MedComm – Biomaterials and Applications,
Journal Year:
2023,
Volume and Issue:
2(2)
Published: April 14, 2023
Abstract
Copper
(Cu)
is
an
essential
trace
element
in
the
human
body
that
involved
formation
of
several
natural
enzymes,
such
as
superoxide
dismutase
and
cyclooxygenase.
Due
to
high
density
outer
electron
cloud
Cu,
which
allows
transfer
multiple
electrons,
Cu
often
used
catalytic
center
various
metabolic
enzymes.
However,
both
deficiency
excessive
accumulation
can
result
irreversible
damage
cells.
Therefore,
strategies
regulate
metabolism,
exhaustion
supplementation,
have
emerged
attractive
approaches
anticancer
therapy,
due
potential
damages
caused
by
metabolism
disorders.
Notably,
recent
advancements
nanotechnology
enabled
development
nanomaterials
making
this
therapy
applicable
vivo.
In
review,
we
provide
a
systematic
discussion
physical
chemical
properties
summarize
applications
metabolism‐based
antitumor
therapy.
Finally,
outline
future
directions
challenges
nano‐Cu
emphasizing
scientific
problems
technical
bottlenecks
need
be
addressed
for
successful
clinical
translation.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(21)
Published: Feb. 24, 2024
Engineered
bacteria
are
widely
used
in
cancer
treatment
because
live
facultative/obligate
anaerobes
can
selectively
proliferate
at
tumor
sites
and
reach
hypoxic
regions,
thereby
causing
nutritional
competition,
enhancing
immune
responses,
producing
anticancer
microbial
agents
situ
to
suppress
growth.
Despite
the
unique
advantages
of
bacteria-based
biotherapy,
insufficient
efficiency
limits
its
application
complete
ablation
malignant
tumors.
The
combination
nanomedicine
engineered
has
attracted
increasing
attention
owing
their
striking
synergistic
effects
treatment.
that
function
as
natural
vehicles
effectively
deliver
nanomedicines
sites.
Moreover,
provide
an
opportunity
enhance
by
modulating
TME
substrates
support
nanomedicine-mediated
reactions.
Nanomedicine
exhibits
excellent
optical,
magnetic,
acoustic,
catalytic
properties,
plays
important
role
promoting
bacteria-mediated
biotherapies.
therapy
comprehensively
summarized
this
review.
Attention
is
paid
not
only
fabrication
nanobiohybrid
composites,
but
also
interpromotion
mechanism
between
therapy.
Additionally,
recent
advances
bacteria-synergized
multimodal
therapies
highlighted.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 30, 2024
Natural
polyphenolic
compound
rosmarinic
acid
(RA)
has
good
antitumor
activity.
However,
the
distinctive
tumor
microenvironment,
characterized
by
low
pH
and
elevated
levels
of
glutathione
(GSH),
enhances
tolerance
tumors
to
singular
anti-tumor
treatment
mode
using
RA,
resulting
in
unsatisfactory
therapeutic
efficacy.
Targeting
nonapoptotic
programmed
cell
death
processes
may
provide
another
impetus
inhibit
growth.
RA
possesses
capability
coordinate
with
metal
elements.
To
solve
effect
restriction
above
single
mode,
it
is
proposed
construct
a
self-assembled
nanocomposite,
Fe-RA.
Under
Fe-RA
nanocomposite
exerts
characteristics
POD-like
enzyme
activity
depletion
GSH,
producing
large
amount
hydroxyl
radical
(·OH)
while
disrupting
antioxidant
defense
system
cells.
Moreover,
due
enhanced
permeability
retention
(EPR),
can
transport
Fe
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: May 2, 2024
As
a
new
form
of
regulated
cell
death,
ferroptosis
has
unraveled
the
unsolicited
theory
intrinsic
apoptosis
resistance
by
cancer
cells.
The
molecular
mechanism
depends
on
induction
oxidative
stress
through
excessive
reactive
oxygen
species
accumulation
and
glutathione
depletion
to
damage
structural
integrity
Due
their
high
loading
tunability,
nanocarriers
can
escort
delivery
ferro-therapeutics
desired
site
enhanced
permeation
or
retention
effect
active
targeting.
This
review
shed
light
necessity
iron
in
growth
fascinating
features
regulating
cycle
metastasis.
Additionally,
we
discussed
ferroptosis-mediated
therapy
using
nanoplatforms
chemical
basis
overcoming
barriers
therapy.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(12), P. 8567 - 8575
Published: March 15, 2024
Ferroptosis
as
a
promising
method
of
cancer
treatment
heavily
relies
on
the
intracellular
iron
ion
level.
Herein,
new
iron-supplement
nanodrug
was
developed
by
conjugating
transferrin-homing
peptide
T10
surface
cross-linked
lipoic
acid
vesicles
(T10@cLAV),
which
could
hijack
blood
transferrin
(Tf)
and
specifically
deliver
it
to
tumor
cells
elevate
Fe2+
Meanwhile,
degradation
product
cLAV,
dihydrolipoic
acid,
regenerate
further
boost
ferroptosis.
The
results
disclosed
that
T10@cLAV
achieved
inhibition
comparable
cisplatin
at
dose
low
5
mg/kg
in
HeLa
tumor-bearing
nude
mice
model
caused
no
toxicity
up
300
mg/kg.
This
tactful
strategy
hijacking
Tf
is
superior
current
strategies:
one
induction
ferritin
degradation,
limited
content
ferritin,
other
delivery
iron-based
materials,
easily
causes
adverse
effects.
