Polyunsaturated Fatty Acids and Human Health: A Key to Modern Nutritional Balance in Association with Polyphenolic Compounds from Food Sources DOI Creative Commons
Magdalena Mititelu,

Dumitru Lupuliasa,

Sorinel Marius Neacșu

et al.

Foods, Journal Year: 2024, Volume and Issue: 14(1), P. 46 - 46

Published: Dec. 27, 2024

Polyunsaturated fatty acids (PUFAs) are vital dietary elements that play a significant role in human nutrition. They highly regarded for their positive contributions to overall health and well-being. Beyond the fact they provide substantial supply of energy body (a saturated fats can also perform), these unsaturated and, especially, essential ones involved cell membrane structure, blood pressure regulation, coagulation; participate proper functioning immune system assimilation fat-soluble vitamins; influence synthesis pro- anti-inflammatory substances; protect cardiovascular system. Modern diets like Western diet American rich found especially fast food products, sweets, processed foods, has led an increase prevalence metabolic diseases worldwide (obesity, type II diabetes, gout, disease). Nutritionists have drawn attention moderate consumption need intake detriment ones. This paper examines biochemical roles polyunsaturated fats, particularly acids, contrasts benefits with detrimental effects fat overconsumption. Furthermore, it highlights necessity shifts towards increased PUFA mitigate global burden diet-related issues. The co-occurrence PUFAs polyphenols plant-based foods sophistication nature’s design. These bioactive compounds not randomly distributed but present humans consumed together historically. From traditional Mediterranean, which pairs olive oil (PUFAs polyphenols) vegetables legumes, Asian cuisines combining sesame seeds turmeric, cultural practices long harnessed this natural synergy.

Language: Английский

A Balanced Dietary Ratio of n-6:n-3 Polyunsaturated Fatty Acids Exerts an Effect on Total Fatty Acid Profile in RBCs and Inflammatory Markers in Subjects with Obesity DOI Open Access
Karina González‐Becerra, Elisa Barrón‐Cabrera, José Francisco Muñoz‐Valle

et al.

Healthcare, Journal Year: 2023, Volume and Issue: 11(16), P. 2333 - 2333

Published: Aug. 18, 2023

The n-3 polyunsaturated fatty acids (PUFAs) can reduce inflammatory markers and may therefore be useful in obesity management. aim of this study was to analyze the effect supplementation with PUFAs on total acid profile red blood cells (RBCs), as well biochemical markers, subjects obesity. consisted a randomized placebo-controlled, double-blind clinical trial involving 41 during 4-month follow-up. Individuals were randomly assigned two groups: PUFA (1.5 g fish oil) placebo sunflower oil). Anthropometric, biochemical, dietetic, cytokine profiles RBCs measured. Both groups increased their intake DHA incorporation RBCs. However, group showed reduction serum IL-8 MCP-1 at end study. A multiple linear regression model adjusted by body fat mass sex that an increase decreased levels both Our results highlight role dietary usefulness exerting beneficial anti-inflammatory effects.

Language: Английский

Citations

35
Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment DOI Creative Commons

Dong Yan,

Shuyu Ye,

Yue He

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 5, 2023

Inflammatory Bowel Disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract. Though pathogenesis IBD remains unclear, diet increasingly recognized as pivotal factor influencing its onset and progression. Fatty acids, essential components dietary lipids, play diverse roles in IBD, ranging from anti-inflammatory immune-regulatory functions to gut-microbiota modulation barrier maintenance. Short-chain fatty acids (SCFAs), products indigestible fiber fermentation by gut microbiota, have strong properties are seen key protective factors against IBD. Among long-chain saturated trans ω-6 polyunsaturated exhibit pro-inflammatory effects, while oleic acid ω-3 display actions. Lipid mediators derived serve bioactive molecules, immune cell offering both benefits. Recent research has also highlighted potential medium- very modulating inflammation, mucosal barriers, microbiota Given these insights, intervention supplementation with short-chain emerging therapeutic strategies for This review elucidates impact various lipid on delves into avenues stemming compounds.

Language: Английский

Citations

32
Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake DOI Open Access
Sevag Hamamah,

Arman Amin,

Abdul Latif Al-Kassir

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3365 - 3365

Published: July 28, 2023

Obesity is a multifactorial disease that continues to increase in prevalence worldwide. Emerging evidence has shown the development of obesity may be influenced by taxonomic shifts gut microbiota response consumption dietary fats. Further, these alterations have been promote important changes satiation signals including hormones (leptin, ghrelin, GLP-1, peptide YY and CCK) orexigenic anorexigenic neuropeptides (AgRP, NPY, POMC, CART) influence hyperphagia therefore obesity. In this review, we highlight mechanisms which can both locally gastrointestinal tract via microbiota-gut-brain communication. Then, describe effects interventions associated on satiety through microbiota-dependent mechanisms. Lastly, present optimizing therapies prebiotics, probiotics, synbiotics weight loss surgery help restore beneficial enhancing reduce subsequent Overall, better understanding fats induce taxonomical their impact signaling pathways will develop more targeted therapeutic delaying onset furthering its treatment.

Language: Английский

Citations

27
Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers DOI Creative Commons

Yang Sun,

Xiang Zhang, Dong Hang

et al.

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(8), P. 1386 - 1400.e8

Published: Aug. 1, 2024

Changes in plasma and fecal metabolomes colorectal cancer (CRC) progression (normal-adenoma-CRC) remain unclear. Here, samples were collected from four independent cohorts of 1,251 individuals (422 CRC, 399 adenoma [CRA], 430 normal controls [NC]). By metabolomic profiling, signature metabolites with consistent shift across NC, CRA, CRC are identified, including CRC-enriched oleic acid CRC-depleted allocholic acid. Oleic exhibits pro-tumorigenic effects cells, patient-derived organoids, two murine models, whereas has opposing effects. integrative analysis, we found that or directly binds to α-enolase farnesoid X receptor-1 respectively, modulate cancer-associated pathways. Clinically, establish a panel 17 accurately diagnoses discovery three validation (AUC = 0.848–0.987). Overall, characterize metabolite signatures, mechanistic significance, diagnostic potential CRC.

Language: Английский

Citations

16
ω-6 and ω-3 Polyunsaturated Fatty Acids: Inflammation, Obesity and Foods of Animal Resources DOI Creative Commons

Hwa Yeong Jeong,

Yang Soo Moon, Kwang Keun Cho

et al.

Food Science of Animal Resources, Journal Year: 2024, Volume and Issue: 44(5), P. 988 - 1010

Published: July 31, 2024

Obesity, as defined by the World Health Organization (WHO), is excessive fat accumulation that can pose health risks and a disorder of energy homeostasis system. In typical westernized diets, ω-6 polyunsaturated fatty acids (PUFAs) vastly exceed amount ω-3 PUFAs, with ω-6/ω-3 ratios ranging from 10:1 to 25:1. such arachidonic acid (AA), have pro-inflammatory effects increase obesity. On other hand, including eicosapentaenoic (EPA) docosahexaenoic (DHA), anti-inflammatory anti-obesity effects. LA (linoleic acid) ALA (alpha-linolenic are synthesized in almost all higher plants, algae, some fungi. However, humans animals, they essential (EFA) must be consumed through diet or supplementation. Therefore, balancing LA/ALA for obesity prevention human health. Monogastric animals pigs chickens produce meat eggs fortified PUFAs controlling dietary (FA). Additionally, ruminant feeder cattle lactating dairy cows opt feed supplementation sources rumen-protected microencapsulated pasture finishing. This method conjugated linoleic (CLA) meat, milk, cheese. A high ratio associated pro-inflammation obesity, whereas balanced reduces inflammation probiotics containing lactic bacteria necessary, which converting into functional metabolites HYA (10-hydroxy-cis-12-octadecenoic CLA.

Language: Английский

Citations

12
The Role of Omega- 3 Polyunsaturated Fatty Acids in Diabetes Mellitus Management: A Narrative Review DOI Creative Commons
Sümeyra Şahin Bayram, Gül Kızıltan

Current Nutrition Reports, Journal Year: 2024, Volume and Issue: 13(3), P. 527 - 551

Published: July 20, 2024

Abstract Purpose of Review Diabetes mellitus (DM) is a group metabolic illnesses characterized by elevated levels glucose in the bloodstream as result abnormalities generation or function insulin. Medical Nutrition Therapy (MNT) an essential component diabetes management. Dietary fats are both prevention and progression chronic diseases. Omega-3 polyunsaturated fatty acids recognized for their advantageous impact on health. They assist controlling blood sugar lipid profile patients with all types diabetes. Furthermore, they reduce occurrence cardiovascular events death linked to DM. Recent Findings After evaluating antioxidant, anti-inflammatory, antilipidemic, antidiabetic mechanisms omega-3 acid supplements, well results from randomized controlled studies, it clear that these supplements have positive effects preventing treating diabetes, complications related specifically Summary However, current evidence does not support use supplementation people purpose events. People suggested include fish foods high diet twice week, prescribed general population.

Language: Английский

Citations

10
Transplanting network pharmacology technology into food science research: A comprehensive review on uncovering food‐sourced functional factors and their health benefits DOI

Qing Shen,

Lijun Ge,

Weibo Lu

et al.

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(5)

Published: Sept. 1, 2024

Abstract Network pharmacology is an emerging interdisciplinary research method. The application of network to reveal the nutritional effects and mechanisms active ingredients in food great significance promoting development functional food, facilitating personalized nutrition, exploring health effects. This article systematically reviews field science using a literature review progress discussed, factors on basis are explored. Additionally, limitations challenges future directions prospects proposed. serves as important tool action benefits food. It helps conduct in‐depth biological activities individual ingredients, composite foods, compounds assessment potential components. Moreover, it can help control enhance their functionality through relevant information during production processing samples guarantee safety. further analyzed summarized. Combining machine learning, artificial intelligence, clinical experiments, vitro validation, achievement transformation factor driven by for research.

Language: Английский

Citations

10
Variability in Morphological Traits and Nutritional Profiles of Adult Eriocheir sinensis in Different Aquacultural Regions DOI Creative Commons
Wenrong Feng,

Qinghong He,

Jianlin Li

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(2), P. 243 - 243

Published: Jan. 16, 2025

Eriocheir sinensis is a species of significant economic importance in China's aquaculture industry. In order to investigate the variations morphologic and nutritional profiles farmed crabs across diverse farming regions, E. were collected from six aquafarms located primary cultivation areas China. The findings revealed specific morphological indices, but these are insufficient for clear regional distinction using PCA. Essential amino acid (EAA) levels varied by tissue gender, with ovaries YY (Yongyan Anhui province) group showing highest levels, while hepatopancreas females JX (Jianxian Jiangxi had lowest. analysis fatty contents that muscles rich PUFAs, whereas MUFAs dominant gonads. significantly higher than testes, notably HZ (Huzhou Zhejiang province), EZ (Ezhou Hubei YY, groups. Furthermore, PCA based on proximate composition, acids, acids distinct categorizations various regions. conclusion, highlight morphology composition sinensis, suggesting need tailored practices optimize quality output.

Language: Английский

Citations

1
Association Between Atherogenic, Thrombogenic, and Lipophilic Indices and the Odds of Diabetic Nephropathy in Type 2 Diabetic Patients: A Case–Control Study DOI Creative Commons
Behnood Abbasi,

Elham Ghanbarzadeh,

Bita Panahizadeh

et al.

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(3)

Published: March 1, 2025

The quality of fats in the diet affects development chronic kidney disease. In this study, we aimed to understand relationship between dietary fat markers and risk diabetic nephropathy (DN) patients with Type 2 diabetes (T2DM).In case retrospective 309 T2DM (151 DN, 158 without DN) were included. A 147 item questionnaire measuring food frequency International Physical Activity Questionnaire (IPAQ) used. Anthropometric indices, biochemical factors measured or recorded from patient's files. Quantitative Insulin Sensitivity Check Index (QUICKI), Homeostatic Model Assessment for Resistance (HOMA-IR), atherogenic, thrombogenic, lipophilic indices calculated. Modified nutritionist IV software USDA composition table Odds ratios (OR) 95% confidence intervals (CI) obtained using a case-control design. Age, BMI, energy 1 physical activity, blood glucose, level insulin, lipid profile, creatinine level, CRP adjusted as interventions 2. Compared control subjects, had significantly higher body mass index (BMI), fasting sugar (FBS), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C) well lower intakes energy, carbohydrates, mono-and polyunsaturated fatty acids, fiber, compared controls. After adjustment possible confounders, highest quartile atherogenic (OR: 3.49, CI: 1.65-7.41), thrombogenic 4.3, 1.86-8.72), 3.50, 1.62-7.52) odds DN than those lowest quartile. There was considerable (including indices) chance developing nephropathy.

Language: Английский

Citations

1
Translational Approaches with Antioxidant Phytochemicals against Alcohol-Mediated Oxidative Stress, Gut Dysbiosis, Intestinal Barrier Dysfunction, and Fatty Liver Disease DOI Creative Commons

Jacob W. Ballway,

Byoung‐Joon Song

Antioxidants, Journal Year: 2021, Volume and Issue: 10(3), P. 384 - 384

Published: March 4, 2021

Emerging data demonstrate the important roles of altered gut microbiomes (dysbiosis) in many disease states peripheral tissues and central nervous system. Gut dysbiosis with decreased ratios Bacteroidetes/Firmicutes other changes are reported to be caused by various environmental factors, such as ethanol (e.g., alcohol drinking), Western-style high-fat diets, high fructose, etc. It is also genetic including polymorphisms epigenetic different individuals. dysbiosis, impaired intestinal barrier function, elevated serum endotoxin levels can observed human patients and/or experimental rodent models exposed these factors or certain states. However, leaky normalized through lifestyle alterations increased consumption healthy diets fruits vegetables containing kinds antioxidant phytochemicals. In this review, we describe mechanisms gut, endotoxemia, fatty liver a specific focus on alcohol-associated pathways. We mention translational approaches discussing benefits phytochemicals their metabolites against alcohol-mediated oxidative stress, dysfunction, disease.

Language: Английский

Citations

56