Mesenchymal Stem Cells for Treating Alzheimer’s Disease: Cell Therapy and Chemical Reagent Pretreatment DOI
Kexin Zhang,

Xinzhe Du,

Yao Gao

et al.

Journal of Alzheimer s Disease, Journal Year: 2023, Volume and Issue: 93(3), P. 863 - 878

Published: April 25, 2023

As the size of population aged 65 and older continues to grow, incidence mortality rates Alzheimer’s disease (AD) are increasing annually. Unfortunately, current treatments only treat symptoms temporarily do not alter patients’ life expectancy or course AD. Mesenchymal stem cells (MSCs) have shown a certain therapeutic potential in neurodegenerative diseases including AD due their neuroinflammatory regulation neuroprotective effects. However, low survival homing MSCs after transplantation seriously affect effectiveness. Therefore, appropriate vitro preconditioning is necessary increase improve effectiveness treating Here we summarize mechanisms chemical reagents used for pretreatment MSCs.

Language: Английский

Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil DOI
Zhongming Yang, Carlos L. Céspedes, Zhongguo Yang

et al.

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 50

Published: Jan. 4, 2025

Cancer is the world's second most common cause of death, with colon cancer (CC) ranking third in prevalence and cancer-related fatalities. CC originates or rectum influenced by genetic mutations, lifestyle, diet. Although chemotherapy, especially 5-fluorouracil (5-FU), fundamental to treatment has improved patient survival, its benefits are often limited significant side effects emerging drug resistance. Recently, plant-based foods have drawn interest research for their natural bioactive compounds relatively low toxicity. Certain plant not only exhibit anti-cancer activity but may also boost effectiveness 5-FU while reducing adverse effects. Despite evidence suggesting a synergistic effect between 5-FU, this area remains fragmented. This review consolidates current on including fruits, vegetables, legumes, tea bioactives treatment. Besides, it explores mechanisms through which these enhance efficacy reduce effects, evaluates clinical application prospects, identifies challenges future directions. comprehensive analysis aims provide scientific foundation integrated CC, highlighting potential enhancing chemotherapy associated toxicities.

Language: Английский

Citations

6
Plants as a Source of Anticancer Agents: From Bench to Bedside DOI Creative Commons
Wamidh H. Talib, Safa Daoud, Asma Ismail Mahmod

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(15), P. 4818 - 4818

Published: July 27, 2022

Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack selectivity and serious side effects. hallmarks biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple a promising strategy to treat cancer. The diversity in chemical structure relatively low toxicity make plant-derived natural products source for development new more effective that have capacity target In this review, we discussed activities ten extracted from plants. majority these inhibit targeting hallmarks, many chemicals reached clinical applications. Studies review provide solid ground researchers physicians design combination using products.

Language: Английский

Citations

46
The science of resveratrol, formulation, pharmacokinetic barriers and its chemotherapeutic potential DOI

Imogen Robertson,

Tung Wai Hau,

Farheen Sami

et al.

International Journal of Pharmaceutics, Journal Year: 2022, Volume and Issue: 618, P. 121605 - 121605

Published: Feb. 26, 2022

Language: Английский

Citations

45
A systematic review of the therapeutic effects of resveratrol in combination with 5-fluorouracil during colorectal cancer treatment: with a special focus on the oxidant, apoptotic, and anti-inflammatory activities DOI Creative Commons

Hossein Moutabian,

Mehrsa Majdaeen, Ruhollah Ghahramani‐Asl

et al.

Cancer Cell International, Journal Year: 2022, Volume and Issue: 22(1)

Published: April 2, 2022

5-fluorouracil (5-FU), an effective chemotherapy drug, is commonly applied for colorectal cancer treatment. Nevertheless, its toxicity to normal tissues and the development of tumor resistance are main obstacles successful hence, clinical application limited. The use resveratrol can increase 5-FU-induced cytotoxicity mitigate unwanted adverse effects. This study aimed review potential therapeutic effects in combination with 5-FU against cancer.

Language: Английский

Citations

43
Resveratrol as sensitizer in colorectal cancer plasticity DOI Creative Commons
Aranka Brockmueller, Anjana Sajeev, Lenka Koklesová

et al.

Cancer and Metastasis Reviews, Journal Year: 2023, Volume and Issue: 43(1), P. 55 - 85

Published: July 29, 2023

Abstract Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a leading cause of deaths worldwide. Chemotherapy as monotherapy can lead to significant side effects and chemoresistance that be linked several resistance-activating biological processes, including an increase in inflammation, cellular plasticity, multidrug resistance (MDR), inhibition the sentinel gene p53, apoptosis. As consequence, tumor cells escape effectiveness chemotherapeutic agents. This underscores need for cross-target therapeutic approaches are not only pharmacologically safe but also modulate multiple potent signaling pathways sensitize overcome standard drugs. In recent years, scientists have been searching natural compounds used chemosensitizers addition conventional medications synergistic CRC. Resveratrol, polyphenolic phytoalexin found various fruits vegetables such peanuts, berries, red grapes, is one most effective chemopreventive Abundant vitro vivo studies shown resveratrol, interaction with drugs, chemosensitizer CRC agents thus prevents drug by modulating pathways, transcription factors, epithelial-to-mesenchymal transition-plasticity, proliferation, metastasis, angiogenesis, cell cycle, The ability resveratrol modify subcellular may suppress plasticity reversal critical parameters understanding its anti-cancer effects. this review, we focus on chemosensitizing properties and, thus, potential importance additive ongoing treatments. Graphical abstract

Language: Английский

Citations

30
Combination Chemotherapy with Selected Polyphenols in Preclinical and Clinical Studies—An Update Overview DOI Creative Commons
Cvijeta Jakobušić Brala, Ana Marković,

Azra Kugić

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(9), P. 3746 - 3746

Published: April 26, 2023

This review article describes studies published over the past five years on combination of polyphenols, which are most studied in field anticancer effects (curcumin, quercetin, resveratrol, epigallocatechin gallate, and apigenin) chemotherapeutics such as cisplatin, 5-fluorouracil, oxaliplatin, paclitaxel, etc. According to WHO data, research has been limited cancers with highest morbidity rate (lung, colorectal, liver, gastric, breast cancer). A systematic articles (from January 2018 2023) was carried out help all Web Science databases available base clinical studies. Based preclinical presented this review, polyphenols can enhance drug efficacy reduce chemoresistance through different molecular mechanisms. Considering large number studies, curcumin could be a molecule future chemotherapy cocktails. One main problems is related bioavailability polyphenols. The design new co-delivery system for drugs essential research. Some work synergy chemotherapeutic drugs, but some act antagonistically, so caution always required.

Language: Английский

Citations

29
Mechanisms of Action of Fruit and Vegetable Phytochemicals in Colorectal Cancer Prevention DOI Creative Commons
Teresita Alzate Yepes, Lorena Pérez-Palacio, Estefanía Martínez

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(11), P. 4322 - 4322

Published: May 24, 2023

Colorectal cancer (CRC) is the third most common worldwide and its incidence expected to increase by almost 80% 2030. CRC apparition related poor diet, mainly due low consumption of phytochemicals present in fruits vegetables. Hence, this paper reviews promising literature, presenting scientific evidence regarding potential chemopreventive effects. Moreover, reveals structure action mechanisms that these are involved in. The review vegetables rich such as carrots green leafy vegetables, well some pineapple, citrus fruits, papaya, mango, Cape gooseberry, have antioxidant, anti-inflammatory, properties can promote a healthy colonic environment. Fruits daily diet antitumor regulating cell signaling and/or proliferation pathways. plant products recommended reduce risk CRC.

Language: Английский

Citations

26
Progress in the Treatment of Central Nervous System Diseases Based on Nanosized Traditional Chinese Medicine DOI Creative Commons
Jing Li,

Qingyin Long,

Huang Ding

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 28, 2024

Abstract Traditional Chinese Medicine (TCM) is widely used in clinical practice to treat diseases related central nervous system (CNS) damage. However, the blood‐brain barrier (BBB) constitutes a significant impediment effective delivery of TCM, thus substantially diminishing its efficacy. Advances nanotechnology and applications TCM (also known as nano‐TCM) can deliver active ingredients or components across BBB targeted brain region. This review provides an overview physiological pathological mechanisms systematically classifies common CNS types nanocarriers that effectively brain. Additionally, drug strategies for nano‐TCMs utilize vivo properties vitro devices bypass cross are discussed. further focuses on application treatment various diseases. Finally, this article anticipates design strategy with higher efficiency probes their potential treating wider range

Language: Английский

Citations

12
Nanoparticle‐Based Drug Delivery Platform for Simultaneous Administration of Phytochemicals and Chemotherapeutics: Emerging Trends in Cancer Management DOI Creative Commons
S.M. Kawish, Shwetakshi Sharma, Priya Gupta

et al.

Particle & Particle Systems Characterization, Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

Abstract Despite progress in cancer treatments, it remains a leading cause of death worldwide. Current chemotherapy is often hampered by side effects, tissue damage, and drug resistance. To overcome these limitations, research exploring new approaches to improve efficacy reduce its effects. A promising strategy involves combining chemotherapeutic drugs with phytochemicals, which are active compounds derived from plants. Nanotechnology plays crucial role delivering often‐hydrophobic drugs, enhancing their bioavailability solubility. This area represents significant convergence nanotechnology both conventional pharmaceuticals botanical compounds. Global studies increasingly demonstrating the potential combination therapies inhibit cell growth laboratory preclinical models. These suggest synergistic or additive effects that lead improved treatment outcomes. article focuses on recent advancements nano‐drug delivery systems, specifically those designed for simultaneous phytochemicals. It explores selection phytochemicals based anticancer properties, outlines design considerations nanocarriers, discusses how physicochemical characteristics influence release kinetics. Additionally, review examines nanoformulations integrate synthetic natural components, highlighting herbal oils medicines treatment.

Language: Английский

Citations

11
Role of mitochondria in doxorubicin-mediated cardiotoxicity: from molecular mechanisms to therapeutic strategies DOI Creative Commons
Tianen Wang,

Guoli Xing,

Tong Fu

et al.

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(5), P. 809 - 816

Published: Jan. 1, 2024

This comprehensive review delves into the pivotal role of mitochondria in doxorubicin-induced cardiotoxicity, a significant complication limiting clinical use this potent anthracycline chemotherapeutic agent.Doxorubicin, while effective against various malignancies, is associated with dose-dependent potentially leading to irreversible cardiac damage.The meticulously dissects molecular mechanisms underpinning particularly focusing on mitochondrial dysfunction, central player adverse effect.Central discussion concept quality control (MQC), including dynamics (fusion/fission balance) and mitophagy.The presents evidence linking aberrations these processes cardiotoxicity doxorubicin-treated patients.It elucidates how doxorubicin disrupts dynamics, an imbalance between fission fusion, impairs mitophagy, culminating accumulation dysfunctional subsequent cell damage.Furthermore, explores emerging therapeutic strategies targeting dysfunction.It highlights potential modulating enhancing mitophagy mitigate damage.These include pharmacological interventions inhibitors, fusion promoters, agents that modulate underscores promising results from preclinical studies advocating for more extensive trials validate approaches human patients.In conclusion, offers valuable insights intricate relationship dysfunction doxorubicin-mediated cardiotoxicity.It need continued research targeted therapies as means improve safety profile doxorubicin, thereby overall treatment outcomes cancer patients.

Language: Английский

Citations

8