinical fields. This review summarizes categories, structures, conversion properties time. synergistic strategies responsive combined other approaches including chemotherapy, chemodynamic therapy, photodynamic radiotherapy are summarized. future challenges perspectives on these systems construction discussed.

Language: Английский

Citations

203

Defect engineering in nanozymes DOI
Yu Wu, Weiqing Xu, Lei Jiao

et al.

Materials Today, Journal Year: 2021, Volume and Issue: 52, P. 327 - 347

Published: Nov. 29, 2021

Language: Английский

Citations

171

Microenvironment-driven sequential ferroptosis, photodynamic therapy, and chemotherapy for targeted breast cancer therapy by a cancer-cell-membrane-coated nanoscale metal-organic framework DOI
Weilun Pan, Yong Tan, Wei Meng

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 283, P. 121449 - 121449

Published: March 1, 2022

Language: Английский

Citations

167

Persistent Regulation of Tumor Hypoxia Microenvironment via a Bioinspired Pt‐Based Oxygen Nanogenerator for Multimodal Imaging‐Guided Synergistic Phototherapy DOI Creative Commons
Qing You, Kaiyue Zhang, Jingyi Liu

et al.

Advanced Science, Journal Year: 2020, Volume and Issue: 7(17)

Published: July 29, 2020

Multifunctional nanoplatforms for imaging-guided synergistic antitumor treatment are highly desirable in biomedical applications. However, anticancer is largely affected by the pre-existing hypoxic tumor microenvironment (TME), which not only causes resistance of tumors to photodynamic therapy (PDT), but also promotes tumorigenesis and progression. Here, a continuous O

Language: Английский

Citations

156

Near-infrared inorganic nanomaterial-based nanosystems for photothermal therapy DOI
Yufei Wang, Hong‐Min Meng, Zhaohui Li

et al.

Nanoscale, Journal Year: 2021, Volume and Issue: 13(19), P. 8751 - 8772

Published: Jan. 1, 2021

We summarize the recent advances in near-infrared inorganic nanomaterial-based nanosystems for photothermal therapy this review.

Language: Английский

Citations

147

Recent advances in the development of near-infrared organic photothermal agents DOI
Lu Li, Xue Han, Mingfeng Wang

et al.

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 417, P. 128844 - 128844

Published: Feb. 7, 2021

Language: Английский

Citations

146