Brain Behavior & Immunity - Health,
Journal Year:
2023,
Volume and Issue:
31, P. 100645 - 100645
Published: June 11, 2023
Preclinical
studies
suggest
learned
immune
system
responses
to
alcohol
cues
and
consumption
may
contribute
alcohol's
pharmacodynamic
properties
and/or
Alcohol
Use
Disorder
(AUD)
pathogenesis.
Mechanistically,
these
alterations
be
associated
with
increased
craving
consumption,
both
acutely
over
time.
We
sought
characterize
this
relationship
in
a
randomized,
counter-balanced,
crossover
neuroimaging
experiment
which
took
place
between
June
2020-November
2021.
Journal of Neurochemistry,
Journal Year:
2020,
Volume and Issue:
157(5), P. 1495 - 1524
Published: Dec. 26, 2020
Abstract
Our
gut
harbours
trillions
of
microorganisms
essential
for
the
maintenance
homeostasis
and
host
physiology
in
health
disease.
In
last
decade,
there
has
been
a
growing
interest
understanding
bidirectional
pathway
communication
between
our
microbiota
central
nervous
system.
With
regard
to
reward
processes
is
accumulating
evidence
from
both
animal
human
studies
that
this
axis
may
be
key
factor
gating
valence.
Focusing
on
mesocorticolimbic
pathway,
we
will
discuss
how
intestinal
involved
regulating
brain
functions,
natural
(i.e.
eating,
social
or
sexual
behaviours)
non‐natural
reinforcers
(drug
addiction
behaviours
including
those
relevant
alcohol,
psychostimulants,
opioids
cannabinoids).
We
integrate
preclinical
clinical
suggesting
microbiota‐gut‐brain
could
implicated
development
disorders
associated
with
alterations
system
it
targeted
as
promising
therapeutic
strategy.
image
Cover
Image
issue:
https://doi.org/10.1111/jnc.15065
.
Psychological Medicine,
Journal Year:
2023,
Volume and Issue:
53(15), P. 7151 - 7160
Published: March 21, 2023
Abstract
Background
Accumulating
evidence
suggests
that
positive
and
negative
emotions,
as
well
emotion
regulation,
play
key
roles
in
human
health
disease.
Recent
work
has
shown
the
gut
microbiome
is
important
modulating
mental
physical
through
gut–brain
axis.
Yet,
its
association
with
emotions
regulation
are
understudied.
Here
we
examined
whether
two
strategies
(i.e.
cognitive
reappraisal
suppression),
were
associated
composition
functional
pathways
healthy
women.
Methods
Participants
from
Mind-Body
Study
(
N
=
206,
mean
age
61),
a
sub-study
of
Nurses'
Health
II
cohort.
In
2013,
participants
completed
measures
emotion-related
factors.
Two
pairs
stool
samples
collected,
6
months
apart,
3
after
factors
completed.
Analyses
associations
microbial
diversity,
overall
structure,
specific
species/pathways
adjusted
for
relevant
covariates.
Results
Alpha
diversity
was
negatively
suppression.
multivariate
analysis,
inversely
relative
abundance
Firmicutes
bacterium
CAG
94
Ruminococcaceae
D16
,
while
directly
correlated
these
same
species.
At
metabolic
pathway
level,
related
to
biosynthesis
pantothenate,
coenzyme
A,
adenosine.
Conclusions
These
findings
offer
supporting
linkages
regulatory
processes
highlight
importance
incorporating
our
understanding
their
health.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 5, 2024
The
epidemic
of
alcohol
abuse
affects
millions
people
worldwide.
Relevant
evidence
supports
the
notion
that
gut
microbiota
(GM)
plays
a
crucial
role
in
central
nervous
system
(CNS)
function,
and
its
composition
undergoes
changes
following
consumption.
Therefore,
purpose
this
study
was
to
investigate
effect
reconstructing
by
fecal
transplantation
(FMT)
on
dependence.
Here,
we
established
an
dependence
model
with
C57BL/6J
mice
proved
FMT
treatment
improved
anxiety-like
behavior
alcohol-seeking
alcohol-dependent
mice.
Additionally,
found
expression
intestinal
intercellular
tight
junction
structure
proteins
ZO-1
occludin
significantly
increased
after
FMT.
repaired
permeability
decreased
levels
lipopolysaccharide
(LPS)
proinflammatory
factors.
Moreover,
serotonin
(5-hydroxytryptamine,
5-HT)
content
mouse
brain
tissues
receiving
microbiome
from
healthy
16S
rRNA
sequencing
demonstrated
markedly
reshaped
elicited
barrier
5-HT
levels.
Collectively,
our
results
revealed
has
palliative
explored
underlying
mechanisms,
which
provides
new
strategies
for
The
cognitive
complexities
of
emotions
and
individualized
coping
strategies
make
it
a
difficult
space
for
design.
Collecting
first-person
data
can
provide
nuanced
understanding
the
lived
experience
emotional
life,
to
better
inform
design
wearable
technologies
self-regulation.
We
present
preliminary
study
our
phenomenological
approach
autobiographical
methodology
is
unique
intertwining
activities
mindfulness
exercises,
as
strategy
controlling
repercussions.
Self-observation
documentation
included
journaling
sketching
using
Inside-Out
Probe
workbook,
followed
by
material
prototyping
testing
in-the-wild.
Breathing
Scarf
prototype
embodies
considerations.
In
designing
one
support
personalized
self-regulation
strategies,
key
considerations
include
personal
comfort,
ownership,
individual-over-social
meaning-making.
Of
equal
importance
in
research
process
are
well-being
designer/researcher,
ability
self-regulate
emotions,
ethics
care
emotion
work.
Foods,
Journal Year:
2024,
Volume and Issue:
13(7), P. 1089 - 1089
Published: April 2, 2024
The
interplay
among
gut
microbiota,
intestines,
and
liver
is
crucial
in
preventing
acute
alcoholic
injury.
In
this
study,
the
hepatoprotective
potential
of
polysaccharides
from
Eucommia
ulmoides
Oliv.
leaves
(EULP)
on
injury
Kunming
male
mice
was
investigated.
structural
features
suggested
that
EULP
appeared
as
a
heterogeneous
mixture
with
molecular
weight
186132
Da.
A
14-day
pretreatment
ameliorated
alcoholic-induced
hepatic
inflam
mation
(TNF-α,
IL-6,
IL-10),
oxidative
stress
(GSH,
SOD,
T-AOC),
damage
(ALT
AST)
via
enhancing
intestinal
barrier
(Occludin,
Claudin
1,
ZO-1)
modulating
microbiome,
which
subsequently
inhibiting
endotoxemia
balancing
homeostasis
gut–liver
axis.
restored
composition
flora
an
increase
relative
abundance
Lactobacillaceae
decrease
Lachnospiraceae
Verrucomicrobiaceae.
Notably,
prolonged
(14
days)
but
no
single
gavage
achieved
excellent
hepatoprotection.
These
findings
endorsed
functional
food
for
mitigating
alcoholic-induce
d
damage,
attributed
to
its
anti-inflammatory,
antioxidant,
prebiotic
properties
facilitated
by
microbiota–gut–liver
Brain Sciences,
Journal Year:
2024,
Volume and Issue:
14(5), P. 453 - 453
Published: April 30, 2024
In
this
narrative,
comprehensive,
and
updated
review
of
the
literature,
we
summarize
evidence
about
effectiveness
interventions
aimed
at
reducing
emotion
dysregulation
improving
regulation
in
children,
adolescents,
adults.
After
introducing
from
a
theoretical
standpoint,
discuss
factors
commonly
associated
with
regulation,
including
neurobiological
neuropsychological
mechanisms,
role
childhood
adverse
experiences
psycho–social
onset
dysregulation.
We
then
present
pharmacological
non-pharmacological
aiming
promoting
across
lifespan.
Although
our
was
not
intended
as
traditional
systematic
review,
search
only
restricted
to
reviews
meta-analyses,
highlighted
important
implications
provided
recommendations
for
clinical
practice
future
research
field.
