Effectiveness of Fecal Microbiota Transplantation in Nociplastic Pain Management: A Systematic Review DOI Creative Commons
Sebastián Eustaquio Martín Pérez,

Hakim Al Lal Abdel Lah,

Nelda Garcia

et al.

Gastrointestinal Disorders, Journal Year: 2025, Volume and Issue: 7(1), P. 5 - 5

Published: Jan. 8, 2025

Nociplastic pain, commonly observed in conditions such as Fibromyalgia, chronic fatigue syndrome, and irritable bowel arises from altered central pain processing involves complex mechanisms, including interactions between the gut–brain axis immune dysregulation. Conventional therapies often fail to address this type of effectively, leading interest alternative approaches fecal microbiota transplantation. This technique has been proposed restore gut microbial balance modulate systemic inflammation, neuroinflammation, neurotransmitter signaling. systematic review, conducted according Preferred Reporting Items for Systematic Reviews Meta-analyses guidelines registered International Prospective Register (CRD42024611939), evaluated 13 studies with n = 409 participants, clinical trials, case reports, retrospective analyses. A quality assessment was performed using appraisal tools Cochrane RoB 2, ROBINS-I, NOS, CARE. The results suggest that transplantation may reduce intensity improve life, particularly patients Fibromyalgia syndrome. However, outcomes Chronic Fatigue Syndrome psoriatic arthritis were inconsistent limited by methodological flaws, small sample sizes, variability protocols donor selection. Although adverse events minimal, current evidence is insufficient support widespread use. High-quality, standardized are needed confirm efficacy Until then, its application should remain experimental interpreted caution.

Language: Английский

Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeutic Targeting of the Microbiome DOI Open Access
Brian Bicknell, Ann Liebert, Thomas J. Borody

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9577 - 9577

Published: May 31, 2023

The human gut microbiome contains the largest number of bacteria in body and has potential to greatly influence metabolism, not only locally but also systemically. There is an established link between a healthy, balanced, diverse overall health. When becomes unbalanced (dysbiosis) through dietary changes, medication use, lifestyle choices, environmental factors, ageing, this profound effect on our health linked many diseases, including metabolic inflammatory neurological diseases. While humans largely association dysbiosis with disease, animal models, causative can be demonstrated. brain particularly important maintaining health, strong neurodegenerative neurodevelopmental This suggests that microbiota composition used make early diagnosis diseases modifying microbiome-gut-brain axis might present therapeutic target for have proved intractable, aim altering trajectory such as Alzheimer's Parkinson's multiple sclerosis, autism spectrum disorder, attention-deficit hyperactivity among others. other potentially reversible migraine, post-operative cognitive dysfunction, long COVID, which considered models therapy disease. role traditional methods microbiome, well newer, more novel treatments faecal transplants photobiomodulation, are discussed.

Language: Английский

Citations

66
Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions DOI Creative Commons
Kenji Hashimoto

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(9), P. 3625 - 3637

Published: Sept. 1, 2023

Abstract The human body harbors a diverse ecosystem of microorganisms, including bacteria, viruses, and fungi, collectively known as the microbiota. Current research is increasingly focusing on potential association between microbiota various neuropsychiatric disorders. resides in parts body, such oral cavity, nasal passages, lungs, gut, skin, bladder, vagina. gut gastrointestinal tract has received particular attention due to its high abundance role psychiatric neurodegenerative However, presents other tissues, though less abundant, also plays crucial immune system homeostasis, thus influencing development progression For example, imbalance associated periodontitis might increase risk for Additionally, studies using postmortem brain samples have detected widespread presence bacteria brains patients with Alzheimer’s disease. This article provides an overview emerging host disorders discusses future directions, underlying biological mechanisms, reliable biomarkers microbiota, microbiota-targeted interventions, this field.

Language: Английский

Citations

51
Fecal microbiota transplantation attenuates Alzheimer’s disease symptoms in APP/PS1 transgenic mice via inhibition of the TLR4-MyD88-NF-κB signaling pathway-mediated inflammation DOI Creative Commons
Xiang Li,

Qingyong Ding,

Xinxin Wan

et al.

Behavioral and Brain Functions, Journal Year: 2025, Volume and Issue: 21(1)

Published: Jan. 8, 2025

Alzheimer's disease (AD) is a prevalent and progressive neurodegenerative disorder that the leading cause of dementia. The underlying mechanisms AD have not yet been completely explored. Neuroinflammation, an inflammatory response mediated by certain mediators, has exhibited to play crucial role in pathogenesis AD. Additionally, disruption gut microbiota found be associated with AD, fecal transplantation (FMT) emerged as potential therapeutic approach. However, precise mechanism FMT treatment remains elusive. In this study, was performed transplanting from healthy wild-type mice into APP/PS1 (APPswe, PSEN1dE9) assess effectiveness mitigating AD-associated inflammation reveal its action. results demonstrated improved cognitive function reduced expression levels factors regulating TLR4/MyD88/NF-κB signaling pathway mice, which accompanied restoration microbial dysbiosis. These findings suggest ameliorate symptoms delay progression mice.

Language: Английский

Citations

2
Fecal Microbiota Transplantation for Treatment of Parkinson Disease DOI
Filip Scheperjans, Reeta Levo, Berta Bosch

et al.

JAMA Neurology, Journal Year: 2024, Volume and Issue: 81(9), P. 925 - 925

Published: July 29, 2024

Importance Dysbiosis has been robustly demonstrated in Parkinson disease (PD), and fecal microbiota transplantation (FMT) shown promising effects preclinical PD models. Objective To assess the safety symptomatic efficacy of colonic single-dose anaerobically prepared FMT. Design, Setting, Participants This was a double-blind, placebo-controlled, randomized clinical trial conducted between November 2020 June 2023 with follow-up period 12 months at 4 hospitals Finland. Patients aged 35 to 75 years Hoehn & Yahr stage 1-3 mild moderate symptom burden dysbiosis were included. Of 229 patients screened, 48 47 received intervention. One patient discontinued due worsening symptoms. Two further excluded before analysis 45 included intention-to-treat analysis. Intervention 2:1 ratio receive FMT or placebo via colonoscopy. Main Outcomes Measures The primary end point change Movement Disorder Society Unified Parkinson’s Disease Rating Scale parts I-III (part III off medication) 6 months. Safety assessed by recording adverse events (AEs). Results median (IQR) age 65 (52.5-70.0) group 66 (59.25-69.75) group; 9 (60.0%) 16 (53.3%) male group, respectively. outcome did not differ groups (0.97 points, 95% CI, −5.10 7.03, P = .75). Gastrointestinal AEs more frequent (16 [53%] vs 1 [7%]; .003). Secondary outcomes post hoc analyses showed stronger increase dopaminergic medication improvement certain motor nonmotor group. Microbiota changes pronounced after but differed donor. Nevertheless, status reversed frequently Conclusions Relevance safe offer clinically meaningful improvements. Further studies—for example, through modified approaches bowel cleansing—are warranted regarding specific impact donor composition conversion on as well needs PD. Trial Registration ClinicalTrials.gov Identifier: NCT04854291

Language: Английский

Citations

15
Taming neuroinflammation in Alzheimer's disease: The protective role of phytochemicals through the gut−brain axis DOI Open Access

Yoonsu Kim,

Jinkyu Lim, Jisun Oh

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117277 - 117277

Published: Aug. 9, 2024

Language: Английский

Citations

14
The microbiota-gut-brain-immune interface in the pathogenesis of neuroinflammatory diseases: a narrative review of the emerging literature DOI Creative Commons
Alison Warren, Yvonne Nyavor,

Nikkia Zarabian

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 16, 2024

Importance Research is beginning to elucidate the sophisticated mechanisms underlying microbiota-gut-brain-immune interface, moving from primarily animal models human studies. Findings support dynamic relationships between gut microbiota as an ecosystem (microbiome) within (host) and its intersection with host immune nervous systems. Adding this effects on epigenetic regulation of gene expression further complicates strengthens response. At heart inflammation, which manifests in a variety pathologies including neurodegenerative diseases such Alzheimer’s disease, Parkinson’s Multiple Sclerosis (MS). Observations Generally, research date limited has focused bacteria, likely due simplicity cost-effectiveness 16s rRNA sequencing, despite lower resolution inability determine functional ability/alterations. However, omits all other fungi, viruses, phages, are emerging key members microbiome. Much been done pre-clinical and/or small studies more developed parts world. The observed promising but cannot be considered reliable or generalizable at time. Specifically, causal determined currently. More followed by then little MS. data for MS encouraging this. Conclusions relevance While still nascent, interface may missing link, hampered our progress understanding, let alone preventing, managing, putting into remission diseases. Relationships must first established humans, have shown poorly translate complex physiology environments, especially when investigating microbiome where often overly simplistic. Only can robust conducted humans using mechanistic model

Language: Английский

Citations

9
The Gut Microbiota Modulates Neuroinflammation in Alzheimer's Disease: Elucidating Crucial Factors and Mechanistic Underpinnings DOI Creative Commons
Jin Yang, Junyi Liang,

Niyuan Hu

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(10)

Published: Oct. 1, 2024

Alzheimer's disease (AD) is characterized by progressive cognitive decline and neuronal loss, commonly linked to amyloid-β plaques, neurofibrillary tangles, neuroinflammation. Recent research highlights the gut microbiota as a key player in modulating neuroinflammation, critical pathological feature of AD. Understanding role this process essential for uncovering new therapeutic avenues gaining deeper insights into AD pathogenesis.

Language: Английский

Citations

8
Astrocytes in aging DOI Creative Commons
Lara Labarta-Bajo, Nicola J. Allen

Neuron, Journal Year: 2025, Volume and Issue: 113(1), P. 109 - 126

Published: Jan. 1, 2025

Language: Английский

Citations

1
Gut Microbiota-Based Interventions for Parkinson’s Disease: Neuroprotective Mechanisms and Current Perspective DOI
Deepak Kumar, Mahendra Bishnoi, Kanthi Kiran Kondepudi

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Language: Английский

Citations

1
Using synthetic biology to understand the gut-brain axis DOI Creative Commons
Angela Cesaro, Esther Broset, Gregory J. Salimando

et al.

Cell Reports Physical Science, Journal Year: 2025, Volume and Issue: unknown, P. 102458 - 102458

Published: Feb. 1, 2025

Language: Английский

Citations

1