Journal of Colloid and Interface Science, Journal Year: 2021, Volume and Issue: 607, P. 1825 - 1835
Published: Oct. 8, 2021
Language: Английский
Biomacromolecules, Journal Year: 2020, Volume and Issue: 21(8), P. 2983 - 3006
Published: July 16, 2020
Wound healing is usually accompanied by bacterial infection. The excessive use of synthetic antibiotics leads to drug resistance, posing a significant threat human health. Hydrogel-based wound dressings aimed at mitigating infections have emerged as an effective treatment. review presented herein particularly focuses on the hydrogels originating from natural polymers. To further enhance performance dressings, various strategies and approaches been developed endow with excellent broad-spectrum antibacterial activity. Those that are summarized in current intrinsic or stimuli-triggered bactericidal properties others serve vehicles for loading agents without antibiotics. Specific attention paid antimicrobial mechanisms hydrogels. Practical applications accelerate employing these antibiotic-free also introduced along discussion challenges perspectives leading new technologies.
Language: Английский
Citations
284
Advanced Science, Journal Year: 2020, Volume and Issue: 7(10)
Published: April 6, 2020
The development of antimicrobial drug resistance among pathogenic bacteria and fungi is one the most significant health issues 21st century. Recently, advances in nanotechnology have led to nanomaterials, particularly metals that exhibit properties. These metal nanomaterials emerged as promising alternatives traditional therapies. In this review, a broad overview their synthesis, properties, interactions with micro-organisms first provided. Secondly, range demonstrate passive properties are outlined in-depth analysis comparison stimuli-responsive provided, which represent next generation microbiocidal nanomaterials. stimulus applied activate such includes light (including photocatalytic photothermal) magnetic fields, can induce hyperthermia kinetically driven activation. Broadly, review aims summarize currently available research provide future scope for nanomaterial-based technologies, those be activated through externally stimuli.
Language: Английский
Citations
276
Theranostics, Journal Year: 2019, Volume and Issue: 10(2), P. 757 - 781
Published: Dec. 6, 2019
The marked augment of drug-resistance to traditional antibiotics underlines the crying need for novel replaceable antibacterials.Research advances have revealed considerable sterilization potential two-dimension graphene-based nanomaterials.Subsequently, two-dimensional nanomaterials beyond graphene (2D NBG) as antibacterials also demonstrated their power disinfection due unique physicochemical properties and good biocompatibility.Therefore, exploration antibacterial mechanisms 2D NBG is vital manipulate future applications.Herein, we summarize recent research progress NBG-based agents, starting with a detailed introduction relevant mechanisms, including direct contact destruction, oxidative stress, photo-induced antibacterial, control drug/metallic ions releasing, multi-mode synergistic antibacterial.Then, effect on activities discussed.Additionally, summary different kinds given, such transition-metal dichalcogenides/oxides, metal-based compounds, nitride-based nanomaterials, black phosphorus, transition metal carbides, nitrides.Finally, rationally analyze current challenges new perspectives study more effective agents.This review not only can help researchers grasp status antibacterials, but may catalyze breakthroughs in this fast-growing field.
Language: Английский
Citations
211
Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 427, P. 132039 - 132039
Published: Aug. 26, 2021
Language: Английский
Citations
202
Research, Journal Year: 2021, Volume and Issue: 2021
Published: Jan. 1, 2021
Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells develop thermal resistance, and thus, efficacy PTT may dramatically decreased. In meantime, uncontrollable diffusion pose a threat surrounding healthy tissues. Recently, low-temperature (also known mild or mild-temperature PTT) demonstrated its remarkable capacity conquering these obstacles shown excellent performance bacterial elimination, wound healing, cancer treatments. Herein, we summarize recently proposed strategies for achieving based on nanomaterials introduce synthesis, characteristics, applications nanoplatforms. Additionally, combination other therapeutic modalities defeating cancers synergistic effect combined treatments are discussed. Finally, current limitations future directions inspiring more researchers make contributions promoting toward successful preclinical clinical disease
Language: Английский
Citations
193
Pharmaceutics, Journal Year: 2020, Volume and Issue: 12(6), P. 499 - 499
Published: May 30, 2020
Nanomaterial-based wound healing has tremendous potential for treating and preventing infections with its multiple benefits compared traditional treatment approaches. In this regard, the physiochemical properties of nanomaterials enable researchers to conduct extensive studies on wound-healing applications. Nonetheless, issues concerning use in accelerating efficacy existing medical treatments remain unresolved. The present review highlights novel approaches focusing recent innovative strategies infection controls based nanomaterials, including nanoparticles, nanocomposites, scaffolds, which are elucidated detail. addition, as carriers therapeutic agents associated applications been addressed. Finally, nanomaterial-based scaffolds their premise future have described. We believe that in-depth analytical review, insights, challenges described herein will provide an up-to-date reference nanomedicine can enhance
Language: Английский
Citations
187
Cell Reports Physical Science, Journal Year: 2020, Volume and Issue: 1(11), P. 100245 - 100245
Published: Nov. 1, 2020
Recently, photoactivated sterilization, as a rapid, effective, and antibiotic-free antibacterial method, has attracted increasing attention from researchers. Many outstanding photoresponsive materials, including photocatalysts, photosensitizers (PSs), photothermal have been developed applied to microbial inactivation treat infectious bacterial diseases. This mini-review aims provide insights gathered studying materials systems, (1) reactive oxygen species (ROS)-based photodynamic therapy (PDT) (2) hyperthermia-based (PTT). In addition, potential application fields for these methods, the remaining challenges using inactivation, perspectives future, prospective research directions are discussed in depth.
Language: Английский
Citations
176
ACS Applied Materials & Interfaces, Journal Year: 2020, Volume and Issue: unknown
Published: June 1, 2020
Bacteria-infected wounds are attracting increasing attention, as antibiotic misuse and multidrug-resistant bacteria complicate their treatment. Herein, we reported a photothermal activity-based drug consisting of β-cyclodextrin (βCD)-functionalized graphene oxide (GO) near-infrared light-responsive nanovehicles combined with the nitric donor BNN6, in methacrylate-modified gelatin (GelMA)/hyaluronic acid graft dopamine (HA-DA) hydrogel. The synergistic effects gas therapies expected to improve antibacterial efficiency reduce resistance. results revealed that GelMA/HA-DA/GO-βCD-BNN6 was an ideal material improved collagen deposition angiogenesis promoted wound healing mouse model full-thickness skin repair, compared commercially available Aquacel Ag dressing. We developed multifunctional nanocomposite hydrogel exhibited angiogenic properties, adhesiveness, mechanical properties enhance regeneration bacteria-infected wounds.
Language: Английский
Citations
172
Advanced Science, Journal Year: 2022, Volume and Issue: 9(27)
Published: July 25, 2022
Due to the abuse of antibiotics and emergence multidrug resistant microorganisms, medical devices, related biomaterials are at high risk microbial infection during use, placing a heavy burden on patients healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, antibacterial by making use coordination between phenolic ligands metal ions. Further, MPNs received widespread attention antimicrobial infections due their facile synthesis process, biocompatibility, brought about polyphenols In this review, different categories based (nanoparticles, coatings, capsules, hydrogels) fabrication strategies summarized, research advances applications biomedical fields (e.g., skin repair, bone regeneration, etc.) highlighted.
Language: Английский
Citations
172
Exploration, Journal Year: 2023, Volume and Issue: 3(1)
Published: Feb. 1, 2023
Bacterial infection has become one of the leading causes death worldwide, particularly in low-income countries. Despite fact that antibiotics have provided successful management bacterial infections, long-term overconsumption and abuse contributed to emergence multidrug resistant bacteria. To address this challenge, nanomaterials with intrinsic antibacterial properties or serve as drug carriers been substantially developed an alternative fight against infection. Systematically deeply understanding mechanisms is extremely important for designing new therapeutics. Recently, nanomaterials-mediated targeted bacteria depletion either a passive active manner most promising approaches treatment by increasing local concentration around cells enhance inhibitory activity reduce side effects. Passive targeting approach widely explored searching nanomaterial-based alternatives antibiotics, while strategy relies on biomimetic biomolecular surface feature can selectively recognize In review article, we summarize recent developments field therapy based nanomaterials, which will promote more innovative thinking focusing multidrug-resistant
Language: Английский
Citations
171