Gut commensal Alistipes shahii improves experimental colitis in mice with reduced intestinal epithelial damage and cytokine secretion DOI Creative Commons
Xiang Fei Lin,

Mingchao Xu,

Ruiting Lan

et al.

mSystems, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

ABSTRACT The commensal bacterium Alistipes shahii is a core microbe of the human gut microbiome and its abundance negatively correlated with inflammatory bowel diseases (IBDs). However, fundamental role in regulating response remains unknown. Using dextran sulfate sodium (DSS)-induced colitis mouse model, we examined effect A. strain As360 intervention on host found that alleviated disease activity index, colon shortening, colonic histopathological lesion. levels tight junction proteins (mainly ZO1 claudin-1) were decreased DSS-induced mice, whereas these elevated mice treatment. In addition, treatment led to alterations cytokine release, especially an increase IL10. It also reduced expressions mtor Nlrp3 increased expression mTOR inhibitor Ddit4 at transcriptional level. 16S rRNA amplicon sequencing Bacteroides , producer short-chain fatty acids (SCFAs), was enriched fecal samples Metabolic analyses that, following treatment, SCFAs content lactic acid cecal content. These findings suggest supplementation promising strategy prevent colitis. IMPORTANCE As one microbes keystone species gut, has potential inhibit inflammation improve (IBDs) conditions. this study, experimentally demonstrated oral administration symptoms colitis, altered release cellular factors, intestinal epithelial barrier damage, changed microbiota metabolites. provide deeper understanding beneficial effects perspective for better strategies IBD.

Language: Английский

Inflammation and malnutrition in inflammatory bowel disease DOI
Sara Massironi, Chiara Viganò, Andrea Palermo

et al.

˜The œLancet. Gastroenterology & hepatology, Journal Year: 2023, Volume and Issue: 8(6), P. 579 - 590

Published: March 15, 2023

Language: Английский

Citations

145
Intestinal epithelial cell metabolism at the interface of microbial dysbiosis and tissue injury DOI Creative Commons
Eva Rath, Dirk Haller

Mucosal Immunology, Journal Year: 2022, Volume and Issue: 15(4), P. 595 - 604

Published: April 1, 2022

The intestinal epithelium represents the most regenerative tissue in human body, located proximity to dense and functionally diverse microbial milieu of microbiome. Episodes injury incomplete healing are a prerequisite for immune reactivation account recurrent, chronically progressing phenotypes inflammatory bowel diseases (IBD). Mitochondrial dysfunction associated changes epithelial functions emerging concepts pathogenesis IBD, suggesting impaired metabolic flexibility cells affects capacity tissue. Next rendering mucosa susceptible triggers, reprogramming is implicated shaping adverse environments. In this review, we introduce concept “metabolic injury” as cell autonomous mechanism wounding response mitochondrial perturbation. Furthermore, highlight metabolism intersection microbiome, regeneration.

Language: Английский

Citations

84
Diet fuelling inflammatory bowel diseases: preclinical and clinical concepts DOI Creative Commons
Timon E. Adolph, Jingwan Zhang

Gut, Journal Year: 2022, Volume and Issue: 71(12), P. 2574 - 2586

Published: Sept. 16, 2022

The diet and gut microbiota have been extensively interrogated as a fuel for inflammation in inflammatory bowel diseases (IBDs) the last few years. Here, we review how specific nutrients, typically enriched Western diet, instigate or deteriorate experimental genetically susceptible host discuss microbiota-dependent independent mechanisms. We depict study landscape of nutritional trials paediatric adult IBD delineate common grounds dietary advice. Conclusively, reflects critical rheostat microbial dysbiosis IBD. Dietary restriction by exclusive enteral nutrition, with without exclusion is effectively treating Crohn’s disease, while are less conclusive. Insights into molecular mechanisms therapy will change perception allow us to enter era precision nutrition. To achieve this, need carefully designed scientific rigour comparable medical trials, which also requires action from stake holders. Establishing evidence-based does not only hold promise avoid long-term immunosuppression, but provide widely accessible at low cost. Identification culprits disturbing health bears potential prevent allows informed decision making food politics.

Language: Английский

Citations

80
Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeutic Targeting of the Microbiome DOI Open Access
Brian Bicknell, Ann Liebert, Thomas J. Borody

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9577 - 9577

Published: May 31, 2023

The human gut microbiome contains the largest number of bacteria in body and has potential to greatly influence metabolism, not only locally but also systemically. There is an established link between a healthy, balanced, diverse overall health. When becomes unbalanced (dysbiosis) through dietary changes, medication use, lifestyle choices, environmental factors, ageing, this profound effect on our health linked many diseases, including metabolic inflammatory neurological diseases. While humans largely association dysbiosis with disease, animal models, causative can be demonstrated. brain particularly important maintaining health, strong neurodegenerative neurodevelopmental This suggests that microbiota composition used make early diagnosis diseases modifying microbiome-gut-brain axis might present therapeutic target for have proved intractable, aim altering trajectory such as Alzheimer's Parkinson's multiple sclerosis, autism spectrum disorder, attention-deficit hyperactivity among others. other potentially reversible migraine, post-operative cognitive dysfunction, long COVID, which considered models therapy disease. role traditional methods microbiome, well newer, more novel treatments faecal transplants photobiomodulation, are discussed.

Language: Английский

Citations

68
Cordyceps militaris polysaccharide alleviates diabetic symptoms by regulating gut microbiota against TLR4/NF-κB pathway DOI
Huajie Zhao, Min Li, Liang Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 230, P. 123241 - 123241

Published: Jan. 11, 2023

Language: Английский

Citations

49
Gut microbiota modulate distal symmetric polyneuropathy in patients with diabetes DOI Creative Commons
Junpeng Yang, Xueli Yang, Guojun Wu

et al.

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(9), P. 1548 - 1562.e7

Published: July 13, 2023

The pathogenic mechanisms underlying distal symmetric polyneuropathy (DSPN), a common neuropathy in patients with diabetes mellitus (DM), are not fully understood. Here, we discover that the gut microbiota from DSPN can induce phenotype exhibiting more severe peripheral db/db mice. In randomized, double-blind, and placebo-controlled trial (ChiCTR1800017257), compared to 10 who received placebo, was significantly alleviated 22 fecal transplants healthy donors, independent of glycemic control. bacterial genomes correlated Toronto Clinical Scoring System (TCSS) score were organized two competing guilds. Increased guild 1, which had higher capacity butyrate production, decreased 2, harbored genes synthetic pathway endotoxin, associated improved barrier integrity proinflammatory cytokine levels. Moreover, matched enterotype between recipients showed better therapeutic efficacy enriched 1 suppressed 2. Thus, changes these guilds may play causative role have potential for targeting.

Language: Английский

Citations

43
Development of Polymethine Dyes for NIR‐II Fluorescence Imaging and Therapy DOI
Xin Chen,

Jieyan Li,

Shubham Roy

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)

Published: March 5, 2024

Fluorescence imaging in the second near-infrared window (NIR-II) is burgeoning because of its higher fidelity monitoring physiological and pathological processes than clinical visible/the fluorescence imaging. Notably, heavily dependent on agents. So far, indocyanine green, one polymethine dyes, with good biocompatibility renal clearance only dye approved by Food Drug Administration, but it shows relatively low NIR-II brightness. Importantly, tremendous efforts are devoted to synthesizing dyes for preclinically clinically. They have shown feasibility customization structure properties fulfill various needs therapy. Herein, a timely update special focus molecular design strategies fluorescent, photoacoustic, multimodal imaging, offered. Furthermore, progress sensing biomarkers even reporting drug release illustrated. Moreover, imaging-guided therapies summarized regarding chemo-, photothermal, photodynamic, approaches. In addition, artificial intelligence pointed out potential expedite development. This comprehensive review will inspire interest among wide audience offer handbook people an dyes.

Language: Английский

Citations

23
Recent advances in the epithelial barrier theory DOI Creative Commons
Yağız Pat, Duygu Yazıcı, Paolo D’Avino

et al.

International Immunology, Journal Year: 2024, Volume and Issue: 36(5), P. 211 - 222

Published: Jan. 16, 2024

Abstract The epithelial barrier theory links the recent rise in chronic non-communicable diseases, notably autoimmune and allergic disorders, to environmental agents disrupting barrier. Global pollution toxic agent exposure have worsened over six decades because of uncontrolled growth, modernization, industrialization, affecting human health. Introducing new chemicals without any reasonable control their health effects through these years has led documented adverse effects, especially on skin mucosal barriers. These substances, such as particulate matter, detergents, surfactants, food emulsifiers, micro- nano-plastics, diesel exhaust, cigarette smoke, ozone, been shown compromise integrity. This disruption is linked opening tight-junction barriers, inflammation, cell death, oxidative stress, metabolic regulation. Consideration must be given interplay underlying inflammatory medications, affected tissues. review article discusses detrimental effect barrier-damaging compounds involves cellular molecular mechanisms.

Language: Английский

Citations

22
Heavy arch: from inflammatory bowel diseases to metabolic disorders DOI Creative Commons
Timon E. Adolph,

Moritz Meyer,

A Jukic

et al.

Gut, Journal Year: 2024, Volume and Issue: 73(8), P. 1376 - 1387

Published: May 22, 2024

Background Metabolic disorders and inflammatory bowel diseases (IBD) have captured the globe during Westernisation of lifestyle related dietary habits over last decades. Both disease entities are characterised by complex heterogeneous clinical spectra linked to distinct symptoms organ systems which, on a first glimpse, do not many commonalities in practice. However, experimental studies indicate common backbone mechanisms metabolic gut inflammation, emerging evidence suggests an intricate interplay between IBD. Objective We depict parallels IBD diseases, easily overlooked routine. Design provide overview recent literature discuss implications morbidity patients with for researchers, clinicians healthcare providers. Conclusion The Western diet microbial perturbation serve as fuel inflammation beyond gut. syndrome increasingly affect IBD, expected negative impact both risk complications. This concept implies that tackling obesity pandemic exerts beneficial effects health.

Language: Английский

Citations

20
Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine DOI Creative Commons
Yanhong Duo, Lei Han, Yaoqiang Yang

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(20), P. 11242 - 11347

Published: Oct. 9, 2024

Biopsy, including tissue and liquid biopsy, offers comprehensive real-time physiological pathological information for disease detection, diagnosis, monitoring. Fluorescent probes are frequently selected to obtain adequate on processes in a rapid minimally invasive manner based their advantages biopsy. However, conventional fluorescent have been found show aggregation-caused quenching (ACQ) properties, impeding greater progresses this area. Since the discovery of aggregation-induced emission luminogen (AIEgen) promoted advancements molecular bionanomaterials owing unique high quantum yield (QY) signal-to-noise ratio (SNR),

Language: Английский

Citations

19