State-of-the-science of endocrine disrupting chemicals, 2012

Toxicology Letters, Journal Year: 2012, Volume and Issue: 211, P. S3 - S3

Published: May 11, 2012

Language: Английский

---

Physiological and molecular determinants of embryo implantation

Molecular Aspects of Medicine, Journal Year: 2013, Volume and Issue: 34(5), P. 939 - 980

Published: Jan. 2, 2013

Language: Английский

---

Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing

Fertility and Sterility, Journal Year: 2008, Volume and Issue: 90(4), P. 911 - 940

Published: Oct. 1, 2008

Language: Английский

---

Biology of progesterone action during pregnancy recognition and maintenance of pregnancy

Frontiers in bioscience, Journal Year: 2002, Volume and Issue: 7(1-3), P. d1879 - d1879

Published: Jan. 1, 2002

Progesterone is the hormone of pregnancy and unequivocally required in all mammals for maternal support conceptus (embryo/fetus associated membranes) survival development. The actions progesterone are mediated by receptor (PR). However, endometrial lumenal (LE) glandular epithelia (GE) a number species exhibit loss PR expression prior to stages uterine receptivity implantation. In sheep, becomes undetectable LE after Day 11 then GE 13. Loss appears be onset differentiated functions terms production secretory proteins, such as milk proteins (UTMP) osteopontin (OPN). Therefore, on during most gestation appear stroma that remains PR-positive throughout pregnancy. Stromal cells produce several growth factors, hepatocyte factor (HGF) fibroblast factors-7 -10 (FGF-7, FGF-10), have receptors expressed specifically epithelia. These factors may progesterone-responsive mediate epithelial-mesenchymal interactions crucial Studies gland knockout (UGKO) ewe indicate glands and, default, their secretions peri-implantation growth. A complex servomechanism, involving hormones from ovary well endogenous betaretroviruses GE, proposed regulate differentiation function gestation. At estrus, estrogen increases High levels Jaagsiekte sheep retroviruses (enJSRVs) response increasing hypothesized stimulate trophoblast proliferation interferon (IFN) tau. IFN tau, recognition produced Days 10 21, acts paracrine manner PR-negative superficial inhibit transcription alpha (ER) oxytocin (OTR) genes. tau maintain corpus luteum abrogating release luteolytic pulses prostaglandin F2 (PGF) epithelium. antiluteolytic effects dependent progesterone. stimulation over 8-10 days suppresses gene GE. concomitant with decreases mucin glycoprotein one (MUC-1), an inhibitor blastocyst As begins implantation 15, binucleate trophectodermal differentiate placental lactogen (PL), member prolactin (PRL) (GH) family. PL stimulates UTMP OPN. Interestingly, require absence exposure During mid-pregnancy, mononuclear GH can also act progestinized uterus hypertrophy function. this servomechanism hyperplasia 20 50 maximal when majority fetal development occurs

Language: Английский

---

Progesterone and Placental Hormone Actions on the Uterus: Insights from Domestic Animals1

Biology of Reproduction, Journal Year: 2004, Volume and Issue: 71(1), P. 2 - 10

Published: July 1, 2004

Progesterone is unequivocally required for maternal support of conceptus (embryo/fetus and associated extraembryonic membranes) survival development. In cyclic sheep, progesterone paradoxically involved in suppressing then initiating development the endometrial luteolytic mechanism. pregnant negatively autoregulates receptor (PR) gene expression luminal (LE) superficial glandular epithelium (GE). PR loss closely followed by increases epithelial estrogen (ERα) oxytocin (OTR), allowing to induce uterine release prostaglandin F2α pulses. produces interferon tau (IFNτ) that acts on endometrium inhibit transcription ERα thus After Day 13 pregnancy, epithelia do not express PR, whereas stroma myometrium remain positive. The absence GE onset differentiated function glands during pregnancy. sequential, overlapping actions progesterone, IFNτ, placental lactogen (PL), growth hormone (GH) comprise a hormonal servomechanism regulates gland morphogenesis terminal gestation. pigs, estrogen, pregnancy-recognition signal, fibroblast factor 7 (FGF-7) LE that, turn, stimulates proliferation functions trophectoderm, which expresses FGF-7. Strategic manipulation these physiological mechanisms may offer therapeutic schemes improve capacity, survival, reproductive health domestic animals humans.

Language: Английский

---

The progesterone receptor regulates implantation, decidualization, and glandular development via a complex paracrine signaling network

Molecular and Cellular Endocrinology, Journal Year: 2011, Volume and Issue: 357(1-2), P. 108 - 118

Published: Nov. 18, 2011

Language: Английский

---

Extracellular Vesicles in Luminal Fluid of the Ovine Uterus

PLoS ONE, Journal Year: 2014, Volume and Issue: 9(3), P. e90913 - e90913

Published: March 10, 2014

Microvesicles and exosomes are nanoparticles released from cells can contain small RNAs, mRNA proteins that affect at distant sites. In sheep, endogenous beta retroviruses (enJSRVs) expressed in the endometrial epithelia of uterus be transferred to conceptus trophectoderm. One potential mechanism enJSRVs transfer is via exosomes/microvesicles. Therefore, studies were conducted evaluate uterine luminal fluid (ULF) sheep. Exosomes/microvesicles (hereafter referred as extracellular vesicles) isolated ULF day 14 cyclic pregnant ewes using ExoQuick-TC. Transmission electron microscopy nanoparticle tracking analysis found isolates contained vesicles ranged 50 200 nm diameter. The positive for two common markers (CD63 HSP70) by Western blot analysis. Proteins determined mass spectrometry Extracellular vesicle RNA was analyzed RNAs sequencing RT-PCR. a large number miRNAs including 81 conserved mature miRNAs. Cyclic env gag could delivered heterologous vitro. These support hypothesis deliver conceptus, which important regulate trophectoderm development. Importantly, these idea containing select miRNAs, present likely have biological role conceptus-endometrial interactions establishment maintenance pregnancy.

Language: Английский

---

Unus pro omnibus, omnes pro uno: A novel, evidence-based, unifying theory for the pathogenesis of endometriosis

Medical Hypotheses, Journal Year: 2017, Volume and Issue: 103, P. 10 - 20

Published: March 31, 2017

Language: Английский

---

Extracellular Vesicles Originate from the Conceptus and Uterus During Early Pregnancy in Sheep1

Biology of Reproduction, Journal Year: 2016, Volume and Issue: 94(3)

Published: Jan. 28, 2016

Cells release diverse types of membrane-bound vesicles endosomal and plasma membrane origin, termed exosomes microvesicles, respectively. Extracellular (EVs) represent an important mode intercellular communication by transferring select RNAs, proteins, lipids between cells. The present studies tested the hypothesis that elongating ovine conceptus uterus produces EVs mediate conceptus-maternal interactions during early pregnancy. In Study 1, were purified from uterine luminal fluid Day 14 cyclic sheep. fluorescently labeled with PKH67 dye infused into lumen pregnant sheep for 6 days using osmotic pump. On 14, observed in trophectoderm epithelia, but not stroma or myometrium. 2, conceptuses cultured ex vivo 24 h found to culture medium. Proteomics analysis conceptus-derived identified 231 proteins enriched extracellular space several protein classes, including proteases, protease inhibitors, chaperones chaperonins. RNA sequencing detected expression 512 mRNAs. top-expressed genes overrepresented ribosomal functions components. Isolated Labeled ovary other maternal tissues. These support ideas emanate both are involved those cells establishment pregnancy

Language: Английский

---

Uterine Glands: Developmental Biology and Functional Roles in Pregnancy

Endocrine Reviews, Journal Year: 2019, Volume and Issue: 40(5), P. 1424 - 1445

Published: May 10, 2019

All mammalian uteri contain glands in the endometrium that develop only or primarily after birth. Gland development adenogenesis postnatal uterus is intrinsically regulated by proliferation, cell-cell interactions, growth factors and their inhibitors, as well transcription factors, including forkhead box A2 (FOXA2) estrogen receptor α (ESR1). Extrinsic regulating originate from other organs, ovary, pituitary, mammary gland. The infertility recurrent pregnancy loss observed uterine gland knockout sheep mouse models support a primary role for secretions products of success. Recent studies mice revealed glandular epithelia govern postimplantation establishment through effects on stromal cell decidualization placental development. In humans, and, inference, are hypothesized to be critical blastocyst survival implantation embryo during first trimester before onset fetal-maternal circulation. A variety hormones placenta, cells impact secretory function pregnancy. This review summarizes new information related developmental biology discusses novel perspectives functional roles

Language: Английский

---