Small,
Journal Year:
2019,
Volume and Issue:
15(49)
Published: Nov. 8, 2019
Abstract
Targeting
programmed
cell
death
protein
1
(PD‐1)/programmed
ligand
(PD‐L1)
immunologic
checkpoint
blockade
with
monoclonal
antibodies
has
achieved
recent
clinical
success
in
antitumor
therapy.
However,
therapeutic
exhibit
several
issues
such
as
limited
tumor
penetration,
immunogenicity,
and
costly
production.
Here,
Bristol‐Myers
Squibb
nanoparticles
(NPs)
are
prepared
using
a
reprecipitation
method.
The
NPs
have
advantages
including
passive
targeting,
hydrophilic
nontoxic
features,
100%
drug
loading
rate.
BMS‐202
is
small‐molecule
inhibitor
of
the
PD‐1/PD‐L1
interaction
that
developed
by
BMS.
Transfer
to
4T1
tumor‐bearing
mice
results
markedly
slower
growth
same
degree
treatment
anti‐PD‐L1
antibody
(α‐PD‐L1).
Consistently,
combination
Ce6
or
α‐PD‐L1
parallel
shows
more
efficacious
antimetastatic
effects,
accompanied
enhanced
dendritic
maturation
infiltration
antigen‐specific
T
cells
into
tumors.
Thus,
inhibition
rates
primary
distant
tumors
reach
>90%.
In
addition,
able
attack
spreading
metastatic
lung
offer
immune‐memory
protection
prevent
relapse.
These
indicate
possess
effects
similar
therapies
Therefore,
this
work
reveals
possibility
replacing
used
immunotherapy
for
NPs.
Advanced Materials,
Journal Year:
2019,
Volume and Issue:
31(39)
Published: July 22, 2019
Abstract
Catalysis
and
medicine
are
often
considered
as
two
independent
research
fields
with
their
own
respective
scientific
phenomena.
Promoted
by
recent
advances
in
nanochemistry,
large
numbers
of
nanocatalysts,
such
nanozymes,
photocatalysts,
electrocatalysts,
have
been
applied
vivo
to
initiate
catalytic
reactions
modulate
biological
microenvironments
for
generating
therapeutic
effects.
The
rapid
growth
biomedical
applications
nanocatalysts
has
led
the
concept
“nanocatalytic
medicine,”
which
is
expected
promote
further
advance
a
subdiscipline
nanomedicine.
high
efficiency
selectivity
catalysis
that
chemists
strived
achieve
past
century
can
be
ingeniously
translated
into
efficacy
mitigated
side
effects
theranostics
using
medicine”
steer
optimized
outcomes.
Here,
rationale
behind
construction
nanocatalytic
eludicated
based
on
essential
reaction
factors
(catalysts,
energy
input,
reactant).
Recent
this
burgeoning
field
then
comprehensively
presented
mechanisms
nanosystems
conferred
theranostic
functions
discussed
detail.
It
believed
an
emerging
modality
will
play
more
important
role
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
33(4)
Published: Dec. 2, 2020
Abstract
The
past
decades
have
witnessed
hyperthermia
therapy
(HTT)
as
an
emerging
strategy
against
malignant
tumors.
Nanomaterial‐based
photothermal
(PTT)
and
magnetic
(MHT),
highly
effective
noninvasive
treatment
models,
offer
advantages
over
other
strategies
in
the
of
different
types
However,
both
PTT
MHT
cannot
completely
cure
cancer
due
to
recurrence
distal
metastasis.
In
recent
years,
immunotherapy
has
attracted
widespread
attention
owing
its
capability
activate
body's
own
natural
defense
identify,
attack,
eradicate
cells.
Significant
efforts
been
devoted
studying
activated
immune
responses
caused
by
hyperthermia‐ablated
this
article,
synergistic
mechanism
HTT
immunotherapy,
including
immunogenic
cell
death
reversal
immunosuppressive
tumor
microenvironment
is
discussed.
reports
combination
or
HTT‐based
multimodal
with
immunoadjuvant
exploitation,
checkpoint
blockade
therapy,
adoptive
cellular
are
summarized.
As
highlighted,
these
could
achieve
synergistically
enhanced
therapeutic
outcomes
primary
tumors
metastatic
lesions,
prevent
recurrence,
prolong
survival
period.
Finally,
current
challenges
prospective
developments
HTT‐synergized
also
reviewed.
Advanced Materials,
Journal Year:
2019,
Volume and Issue:
31(27)
Published: May 16, 2019
Tumor
hypoxia
compromises
the
therapeutic
efficiency
of
photodynamic
therapy
(PDT)
as
local
oxygen
concentration
plays
an
important
role
in
generation
cytotoxic
singlet
(1
O2
).
Herein,
a
versatile
mesoporous
nanoenzyme
(NE)
derived
from
metal-organic
frameworks
(MOFs)
is
presented
for
situ
endogenous
to
enhance
PDT
efficacy
under
bioimaging
guidance.
The
NE
constructed
by
first
coating
manganese-based
MOFs
with
silica,
followed
facile
annealing
process
ambient
atmosphere.
After
removing
silica
shell
and
post-modifying
polydopamine
poly(ethylene
glycol)
improving
biocompatibility,
obtained
loaded
chlorin
e6
(Ce6),
commonly
used
photosensitizer
PDT,
high
loading
capacity.
Upon
through
catalytic
reaction
between
amount
H2
,
hypoxic
tumor
microenvironment
relieved.
Thus,
Ce6-loaded
serves
-activated
supplier
increase
significantly
enhanced
antitumor
vitro
vivo.
In
addition,
also
shows
T2
-weighted
magnetic
resonance
imaging
ability
its
vivo
tracking.
This
work
presents
interesting
biomedical
use
MOF-derived
multifunctional
theranostic
agent
cancer
therapy.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(38), P. 16381 - 16384
Published: June 2, 2020
Abstract
Despite
the
widespread
applications
of
manganese
oxide
nanomaterials
(MONs)
in
biomedicine,
intrinsic
immunogenicity
MONs
is
still
unclear.
MnO
x
nanospikes
(NSs)
as
tumor
microenvironment
(TME)‐responsive
nanoadjuvants
and
immunogenic
cell
death
(ICD)
drugs
are
proposed
for
cancer
nanovaccine‐based
immunotherapy.
NSs
with
large
mesoporous
structures
show
ultrahigh
loading
efficiencies
ovalbumin
fragment.
The
combination
ICD
via
chemodynamic
therapy
ferroptosis
inductions,
well
antigen
stimulations,
presents
a
better
synergistic
immunopotentiation
action.
Furthermore,
obtained
nanovaccines
achieve
TME‐responsive
magnetic
resonance/photoacoustic
dual‐mode
imaging
contrasts,
while
effectively
inhibiting
primary/distal
growth
metastasis.
Advanced Science,
Journal Year:
2019,
Volume and Issue:
6(10)
Published: March 13, 2019
Combined
phototherapy
and
immunotherapy
demonstrates
strong
potential
in
the
treatment
of
metastatic
cancers.
An
upconversion
nanoparticle
(UCNP)
based
antigen-capturing
nanoplatform
is
designed
to
synergize
phototherapies
immunotherapy.
In
particular,
this
constructed
via
self-assembly
DSPE-PEG-maleimide
indocyanine
green
(ICG)
onto
UCNPs,
followed
by
loading
photosensitizer
rose
bengal
(RB).
ICG
significantly
enhances
RB-based
photodynamic
therapy
efficiency
UCNP/ICG/RB-mal
upon
activation
a
near-infrared
(NIR)
laser,
simultaneously
achieving
selective
photothermal
therapy.
Most
importantly,
tumor-derived
protein
antigens,
arising
from
phototherapy-treated
tumor
cells,
can
be
captured
retained
situ,
due
functionality
maleimide,
which
further
enhance
antigen
uptake
presentation
antigen-presenting
cells.
The
synergized
photothermal,
photodynamic,
immunological
effects
using
light-activated
induces
tumor-specific
immune
response.
experiments,
intratumoral
administration
UCNP/ICG/RB-mal,
noninvasive
irradiation
with
an
NIR
destroys
primary
tumors
inhibits
untreated
distant
tumors,
poorly
immunogenic,
highly
4T1
mammary
model.
With
simultaneous
use
anti-CTLA-4,
about
84%
treated
tumor-bearing
mice
achieve
long-term
survival
34%
develop
immunity.
Overall,
provides
promising
approach
for
Small,
Journal Year:
2019,
Volume and Issue:
15(51)
Published: Nov. 20, 2019
Abstract
Glucose
oxidase
(GOx)
can
react
with
intracellular
glucose
and
oxygen
(O
2
)
to
produce
hydrogen
peroxide
(H
O
gluconic
acid,
which
cut
off
the
nutrition
source
of
cancer
cells
consequently
inhibit
their
proliferation.
Therefore,
GOx
is
recognised
as
an
ideal
endogenous
oxido‐reductase
for
starvation
therapy.
This
process
further
regulate
tumor
microenvironment
by
increasing
hypoxia
acidity.
Thus,
offers
new
possibilities
elaborate
design
multifunctional
nanocomposites
However,
natural
expensive
prepare
purify
exhibits
immunogenicity,
short
in
vivo
half‐life,
systemic
toxicity.
Furthermore,
highly
prone
degrade
after
exposure
biological
conditions.
These
intrinsic
shortcomings
will
undoubtedly
limit
its
biomedical
applications.
Accordingly,
some
nanocarriers
be
used
protect
from
surrounding
environment,
thus
controlling
or
preserving
activity.
A
variety
including
hollow
mesoporous
silica
nanoparticles,
metal–organic
frameworks,
organic
polymers,
magnetic
nanoparticles
are
summarized
construction
GOx‐based
multimodal
synergistic
In
addition,
current
challenges
promising
developments
this
area
highlighted.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(15)
Published: March 6, 2021
Subcellular
organelle-targeted
nanoformulations
for
cancer
theranostics
are
receiving
increasing
attention
owing
to
their
benefits
of
precise
drug
delivery,
maximized
therapeutic
index,
and
reduced
off-target
side
effects.
Herein,
a
multichannel
calcium
ion
(Ca
Angewandte Chemie International Edition,
Journal Year:
2019,
Volume and Issue:
58(41), P. 14758 - 14763
Published: Aug. 20, 2019
Reactive
oxygen
species
(ROS)
can
be
used
not
only
as
a
therapeutic
agent
for
chemodynamic
therapy
(CDT),
but
also
stimulus
to
activate
release
of
antitumor
drugs,
achieving
enhanced
efficacy
through
the
combination
CDT
and
chemotherapy.
Here
we
report
pH/ROS
dual-responsive
nanomedicine
consisting
β-lapachone
(Lap),
pH-responsive
polymer,
ROS-responsive
polyprodrug.
In
intracellular
acidic
environment,
realize
pH-triggered
disassembly.
The
released
Lap
efficiently
generate
hydrogen
peroxide,
which
will
further
converted
into
highly
toxic
hydroxyl
radicals
via
Fenton
reaction.
Subsequently,
ROS-induced
cleavage
thioketal
linker,
doxorubicin
is
from
vivo
results
indicate
that
cascade
ROS
generation
antitumor-drug
effectively
inhibit
tumor
growth.
This
design
with
reactions
offers
promising
strategy
enhance
efficacy.
Advanced Science,
Journal Year:
2020,
Volume and Issue:
7(17)
Published: July 17, 2020
Abstract
Light‐responsive
inorganic
biomaterials
are
an
emerging
class
of
materials
used
for
developing
noninvasive,
noncontact,
precise,
and
controllable
medical
devices
in
a
wide
range
biomedical
applications,
including
photothermal
therapy,
photodynamic
drug
delivery,
regenerative
medicine.
Herein,
is
discussed,
carbon‐based
nanomaterials,
gold
nanoparticles,
graphite
carbon
nitride,
transition
metal
dichalcogenides,
up‐conversion
nanoparticles
that
the
design
light‐responsive
devices.
The
importance
these
explored
to
light‐guided
nanovehicle,
modulate
cellular
behavior,
as
well
regulate
extracellular
microenvironments.
Additionally,
future
perspectives
on
clinical
use
highlighted.