Microbiota and Lifestyle: A Special Focus on Diet

Nutrients, Journal Year: 2020, Volume and Issue: 12(6), P. 1776 - 1776

Published: June 15, 2020

It is widely known that a good balance and healthy function for bacteria groups in the colon are necessary to maintain homeostasis preserve health. However, lack of consensus on what defines gut microbiota multitude factors influence human composition complicate development appropriate dietary recommendations our microbiota. Furthermore, varied response intake probiotics prebiotics observed adults suggests existence potential inter- intra-individual factors, which might account changes greater extent than diet. The changing habits worldwide involving consumption processed foods containing artificial ingredients, such as sweeteners; coincident rise emotional disorders; worsening other lifestyle habits, smoking drug consumption, sleep, can together contribute dysbiosis health impairment, well chronic diseases. This review summarizes current literature effects specific ingredients (probiotics, prebiotics, alcohol, refined sugars sweeteners, fats) involved, dramatically increasing nowadays.

Language: Английский

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Gut Microbiota during Dietary Restrictions: New Insights in Non-Communicable Diseases

Microorganisms, Journal Year: 2020, Volume and Issue: 8(8), P. 1140 - 1140

Published: July 28, 2020

In recent decades, there has been a growing interest in dietary restrictions for their promising effects on longevity and health span. Indeed, these strategies are supposed to delay the onset burden of non-communicable diseases (NCDs) such as obesity, diabetes, cancer neurological gastrointestinal inflammatory diseases. At same time, gut microbiota shown play crucial role NCDs since it is actively involved maintaining homeostasis through its impact nutrients metabolism, barrier, immune system. There evidence that could slow down age-related changes types numbers bacteria, which may counteract dysbiosis. The beneficial positively influence host barrier permeability, brain functions, subsequently, postpone prolonging These new insights lead development novel modulating with end goal treating/preventing NCDs. This review provides an overview animal human studies focusing variations during different restriction, order highlight close relationship between balance host’s benefits induced by nutritional regimens.

Language: Английский

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Vegetarian Diet: An Overview through the Perspective of Quality of Life Domains

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(8), P. 4067 - 4067

Published: April 12, 2021

Vegetarianism has gained more visibility in recent years. Despite the well-described effects of a vegetarian diet on health, its influence quality life individuals who follow it still needs to be properly investigated. Quality relates subjective perception well-being and functionality, encompasses four main domains: physical, psychological, social, environmental. The adoption diet, despite being dietary pattern, could potentially influenced by all these domains, either positively or negatively. This review aims present an overview background, conceptualization, features, potential vegetarianism domains. choice adopting have positive outcomes, such as better physical feelings related morally correct attitude, increased sense belonging (to community), lower environmental impact. Other factors, however, negative impact those choosing abstain from meats other animal products, especially when they go beyond one’s control. These include environment, social/cultural group which person is inserted, gender-based differences, economic aspects, limited access wide variety plant-based foods. It important understand diet—beyond nutritional aspects. Not only do studies this area provide consistent data, but may also contribute mitigating factors that might prevent already it.

Language: Английский

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The Role of Gut Barrier Dysfunction and Microbiome Dysbiosis in Colorectal Cancer Development

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 11

Published: April 15, 2021

Accumulating evidence indicates that breakdown of the+ protective mucosal barrier the gut plays a role in colorectal cancer (CRC) development. Inflammation and oxidative stress colonic epithelium are thought to be involved carcinogenesis integrity may increase exposure colonocytes toxins from milieu, enhancing inflammatory processes release Reactive Oxygen Species (ROS). The aetiological importance microbiome its composition – influenced by consumption processed meats, red meats alcoholic drinks, smoking, physical inactivity, obesity - CRC development is also increasingly being recognized. has diverse roles, such as nutrient metabolism immune modulation. However, microbial encroachment towards promote inflammation even translocation species across lumen. Recent research suggests factors modify above mechanisms, e.g., Western diet, alter microbiota, degrade barrier, expose toxins. it remains unclear how obesity, lifestyle metabolic contribute gut-barrier integrity, leading disturbance, colonocyte damage, potentially This review will discuss interactive roles dysfunction, dysbiosis, endogenous another mechanism development, biomarkers function provide avenues for disease, prevention detection.

Language: Английский

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Elucidating the role of diet in maintaining gut health to reduce the risk of obesity, cardiovascular and other age-related inflammatory diseases: recent challenges and future recommendations

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 4, 2024

A healthy balanced diet is crucial in protecting the immune system against infections and diseases. Poor diets, such as Western diet, contribute to development of metabolic diseases, hypertension, obesity. Microbiota, primarily composed different microorganisms residing gastrointestinal tract (GIT), also play a significant role maintaining gut health. Polyphenols probiotics found fruits, vegetables, whole grains, legumes, nuts, seeds promote health support growth beneficial bacteria. Different types their categories, impact on are mentioned. The relationship between health, risk developing obesity, cardiovascular inflammatory diseases discussed this review article. rationale behind concludes future recommendations for reducing occurrence cardiometabolic other There need standardized research methods, long-term studies, translating scientific knowledge into practical dietary recommendations.

Language: Английский

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Mediterranean diet in the management and prevention of obesity

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 174, P. 112121 - 112121

Published: Feb. 17, 2023

The current pandemic of obesity represents a major global public health problem, mainly due to its association with chronic non-communicable disabling conditions and increased mortality. Population aging increases the chances diseases allowing longer exposure risk factors for these conditions. Obesity is factor contributing pathological aging. Numerous epidemiological studies have shown that death cardiovascular disease cancer progressively as overweight rise. Nutrition research now focused on effects combinations foods in dietary patterns instead those single nutrients or foods. model largest body evidence benefit traditionally followed by inhabitants some Mediterranean countries. There confirming inverse adhering diet obesity. Four meta-analyses randomized controlled trials, including up 16 greater reduction weight BMI MedDiet compared other diets, while meta-analysis 7 prospective cohort studies, found reduced becoming obese gaining over time associated higher adherence MedDiet. This narrative review examines reporting associations overweight/obesity age-associated related

Language: Английский

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The Influence of Dietary Factors on the Gut Microbiota

Microorganisms, Journal Year: 2022, Volume and Issue: 10(7), P. 1368 - 1368

Published: July 7, 2022

There is increasing evidence that diet influences the relationship between gut microbiota and individual health outcomes. Nutrient intake affects composition of microbial community provides metabolites influence host physiology. Dietary patterns, including macronutrient balance feeding/fasting cycles which may be manipulated with dietary regimens based on caloric restriction periods, homeostasis through its impact ecosystem. Along same line, prebiotic probiotic ingredients additives in foods, as well degree food processing have consequences related immune metabolic response human host. Acquiring knowledge these aspects, especially an -omics-integral approach, might provide basis for personalized nutritional interventions directed to avoid dysbiosis contribute prevention major chronic degenerative diseases. Despite vast scientific supporting factors function, underlying mechanisms their potential are far from clear. a lack well-designed longitudinal studies performed target population groups whose patterns can particularly relevant future health, case infants, pregnant women, or athletes.

Language: Английский

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A comprehensive review on infant formula: nutritional and functional constituents, recent trends in processing and its impact on infants’ gut microbiota

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: June 21, 2023

Human milk is considered the most valuable form of nutrition for infants their growth, development and function. So far, there are still some cases where feeding human not feasible. As a result, market infant formula widely increasing, become an alternative or substitute breastfeeding. The nutritional value can be improved by adding functional bioactive compounds like probiotics, prebiotics, oligosaccharides, vitamins, minerals, taurine, inositol, osteopontin, lactoferrin, gangliosides, carnitine etc. For processing formula, diverse thermal non-thermal technologies have been employed. Infant either in powdered form, which requires reconstitution with water ready-to-feed liquid among powder readily available, shelf-stable vastly marketed. Infants' gut microbiota complex ecosystem nutrient composition recognized to lasting effect on it. Likewise, establishment closely parallels host immune growth. Therefore, it must contemplated as important factor consideration while developing formulas. In this review, we focused formulation manufacturing safe nutritious equivalent aligning infant's needs its ultimate impact infants' microbiota.

Language: Английский

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Breaking the barriers: the role of gut homeostasis in Metabolic-Associated Steatotic Liver Disease (MASLD)

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: March 21, 2024

Obesity, insulin resistance (IR), and the gut microbiome intricately interplay in Metabolic-associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic Fatty (NAFLD), a growing health concern. The complex progression of MASLD extends beyond liver, driven by "gut-liver axis," where diet, genetics, gut-liver interactions influence disease development. pathophysiology involves excessive liver fat accumulation, hepatocyte dysfunction, inflammation, fibrosis, with subsequent risk hepatocellular carcinoma (HCC). gut, tripartite barrier, mechanical, immune, microbial components, engages constant communication liver. Recent evidence links dysbiosis disrupted barriers to systemic inflammation progression. Toll-like receptors (TLRs) mediate immunological crosstalk between recognizing structures triggering immune responses. "multiple hit model" development factors like resistance, dysbiosis, genetics/environmental elements disrupting axis, leading impaired intestinal barrier function increased permeability. Clinical management strategies encompass dietary interventions, physical exercise, pharmacotherapy targeting bile acid (BA) metabolism, modulation approaches through prebiotics, probiotics, symbiotics, fecal microbiota transplantation (FMT). This review underscores microbiome, their impact on therapeutic prospects.

Language: Английский

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Dietary Implications of the Bidirectional Relationship between the Gut Microflora and Inflammatory Diseases with Special Emphasis on Irritable Bowel Disease: Current and Future Perspective

Nutrients, Journal Year: 2023, Volume and Issue: 15(13), P. 2956 - 2956

Published: June 29, 2023

The immune system is vital for safeguarding the human body against infections and inflammatory diseases. role of diet meal patterns in modulating function complex, highlighting this topic crucial identifying potential ways to improve health. In Europe, Mediterranean Western are most common dietary patterns, gaining an understanding how they affect essential public There numerous diseases that observed younger older people. Some include polymyalgia rheumatica (PMR), spinal muscular atrophy (SMA), vasculitis, sarcopenia, cirrhosis, cancer, fibromyalgia, but main focus review article on irritable bowel disease (IBD). general, choices can have immense impact microbial flora gut people with intake Mediterranean-style foods promotes growth healthy bacteria enhances system. On other hand, it mostly seen Western-style leads harmful contributes inflammation development by weakening Additionally, brain function, leading mood disorders, such as anxiety depression. Rare diseases, psoriasis sarcoidosis, interest article. All above-mentioned rare a certain relationship microbiota gut. microbiome plays significant IBD; fiber prebiotic interventions may represent promising adjunct therapies pediatric IBD targeting microbiome. By advancing good overall arrangement microorganisms stomach through mediations, working side effects alleviating might be conceivable. affected differently various fatty acid types. also involvement genetics progression IBD, transcriptional factors, one gene LCT gene, which encodes lactase, enzyme responsible digesting lactose

Language: Английский

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