The Power of Predictions: An Emerging Paradigm for Psychological Research

Current Directions in Psychological Science, Journal Year: 2019, Volume and Issue: 28(3), P. 280 - 291

Published: April 16, 2019

The last two decades of neuroscience research has produced a growing number studies that suggest the various psychological phenomena are by predictive processes in brain. When considered together, these form coherent, neurobiologically-inspired program for guiding about mind and behavior. In this paper, we briefly consider common assumptions hypotheses unify an emerging framework discuss its ramifications, both improving replicability robustness innovating theory suggesting alternative ontology human mind.

Language: Английский

---

Evolving perspectives on the sources of the frequency-following response

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Nov. 6, 2019

Abstract The auditory frequency-following response (FFR) is a non-invasive index of the fidelity sound encoding in brain, and used to study integrity, plasticity, behavioral relevance neural sound. In this Perspective, we review recent evidence suggesting that, humans, FFR arises from multiple cortical subcortical sources, not just subcortically as previously believed, illustrate how complex sounds can enhance wider field neuroscience. Far being use only basic processes, an uncommonly multifaceted yielding wealth information, with much yet be tapped.

Language: Английский

---

Making Sense of Mismatch Negativity

Frontiers in Psychiatry, Journal Year: 2020, Volume and Issue: 11

Published: June 11, 2020

Evoked potentials provide valuable insight into brain processes that are integral to our ability interact effectively and efficiently in the world. The mismatch negativity (MMN) component of evoked potential has proven highly informative on ways which sensitivity regularity contributes perception cognition. This review offers a compendium research MMN with view scaffolding an appreciation for its use as tool explore way regularities contribute predictions about sensory environment over many timescales. In compiling this work interest index encoding memory addressed, well attention. Perspectives possible underlying computational reviewed recent observations invite consideration how relates we learn, what learn why.

Language: Английский

---

Neural generators of the frequency-following response elicited to stimuli of low and high frequency: A magnetoencephalographic (MEG) study

NeuroImage, Journal Year: 2021, Volume and Issue: 231, P. 117866 - 117866

Published: Feb. 15, 2021

The frequency-following response (FFR) to periodic complex sounds has gained recent interest in auditory cognitive neuroscience as it captures with great fidelity the tracking accuracy of sound features ascending system. Seminal studies suggested FFR a correlate subcortical encoding, yet aiming locate its sources challenged this assumption, demonstrating that receives some contribution from cortex. Based on frequency-specific phase-locking capabilities along hierarchy, we hypothesized FFRs higher frequencies would receive less cortical than those lower frequencies, hence supporting major involvement for these high frequency sounds. Here, used magnetoencephalographic (MEG) approach trace neural elicited healthy adults (N = 19) low (89 Hz) and (333 were clearly observable MEG comparable obtained simultaneous electroencephalographic recordings. Distributed source modeling analyses revealed midbrain, thalamic, contributions FFR, arranged configurations. Our results showed main high-frequency originated inferior colliculus medial geniculate body thalamus, no significant contribution. In contrast, low-frequency had located cortices, also received originating midbrain thalamic structures. These findings support multiple generator hypothesis are relevant our understanding encoding suggesting hierarchical organization periodicity encoding.

Language: Английский

---

Dynamic models for musical rhythm perception and coordination

Frontiers in Computational Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: May 17, 2023

Rhythmicity permeates large parts of human experience. Humans generate various motor and brain rhythms spanning a range frequencies. We also experience synchronize to externally imposed rhythmicity, for example from music song or the 24-h light-dark cycles sun. In context music, humans have ability perceive, generate, anticipate rhythmic structures, example, “the beat.” Experimental behavioral studies offer clues about biophysical neural mechanisms that underlie our abilities, different areas are involved but many open questions remain. this paper, we review several theoretical computational approaches, each centered at levels description, address specific aspects musical generation, perception, attention, perception-action coordination, learning. survey methods results applications dynamical systems theory, neuro-mechanistic modeling, Bayesian inference. Some frameworks rely on synchronization intrinsic span relevant frequency range; some formulations involve real-time adaptation schemes error-correction align phase dedicated circuit; others learning dynamically adjusting expectations make rhythm tracking predictions. Each while initially designed answer questions, offers possibility being integrated into larger framework provides insights perceive patterns.

Language: Английский

---

Neuronal responses to omitted tones in the auditory brain: A neuronal correlate for predictive coding

Science Advances, Journal Year: 2023, Volume and Issue: 9(24)

Published: June 14, 2023

Prediction provides key advantages for survival, and cognitive studies have demonstrated that the brain computes multilevel predictions. Evidence predictions remains elusive at neuronal level because of complexity separating neural activity into stimulus responses. We overcome this challenge by recording from single neurons cortical subcortical auditory regions in anesthetized awake preparations, during unexpected omissions interspersed a regular sequence tones. find subset responds reliably to omitted In animals, omission responses are similar but larger more frequent, indicating arousal attentional state levels affect degree which neuronally represented. Omission-sensitive also responded frequency deviants, with their getting emphasized state. Because occur absence sensory input, they provide solid empirical evidence implementation predictive process.

Language: Английский

---

Neural correlates of novelty detection in the primary auditory cortex of behaving monkeys

Cell Reports, Journal Year: 2024, Volume and Issue: 43(3), P. 113864 - 113864

Published: Feb. 27, 2024

The neural mechanisms underlying novelty detection are not well understood, especially in relation to behavior. Here, we present single-unit responses from the primary auditory cortex (A1) two monkeys trained detect deviant tones amid repetitive ones. Results show that can sounds, and there is a strong correlation between late neuronal (250–350 ms after onset) monkeys' perceptual decisions. magnitude timing of both behavioral increased by larger frequency differences standard increasing number preceding deviant. This suggests A1 neurons encode behaving monkeys, influenced stimulus relevance expectations. study provides evidence supporting aspects predictive coding sensory cortex.

Language: Английский

---

Prediction error signaling explains neuronal mismatch responses in the medial prefrontal cortex

PLoS Biology, Journal Year: 2020, Volume and Issue: 18(12), P. e3001019 - e3001019

Published: Dec. 21, 2020

The mismatch negativity (MMN) is a key biomarker of automatic deviance detection thought to emerge from 2 cortical sources. First, the auditory cortex (AC) encodes spectral regularities and reports frequency-specific deviances. Then, more abstract representations in prefrontal (PFC) allow detect contextual changes potential behavioral relevance. However, precise location time asynchronies between neuronal correlates underlying this frontotemporal network remain unclear elusive. Our study presented oddball paradigms along with “no-repetition” controls record responses spiking activity local field potentials at rat medial PFC. Whereas system are mainly induced by stimulus-dependent effects, we found that responsiveness PFC was driven unpredictability, yielding context-dependent, comparatively delayed, robust longer-lasting mostly comprised prediction error signaling activity. This characteristically different composition discarded could be simply inherited or amplified downstream system. Conversely, it plausible for exert top-down influences on AC, since exhibited flexible potent predictive processing, capable suppressing redundant input efficiently than AC. Remarkably, course observed AC combined coincided large-scale MMN-like signals reported brain, thereby linking microscopic, mesoscopic, macroscopic levels detection.

Language: Английский

---

Corticothalamic Pathways in Auditory Processing: Recent Advances and Insights From Other Sensory Systems

Frontiers in Neural Circuits, Journal Year: 2021, Volume and Issue: 15

Published: Aug. 19, 2021

The corticothalamic (CT) pathways emanate from either Layer 5 (L5) or 6 (L6) of the neocortex and largely outnumber ascending, thalamocortical pathways. CT provide anatomical foundations for an intricate, bidirectional communication between thalamus cortex. They act as dynamic circuits information transfer with ability to modulate even drive response properties target neurons at each synaptic node circuit. L6 feedback enable cortex shape nature its driving inputs, by directly modulating sensory message arriving thalamus. L5 can postsynaptic initiate a transthalamic corticocortical circuit which cortical areas communicate other. For this reason, place heart through hierarchy. Recent evidence goes further suggest that via regulates functional connectivity within across regions, might be engaged in cognition, behavior, perceptual inference. As descending reciprocal context-dependent cortex, we venture projections are particularly interesting context hierarchical inference formulations such those contemplated predictive processing schemes, so far heavily rely on implementations. We discuss recent proposals suggesting thalamus, higher order pathways, could coordinate contextualize hierarchies. will explore these ideas focus auditory system.

Language: Английский

---

Reduced Auditory Mismatch Negativity Reflects Impaired Deviance Detection in Schizophrenia

Schizophrenia Bulletin, Journal Year: 2020, Volume and Issue: 46(4), P. 937 - 946

Published: Jan. 19, 2020

The auditory mismatch negativity (MMN) is a translatable electroencephalographic biomarker automatically evoked in response to unattended sounds that robustly associated with cognitive and psychosocial disability patients schizophrenia. Although recent animal studies have tried clarify the neural substrates of MMN, nature schizophrenia-related deficits unknown. In this study, we applied novel paradigm developed from translational model carefully deconstruct constituent neurophysiological processes underlying MMN generation. Patients schizophrenia (N = 25) healthy comparison subjects (HCS; N 27) underwent testing using both conventional oddball "many-standards paradigm" was specifically subcomponent adaptation deviance detection are presumed underlie MMN. Using paradigm, exhibited large effect size duration frequency consistent many previous studies. Furthermore, showed selective impairments but no impairment repeated tones. These findings support use many-standards for deconstructing implications these measures accelerate development new treatments target perceptual related disorders.

Language: Английский

---