Effects of a Novel Magnetic Nanomaterial on Oral Biofilms DOI Creative Commons
Yanru Chen, Zhiyu Li, Yu Wei

et al.

International Dental Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Dental caries is one of the most common oral chronic infectious diseases, and novel antibacterial materials must be developed to control plaque inhibit formation dental caries. Combining magnetic nanomaterials with agents decrease bacterial biofilm has been a hot topic in biomedical field. The present study nanomaterial chemically combined dimethylaminododecyl methacrylate (DMADDM) initially investigated its inhibiting effects on biofilms by using traditional caries-related bacteria saliva flora models. successfully loaded DMADDM according thermogravimetric analysis, Fourier transform infrared spectroscopy, x-ray diffraction, vibrating sample magnetometry, scanning electron microscopy, transmission microscopy results. Further, nanoparticle Fe

Language: Английский

Drug delivery strategies for antibiofilm therapy DOI
Victor Choi, Jennifer Rohn, Paul Stoodley

et al.

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(9), P. 555 - 572

Published: May 31, 2023

Language: Английский

Citations

70
Recent updates and feasibility of nanodrugs in the prevention and eradication of dental biofilm and its associated pathogens—A review DOI

Kannika Parameshwari Kannan,

Vinothini Gunasekaran,

Pavithra Sreenivasan

et al.

Journal of Dentistry, Journal Year: 2024, Volume and Issue: 143, P. 104888 - 104888

Published: Feb. 9, 2024

Language: Английский

Citations

26
New strategies and mechanisms for targeting Streptococcus mutans biofilm formation to prevent dental caries: A review DOI Creative Commons

Zhen Gao,

Xiaoyong Chen, Chen Wang

et al.

Microbiological Research, Journal Year: 2023, Volume and Issue: 278, P. 127526 - 127526

Published: Oct. 14, 2023

Language: Английский

Citations

34
Rational Designs of Biomaterials for Combating Oral Biofilm Infections DOI

Zhengrong Yin,

Yaxi Liu,

Annikaer Anniwaer

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 11, 2023

Oral biofilms, which are also known as dental plaque, the culprit of a wide range oral diseases and systemic diseases, thus contributing to serious health risks. The manner how achieve good control biofilms has been an increasing public concern. Novel antimicrobial biomaterials with highly controllable fabrication functionalization have proven be promising candidates. However, previous reviews generally emphasized physicochemical properties, action mode, application effectiveness those biomaterials, whereas insufficient attention given design rationales tailored different infection types scenarios. To offer guidance for better diversification anti-oral-biofilm this review details up-to-date in three aspects: core strategies combating biofilm, well advanced antibiofilm capacity multiple functions based on improvement or combination abovementioned strategies. Thereafter, insights existing challenges future biomaterial-assisted biofilm treatments proposed, hoping provide theoretical basis reference subsequent biomaterials.

Language: Английский

Citations

30
Targeting bacterial biofilm-related genes with nanoparticle-based strategies DOI Creative Commons
Shima Afrasiabi, Alireza Partoazar

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: May 22, 2024

Persistent infection caused by biofilm is an urgent in medicine that should be tackled new alternative strategies. Low efficiency of classical treatments and antibiotic resistance are the main concerns persistent due to formation which increases risk morbidity mortality. The gene expression patterns cells differed from those planktonic cells. One promising approaches against biofilms nanoparticle (NP)-based therapy NPs with multiple mechanisms hinder bacterial or forms. For instance, such as silver (Ag), zinc oxide (ZnO), titanium dioxide (TiO 2 ), copper (Cu), iron (Fe 3 O 4 ) through different strategies interfere bacteria associated biofilm. can penetrate into structure affect efflux pump, quorum-sensing, adhesion-related genes, lead inhibit development. Therefore, understanding targeting genes molecular basis point therapeutic targets make possible control infections. In parallel, impact on environment their cytotoxicity avoided controlled exposure safety assessments. This study focuses biofilm-related potential for inhibition highly effective NPs, especially metal NPs.

Language: Английский

Citations

15
Nanomaterial-enabled anti-biofilm strategies: new opportunities for treatment of bacterial infections DOI Creative Commons

Yijia Xie,

Huanhuan Liu, Zihao Teng

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Biofilms play a pivotal role in bacterial pathogenicity and antibiotic resistance, representing major challenge the treatment of infections. The limited diffusion inactivation efficacy antibiotics within biofilms hinder their clearance, while increasing dosage may enhance effectiveness, it also promotes resistance. Nano-delivery systems that target antimicrobial agents directly to offer promising strategy overcome this challenge. This review summarizes resistance mechanisms therapeutic challenges associated with biofilms, focus on recent advances nano-delivery such as liposomes, nanoemulsions, cell membrane vesicles (CMVs), polymers, dendrimers, nanogels, inorganic nanoparticles, metal-organic frameworks (MOFs). Furthermore, explores potential applications biofilm provides recommendations guide future research development field.

Language: Английский

Citations

1
Nanoparticle formulations for therapeutic delivery, pathogen imaging and theranostic applications in bacterial infections DOI Creative Commons
Lai Jiang, Linyu Ding, Gang Liu

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(5), P. 1545 - 1570

Published: Jan. 1, 2023

Pathogenic bacterial infections represent an ever-growing crisis, now significantly threatening life expectancy across the worldwide population and thus novel approaches to tackle this issue are urgently needed.The application of nanotechnology in recent years has opened up new horizons selective or specific delivery drugs imaging agents infectious sites.In particular, development nanoparticles for both active substances infection sites is gathering much interest.Although still its infancy, field antibacterial nanomedicines provides exciting possibilities combat multi-resistant shows great promise personalized medicine stewardship.This review examines nanoparticle-based formulations used therapeutic delivery, pathogen tracking diagnosis, combined "theranostic" more effectively treating infections.

Language: Английский

Citations

21
Targeted pH-responsive chitosan nanogels with Tanshinone IIA for enhancing the antibacterial/anti-biofilm efficacy DOI
Mingxia Wang,

Tariq Muhammad,

Huiling Gao

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 237, P. 124177 - 124177

Published: March 25, 2023

Language: Английский

Citations

20
Recent advances of cell membrane-coated nanoparticles for therapy of bacterial infection DOI Creative Commons
Yue Song,

Xia Zheng,

Juan Hu

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 17, 2023

The rapid evolution of antibiotic resistance and the complicated bacterial infection microenvironments are serious obstacles to traditional therapy. Developing novel antibacterial agents or strategy prevent occurrence enhance efficiency is utmost importance. Cell membrane-coated nanoparticles (CM-NPs) combine characteristics naturally occurring membranes with those synthetic core materials. CM-NPs have shown considerable promise in neutralizing toxins, evading clearance by immune system, targeting specific bacteria, delivering antibiotics, achieving responsive released microenvironments, eradicating biofilms. Additionally, can be utilized conjunction photodynamic, sonodynamic, photothermal therapies. In this review, process for preparing briefly described. We focus on functions recent advances applications several types infection, including derived from red blood cells, white platelet, bacteria. other such as dendritic genetically engineered gastric epithelial cells plant-derived extracellular vesicles introduced well. Finally, we place a perspective CM-NPs’ list challenges encountered field preparation application standpoint. believe that technology will reduce threats posed bacteria save lives infectious diseases future.

Language: Английский

Citations

18
Multifunctional magnesium organic framework-based photothermal and pH dual-responsive mouthguard for caries prevention and tooth self-healing promotion DOI Creative Commons
Qun Li, Jin‐Biao Liu, Huijie Liu

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 29, P. 72 - 84

Published: June 29, 2023

Caries is considered to be the most prevalent non-communicable disease in humans, mainly deriving from acidogenic bacterial biofilm and resulting demineralization decomposition of hard dental tissue. Herein, a composite responsive foam brace loaded with magnesium organic framework (MPC) designed for caries prevention tooth remineralization. MPC can intelligently release antibacterial molecules (gallic acid) mineralized ions (Mg2+, Ca2+ PO43-) under acidic conditions (pH < 5.5) infection, regulating pH killing bacteria. Additionally, due excellent photothermal conversion efficiency, further enhance destruction by inhibiting virulence genes destroying adhesion near-infrared light irradiation (808 nm). More importantly, not only reverse cariogenic environment at both microbial levels, but also promote self-healing demineralized teeth terms micro-structure mechanical properties.

Language: Английский

Citations

18