Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Advanced Engineering Materials, Journal Year: 2023, Volume and Issue: 25(21)

Published: Aug. 29, 2023

Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, robots, wearable devices, sensors, self‐expanding structures, and biomedical thanks to their ability change shapes functional properties in response external stimuli including light, humidity, heat, pH, electric field, solvent, magnetic field or combinations two more these stimuli. In recent years, additive manufacturing (AM) aka 3D printing technology SRPs, also known as 4D printing, has gained phenomenal attention different engineering fields, its unique develop complex, personalized, innovative undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, other complex morphological transformations. Herein, an effort made provide insightful information about the AM techniques, type applications including, but not limited tissue engineering, bionics, construction, smart textiles. This article incorporates current challenges prospects, hoping basis utilization this fields. It is expected that amalgamation with SRPs would unparalleled advantages arenas.

Language: Английский

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3D printing of stimuli-responsive hydrogel materials: Literature review and emerging applications

Giant, Journal Year: 2023, Volume and Issue: 17, P. 100209 - 100209

Published: Nov. 15, 2023

Additive manufacturing (AM) aka three-dimensional (3D) printing has been a well-established and unparalleled technology, which is expanding the boundaries of materials science exhibiting an enormous potential to fabricate intricate geometries for healthcare, electronics, construction sectors. In contemporary era, combination AM technology stimuli-responsive hydrogels (SRHs) helps create dynamic functional structures with extreme accuracy, are capable changing their shape, functional, or mechanical properties in response environmental cues such as humidity, heat, light, pH, magnetic field, electric etc. 3D SRHs permits creation on-demand dynamically controllable shapes excellent control over various self-repair, self-assembly, multi-functionality, These accelerate researchers think unthinkable applications. Additively manufactured objects have shown applications like tissue engineering, drug delivery, soft robots, sensors, other biomedical devices. The current review provides recent progress SRHs, more focus on techniques, stimuli mechanisms, shape morphing behaviors, Finally, trends future roadmap additively smart different also presented, will be helpful research. This holds great promise providing fundamental knowledge about diverse

Language: Английский

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3D printing of magneto-active smart materials for advanced actuators and soft robotics applications

European Polymer Journal, Journal Year: 2024, Volume and Issue: 205, P. 112718 - 112718

Published: Jan. 2, 2024

In the contemporary era, novel manufacturing technologies like additive (AM) have revolutionized different engineering sectors including biomedical, aerospace, electronics, etc. Four-dimensional (4D) printing aka AM of smart materials is gaining popularity among scientific community, which has excellent ability to make soft structures such as robots, actuators, and grippers. These are developed by applying various stimuli pH, temperature, magnetic field, many combinations onto materials. Stimuli in 3D permit shape-morphing behaviors bending, twisting, folding, swelling, rolling, shrinking, origami, or locomotion. A wide variety can be fabricated through incorporation hard particles into resulting magneto-active (MASMs). With this integration, magneto-thermal coupling actuation allows diverse magneto-deformations, facilitating development personalized devices that capable enhanced deformation. review, guidelines provided on for MASMs polymers (MAPs), composites, hydrogels (MAHs) booming flexible wearable biomimetic devices. Moreover, 3D-printed robotics an outstanding capacity adapt complicated situations advanced actuating applications. Finally, some current challenges emerging areas exciting technology been proposed. Lastly, it anticipated technological advancements developing intelligent will a significant impact design real-world

Language: Английский

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Recent Progress of the Vat Photopolymerization Technique in Tissue Engineering: A Brief Review of Mechanisms, Methods, Materials, and Applications

Polymers, Journal Year: 2023, Volume and Issue: 15(19), P. 3940 - 3940

Published: Sept. 29, 2023

Vat photopolymerization (VP), including stereolithography (SLA), digital light processing (DLP), and volumetric printing, employs UV or visible to solidify cell-laden photoactive bioresin contained within a vat in point-by-point, layer-by-layer, manner. VP-based bioprinting has garnered substantial attention both academia industry due its unprecedented control over printing resolution accuracy, as well rapid speed. It holds tremendous potential for the fabrication of tissue- organ-like structures field regenerative medicine. This review summarizes recent progress VP fields tissue engineering First, it introduces mechanism photopolymerization, followed by an explanation technique commonly used biomaterials. Furthermore, application was discussed. Finally, challenges facing are discussed, future trends projected.

Language: Английский

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Advances in 3D bioprinting for regenerative medicine applications

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract Biofabrication techniques allow for the construction of biocompatible and biofunctional structures composed from biomaterials, cells biomolecules. Bioprinting is an emerging 3D printing method which utilizes biomaterial-based mixtures with other biological constituents into printable suspensions known as bioinks. Coupled automated design protocols based on different modes droplet deposition, bioprinters are able to fabricate hydrogel-based objects specific architecture geometrical properties, providing necessary environment that promotes cell growth directs differentiation towards application-related lineages. For preparation such bioinks, various water-soluble biomaterials have been employed, including natural synthetic biopolymers, inorganic materials. Bioprinted constructs considered be one most promising avenues in regenerative medicine due their native organ biomimicry. a successful application, bioprinted should meet particular criteria optimal response, mechanical properties similar target tissue, high levels reproducibility fidelity, but also increased upscaling capability. In this review, we highlight recent advances bioprinting, focusing regeneration tissues bone, cartilage, cardiovascular, neural, skin organs liver, kidney, pancreas lungs. We discuss rapidly developing co-culture bioprinting systems used resemble complexity crosstalk between populations regeneration. Moreover, report basic physical principles governing ideal bioink biomaterials’ potential. examine critically present status regarding its applicability current limitations need overcome establish it at forefront artificial production transplantation.

Language: Английский

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Liver bioprinting within a novel support medium with functionalized spheroids, hepatic vein structures, and enhanced post-transplantation vascularization

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122681 - 122681

Published: June 25, 2024

Cell-laden bioprinting is a promising biofabrication strategy for regenerating bioactive transplants to address organ donor shortages. However, there has been little success in reproducing transplantable artificial organs with multiple distinctive cell types and physiologically relevant architecture. In this study, an omnidirectional printing embedded network (OPEN) presented as support medium 3D printing. The state-of-the-art due its one-step preparation, fast removal, versatile ink compatibility. To test the feasibility of OPEN, exceptional primary mouse hepatocytes (PMHs) endothelial line-C166, were used print hepatospheroid-encapsulated-artificial livers (HEALs) vein structures following predesigned anatomy-based paths OPEN. PMHs self-organized into hepatocyte spheroids within matrix, whereas entire cross-linked structure remained intact minimum ten days cultivation. Cultivated HEALs maintained mature hepatic functions marker gene expression at higher level than conventional 2D conditions vitro. C166-laden promoted endogenous neovascularization vivo compared hepatospheroid-only liver prints two weeks transplantation. Collectively, proposed platform enables manufacture tissues or resembling anatomical architecture, broad implications function replacement clinical applications.

Language: Английский

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3D printed arrowroot starch-gellan scaffolds for wound healing applications

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130604 - 130604

Published: March 5, 2024

Language: Английский

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The Material World of 3D‐Bioprinted and Microfluidic‐Chip Models of Human Liver Fibrosis

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Nov. 14, 2023

Biomaterials are extensively used to mimic cell-matrix interactions, which essential for cell growth, function, and differentiation. This is particularly relevant when developing in vitro disease models of organs rich extracellular matrix, like the liver. Liver involves a chronic wound-healing response with formation scar tissue known as fibrosis. At early stages, liver can be reverted, but progresses, reversion no longer possible, there cure. Research new therapies hampered by lack adequate that replicate mechanical properties biochemical stimuli present fibrotic Fibrosis associated changes composition matrix directly influence behavior. could play an role better emulating microenvironment. In this paper, recent cutting-edge biomaterials creating human fibrosis revised, combination cells, bioprinting, and/or microfluidics. These technologies have been instrumental intricate structure unhealthy promote medium perfusion improves growth respectively. A comprehensive analysis impact material hints cell-material interactions tridimensional context provided.

Language: Английский

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Applications of Light-Based 3D Bioprinting and Photoactive Biomaterials for Tissue Engineering

Materials, Journal Year: 2023, Volume and Issue: 16(23), P. 7461 - 7461

Published: Nov. 30, 2023

The emergence of additive manufacturing, commonly referred to as 3D printing, has led a revolution in the field biofabrication. Numerous types bioprinting, including extrusion inkjet and lithography-based have been developed played pivotal roles driving multitude pioneering breakthroughs fields tissue engineering regenerative medicine. Among all bioprinting methods, light-based utilizes light crosslink or solidify photoreactive biomaterials, offering unprecedented spatiotemporal control over biomaterials enabling creation structures with extremely high resolution precision. However, lack suitable photoactive hindered application engineering. development only recently expanded. Therefore, this review summarizes latest advancements technologies, techniques, photo-initiators (PIs), their corresponding applications. Moreover, challenges facing are discussed, future directions proposed.

Language: Английский

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The cutting‐edge progress in bioprinting for biomedicine: principles, applications, and future perspectives

MedComm, Journal Year: 2024, Volume and Issue: 5(10)

Published: Sept. 23, 2024

Bioprinting is a highly promising application area of additive manufacturing technology that has been widely used in various fields, including tissue engineering, drug screening, organ regeneration, and biosensing. Its primary goal to produce biomedical products such as artificial implant scaffolds, tissues organs, medical assistive devices through software-layered discrete numerical control molding. Despite its immense potential, bioprinting still faces several challenges. It requires concerted efforts from researchers, engineers, regulatory bodies, industry stakeholders are principal overcome these challenges unlock the full potential bioprinting. This review systematically discusses principles, applications, future perspectives while also providing topical overview research progress over past two decades. The most recent advancements comprehensively reviewed here. First, printing techniques methods summarized along with related bioinks supporting structures. Second, interesting representative cases regarding applications biosensing introduced detail. Finally, remaining suggestions for directions proposed discussed. one areas fields. aims devices. perspectives, which provides description

Language: Английский

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