Emerging Sonodynamic Therapy‐Based Nanomedicines for Cancer Immunotherapy

Advanced Science, Journal Year: 2022, Volume and Issue: 10(2)

Published: Nov. 27, 2022

Cancer immunotherapy effect can be greatly enhanced by other methods to induce immunogenic cell death (ICD), which has profoundly affected as a highly efficient paradigm. However, these treatments have significant limitations, either causing damage of the immune system or limited superficial tumors. Sonodynamic therapy (SDT) ICD promote without affecting because its excellent spatiotemporal selectivity and low side effects. Nevertheless, SDT is still reactive oxygen species yield complex tumor microenvironment. Recently, some emerging SDT-based nanomedicines made numerous attractive encouraging achievements in field cancer due high immunotherapeutic efficiency. this cross-cutting research far from being widely explored huge professional barriers. Herein, characteristics microenvironment mechanisms are firstly systematically summarized. Subsequently, therapeutic mechanism fully summarized, advantages limitations discussed. The representative advances for further highlighted. Finally, application prospects challenges future clinical translation

Language: Английский

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Metal-Phenolic Network-Enabled Lactic Acid Consumption Reverses Immunosuppressive Tumor Microenvironment for Sonodynamic Therapy

ACS Nano, Journal Year: 2021, Volume and Issue: 15(10), P. 16934 - 16945

Published: Oct. 18, 2021

Nanomedicine has revolutionized cancer therapeutic strategies but not completely changed the outcomes of tricky tumors that evolve a sophisticated immunosuppressive tumor microenvironment (TME) such as acidification. Here, metal-phenolic network-based nanocomplex embedded with lactate oxidase (LOX) and mitochondrial respiration inhibitor atovaquone (ATO) was constructed for TME remodeling sonodynamic therapy (SDT). In this nanocomplex, sonosensitizer chlorin e6-conjugated polyphenol derivative can induce generation lethal reactive oxygen species upon ultrasound irradiation. LOX served catalyst intracellular lactic acid exhaustion, ATO led to dysfunction decrease consumption. This reversed status by alleviating hypoxia acidic TME, achieving characteristic enhancement SDT inhibition proliferation metastasis.

Language: Английский

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Macrophage-Targeted Sonodynamic/Photothermal Synergistic Therapy for Preventing Atherosclerotic Plaque Progression Using CuS/TiO₂ Heterostructured Nanosheets

ACS Nano, Journal Year: 2022, Volume and Issue: 16(7), P. 10608 - 10622

Published: June 27, 2022

Sonodynamic therapy (SDT) and photothermal (PTT) are two effective strategies for the treatment of atherosclerotic plaques. However, low yield reactive oxygen species (ROS) conventional organic sonosensitizers biosafety hyperthermia limit therapeutic efficacy SDT PTT. Herein, we report copper sulfide/titanium oxide heterostructure nanosheets modified with hyaluronic acid (HA) PEG (HA-HNSs) low-intensity sonodynamic mild-photothermal synergistic early CuS/TiO2 (HNSs) show high electron–hole separation efficiency superior performance, because it has surface energy crystal facets as well a narrow band. Moreover, HNSs exhibit intense absorbance in NIR-II region, which endows excellent performance. With further modification HA, HA-HNSs can selectively target intraplaque proinflammatory macrophages through CD44-HA interaction. Because reduces expression heat shock protein 90 PTT facilitates sonocatalytic process, combination based on could synergistically induce macrophage apoptosis. More importantly, prevents progression plaque by removing lesional mitigating inflammation. Taken together, this work provides macrophage-targeting sonodynamic/photothermal therapy, is an translational clinical intervention

Language: Английский

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Conferring BiVO₄ Nanorods with Oxygen Vacancies to Realize Enhanced Sonodynamic Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(44)

Published: Sept. 9, 2022

Abstract Owing to the high depth of tissue penetration, non‐invasiveness, and controllability, ultrasound (US)‐mediated sonodynamic therapy (SDT) has shown broad application prospects for tumor treatment. However, electron‐hole separation inefficiency sonosensitizers hypoxia remain two major challenges limiting effect SDT. Here, ultrafine photoetched bismuth vanadate (BiVO 4 ) nanorods modified with DSPE‐PEG 2000 (PEBVO@PEG NRs) were fabricated achieve in situ self‐supply oxygen (O 2 reactive species (ROS) hypoxic therapy. The photoetching approach could enhance charge by inducing enriched vacancies on surface BiVO , thereby improving generation efficiency ROS O . PEBVO@PEG overcome main obstacles traditional SDT process show promising therapeutic effects, thus providing new strategies performance sonosensitizer elimination.

Language: Английский

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Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 1, 2023

The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers the antitumor immune response. Here, we report a denaturation-and-penetration strategy use tin monosulfide nanoparticles (SnSNPs) as nano-sonosensitizers that can overcome stromal barrier for management triple-negative breast cancer (TNBC). SnSNPs possess narrow bandgap (1.18 eV), allowing efficient electron (e-)-hole (h+) pair separation to generate reactive oxygen species under US activation. More importantly, display mild photothermal properties in situ denature collagen facilitate deep into mass upon near-infrared irradiation. This approach significantly enhances sonodynamic therapy (SDT) by boosts immunity. In mouse models malignant TNBC hepatocellular carcinoma (HCC), combination robust SDT enhanced cytotoxic T lymphocyte infiltration achieves remarkable anti-tumor efficacy. study presents an innovative enhance immunity using strategy, offering potential combined sono-immunotherapy nanomedicine field.

Language: Английский

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Two-Dimensional MXene-Originated In Situ Nanosonosensitizer Generation for Augmented and Synergistic Sonodynamic Tumor Nanotherapy

ACS Nano, Journal Year: 2022, Volume and Issue: 16(6), P. 9938 - 9952

Published: May 31, 2022

Despite the merits of high tissue-penetrating depth, no ionizing radiation, and low cost, sonodynamic therapy (SDT) still suffers from a quantum yield reactive oxygen species (ROS), limited delivery efficiency, potential toxicity sonosensitizers. Different direct sonosensitizers into tumor tissue for SDT, this work reports fabrication two-dimensional (2D) nanosonosensitizers/nanocatalysts (Ti3C2/CuO2@BSA) in situ generation nanosonosensitizers by responding to microenvironment, achieving high-performance synergistic sonodynamic/chemodynamic therapy. CuO2 nanoparticle integration on 2D Ti3C2 MXene achieved H2O2 an acidic microenvironment oxidizing produce TiO2 nanosonosensitizers, accompanied enhanced separation electrons (e-) holes (h+) carbon matrix after oxidation, further augmenting SDT efficacy. Ultrasound irradiation during process also Cu-initiated Fenton-like reaction more ROS synergizing The experimental results confirm demonstrate therapeutic effects chemodynamic nanotherapy both vitro vivo. antitumor mechanisms therapies are associated with upregulation oxidative phosphorylation, generation, apoptosis as demonstrated RNA sequencing. This thus provides distinct paradigm MXene-originated nanosonosensitizer augmented nanotherapy.

Language: Английский

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Recent progress of metal‐based nanomaterials with anti‐tumor biological effects for enhanced cancer therapy

Exploration, Journal Year: 2023, Volume and Issue: 3(5)

Published: June 30, 2023

Abstract Metal‐based nanomaterials have attracted broad attention recently due to their unique biological physical and chemical properties after entering tumor cells, namely effects. In particular, the abilities of Ca 2+ modulate T cell receptors activation, K + regulate stem differentiation, Mn activate STING pathway, Fe 2+/3+ induce ferroptosis enhance catalytic therapy, make metal ions metal‐based play crucial roles in cancer treatments. Therefore, superior advantages characteristics microenvironment, we will summarize recent progress anti‐tumor effects nanomaterials. Based on different this review mainly focuses following five aspects: (1) metal‐enhanced radiotherapy sensitization, (2) (3) ferroptosis, (4) pyroptosis, (5) immunotherapy. At same time, shortcomings therapy are also discussed, future research directions been prospected. The highlights promising biosafety, potent efficacy for in‐depth various mechanism studies provide novel ideas application

Language: Английский

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Piezo-Augmented Sonosensitizer with Strong Ultrasound-Propelling Ability for Efficient Treatment of Osteomyelitis

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 2546 - 2557

Published: Jan. 19, 2022

The successful treatment of osteomyelitis remains a great challenge in the field orthopedics. clinical method for treating refractory bone infection requires combination therapy long-term systemic antibiotics administration and surgical debridement. It is highly desirable to develop an antibiotic-free, noninvasive, rapid strategy eradicate osteomyelitis. Herein, we fabricate piezoelectric-enhanced sonosensitizer that consists porphyrin-based hollow metal–organic framework (HNTM), MoS2 nanosheets, red cell (RBC) membrane. We find ultrasound (US)-induced piezoelectric polarization can improve charge transfer HNTM at heterointerface HNTM-MoS2, increasing production reactive oxygen species (ROS). Besides, increases asymmetric shape HNTM, leading strong US-propelling ability HNTM–MoS2. produced ROS mechanical force kill methicillin-resistant Staphylococcus aureus (MRSA) with antibacterial efficiency 98.5% under 15 min US treatment, resulting intracellular DNA damage increased oxidative stress disturbance purine metabolism, tryptophan pantothenate CoA biosynthesis MRSA. Together toxin neutralization ability, RBC-HNTM-MoS2 successfully eliminates suppresses inflammation loss. This work provides another developing efficient through piezoelectric-assisted sonocatalysis enhancing ability.

Language: Английский

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Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet‐Based Sonosensitizers Via Crystalline‐to‐Amorphous Phase Transformation

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(17)

Published: Feb. 13, 2023

Abstract Sonodynamic therapy (SDT) has been a promising therapeutic modality for cancer because of its superior advantages compared with other strategies. However, the current sonosensitizers used SDT normally exhibit low activity ultrasound (US)‐induced reactive oxygen species (ROS) generation. Herein, crystalline‐to‐amorphous phase transformation is reported as simple but powerful strategy to engineer ultrathin 2D CoW‐LDH and NiW‐LDH nanosheets highly efficient SDT. The from polycrystalline amorphous ones achieved through acid etching treatment. Importantly, one, (a‐CoW‐LDH) possess higher ROS generation under US irradiation, which ≈17 times commercial TiO 2 sonosensitizer. results suggest that enhanced performance a‐CoW‐LDH US‐induced may be attributed transformation‐induced defect electronic structure changes. After polyethylene glycol modification, can serve high‐efficiency sonosensitizer achieve cell death in vitro tumor eradication vivo irradiation.

Language: Английский

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Cancer cell membrane-coated C-TiO2 hollow nanoshells for combined sonodynamic and hypoxia-activated chemotherapy

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 152, P. 562 - 574

Published: Sept. 5, 2022

Language: Английский

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