Cancer Risk in Hashimoto’s Thyroiditis: a Systematic Review and Meta-Analysis

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: July 12, 2022

Objective Research data suggest that patients with Hashimoto’s thyroiditis may increase the risk of cancer. However, existing research is inconsistent this view. Therefore, to investigate effect on developing cancer, we conducted study. Methods We searched PubMed and Embase databases from database establishment until March 2022. After rigorous literature screening by two authors, 23 studies met inclusion criteria were identified, required independently extracted. Results retrieved 3591 records, after screening, 11 case-control 12 cohort included in analysis. Data analysis suggested had an increased breast urogenital digestive organs hematologic a low respiratory cancers. Conclusions This systematic review meta-analysis showed HT have significantly thyroid cancers, lung system blood prolactinoma people without HT. Systematic Review Registration https://www.crd.york.ac.uk/prospero/ , identifier CRD 42022320741.

Language: Английский

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A comprehensive review of Rubia cordifolia L.: Traditional uses, phytochemistry, pharmacological activities, and clinical applications

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 9, 2022

Rubia cordifolia (family: Rubiaceae) L ( R. ) is a perennial botanical drug climbing vine. As the main part of traditional Chinese medicine, rhizome has long history. A great number literary studies have reported that it can be used for improvement blood circulation, hemostasis, activation collaterals, etc. When comes to wide application in we systematically review its uses, phytochemistry and pharmacological effects. Literatures were searched using several scientific databases, including China National Knowledge Infrastructure (CNKI), Baidu Scholar , PubMed Web Science other professional websites. Kew Botanical Garden iPlant obtaining names plant images . In addition, information was also gathered from books herbal Pharmacopoeia Materia Medica So far, many prescriptions containing been widely clinical treatment abnormal uterine bleeding, primary dysmenorrhea gynecological diseases, allergic purpura, renal hemorrhage diseases. The more than 100 compounds are found such as bicyclic peptides, terpenes, polysaccharides, trace elements, flavonoids, quinones. Among them, quinones peptides types components with highest contents modern revealed derived anti-tumor, anti-oxidative, anti-platelet aggregation, anti-inflammatory However, most preclinical. mechanism not thoroughly studied. there few pharmacokinetic toxicity therefore safety data lacking. To sum up, this first time summarizes systemic integrated chemical compositions, actions applications which provides novel full-scale insight development, medicinal value, future.

Language: Английский

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Monocyte-to-lymphocyte ratio predicts mortality and cardiovascular mortality in the general population

International Journal of Cardiology, Journal Year: 2023, Volume and Issue: 379, P. 118 - 126

Published: March 9, 2023

Language: Английский

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The prognostic predictive value of systemic immune index and systemic inflammatory response index in nasopharyngeal carcinoma: A systematic review and meta-analysis

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 3, 2023

To study the predictive value of systemic immune index (SII) and inflammatory response (SIRI) in prognosis patients with nasopharyngeal carcinoma.Two researchers independently searched PubMed, Cochrane, Embase, Web Science databases (until March 18, 2022) for all studies on SII, SIRI, carcinoma. Quality assessment included was assessed using Newcastle-Ottawa Scale (NOS). In addition, a bivariate mixed-effects model used to explore value.A total 9 that satisfied requirements were included, involving, 3187 The results meta-analysis showed SII could be an independent predictor OS (HR=1.78, 95%CI [1.44-2.20], Z=5.28, P<0.05), also PFS (HR=1.66, [1.36-2.03], Z=4.94, P<0.05). SIRI serve as (HR=2.88, [1.97-4.19], Z=5.51, ROC area 0.63, sensitivity 0.68 (95%CI [0.55-0.78]), specificity 0.55 [0.47-0.62]), which indicated had certain OS.SII can predictors predict survival status carcinoma have accuracy. Therefore, should considered update risk systems.https://www.ytyhdyy.com/, identifier PROSPERO (CRD42022319678).

Language: Английский

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Potential use of antioxidants for the treatment of chronic inflammatory diseases

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 16, 2024

The excessive production of various reactive oxidant species over endogenous antioxidant defense mechanisms leads to the development a state oxidative stress, with serious biological consequences. consequences stress depend on balance between generation and include damage biomolecules, disruption signal transduction, mutation, cell apoptosis. Accumulating evidence suggests that is involved in physiopathology debilitating illnesses associated chronic inflammation, including cardiovascular diseases, diabetes, cancer, or neurodegenerative processes, need continuous pharmacological treatment. Oxidative inflammation are tightly linked pathophysiological one which can be simply promoted by another. Although, many trials have been unsuccessful (some showed either no effect even harmful effects) human patients as preventive curative measure, targeting remains an interesting therapeutic approach for new agents design novel anti-inflammatory drugs reliable safety profile. In this regard, several natural compounds were explored potential options treatment inflammatory diseases. Several metalloenzymes, such superoxide dismutase, catalase, glutathione peroxidase, among essential enzymes maintain low nanomolar physiological concentrations (O 2 •−) hydrogen peroxide (H O ), major redox signaling molecules, thus play important roles alteration homeostasis. These become striking source motivation catalytic enhance action these under pathological conditions related inflammation. This review focused representatives synthetic antioxidants drug candidates

Language: Английский

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Inflammation and cancer: friend or foe?

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 10, 2024

Chronic inflammation plays a crucial role in the onset and progression of pathologies like neurodegenerative cardiovascular diseases, diabetes, cancer, since tumor development chronic are linked, sharing common signaling pathways. At least 20% breast colorectal cancers associated with triggered by infections, irritants, or autoimmune diseases. Obesity, inflammation, cancer interconnection underscore importance population-based interventions maintaining healthy body weight, to disrupt this axis. Given that dietary inflammatory index is correlated an increased risk adopting anti-inflammatory diet supplemented nutraceuticals may be useful for prevention. Natural products their derivatives offer promising antitumor activity favorable adverse effect profiles; however, natural bioactive drugs challenging due variability complexity, requiring rigorous research processes. It has been shown combining products, such as non-steroidal (NSAIDs), corticosteroids, statins, plant-derived demonstrate clinical utility accessible adjuvants traditional therapeutic approaches, known safety profiles. Pharmacological approaches targeting multiple proteins involved pathogenesis emerge particularly option. systemic multifactorial nature comprehensive strategies essential long term success therapy. To gain insights into carcinogenic phenomena discover diagnostic clinically relevant biomarkers, pivotal understand genetic variability, environmental exposure, habits, TME composition, establish based on molecular analysis. Furthermore, use endocannabinoid, cannabinoid, prostamide-type compounds potential targets biomarkers requires further investigation. This review aims elucidate specific etiological agents mediators contributing persistent reactions development. explores treatment, emphasizing urgent need cost-effective address cancer-associated inflammation.

Language: Английский

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Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2911 - 2911

Published: March 2, 2024

This paper delves into the diverse and significant roles of curcumin, a polyphenolic compound from Curcuma longa plant, in context cancer inflammatory diseases. Distinguished by its unique molecular structure, curcumin exhibits potent biological activities including anti-inflammatory, antioxidant, potential anticancer effects. The research comprehensively investigates curcumin’s interactions with key proteins involved progression response, primarily through docking studies. In cancer, effectiveness is determined examining interaction pivotal like CDK2, CK2α, GSK3β, DYRK2, EGFR, among others. These suggest role impeding cell proliferation survival. Additionally, highlights impact on inflammation influence such as COX-2, CRP, PDE4, MD-2, which are central to pathway. vitro clinical studies extensively reviewed, shedding light binding mechanisms, pharmacological impacts, therapeutic application various cancers conditions. understanding functionality agent. Conclusively, this review emphasizes promise treating wide range health issues, attributed complex chemistry broad properties. points towards growing importance multi-faceted natural medical scientific community.

Language: Английский

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New 1,2,4-triazole based eugenol derivatives as antiCOX-2 and anticancer agents

Journal of Umm Al-Qura University for Applied Sciences, Journal Year: 2024, Volume and Issue: 10(3), P. 555 - 566

Published: Feb. 19, 2024

Abstract Due to chronic inflammation, elevated cyclooxygenase (COX-2) level leads tumorigenesis, proliferation, invasion, angiogenesis and metastasis. Therefore, suppression of COX-2 enzyme is a fascinating approach in cancer treatment. In the present study, natural product eugenol was modified develop new 1,2,4-triazole derivatives as antiCOX-2 antiproliferative agents. The structures newly prepared were established using sophisticated analytical techniques. result showed compound 10 be equipotent doxorubicin towards MDA-MB 231 PC-3 cells with IC 50 1.42 5.69 μM, respectively potent inhibitor 0.28 μM. Compound also non carcinogenic, mutagenic good drug likeness property depicted by silico physicochemical pharmacokinetic studies. docking results against protein highest binding energy for which found consistent cytoxicity results. conclusion, could harness cell proliferation promising candidate therapy.

Language: Английский

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Phytochemical synergies in BK002: advanced molecular docking insights for targeted prostate cancer therapy

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 17, 2025

Achyranthes japonica (Miq.) Nakai (AJN) and Melandrium firmum (Siebold Zucc.) Rohrb. (MFR) are medicinal plants recognized for their bioactive phytochemicals, including ecdysteroids, anthraquinones, flavonoids. This study investigates the anticancer properties of key constituents these plants, focusing on BK002 formulation, a novel combination AJN MFR. Specifically, research employs advanced molecular docking in silico analyses to assess interactions compounds ecdysterone, inokosterone, 20-hydroxyecdysone (20-HE) with prostate cancer-related network proteins, 5α-reductase, CYP17, DNMT1, Dicer, PD-1, PD-L1. Molecular techniques were applied evaluate binding affinities contributions against cancer-hub targets. The primary focus was enzymes like 5α-reductase which central androgen biosynthesis, as well proteins such DNA methyltransferase 1 (DNMT1), programmed death-1 (PD-1), death ligand-1 (PD-L1). Based data from cancer patients, target networks identified, followed by analysis components BK002.In assessments conducted safety profiles compounds, providing insights into therapeutic potential. studies revealed that 20-hydroxyecdysonec demonstrated strong critical contributing potential reduction androgenic activity. These also exhibited significant inhibitory PD-L1, suggesting capacity interfere oncogenic immune evasion pathways. Ecdysterone, have ability pathways, favorable affinity further underscore agents cancer. findings provide rationale preclinical clinical investigations, supporting integration regimens aimed at modulating tumor progression responses.

Language: Английский

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The Diagnostic and Prognostic Role of Inflammatory Markers, Including the New Cumulative Inflammatory Index (IIC) and Mean Corpuscular Volume/Lymphocyte (MCVL), in Colorectal Adenocarcinoma

Cancers, Journal Year: 2025, Volume and Issue: 17(6), P. 990 - 990

Published: March 15, 2025

Background: Colorectal cancer affects a large number of patients worldwide, with numerous factors being involved in its etiopathogenesis and chronic inflammation playing an essential role tumor development. In this study, we analyzed compared several markers that are relatively easy to obtain for rapid accurate diagnosis prognosis. Methods: This study included 219 diagnosed colorectal cancer, analyzing the scores derived from their blood cells inflammatory circulating proteins. These neutrophil-to-lymphocyte ratio—NLR; platelet-to-lymphocyte ratio—PLR; lymphocyte-to-monocyte ratio—LMR; systemic immune index—SII; response index—SIRI; aggregate index inflammation—AISI; ratio—dNLR; C-reactive protein-to-albumin ratio—CAR; fibrinogen-to-albumin ratio—FAR. analysis have also introduced two new recently developed markers: cumulative (IIC) ratio between mean corpuscular volume lymphocytes (MCVL). aimed correlate markers’ levels diagnostic stage, clinical characteristics patients, 36 months’ survival time evaluate prognostic capacity accuracy these type cancer. Results: We showed TNM pathological differentiation grade, age gender overall survival, increased associated lower rate. Conclusions: The markers, which perform right patient’s admission, can be helpful both and, mostly, prognosis, sustaining By comparing them, one useful sensitivity specificity prognosis patients.

Language: Английский

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