Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer

Gastroenterology, Journal Year: 2019, Volume and Issue: 158(2), P. 322 - 340

Published: Oct. 3, 2019

Language: Английский

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Epidemiology and Mechanisms of the Increasing Incidence of Colon and Rectal Cancers in Young Adults

Gastroenterology, Journal Year: 2019, Volume and Issue: 158(2), P. 341 - 353

Published: Aug. 5, 2019

Language: Английский

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Smoking and microbiome in oral, airway, gut and some systemic diseases

Journal of Translational Medicine, Journal Year: 2019, Volume and Issue: 17(1)

Published: July 15, 2019

The human microbiome harbors a diverse array of microbes which establishes mutually beneficial relation with the host in healthy conditions, however, dynamic homeostasis is influenced by both and environmental factors. Smoking contributes to modifications oral, lung gut microbiome, leading various diseases, such as periodontitis, asthma, chronic obstructive pulmonary disease, Crohn's ulcerative colitis cancers. However, exact causal relationship between smoking alteration remains be further explored.

Language: Английский

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Recent trends in cancer therapy: A review on the current state of gene delivery

Life Sciences, Journal Year: 2021, Volume and Issue: 269, P. 119087 - 119087

Published: Jan. 19, 2021

Language: Английский

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Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(6), P. 943 - 960.e9

Published: May 15, 2023

Language: Английский

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Fecal Metabolomic Signatures in Colorectal Adenoma Patients Are Associated with Gut Microbiota and Early Events of Colorectal Cancer Pathogenesis

mBio, Journal Year: 2020, Volume and Issue: 11(1)

Published: Feb. 17, 2020

Colorectal adenomas are precursors of CRC. Recently, the gut microbiota, i.e., collection microbes residing in our gut, has been recognized as a key player CRC development. There have number microbiota profiling studies for colorectal adenoma and CRC; however, fewer considered metabolome, which serves chemical interface between host microbiota. Here, we conducted metabolome study analyzed metabolomic profiles together with paired composition profiles. We found several signatures that were associated some potentially indicative future This highlights potential early-driver metabolites pathogenesis guides further targeted experiments thus provides an important stepping stone toward developing better prevention strategies.

Language: Английский

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Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora

Phytomedicine, Journal Year: 2022, Volume and Issue: 102, P. 154217 - 154217

Published: May 27, 2022

Language: Английский

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Gut Microbiota in Colorectal Cancer: Biological Role and Therapeutic Opportunities

Cancers, Journal Year: 2023, Volume and Issue: 15(3), P. 866 - 866

Published: Jan. 30, 2023

Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths worldwide. While CRC thought to be an interplay between genetic and environmental factors, several lines evidence suggest involvement gut microbiota in promoting inflammation tumor progression. Gut refer ~40 trillion microorganisms that inhabit human gut. Advances next-generation sequencing technologies metagenomics have provided new insights into microbial ecology helped linking CRC. Many studies carried out humans animal models emphasized role certain bacteria, such as Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, colibactin-producing Escherichia coli, onset progression Metagenomic opened up avenues for application diagnosis, prevention, treatment This review article summarizes development its use a biomarker predict disease potential therapeutic applications.

Language: Английский

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Changing epidemiology of colorectal cancer — birth cohort effects and emerging risk factors

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 21(1), P. 25 - 34

Published: Sept. 18, 2023

Language: Английский

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Gut microbial metabolites SCFAs and chronic kidney disease

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 18, 2024

The global incidence of Chronic Kidney Disease (CKD) is steadily escalating, with discernible linkage to the intricate terrain intestinal microecology. microbiota orchestrates a dynamic equilibrium in organism, metabolizing dietary-derived compounds, process which profoundly impacts human health. Among these short-chain fatty acids (SCFAs), result from microbial metabolic processes, play versatile role influencing host energy homeostasis, immune function, and intermicrobial signaling, etc. SCFAs emerge as pivotal risk factors CKD's development prognosis. This paper review elucidates impact gut metabolites, specifically SCFAs, on CKD, highlighting their modulating inflammatory responses, oxidative stress, cellular autophagy, milieu, signaling cascades. An in-depth comprehension interplay between kidney disease pathogenesis may pave way for utilization biomarkers CKD progression prognosis or novel adjunctive therapeutic strategies.

Language: Английский

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