The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: June 8, 2023

Interleukin-10 (IL-10) is a pleiotropic cytokine that has fundamental role in modulating inflammation and maintaining cell homeostasis. It primarily acts as an anti-inflammatory cytokine, protecting the body from uncontrolled immune response, mostly through Jak1/Tyk2 STAT3 signaling pathway. On other hand, IL-10 can also have immunostimulating functions under certain conditions. Given pivotal of modulation, this could relevant implications pathologies characterized by hyperinflammatory state, such cancer, or infectious diseases case COVID-19 Post-COVID-19 syndrome. Recent evidence proposed predictor severity mortality for patients with acute post-acute SARS-CoV-2 infection. In context, act endogenous danger signal, released tissues undergoing damage attempt to protect organism harmful hyperinflammation. Pharmacological strategies aimed potentiate restore immunomodulatory action may represent novel promising avenues counteract storm arising hyperinflammation effectively mitigate severe complications. Natural bioactive compounds, derived terrestrial marine photosynthetic organisms able increase expression, useful prevention strategy curb elevation will be discussed here. However, multifaceted nature taken into account attempts modulate its levels.

Language: Английский

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Apigenin: A Bioflavonoid with a Promising Role in Disease Prevention and Treatment

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1353 - 1353

Published: June 18, 2024

Apigenin is a powerful flavone compound found in numerous fruits and vegetables, it offers health-promoting benefits. Many studies have evidenced that this has potential role as an anti-inflammatory antioxidant compound, making promising candidate for reducing the risk of pathogenesis. It also been to positively affect various systems body, such respiratory, digestive, immune, reproductive systems. effective treating liver, lung, heart, kidney, neurological diseases, diabetes, maintaining good oral skin health. Multiple reported capable suppressing types cancer through induction apoptosis cell-cycle arrest, cell migration invasion, reduction inflammation, inhibiting angiogenesis. When used combination with other drugs, apigenin increases their efficacy, reduces side effects, improves response chemotherapy. This review broadly analyzes apigenin’s disease management by modulating biological activities. In addition, described interaction compounds or drugs nanoformulation different pathogeneses. Further extensive research needed explore mechanism action, safety, efficacy prevention treatment.

Language: Английский

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Advances in Flavonoid Research: Sources, Biological Activities, and Developmental Prospectives

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(4), P. 2884 - 2925

Published: March 26, 2024

At present, the occurrence of a large number infectious and non-communicable diseases poses serious threat to human health as well drug development for treatment these diseases. One most significant challenges is finding new candidates that are therapeutically effective have few or no side effects. In this respect, active compounds in medicinal plants, especially flavonoids, potentially useful with wide range pharmacological activities. They naturally present nature valuable many Flavonoids divided into fourteen categories mainly derived from plant extraction, chemical synthesis structural modification, biosynthesis. The modification flavonoids an important way discover drugs, but biosynthesis currently considered promising research direction potential revolutionize production pipeline flavonoids. However, relevant problems such metabolic pathway analyses cell protocols need be addressed on urgent basis. review, techniques assessing biological activities mechanisms their elucidated modes interaction other drugs described. Moreover, novel delivery systems, nanoparticles, bioparticles, colloidals, etc., gradually becoming means addressing issues poor hydrophilicity, lipophilicity, stability, low bioavailability review summarizes latest progress existing therapeutic efficacy, how can solved

Language: Английский

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Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 5, 2023

Inflammatory Bowel Disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract. Though pathogenesis IBD remains unclear, diet increasingly recognized as pivotal factor influencing its onset and progression. Fatty acids, essential components dietary lipids, play diverse roles in IBD, ranging from anti-inflammatory immune-regulatory functions to gut-microbiota modulation barrier maintenance. Short-chain fatty acids (SCFAs), products indigestible fiber fermentation by gut microbiota, have strong properties are seen key protective factors against IBD. Among long-chain saturated trans ω-6 polyunsaturated exhibit pro-inflammatory effects, while oleic acid ω-3 display actions. Lipid mediators derived serve bioactive molecules, immune cell offering both benefits. Recent research has also highlighted potential medium- very modulating inflammation, mucosal barriers, microbiota Given these insights, intervention supplementation with short-chain emerging therapeutic strategies for This review elucidates impact various lipid on delves into avenues stemming compounds.

Language: Английский

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Gut Microbiota and Inflammation Modulation in a Rat Model for Ulcerative Colitis after the Intraperitoneal Administration of Apigenin, Luteolin, and Xanthohumol

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3236 - 3236

Published: March 12, 2024

Ulcerative colitis (UC) is a chronic inflammatory disorder affecting the colon, with symptomatology influenced by factors including environmental, genomic, microbial, and immunological interactions. Gut microbiota dysbiosis, characterized bacterial population alterations, contributes to intestinal homeostasis disruption aberrant immune system activation, thereby exacerbating state. This study assesses therapeutic efficacy of intraperitoneal (IP) injected flavonoids (apigenin, luteolin, xanthohumol) in reduction parameters modulation gut murine model ulcerative colitis. Flavonoids interact modulating their composition serving as substrates for fermentation into other anti-inflammatory bioactive compounds. Our results demonstrate effectiveness luteolin xanthohumol treatment enhancing relative abundance microorganisms, attenuating pro-inflammatory species. Moreover, all three exhibit cytokine levels, strongly demonstrating utility alleviating associated physical UC symptoms. suggests that this molecule potential alternative or co-therapy conventional pharmacological interventions, potentially mitigating adverse effects. A limited impact on observed apigenin, attributed its solubility constraints via chosen administration route, resulting accumulation mesentery.

Language: Английский

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A Systematic Review: Quercetin—Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12091 - 12091

Published: Nov. 11, 2024

The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize existing research quercetin's potential health benefits, therapeutic properties, effectiveness in disease prevention treatment. In addition evaluating for drug development with fewer side effects lower toxicity, type attempts collect scientific evidence addressing roles as an antioxidant, anti-inflammatory, antibacterial, anticancer agent. first part, we analyze various flavonoid compounds, focusing their chemical structure, classification, natural sources. We highlight most recent biological activities reported literature. Among these pay special attention quercetin, detailing its physicochemical process biosynthesis plants. also present sources emphasize such antioxidant anti-inflammatory effects. Additionally, discuss methods enhance bioavailability, analyzing latest effective delivery systems based quercetin.

Language: Английский

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Anti-Inflammatory, Barrier Maintenance, and Gut Microbiome Modulation Effects of Saccharomyces cerevisiae QHNLD8L1 on DSS-Induced Ulcerative Colitis in Mice

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6721 - 6721

Published: April 4, 2023

The use of probiotics has been considered as a new therapy option for ulcerative colitis (UC), and yeast recently received widespread recommendation human health. In this study, the probiotic characteristics four strains, Saccharomyces boulardii CNCMI-745, Kluyveromyces marxianus QHBYC4L2, cerevisiae QHNLD8L1, Debaryomyces hansenii QSCLS6L3, were evaluated in vitro; their ability to ameliorate dextran sulfate sodium (DSS)-induced was investigated. Among these, S. QHNLD8L1 protected against colitis, which reflected by increased body weight, colon length, histological injury relief, decreased gut inflammation markers, intestinal barrier restoration. abundance pathogenic bacteria Escherichia-Shigella Enterococcaceae mice with after treatment. Moreover, enriched beneficial Lactobacillus, Faecalibaculum, Butyricimonas, enhanced carbon metabolism fatty acid biosynthesis function, short chain (SCFAs) production. Taken together, our results indicate great potential supplementation prevention alleviation UC.

Language: Английский

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New Insights of Biological Functions of Natural Polyphenols in Inflammatory Intestinal Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9581 - 9581

Published: May 31, 2023

The intestine is critically crucial for nutrient absorption and host defense against exogenous stimuli. Inflammation-related intestinal diseases, including enteritis, inflammatory bowel disease (IBD), colorectal cancer (CRC), are heavy burdens human beings due to their high incidence devastating clinical symptoms. Current studies have confirmed that responses, along with oxidative stress dysbiosis as critical pathogenesis, involved in most diseases. Polyphenols secondary metabolites derived from plants, which possess convincible anti-oxidative anti-inflammatory properties, well regulation of microbiome, indicating the potential applications enterocolitis CRC. Actually, accumulating based on biological functions polyphenols been performed investigate functional roles underlying mechanisms over last few decades. Based mounting evidence literature, objective this review outline current research progress regarding category, functions, metabolism within intestine, prevention treatment might provide ever-expanding new insights utilization natural polyphenols.

Language: Английский

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Novel applications of Yinhua Miyanling tablets in ulcerative colitis treatment based on metabolomics and network pharmacology

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155366 - 155366

Published: Jan. 21, 2024

Language: Английский

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Egg yolk phosphatidylcholine alleviates DSS-induced colitis in BALB/c mice

Food & Function, Journal Year: 2023, Volume and Issue: 14(20), P. 9309 - 9323

Published: Jan. 1, 2023

Ulcerative colitis (UC) is a common inflammatory bowel disease, whose incidence on the rise worldwide. The drugs commonly used for UC are often associated with number of side effects. Therefore, development effective, food-borne substances in line current needs. Egg yolk phosphatidylcholine (EYPC) one abundant lipids egg and possesses various biological activities. However, its protective effect against has not been clarified. In this study, anti-UC activity EYPC was investigated using dextran sodium sulfate (DSS)-induced model BALB/c mice. results showed that supplementation inhibited DSS-induced colon shortening, spleen index disease increase intestinal structural damage. could down-regulate levels TNF-α, IL-1β, IL-6 MPO restore goblet cells level tight junction (TJ) proteins. Besides, modulated composition gut microbiota, lowered relative abundance pathogenic bacterium Parabacteroides upregulated beneficial bacteria Alistipes Lachnospiraceae_NK4A136_group. These evidenced attenuate mice had potential to prevent treat UC.

Language: Английский

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