Circadian clocks and insulin resistance

Nature Reviews Endocrinology, Journal Year: 2018, Volume and Issue: 15(2), P. 75 - 89

Published: Dec. 7, 2018

Language: Английский

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Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans

Nutrients, Journal Year: 2019, Volume and Issue: 11(6), P. 1234 - 1234

Published: May 30, 2019

Time-restricted feeding (TRF) is a form of intermittent fasting that involves having longer daily period. Preliminary studies report TRF improves cardiometabolic health in rodents and humans. Here, we performed the first study to determine how affects gene expression, circulating hormones, diurnal patterns risk factors Eleven overweight adults participated 4-day randomized crossover where they ate between 8 am 2 pm (early (eTRF)) (control schedule). Participants underwent continuous glucose monitoring, blood was drawn assess factors, expression whole cells. Relative control schedule, eTRF decreased mean 24-hour levels by 4 ± 1 mg/dl (p = 0.0003) glycemic excursions 12 3 0.001). In morning before breakfast, increased ketones, cholesterol, stress response aging SIRT1 autophagy LC3A (all p < 0.04), while evening, it tended increase brain-derived neurotropic factor (BNDF; 0.10) also MTOR 0.007), major nutrient-sensing protein regulates cell growth. altered cortisol several circadian clock genes 0.05). levels, alters lipid metabolism may have anti-aging effects

Language: Английский

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Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes

Diabetologia, Journal Year: 2020, Volume and Issue: 63(3), P. 462 - 472

Published: Jan. 8, 2020

The circadian system generates endogenous rhythms of approximately 24 h, the synchronisation which are vital for healthy bodily function. timing many physiological processes, including glucose metabolism, coordinated by system, and disruptions that desynchronise or misalign these can result in adverse health outcomes. In this review, we cover role its disruption metabolism individuals with type 2 diabetes mellitus. We begin defining then provide an overview regulation metabolism. next discuss impact on control diabetes. Given concurrent high prevalence disruption, understanding mechanisms underlying may aid improving glycaemic control.

Language: Английский

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Circadian disruption and human health

Journal of Clinical Investigation, Journal Year: 2021, Volume and Issue: 131(19)

Published: Sept. 30, 2021

Circadian disruption is pervasive and can occur at multiple organizational levels, contributing to poor health outcomes individual population levels. Evidence points a bidirectional relationship, in that circadian increases disease severity many diseases disrupt rhythms. Importantly, increase the risk for expression development of neurologic, psychiatric, cardiometabolic, immune disorders. Thus, harnessing rich findings from preclinical translational research biology enhance via circadian-based approaches represents unique opportunity personalized/precision medicine overall societal well-being. In this Review, we discuss implications human using bench-to-bedside approach. science applied clinical population-based Given broad regulation health, Review focuses its discussion on selected examples metabolic, cardiovascular, allergic, immunologic disorders highlight interrelatedness between potential interventions, such as bright light therapy exogenous melatonin, well chronotherapy improve and/or modify outcomes.

Language: Английский

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Importance of circadian timing for aging and longevity

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: May 17, 2021

Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR can be achieved by controlling how much and/or when food is provided, as well adjusting nutritional composition. Because these factors are often combined during DR, it unclear which necessary for beneficial effects. Several drugs have been utilized that target nutrient-sensing gene pathways, many of change expression throughout the day, suggesting timing drug administration critical. Here, we discuss dietary pharmacological interventions promote a healthy lifespan influencing energy intake circadian rhythms.

Language: Английский

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Effects of time-restricted feeding on body weight and metabolism. A systematic review and meta-analysis

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2019, Volume and Issue: 21(1), P. 17 - 33

Published: Dec. 6, 2019

Language: Английский

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Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy

Trends in Endocrinology and Metabolism, Journal Year: 2020, Volume and Issue: 31(3), P. 192 - 204

Published: Jan. 1, 2020

Language: Английский

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Exercise metabolism and adaptation in skeletal muscle

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 24(9), P. 607 - 632

Published: May 24, 2023

Language: Английский

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Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3392 - 3392

Published: Feb. 8, 2023

Availability of artificial light and light-emitting devices have altered human temporal life, allowing 24-hour healthcare, commerce production, expanding social life around the clock. However, physiology behavior that evolved in context 24 h solar days are frequently perturbed by exposure to at night. This is particularly salient circadian rhythms, result endogenous biological clocks with a rhythm ~24 h. Circadian rhythms govern features behavior, set precisely primarily during day, though other factors, such as timing meals, can also affect rhythms. significantly affected night shift work because nocturnal light, electronic devices, shifts meals. Night workers increased risk for metabolic disorder, well several types cancer. Others who exposed or late mealtimes show disrupted cardiac disorders. It imperative understand how alter function develop strategies mitigate their negative effects. In this review, we provide an introduction physiological regulation homeostasis suprachiasmatic nucleus (SCN), SCN-mediated hormones display including melatonin glucocorticoids. Next, discuss circadian-gated processes sleep food intake, followed modern lighting disrupts molecular clock Lastly, identify disruptions metabolism increase susceptibility syndrome cardiovascular diseases, various harmful consequences associated on health.

Language: Английский

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Lipid metabolism around the body clocks

Progress in Lipid Research, Journal Year: 2023, Volume and Issue: 91, P. 101235 - 101235

Published: May 15, 2023

Lipids play important roles in energy metabolism along with diverse aspects of biological membrane structure, signaling and other functions. Perturbations lipid are responsible for the development various pathologies comprising metabolic syndrome, obesity, type 2 diabetes. Accumulating evidence suggests that circadian oscillators, operative most cells our body, coordinate temporal homeostasis. In this review we summarize current knowledge on regulation digestion, absorption, transportation, biosynthesis, catabolism, storage. Specifically, focus molecular interactions between functional clockwork biosynthetic pathways major classes cholesterol, fatty acids, triacylglycerols, glycerophospholipids, glycosphingolipids, sphingomyelins. A growing body epidemiological studies associate a socially imposed misalignment common modern society incidence disorders, however disruption rhythms connection has only been recently revealed. Here, highlight recent unravel mechanistic link intracellular clocks, homeostasis diseases based animal models clock innovative translational humans. We also discuss perspectives manipulating oscillators as potentially powerful approach preventing managing disorders human patients.

Language: Английский

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