Nanocatalytic Medicine

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(39)

Published: July 22, 2019

Abstract Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such nanozymes, photocatalysts, electrocatalysts, have been applied vivo to initiate catalytic reactions modulate biological microenvironments for generating therapeutic effects. The rapid growth biomedical applications nanocatalysts has led the concept “nanocatalytic medicine,” which is expected promote further advance a subdiscipline nanomedicine. high efficiency selectivity catalysis that chemists strived achieve past century can be ingeniously translated into efficacy mitigated side effects theranostics using medicine” steer optimized outcomes. Here, rationale behind construction nanocatalytic eludicated based on essential reaction factors (catalysts, energy input, reactant). Recent this burgeoning field then comprehensively presented mechanisms nanosystems conferred theranostic functions discussed detail. It believed an emerging modality will play more important role

Language: Английский

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Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(10)

Published: Jan. 28, 2020

Abstract Despite the comprehensive applications in bioimaging, biosensing, drug/gene delivery, and tumor therapy of manganese oxide nanomaterials (MONs including MnO 2 , MnO, Mn O 3 4 x ) their derivatives, a review article focusing on MON‐based nanoplatforms has not been reported yet. Herein, representative progresses MONs synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, are mainly introduced. First, five kinds primary synthetic methods presented, thermal decomposition method, exfoliation strategy, permanganates reduction adsorption–oxidation hydro/solvothermal. Second, preparations hollow composite materials summarized specially. Then, chemical toxicity discussed. Next, diagnostic imaging sensing outlined. Finally, some rational designs photodynamic therapy, photothermal chemodynamic sonodynamic radiotherapy, magnetic hyperthermia, chemotherapy, gene starvation ferroptosis, immunotherapy, various combination highlighted.

Language: Английский

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Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(4)

Published: Dec. 2, 2020

Abstract The past decades have witnessed hyperthermia therapy (HTT) as an emerging strategy against malignant tumors. Nanomaterial‐based photothermal (PTT) and magnetic (MHT), highly effective noninvasive treatment models, offer advantages over other strategies in the of different types However, both PTT MHT cannot completely cure cancer due to recurrence distal metastasis. In recent years, immunotherapy has attracted widespread attention owing its capability activate body's own natural defense identify, attack, eradicate cells. Significant efforts been devoted studying activated immune responses caused by hyperthermia‐ablated this article, synergistic mechanism HTT immunotherapy, including immunogenic cell death reversal immunosuppressive tumor microenvironment is discussed. reports combination or HTT‐based multimodal with immunoadjuvant exploitation, checkpoint blockade therapy, adoptive cellular are summarized. As highlighted, these could achieve synergistically enhanced therapeutic outcomes primary tumors metastatic lesions, prevent recurrence, prolong survival period. Finally, current challenges prospective developments HTT‐synergized also reviewed.

Language: Английский

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A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(27)

Published: May 16, 2019

Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as local oxygen concentration plays an important role in generation cytotoxic singlet (1 O2 ). Herein, a versatile mesoporous nanoenzyme (NE) derived from metal-organic frameworks (MOFs) is presented for situ endogenous to enhance PDT efficacy under bioimaging guidance. The NE constructed by first coating manganese-based MOFs with silica, followed facile annealing process ambient atmosphere. After removing silica shell and post-modifying polydopamine poly(ethylene glycol) improving biocompatibility, obtained loaded chlorin e6 (Ce6), commonly used photosensitizer PDT, high loading capacity. Upon through catalytic reaction between amount H2 , hypoxic tumor microenvironment relieved. Thus, Ce6-loaded serves -activated supplier increase significantly enhanced antitumor vitro vivo. In addition, also shows T2 -weighted magnetic resonance imaging ability its vivo tracking. This work presents interesting biomedical use MOF-derived multifunctional theranostic agent cancer therapy.

Language: Английский

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MnO_x Nanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(38), P. 16381 - 16384

Published: June 2, 2020

Abstract Despite the widespread applications of manganese oxide nanomaterials (MONs) in biomedicine, intrinsic immunogenicity MONs is still unclear. MnO x nanospikes (NSs) as tumor microenvironment (TME)‐responsive nanoadjuvants and immunogenic cell death (ICD) drugs are proposed for cancer nanovaccine‐based immunotherapy. NSs with large mesoporous structures show ultrahigh loading efficiencies ovalbumin fragment. The combination ICD via chemodynamic therapy ferroptosis inductions, well antigen stimulations, presents a better synergistic immunopotentiation action. Furthermore, obtained nanovaccines achieve TME‐responsive magnetic resonance/photoacoustic dual‐mode imaging contrasts, while effectively inhibiting primary/distal growth metastasis.

Language: Английский

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NIR‐Triggered Phototherapy and Immunotherapy via an Antigen‐Capturing Nanoplatform for Metastatic Cancer Treatment

Advanced Science, Journal Year: 2019, Volume and Issue: 6(10)

Published: March 13, 2019

Combined phototherapy and immunotherapy demonstrates strong potential in the treatment of metastatic cancers. An upconversion nanoparticle (UCNP) based antigen-capturing nanoplatform is designed to synergize phototherapies immunotherapy. In particular, this constructed via self-assembly DSPE-PEG-maleimide indocyanine green (ICG) onto UCNPs, followed by loading photosensitizer rose bengal (RB). ICG significantly enhances RB-based photodynamic therapy efficiency UCNP/ICG/RB-mal upon activation a near-infrared (NIR) laser, simultaneously achieving selective photothermal therapy. Most importantly, tumor-derived protein antigens, arising from phototherapy-treated tumor cells, can be captured retained situ, due functionality maleimide, which further enhance antigen uptake presentation antigen-presenting cells. The synergized photothermal, photodynamic, immunological effects using light-activated induces tumor-specific immune response. experiments, intratumoral administration UCNP/ICG/RB-mal, noninvasive irradiation with an NIR destroys primary tumors inhibits untreated distant tumors, poorly immunogenic, highly 4T1 mammary model. With simultaneous use anti-CTLA-4, about 84% treated tumor-bearing mice achieve long-term survival 34% develop immunity. Overall, provides promising approach for

Language: Английский

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Recent Advances in Glucose‐Oxidase‐Based Nanocomposites for Tumor Therapy

Small, Journal Year: 2019, Volume and Issue: 15(51)

Published: Nov. 20, 2019

Abstract Glucose oxidase (GOx) can react with intracellular glucose and oxygen (O 2 ) to produce hydrogen peroxide (H O gluconic acid, which cut off the nutrition source of cancer cells consequently inhibit their proliferation. Therefore, GOx is recognised as an ideal endogenous oxido‐reductase for starvation therapy. This process further regulate tumor microenvironment by increasing hypoxia acidity. Thus, offers new possibilities elaborate design multifunctional nanocomposites However, natural expensive prepare purify exhibits immunogenicity, short in vivo half‐life, systemic toxicity. Furthermore, highly prone degrade after exposure biological conditions. These intrinsic shortcomings will undoubtedly limit its biomedical applications. Accordingly, some nanocarriers be used protect from surrounding environment, thus controlling or preserving activity. A variety including hollow mesoporous silica nanoparticles, metal–organic frameworks, organic polymers, magnetic nanoparticles are summarized construction GOx‐based multimodal synergistic In addition, current challenges promising developments this area highlighted.

Language: Английский

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A Multichannel Ca²⁺ Nanomodulator for Multilevel Mitochondrial Destruction‐Mediated Cancer Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(15)

Published: March 6, 2021

Subcellular organelle-targeted nanoformulations for cancer theranostics are receiving increasing attention owing to their benefits of precise drug delivery, maximized therapeutic index, and reduced off-target side effects. Herein, a multichannel calcium ion (Ca

Language: Английский

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Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(41), P. 14758 - 14763

Published: Aug. 20, 2019

Reactive oxygen species (ROS) can be used not only as a therapeutic agent for chemodynamic therapy (CDT), but also stimulus to activate release of antitumor drugs, achieving enhanced efficacy through the combination CDT and chemotherapy. Here we report pH/ROS dual-responsive nanomedicine consisting β-lapachone (Lap), pH-responsive polymer, ROS-responsive polyprodrug. In intracellular acidic environment, realize pH-triggered disassembly. The released Lap efficiently generate hydrogen peroxide, which will further converted into highly toxic hydroxyl radicals via Fenton reaction. Subsequently, ROS-induced cleavage thioketal linker, doxorubicin is from vivo results indicate that cascade ROS generation antitumor-drug effectively inhibit tumor growth. This design with reactions offers promising strategy enhance efficacy.

Language: Английский

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Light‐Responsive Inorganic Biomaterials for Biomedical Applications

Advanced Science, Journal Year: 2020, Volume and Issue: 7(17)

Published: July 17, 2020

Abstract Light‐responsive inorganic biomaterials are an emerging class of materials used for developing noninvasive, noncontact, precise, and controllable medical devices in a wide range biomedical applications, including photothermal therapy, photodynamic drug delivery, regenerative medicine. Herein, is discussed, carbon‐based nanomaterials, gold nanoparticles, graphite carbon nitride, transition metal dichalcogenides, up‐conversion nanoparticles that the design light‐responsive devices. The importance these explored to light‐guided nanovehicle, modulate cellular behavior, as well regulate extracellular microenvironments. Additionally, future perspectives on clinical use highlighted.

Language: Английский

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