Frontiers in Molecular Neuroscience,
Journal Year:
2023,
Volume and Issue:
16
Published: Oct. 30, 2023
Stem
cells
have
potential
applications
in
the
field
of
neurological
diseases,
as
they
allow
for
development
new
biological
models.
These
models
can
improve
our
understanding
underlying
pathologies
and
facilitate
screening
therapeutics
context
precision
medicine.
also
been
applied
clinical
tests
to
repair
tissues
functional
recovery.
Nevertheless,
although
promising,
commonly
used
stem
display
some
limitations
that
curb
scope
their
applications,
such
difficulty
obtention.
In
regard,
urine-derived
be
reprogrammed
into
induced
pluripotent
(iPSCs).
However,
obtaining
challenging
due
low
yield
complexity
multi-phased
typically
expensive
differentiation
protocols.
As
an
alternative,
(UDSCs),
included
within
population
cells,
present
a
mesenchymal-like
phenotype
shown
promising
properties
similar
purposes.
Importantly,
UDSCs
differentiated
neuronal-like
auspicious
disease
modeling,
while
overcoming
shortcomings
presented
by
other
these
Thus,
this
review
assesses
current
state
future
perspectives
regarding
ambit
both
modeling
therapeutic
applications.
Journal of Biomedical Science,
Journal Year:
2024,
Volume and Issue:
31(1)
Published: May 9, 2024
Abstract
The
field
of
regenerative
medicine
has
witnessed
remarkable
advancements
with
the
emergence
induced
pluripotent
stem
cells
(iPSCs)
derived
from
a
variety
sources.
Among
these,
urine-derived
(u-iPSCs)
have
garnered
substantial
attention
due
to
their
non-invasive
and
patient-friendly
acquisition
method.
This
review
manuscript
delves
into
potential
application
u-iPSCs
in
advancing
precision
medicine,
particularly
realms
drug
testing,
disease
modeling,
cell
therapy.
U-iPSCs
are
generated
through
reprogramming
somatic
found
urine
samples,
offering
unique
renewable
source
patient-specific
cells.
Their
utility
testing
revolutionized
pharmaceutical
industry
by
providing
personalized
platforms
for
screening,
toxicity
assessment,
efficacy
evaluation.
availability
diverse
genetic
backgrounds
facilitates
development
tailored
therapeutic
approaches,
minimizing
adverse
effects
optimizing
treatment
outcomes.
Furthermore,
demonstrated
allowing
researchers
recapitulate
pathologies
vitro.
not
only
enhances
our
understanding
mechanisms
but
also
serves
as
valuable
tool
discovery
development.
In
addition,
u-iPSC-based
models
offer
platform
studying
rare
genetically
complex
diseases,
often
underserved
traditional
research
methods.
versatility
extends
therapy
applications,
where
they
hold
immense
promise
medicine.
differentiate
various
types,
including
neurons,
cardiomyocytes,
hepatocytes,
enables
replacement
therapies.
approach
can
revolutionize
degenerative
organ
failure,
tissue
damage
immune
rejection
However,
several
challenges
considerations,
such
standardization
protocols,
genomic
stability,
scalability,
must
be
addressed
fully
exploit
u-iPSCs’
conclusion,
this
underscores
transformative
impact
on
highlights
future
prospects
harnessing
innovative
technology
improved
healthcare
Metabolism,
Journal Year:
2024,
Volume and Issue:
152, P. 155786 - 155786
Published: Jan. 10, 2024
Diabetes
presents
a
pressing
healthcare
crisis,
necessitating
innovative
solutions.
Organoid
technologies
have
rapidly
advanced,
leading
to
the
emergence
of
bioengineering
islet
organoids
as
an
unlimited
source
insulin-producing
cells
for
treating
insulin-dependent
diabetes.
This
advancement
surpasses
need
cadaveric
transplantation.
However,
clinical
translation
this
approach
faces
two
major
limitations:
immature
endocrine
function
and
absence
perfusable
vasculature
compared
primary
human
islets.
In
review,
we
summarize
latest
developments
in
functional
vitro
promoting
vascularization
organoid
grafts
before
after
We
highlight
crucial
roles
ensuring
long-term
survival,
maturation,
functionality
organoids.
Additionally,
discuss
key
considerations
that
must
be
addressed
organoid-based
therapy,
including
immaturity,
undesired
heterogeneity,
potential
tumorigenic
risks.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
177, P. 117005 - 117005
Published: June 29, 2024
Urine-derived
stem
cells
(USCs)
have
gained
the
attention
of
researchers
in
biomedical
field
past
few
years
.
Regarding
several
varieties
that
been
used
for
this
purpose,
USCs
demonstrated
mesenchymal
cell-like
properties,
such
as
differentiation
and
immunomodulation.
Furthermore,
they
could
be
differentiated
into
lineages.
This
is
very
interesting
regenerative
techniques
based
on
cell
therapy.
review
will
embark
describing
their
separation,
profiling.
We
specifically
describe
characteristics,
addition
to
potential.
Then,
we
introduce
explore
primary
uses
USCs.
These
involve
thier
utilization
a
platform
produce
cells,
however,
shall
concentrate
therapeutic,
orofacial
applications,
providing
an
in-depth
evaluation
purpose.
The
final
portion
address
limitations
challenges
implementation
dentistry.
Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Abstract
The
intricate
nature
of
oral-maxillofacial
structure
and
function,
coupled
with
the
dynamic
oral
bacterial
environment,
presents
formidable
obstacles
in
addressing
repair
regeneration
bone
defects.
Numerous
characteristics
should
be
noticed
repair,
such
as
irregular
morphology
defects,
homeostasis
between
hosts
microorganisms
cavity
complex
periodontal
structures
that
facilitate
epithelial
ingrowth.
Therefore,
necessitates
restoration
materials
adhere
to
stringent
specific
demands.
This
review
starts
exploring
these
particular
requirements
by
introducing
bones
then
summarizes
classifications
current
respect
composition
structure.
Additionally,
we
discuss
modifications
including
improving
mechanical
properties,
optimizing
surface
topography
pore
adding
bioactive
components
elements,
compounds,
cells
their
derivatives.
Ultimately,
organize
a
range
potential
optimization
strategies
future
perspectives
for
enhancing
materials,
physical
environment
manipulation,
microbial
modulation,
osteo-immune
regulation,
smart
stimuli-responsive
multifaceted
approach
poly-pathic
treatment,
hope
providing
some
insights
researchers
this
field.
In
summary,
analyzes
demands
especially
alveolar
bone,
concludes
corresponding
biomaterials
aims
inspire
research
pursuit
more
effective
treatment
outcomes.
Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 15, 2025
The
regenerative
potential
of
mesenchymal
stromal/stem
cells
(MSCs)
has
been
extensively
studied
in
clinical
trials
the
past
decade.
However,
despite
promising
properties
documented
preclinical
studies,
for
instance
osteoarthritis
(OA),
therapeutic
translation
these
results
patients
not
fully
conclusive.
One
factor
contributing
to
this
barrier
could
be
presence
senescent
OA
joints.
This
study
evaluated
a
novel
approach
treatment
by
combining
adipose
tissue-derived
MSCs
(AD-MSCs)
with
rapamycin,
clinically
approved
immunosuppressive
drug
anti-senescence
properties.
First,
rapamycin
effects
on
senescence
and
fibrosis
markers
were
investigated
freshly
isolated
chondrocytes
immunostaining.
Next,
vitro
differentiation
capacities
AD-MSCs,
their
regulatory
immune
functions
activated
chondrocyte
signature
assessed
rapamycin.
In
chondrocytes,
reduced
marker
p15INK4B
COL1A1
without
affecting
expression
master
chondrogenic
SOX9
COL2.
Rapamycin
also
enhanced
AD-MSC
into
adipocytes.
addition,
improved
immunoregulatory
promoting
factors,
such
as
IDO1,
PTGS2
CD274
(encoding
PD-L1).
Finally,
RNA
sequencing
analysis
showed
that
AD-MSCs
displayed
chondroprotective
co-cultured
chondrocytes.
Our
findings
suggest
combination
enhances
efficacy
senescence-driven
degenerative
diseases
OA,
notably
improving
anti-fibrotic
anti-inflammatory
Trends in biotechnology,
Journal Year:
2024,
Volume and Issue:
42(8), P. 953 - 969
Published: Feb. 17, 2024
Urine-derived
stem
cells
(USCs)
are
a
promising
source
of
for
cell
therapy,
renal
toxicity
drug
testing,
and
disease
biomarker
discovery.
Patients'
own
USCs
can
be
used
precision
medicine.
In
this
review
we
first
describe
the
isolation
characterization
USCs.
We
then
discuss
preclinical
studies
investigating
use
in
exploring
utility
USC-derived
induced
pluripotent
(u-iPSCs)
as
biomarkers
diagnosis.
Finally,
challenges
using
these
applications
provide
insights
into
future
research
directions.
tool
advancing
Further
is
needed
to
explore
their
potential.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(12), P. 9947 - 9947
Published: June 9, 2023
Sulfur
mustard
(SM)
is
a
highly
toxic
chemical
agent
that
causes
severe
tissue
damage,
particularly
to
the
eyes,
lungs,
and
skin.
Despite
advances
in
treatment,
there
need
for
more
effective
therapies
SM-induced
injury.
Stem
cell
exosome
are
emerging
as
promising
approaches
repair
regeneration.
cells
can
differentiate
into
multiple
types
promote
regeneration,
while
exosomes
small
vesicles
deliver
therapeutic
cargo
target
cells.
Several
preclinical
studies
demonstrated
potential
of
stem
cell,
exosome,
or
combination
therapy
various
injury,
showing
improvements
repairing,
inflammation,
fibrosis.
However,
also
challenges
associated
with
these
therapies,
such
requirement
standardized
methods
isolation
characterization,
long-term
safety
efficacy
reduced
injury
therapies.
was
used
eye
lung
limited
data
on
use
skin
this
area
research
may
offer
new
treatment
options
future.
In
review,
we
focused
optimizing
evaluating
their
efficacy,
comparing
other
potentially
eye,
lung,
