Vitamin D Supplementation in Neonatal and Infant MIS-C Following COVID-19 Infection

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3712 - 3712

Published: March 27, 2024

To date, the SARS-CoV-2 pandemic still represents a great clinical challenge worldwide, and effective anti-COVID-19 drugs are limited. For this reason, nutritional supplements have been investigated as adjuvant therapeutic approaches in disease management. Among such supplements, vitamin D has gained interest, due to its immunomodulatory anti-inflammatory actions both adult pediatric populations. Even if there is conflicting evidence about prevention and/or mitigation effectiveness infection, several studies demonstrated strict correlation between hypovitaminosis severity acute COVID-19 MIS-C (multisystem inflammatory syndrome children). This narrative review offers resume of state art D’s role immunity use context current pandemic, specially focusing on manifestations MIS-C. It seems biologically reasonable that interventions aimed at normalizing circulating levels could be beneficial. help clinicians establishing correct prophylaxis supportive therapy with D, well-designed adequately statistically powered trials involving populations needed. Moreover, will also discuss few other nutraceuticals evaluated context.

Language: Английский

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A comprehensive review of research advances in the study of lactoferrin to treat viral infections

Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123340 - 123340

Published: Dec. 1, 2024

Language: Английский

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Poor nutritional status is associated with the severity of omicron infection in the older adults

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 15, 2024

Abstract Background The Omicron wave of Coronavirus disease 2019 (COVID-19) remains the dominant strain worldwide. studies nutritional status in geriatric people with COVID-19 variant are limited. Thus, aim this study was to investigate incidence poor among infected older patients, and explore correlation between severity infection patients. Methods This is a retrospective cross-sectional study. According clinical symptoms, patients were divided into two groups: mild moderate severe. Mini Nutritional Assessment short-form (MNA-SF) conducted when admitted defined as MNA-SF score 0–11. inflammatory markers including neutrophil lymphocyte ratio (NLR), platelet (PLR) systemic index (SII) calculated compared groups. Results Total 324 enrolled, median [interquartile range (IQR)] age 73 (17) years. Overall, 241 cases mild, 83 severe at time diagnosis that 54.3% had status. Patients found be ( P < 0.001) less vaccinated 0.001), longer virus shedding duration = 0.022), more comorbidities (≥ 2) 0.004) higher value NLR PLR SII 0.012). Vaccination, cycle threshold ORF1ab gene (OR CT value) female, negatively connected probability infection. For every 1 increase MNA-SF, odds decreased by 14.8% [adjusted (aOR), 0.852; 95% confidence interval (CI): 0.734–0.988; 0.034]. Conclusions Older likely develop

Language: Английский

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An Update of Carbazole Treatment Strategies for COVID-19 Infection

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(3), P. 1522 - 1522

Published: Jan. 24, 2023

The Coronavirus disease 2019 (COVID-19) outbreak was declared by the World Health Organization (WHO) in March 2020 to be a pandemic and many drugs used at beginning proved useless fighting infection. Lately, there has been approval of some new generation for clinical treatment severe or critical COVID-19 infections. Nevertheless, more are required reduce pandemic’s impact. Several approaches were employed since pandemic, such as immunomodulatory, antiviral, anti-inflammatory, antimicrobial agents, again corticosteroids, angiotensin II receptor blockers, bradykinin B2 antagonists, but them proven ineffective targeting virus. So, identification effectively is strongly needed. It aimed this review collect information so far known about studies treatments. Moreover, observations reported carbazoles can signify potentially useful application; various that introduced into therapeutic equipment fight their molecules basis designing antivirals.

Language: Английский

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The characteristics of PUFAs-rich virgin fish oil as affected by size of tuna eye

Biodiversitas Journal of Biological Diversity, Journal Year: 2023, Volume and Issue: 24(12)

Published: Dec. 28, 2023

Abstract. Trilaksani W, Riyanto B, Ramadhan Sinulingga F, Fauziah S. 2023. The characteristics of PUFAs-rich virgin fish oil as affected by size tuna eye. Biodiversitas 24: 6545-6556. food supplement market expects growth in demand for long-chain omega-3 fatty acids, particularly Eicosapentaenoic Acid (EPA) and Docosahexaenoic (DHA), which play crucial brain development can lower the chances health issues like depression, Myocardial Infarction (MI), thromboembolism, cardiac arrhythmias, have anti-viral effects, boosting immune system during pandemic. Therefore, to meet this demand, exploring new sources is crucial. Tuna eyes emerged a potential source DHA; however, quality standardized sizes pose challenge they are by-products. purpose research was determine how eye yield oil, novel acids. This study determined profile eyes, met standards. investigation covered morphology, chemical composition, heavy metal content, quality, acid related lipid indices (Atherogenicity Index (AI) Thrombogenicity (TI)). For specifications, were classified into three groups based on their diameter, namely 'small' (<6 cm), 'medium' (6-9 'large' (>9 cm). results showed that directly influenced weight, fat yield, with negligible disparity composition except content; larger higher yield. had safe consumption low or undetected metals, oil's oxidative level CODEX standards, revealed DHA most abundant acid, reaching 36.95%. predominance n-3 series values tuna's 9-12 times greater than n-6 values. AI TI 0.33 0.12; 0.47 0.20; 0.55 0.20 large, small, medium respectively. highlights eyes' unique applications industry.

Language: Английский

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The association of dietary approach to stop hypertension (DASH) diet with hospitalization risk in patients with COVID-19

Clinical Nutrition Open Science, Journal Year: 2023, Volume and Issue: 48, P. 55 - 63

Published: March 5, 2023

Given the importance of dietary habits in immune system, current study aimed at investigating association between Dietary Approach to Stop Hypertension (DASH) diet and risk hospitalization due COVID-19.Dietary data 141 patients with COVID-19 were collected using 147-item food frequency questionnaire. DASH score this cross-sectional was calculated based on eight components, including fruits, vegetables, legumes nuts seeds, whole grains, low-fat dairy, red or processed meats, sweetened beverages, sodium. Multivariable logistic regression models applied estimate OR 95% CI for each tertile score.Mean ± SD inpatients (n=74) outpatients (n= 87) 22.5 4.57 25.34 4.23, respectively. The highest 81% lower than lowest (OR=0.19, 95%CI: 0.07-0.55, P trend = 0.001 after adjustment age, sex, BMI, energy intake). Also, more intake vegetables dairy products less sodium, meat significantly associated reduced COVID-19.Our provide evidence that adherence DASH-style COVID-19.

Language: Английский

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Perceptions and Patterns of Dietary Supplements’ Use during COVID-19 among Undergraduate Female Students in Saudi Arabia

Nutrients, Journal Year: 2022, Volume and Issue: 14(18), P. 3728 - 3728

Published: Sept. 9, 2022

(1) Background: During the COVID-19 pandemic, use of Dietary Supplements (DSs) has increased for health promotion purposes. Few data records were found on safe DSs among university students in Saudi Arabia, during COVID-19. This study aimed to assess perceptions and patterns at a selected female university. (2) Methods: A descriptive cross-section design was used. convenient sample undergraduate (n = 651) recruited via email, fill an online validated questionnaire: The nutrition intake Data analyzed using inferential statistics. (3) Results: Among 509 who did not have chronic diseases, 85% them had taken DSs. About 35.5% changed their dietary habits since beginning COVID-19, but 78.6% thought that they needed improve immunity by taking Half 51.2% believed healthy may reduce chance being infected with most used vitamin C (84.3%), followed honey (65.3%), D (47.7%). At top students' references personal judgment or previous knowledge benefits (27.3%). (4) Conclusion: usage impacted pandemic. Taking without doctor's prescription lead several complications. users should be educated effectively about proper as external supplementation.

Language: Английский

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The Perception of Minerals and Their Prevalence in Fortified Foods and Supplements in Japan

Nutrients, Journal Year: 2022, Volume and Issue: 14(13), P. 2586 - 2586

Published: June 22, 2022

People’s intake of some minerals does not meet the nutrient reference values even in high-income countries. Recently, deficiency zinc and/or selenium has been considered to cause greater risk COVID-19 infection and severity. To investigate consumer awareness, we conducted a cross-sectional questionnaire online survey among Japanese people (7500 males 7500 females) concerning their perceptions each mineral prevalence mineral-fortified foods supplements. perception varied: highest was for calcium (91.8%) lowest (44.7%). In addition, only portion participants believed that they consumed sufficient amount mineral; sodium (23.7%), manganese (5.2%). 18.2% them felt could consume enough sodium, though most Japanese’s is excessive. Among mineral-fortified-food mineral-supplement users, purposes these products were maintain health (80.6%), supplement nutrients (48.0%), prevent infectious diseases (23.2%). Only 18.4% knew what took. conclusion, education needed insufficiency/deficiency but also an excess sodium.

Language: Английский

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SARS-CoV-2-induced Host Metabolic Reprogram (HMR): Nutritional Interventions for Global Management of COVID-19 and Post-Acute Sequelae of COVID-19 (PASC)

Journal of Food Bioactives, Journal Year: 2022, Volume and Issue: unknown, P. 1 - 42

Published: June 1, 2022

'Severe acute respiratory syndrome coronavirus 2' (SARS-CoV-2) is a highly transmissible viral pathogen responsible for the ongoing 'coronavirus disease 2019' (COVID-19) pandemic. The current re-purposed antiviral interventions against SARS-CoV-2 are classified into two major groups: Group-1 represents family of drugs, mainly vaccines that directly target virus, and Group-2 includes specific class inhibitors interfere with host-cell machinery, which critical infection replication. Global efforts to control COVID-19 pandemic repurposed therapeutics represent only phased victory. emergence several variants concern (VOCs) has compromised vaccinations pharma-therapeutic protocols, highlights dire necessity conserved domains, less likely mutate in genome. Several bioactive phytochemicals block enzymes such as nsp5/main proteinase (Mpro) RNA-dependent nsp7/nsp8/nsp12 RNA-polymerase (RdRp) complex, extensively investigated this direction. triggers complex human host-pathogen interaction(s) resulting 'host metabolic reprogramming' (HMR), iron (Fe)-redox dysregulation (FeRD), altered mitochondrial function cumulatively disrupt pathways involved cellular energy antioxidant enzyme function; thereby, compromise innate host defense. circulatory/RAAS axis contributes FeRD any alteration or imbalance Fe-redox homeostasis (Fe-R-H) may lead 'new onset' disorders (i.e., diabetes). Such inherent body damage its long-term health consequences post-acute sequelae (PASC) require effective nutritional intervention strategies, particularly at interface organ system functions immune dynamics. PASC indicate an accelerated rate exhaustion patients, due prolonged antigen stimulation (also vaccine exposure). Abnormal metabolism also cause systemic perturbations FeRD), ROS/RNS production, oxidative nitrosative stress, could trigger multi-organ ranging from mild symptoms incapacitating state reduced quality life last weeks longer following recovery COVID-19. five most clinical manifestations include fatigue, headache, attention disorder, hair loss, dyspnea. This narrative review elucidates intricate impairments associated eight physiological systems survivors pulmonary, neuro-cognitive, cardiovascular, renal, gastrointestinal/hepato-biliary, endocrinal, skeleton-muscular, reproductive) – triggered by FeRD, amplified HMR, ACE2/RAAS axis. We have attempted explain epidemic residual, non-viral complications supportive role system-targeted natural plant-based anti-inflammatories, immune-modulators, antioxidants, macro-/micronutrient optimizers manage PASC, newly emerged post-COVID syndrome.

Language: Английский

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[Nutrition Plays a Vital Role in the Prevention and Treatment of COVID-19].

PubMed, Journal Year: 2023, Volume and Issue: 54(1), P. 108 - 113

Published: Jan. 1, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an ongoing global pandemic of disease 2019 (COVID-19). Proper nutritional support helps boost the immunity human body, strengthen high-risk populations' defense against SARS-CoV-2, reduce prevalence COVID-19, prevent mild cases from developing into severe cases, and occurrence adverse symptoms during recovery. Nutritional is important guarantee to provide protection virus infection, promote patient recovery, improve prognosis. Whole food formulas designed according characteristic clinical COVID-19 patients with comprehensive appropriate content, which effectively improves status provides strong technical their quality survival. During critical period prevention control, more emphasis should be placed on essential role efficacy given full play.

Language: Английский

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