Association between gut microbiota development and allergy in infants born during pandemic‐related social distancing restrictions

Allergy, Journal Year: 2024, Volume and Issue: 79(7), P. 1938 - 1951

Published: Feb. 29, 2024

Abstract Background Several hypotheses link reduced microbial exposure to increased prevalence of allergies. Here we capitalize on the opportunity study a cohort infants (CORAL), raised during COVID‐19 associated social distancing measures, identify environmental exposures and dietary factors that contribute early life microbiota development examine their associations with allergic outcomes. Methods Fecal samples were sequenced from at 6 ( n = 351) repeated 12 343) months, using 16S sequencing. Published data pre‐pandemic cohorts included for comparisons. Online questionnaires collected epidemiological information home environment, healthcare utilization, infant health, diseases, diet. Skin prick testing (SPT) was performed 24 320) months age, accompanied by atopic dermatitis food allergy assessments. Results The relative abundance bifidobacteria higher, while environmentally transmitted bacteria such as Clostridia lower in CORAL compared previous cohorts. multiple taxa correlated index. Plant based foods weaning positively impacted development. Bifidobacteria levels butyrate producers negatively AD SPT positivity. allergen sensitization, allergy, did not increase over levels. Conclusions Environmental components significantly impact community assembly. Our results also suggest vertically appropriate supports may be more important than microbes alone protection against diseases infancy.

Language: Английский

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Preparation and synbiotic interaction mechanism of microcapsules of Bifidobacterium animalis F1–7 and human milk oligosaccharides (HMO)

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129152 - 129152

Published: Jan. 2, 2024

Language: Английский

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Bioactive Components of Human Milk and Their Impact on Child’s Health and Development, Literature Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1487 - 1487

Published: May 14, 2024

The composition of human breast milk is an ideal combination substances necessary for the healthy development infant’s body while protecting from pathogens and balanced microbiota. Its dynamic changes with age child, meeting their current needs. study provides a thorough overview components, such as immunological growth factors, hormones, carbohydrates, lipids, minerals, vitamins. Authors focus on capturing most important aspects effects these newborn’s body, also looking specific connections describing given systems. Supplementation use ingredients are discussed. purpose this paper to present state knowledge about bioactive components impact growth, development, health young child.

Language: Английский

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Interactions of human milk oligosaccharides with the immune system

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 14, 2025

Human milk oligosaccharides (HMOs) are abundant, diverse and complex sugars present in human breast milk. HMOs well-characterized barriers to microbial infection by modulating the microbiome they also thought be nutritionally beneficial infant. The structural variety of over 200 HMOs, including neutral, fucosylated sialylated forms, allows them interact with immune system various ways. Clinically, impact allergic diseases, reducing autoimmune inflammatory responses, offer support preterm infant health. This review examines HMO composition associated immunomodulatory effects, interactions cell receptors gut-associated responses. These properties highlight potential for use early stage development as novel immunotherapeutics. research is rapidly evolving promises innovative treatments immune-related conditions improved health outcomes.

Language: Английский

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Clinical Studies on the Supplementation of Manufactured Human Milk Oligosaccharides: A Systematic Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(16), P. 3622 - 3622

Published: Aug. 17, 2023

Human milk oligosaccharides (HMOs) are a major component of human milk. They associated with multiple health benefits and manufactured on large scale for their addition to different food products. In this systematic review, we evaluate the outcomes published clinical trials involving supplementation HMOs. We screened PubMed database Cochrane Library, identifying 26 relevant five publications describing follow-up studies. The varied in study populations, including healthy term infants, infants medical indications, children, adults. tested eight HMO structures individually or as blends varying doses. All included safety tolerance assessments, some also assessed growth, stool characteristics, infections, gut microbiome composition, microbial metabolites, biomarkers. studies consistently found that was safe well tolerated. Infant reported shift towards those observed breastfed intestinal immune markers. Beneficial system effects have been other populations following supplementation. Further needed substantiate understand structure dose dependency.

Language: Английский

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Effects of Human Milk Oligosaccharides in Infant Health Based on Gut Microbiota Alteration

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(2), P. 994 - 1001

Published: Jan. 5, 2023

The primary active components of breast milk are human oligosaccharides (HMOs). HMOs provide many benefits to infants, including regulating their metabolism, immune system, and brain development. Recent studies have emphasized that act as prebiotics by the metabolism intestinal microorganisms produce short-chain fatty acids, which crucial for infant In addition, with different structural characteristics can form microbial compositions. HMOs-induced predominant microbes, Bifidobacterium infantis, B. bifidum, breve, longum, metabolites demonstrated pertinent health-promoting properties. Meanwhile, could also directly reduce occurrence diseases through effects preventing pathogen infection. this review, we address probable function inside HMOs-gut microbiota-infant network, describing physiological functions implications diet on network.

Language: Английский

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The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(5), P. 1361 - 1361

Published: Feb. 27, 2024

Inflammatory bowel diseases (IBDs) have seen an exponential increase in incidence, particularly among pediatric patients. Psychological stress is a significant risk factor influencing the disease course. This review assesses interaction between and progression, focusing on articles that quantified inflammatory markers IBD patients exposed to varying degrees of psychological stress.

Language: Английский

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High hydrostatic pressure is similar to Holder pasteurization in preserving donor milk antimicrobial activity

Pediatric Research, Journal Year: 2024, Volume and Issue: 95(7), P. 1749 - 1753

Published: Jan. 27, 2024

Language: Английский

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Human Milk Oligosaccharides: Potential Applications in COVID-19

Biomedicines, Journal Year: 2022, Volume and Issue: 10(2), P. 346 - 346

Published: Feb. 1, 2022

Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has become a global health crisis with more than four million deaths worldwide. A substantial number of COVID-19 survivors continue suffering from long-COVID syndrome, long-term complication exhibiting chronic inflammation and gut dysbiosis. Much effort is being expended to improve therapeutic outcomes. Human milk oligosaccharides (hMOS) are non-digestible carbohydrates known exert benefits in breastfed infants preventing infection, maintaining immune homeostasis nurturing healthy microbiota. These beneficial effects suggest the hypothesis that hMOS might have applications as receptor decoys, immunomodulators, mucosal signaling agents, prebiotics. This review summarizes biogenesis classification, describes possible mechanisms action upon different phases SARS-CoV-2 discusses challenges opportunities research for clinical COVID-19.

Language: Английский

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Current Advances in Structure–Function Relationships and Dose-Dependent Effects of Human Milk Oligosaccharides

Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(21), P. 6328 - 6353

Published: May 20, 2022

HMOs (human milk oligosaccharides) are the third most important nutrient in breast milk. As complex glycans, play an role regulating neonatal intestinal immunity, resisting viral and bacterial infections, displaying anti-inflammatory characteristics, promoting brain development. Although there have been some previous reports of HMOs, a detailed literature review summarizing structure-activity relationships dose-dependent effects is lacking. Hence, after introducing structures synthetic pathways this summarizes categorizes identified structure-function HMOs. Differential mechanisms different structural utilization by microorganisms summarized. This also emphasizes recent advances interactions between health benefits variance dosage effect based on vitro cell tests, animal experiments, human intervention studies. The potential chemical structure, selection, physiological properties as functional foods vital for further understanding their future applications.

Language: Английский

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