Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 103640 - 103640
Published: Sept. 1, 2024
Language: Английский
Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(10)
Published: Oct. 20, 2023
Abstract Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty deposits in inner walls vessels. These plaques restrict blood flow and lead to complications such as heart attack or stroke. The development atherosclerosis influenced variety factors, including age, genetics, lifestyle, underlying health conditions high pressure diabetes. Atherosclerotic stable form are slow growth, which leads luminal stenosis, with low embolic potential unstable form, contributes risk for thrombotic rapid clinical onset. In this complex scenario atherosclerosis, macrophages participate whole process, initiation, growth eventually rupture wound healing stages artery plaque formation. Macrophages exhibit heterogeneity plasticity, affect evolving microenvironment, e.g., leading excessive lipid accumulation, cytokine hyperactivation, hypoxia, apoptosis necroptosis. metabolic functional transitions response microenvironmental factors not only influence ongoing imminent responses within lesions but also directly dictate atherosclerotic progression regression. review, we discuss origin plaques, their phenotypic diversity, shifts, fate roles they play dynamic atherosclerosis. It describes how interact other cells, particularly T cells. Ultimately, targeting pathways involved macrophage polarization may innovative promising approaches precision medicine. Further insights into landscape biological features offer valuable information optimizing future treatment macrophages.
Language: Английский
Citations
110
Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(5), P. 299 - 315
Published: March 7, 2024
Language: Английский
Citations
105
Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 20(12), P. 764 - 783
Published: Aug. 15, 2023
Language: Английский
Citations
96
Nature Reviews Drug Discovery, Journal Year: 2024, Volume and Issue: 23(6), P. 445 - 460
Published: April 15, 2024
Language: Английский
Citations
82
Cancer Cell, Journal Year: 2024, Volume and Issue: 42(11), P. 1825 - 1863
Published: Oct. 10, 2024
Language: Английский
Citations
70
Autophagy, Journal Year: 2024, Volume and Issue: 20(6), P. 1213 - 1246
Published: March 6, 2024
Macroautophagy/autophagy is a complex degradation process with dual role in cell death that influenced by the types are involved and stressors they exposed to. Ferroptosis an iron-dependent oxidative form of characterized unrestricted lipid peroxidation context heterogeneous plastic mechanisms. Recent studies have shed light on involvement specific autophagy (e.g. ferritinophagy, lipophagy, clockophagy) initiating or executing ferroptotic through selective anti-injury proteins organelles. Conversely, other forms reticulophagy lysophagy) enhance cellular defense against damage. Dysregulated autophagy-dependent ferroptosis has implications for diverse range pathological conditions. This review aims to present updated definition ferroptosis, discuss influential substrates receptors, outline experimental methods, propose guidelines interpreting results.
Language: Английский
Citations
58
Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)
Published: Jan. 24, 2024
Abstract Ferroptosis represents a distinct form of programmed cell death triggered by excessive iron accumulation and lipid peroxidation-induced damage. This mode differentiates from classical in terms morphology biochemistry. stands out for its exceptional biological characteristics has garnered extensive research conversations as death. Its dysfunctional activation is closely linked to the onset diseases, particularly inflammation cancer, making ferroptosis promising avenue combating these conditions. As such, exploring may offer innovative approaches treating cancer inflammatory diseases. Our review provides insights into relevant regulatory mechanisms ferroptosis, examining impact ferroptosis-related factors both physiological pathological perspectives. Describing crosstalk between tumor- inflammation-associated signaling pathways potential inducers overcoming drug-resistant cancers are discussed, aiming inform further novel therapeutic directions relation
Language: Английский
Citations
55
Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: 24(9), P. 654 - 669
Published: April 22, 2024
Language: Английский
Citations
54
Cell Death and Differentiation, Journal Year: 2024, Volume and Issue: 31(4), P. 387 - 404
Published: March 23, 2024
Language: Английский
Citations
44
Immunological Reviews, Journal Year: 2023, Volume and Issue: 321(1), P. 115 - 127
Published: Sept. 4, 2023
Type I interferon (IFN) is a class of proinflammatory cytokines with dual role on malignant transformation, tumor progression, and response to therapy. On the one hand, robust, acute, resolving type IFN responses have been shown mediate prominent anticancer effects, reflecting not only their direct cytostatic/cytotoxic activity (at least some) cells, but also pronounced immunostimulatory functions. In line this notion, signaling has implicated in antineoplastic effects various immunogenic therapeutics, including (but limited to) cell death (ICD)-inducing agents immune checkpoint inhibitors (ICIs). other weak, indolent, non-resolving demonstrated support progression resistance therapy, ability suboptimal cytoprotective activity, promote stemness, favor tolerance chromosomal instability, facilitate establishment an immunologically exhausted microenvironment. Here, we review fundamental aspects context-dependent impact
Language: Английский
Citations
43