Regulation of Bone Remodeling by Metal–Phenolic Networks for the Treatment of Systemic Osteoporosis DOI Creative Commons
Xi Chen, Weihui Wu, Wei Zhu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Osteoporosis is a systemic metabolic disease that impairs bone remodeling by favoring osteoclastic resorption over osteoblastic formation. Nanotechnology-based therapeutic strategies focus on the delivery of drug molecules to either decrease or increase formation rather than regulating entire process, and osteoporosis interventions suffer from this limitation. Here, we present multifunctional nanoparticle based metal-phenolic networks (MPNs) for treatment both osteoclasts osteoblasts. In osteoporotic microenvironment, MPN nanoparticles degrade trigger release bioactive metals (strontium ions, SrII) promote osteogenesis functionalized phenols (epigallocatechin gallate, EGCG) suppress osteoclastogenesis. Injecting these into tail vein an ovariectomized mouse model, trabecular loss has been significantly prevented in femoral head vertebrae, along with increased volume decreased separation. Overall, work represents versatile approach explore nanomaterials related orthopedic diseases.

Language: Английский

Metformin-based nanomedicines for reprogramming tumor immune microenvironment DOI
Jieyu Liu, Xiaoling Li, Yinggang Li

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 15(3), P. 993 - 1016

Published: Dec. 2, 2024

Immunotherapy has transformed current cancer management, and it achieved significant progress over last decades. However, an immunosuppressive tumor microenvironment (TME) diminishes the effectiveness of immunotherapy by suppressing activity immune cells facilitating immune-evasion. Adenosine monophosphate-activated protein kinase (AMPK), a key modulator cellular energy metabolism homeostasis, gained growing attention in anti-tumor immunity. Metformin is usually considered as cornerstone diabetes its role activating AMPK pathway also been extensively explored therapy although findings on remain inconsistent. nanomedicine formulation found to hold potential reprogramming TME through immunometabolic modulation both cells. This review elaborates foundation via metformin-based nanomedicines, offering valuable insights for next generation therapy.

Language: Английский

Citations

34
Nanomedomics DOI

Ganghao Liang,

Wanqing Cao, Dongsheng Tang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(17), P. 10979 - 11024

Published: April 18, 2024

Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles been widely developed for nanomedicine via chemical conjugation or physical encapsulation bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, tumor-targeting Capitalizing on this, several nanoformulations already clinically approved many others are currently being studied in clinical trials. Despite their undoubtful success, the molecular mechanism action vast majority remains poorly understood. To tackle this limitation, herein, review critically discusses strategy applying multiomics analysis study nanomedicines, named nanomedomics, including advantages, applications, future directions. comprehensive understanding could provide valuable insight therefore foster development translation nanomedicines.

Language: Английский

Citations

30
Dendritic Polymer‐Based Nanomedicines Remodel the Tumor Stroma: Improve Drug Penetration and Enhance Antitumor Immune Response DOI
Yuxin Zhang,

Zaixiang Fang,

Dayi Pan

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(25)

Published: March 12, 2024

Abstract The dense extracellular matrix (ECM) in solid tumors, contributed by cancer‐associated fibroblasts (CAFs), hinders penetration of drugs and diminishes their therapeutic outcomes. A sequential treatment strategy remodeling the ECM via a CAF modifier (dasatinib, DAS) is proposed to promote an immunogenic cell death (ICD) inducer (epirubicin, Epi) apoptotic vesicles, ultimately enhancing efficacy against breast cancer. Dendritic poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA)‐based nanomedicines (poly[OEGMA‐Dendron(G2)‐Gly‐Phe‐Leu‐Gly‐DAS] (P‐DAS) poly[OEGMA‐Dendron(G2)‐hydrazone‐Epi] (P‐Epi)) are developed for delivery DAS Epi, respectively. P‐DAS reprograms CAFs reduce collagen downregulating anabolism energy metabolism, thereby reducing deposition. regulated can enhance tumor P‐Epi strengthen its ICD effect, leading amplified antitumor immune response. In cancer‐bearing mice, this approach alleviates barrier, resulting reduced burden increased cytotoxic T lymphocyte infiltration, more encouragingly, synergizes effectively with anti‐programmed 1 (PD‐1) therapy, significantly inhibiting growth preventing lung metastasis. Furthermore, systemic toxicity barely detectable after P‐Epi. This opens new avenue treating desmoplastic tumors metabolically targeting overcome barrier.

Language: Английский

Citations

21
Metal–phenolic network composites: from fundamentals to applications DOI Creative Commons
Zhixing Lin, Hai Liu, Joseph J. Richardson

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(22), P. 10800 - 10826

Published: Jan. 1, 2024

This review provides a guideline for the rational design of metal–phenolic network (MPN) composites—which are fabricated from MPN and one or more functional components ( e.g. , drugs, proteins)—for various applications across diverse disciplines.

Language: Английский

Citations

17
Nanoengineered polymers and other organic materials in lung cancer treatment: Bridging the gap between research and clinical applications DOI Creative Commons

Xuru Jin,

Golnaz Heidari,

Zhidan Hua

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 208, P. 112891 - 112891

Published: Feb. 27, 2024

Cancer remains a major global health challenge, with increasing incidence and mortality rates projected for the coming years. Lung cancer, in particular, poses significant obstacles due to late-stage diagnosis limited treatment options. While advancements molecular diagnostics have been made, there is critical need connect dots between laboratory hospital better lung cancer treatment. Systemic therapy plays crucial role treating advanced-stage recent efforts focused on developing innovative drug delivery techniques. Nanoparticles (NPs) emerged as promising approach treatment, offering enhanced delivery, active targeting, reduced toxicity. Organic-based nanomaterials, like polymeric nanoparticles, solid lipid liposomes hold great potential this field. This review examines application of NPs highlights current therapies, explores organic nanoparticle-based approaches, discusses limitations future perspectives clinical translation.

Language: Английский

Citations

16
Engineered hypoxia-responsive albumin nanoparticles mediating mitophagy regulation for cancer therapy DOI Creative Commons
Wenyan Wang, Shunyu Yao, Jingjing Luo

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 11, 2025

Hypoxic tumors present a significant challenge in cancer therapy due to their ability adaptation low-oxygen environments, which supports tumor survival and resistance treatment. Enhanced mitophagy, the selective degradation of mitochondria by autophagy, is crucial mechanism that helps sustain cellular homeostasis hypoxic tumors. In this study, we develop an azocalix[4]arene-modified supramolecular albumin nanoparticle, co-delivers hydroxychloroquine mitochondria-targeting photosensitizer, designed induce cascaded oxidative stress regulating mitophagy for treatment These nanoparticles are hypoxia-responsive release loaded guest molecules cells. The released disrupts process, thereby increasing further weakening Additionally, upon laser irradiation, photosensitizer generates reactive oxygen species independent oxygen, inducing damage activation. dual action simultaneous spatiotemporal activation flux blockade results enhanced autophagic stress, ultimately driving cell death. Our work highlights effectiveness hydroxychloroquine-mediated combined with mitochondria-targeted cascade-amplified against has been recognized as Here, group fabricates nanoparticle codelivering (HCQ) sulfur-substituted methylated nile blue analog, capable via

Language: Английский

Citations

3
Nano-enabled colorectal cancer therapy DOI
Qingqing Pan, Fan Xi, Li Xie

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 548 - 564

Published: Sept. 9, 2023

Language: Английский

Citations

33
Cascade loop of ferroptosis induction and immunotherapy based on metal‐phenolic networks for combined therapy of colorectal cancer DOI Creative Commons
Yuwei Li,

Yuxi Duan,

Yunyi Li

et al.

Exploration, Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Cancer immunotherapy is the most promising method for tumor therapy, while ferroptosis could activate immunogenicity of cancer and strengthen cellular immune response. However, limited by complex microenvironment, abundant glutathione (GSH) low reactive oxygen species (ROS) seriously weaken Herein, authors report photothermal metal-phenolic networks (MPNs) supplied with buthionine sulfoximine (BSO) reducing levels GSH then trapping cells in cascade loop to eliminate colorectal (CRC). The MPNs coated model antigen ovalbumin can accumulate at site, mediate immunogenic cell death (ICD) under NIR irradiation, initiate tumoricidal immunity. Then activated CD8+ T would release IFN-γ inhibit GPX4 promote induced Fe3+ BSO. Finally, intertumoral intratumoral be involved ferroptosis-dominated cancer-immunity circle CRC eradication, resulting outstanding therapeutic outcomes both primary distant models. Overall, this strategy employs a nanoplatform rapidly stimulate ICD restrain oxidation defense system, which provides approach significantly amplify "cascade loop" induction treatment CRC.

Language: Английский

Citations

15
Current status of mannose receptor-targeted drug delivery for improved anti-HIV therapy DOI
Satish Rojekar, Amol D. Gholap, Namdev Togre

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 372, P. 494 - 521

Published: June 27, 2024

Language: Английский

Citations

14
Homomultivalent Polymeric Nanotraps Disturb Lipid Metabolism Homeostasis and Tune Pyroptosis in Cancer DOI
Jie Zhou, Jiecheng Ji, Xue Li

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)

Published: Jan. 19, 2024

Genetic manipulations and pharmaceutical interventions to disturb lipid metabolism homeostasis have emerged as an attractive approach for the management of cancer. However, research on utilization bioactive materials modulate remains constrained. In this study, heptakis (2,3,6-tri-O-methyl)-β-cyclodextrin (TMCD) is utilized fabricate homomultivalent polymeric nanotraps, surprisingly, its unprecedented ability perturb induce pyroptosis in tumor cells found. Through modulation density TMCD arrayed polymers, one top-performing nanotrap, PTMCD4, exhibits most powerful cholesterol-trapping depletion capacity, thus achieving prominent cytotoxicity toward different types encouraging antitumor effects vivo. The interactions between PTMCD4 biomembranes effectively enable reduction cellular phosphatidylcholine cholesterol levels, provoking damage biomembrane integrity perturbation homeostasis. Additionally, interplays lysosomes also lysosomal stress, activate nucleotide-binding oligomerization domain-like receptor protein 3 inflammasomes, subsequently trigger cell pyroptosis. To sum up, study first introduces dendronized polymers manipulate has shed light another innovative insight cancer therapy.

Language: Английский

Citations

10