International Journal of Nephrology and Renovascular Disease, Journal Year: 2024, Volume and Issue: Volume 17, P. 319 - 332
Published: Dec. 1, 2024
Previous studies have established a correlation between gut microbiota, metabolites, and diabetic nephropathy (DN). However, the inherent limitations of observational studies, including reverse causality confounding factors, made this relationship uncertain.
Language: Английский
Toxins, Journal Year: 2022, Volume and Issue: 14(10), P. 648 - 648
Published: Sept. 20, 2022
The gut microbiota consists of trillions microorganisms, fulfilling important roles in metabolism, nutritional intake, physiology and maturation the immune system, but also aiding abetting progression chronic kidney disease (CKD). human microbiome bacterial species from five major phyla, namely Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, Verrucomicrobia. Alterations members these phyla alter total microbiota, with a decline number symbiotic flora an increase pathogenic bacteria, causing or aggravating CKD. In addition, CKD-associated alteration this intestinal results metabolic changes accumulation amines, indoles phenols, among other uremic metabolites, which have feedforward adverse effect on CKD patients, inhibiting renal functions increasing comorbidities such as atherosclerosis cardiovascular diseases (CVD). A classification toxins according to degree known toxicity based experimental evidence their (number systems affected) overall clinical was selected identify representative small water-soluble compounds, protein-bound compounds middle molecules relation summarized. Gut-derived metabolites accumulating patients further exhibit cell-damaging properties, damage epithelial cell wall, permeability lead translocation bacteria endotoxins into circulatory system. Elevated levels endotoxemia inflammation, accelerating progression. recent years, role pathophysiology has emerged aspect corrective treatment; however, mechanisms by contributes are still not completely understood. Therefore, review summarizes current state research regarding alterations microbiome, toxin production, barrier degradation.
Language: Английский
Citations
42
Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14
Published: Jan. 26, 2023
Background The intestinal microbiota disorder gradually aggravates during the progression of diabetes. Dapagliflozin (DAPA) can improve diabetes and diabetic kidney disease(DKD). However, whether gut plays a role in protection DAPA for DKD remains unclear. Methods To investigate effects on composition disease progression, our study, we performed 16S rRNA gene sequencing fecal samples from db/m mice (control group), db/db (DKD model those treated with (treat group) at three timepoints 14weeks\18weeks\22weeks. Results We found that remarkably prevented weight loss lowered fasting blood glucose eventually delaying DKD. Intriguingly, study strongly suggested there is aggravated dysbacteriosis increased bile acid development More importantly, comparisons relative abundance phylum level partial least squares-discriminant analysis (PLS-DA) plots roughly reflected effect modulating flora time. Specifically, dominant Firmicutes Bacteroidetes was not meaningfully changed among groups 14 weeks as previous studies described. Interestingly, they were altered treat group compared to more protracted intervention 18 22 weeks. Furthermore, decrease Lactobacillus increase norank_f:Muribaculaceae could account differences observed between Conclusion firstly protective may be related dynamic improvement over time, possibly associated impact pool its antioxidation effect.
Language: Английский
Citations
18
Pharmaceutical Biology, Journal Year: 2024, Volume and Issue: 62(1), P. 423 - 435
Published: May 17, 2024
Context Diabetic kidney disease (DKD) affects nearly 40% of diabetic patients, often leading to end-stage renal that requires replacement therapies, such as dialysis and transplantation. The gut microbiota, an integral aspect human evolution, plays a crucial role in this condition. Traditional Chinese medicine (TCM) has shown promising outcomes ameliorating DKD by addressing the microbiota.
Language: Английский
Citations
8
Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13
Published: Oct. 20, 2022
Gut microbiota has been reported to play an important role in diabetic kidney disease (DKD), however, the alterations of gut bacteria have not determined.Studies comparing differences microbiome between patients with DKD and non-DKD individuals using high-throughput sequencing technology, were systematically searched reviewed. Outcomes set as bacterial diversity, microbial composition, correlation clinical parameters DKD. Qualitative data summarized compared through a funnel R script, quantitative estimated by meta-analysis.A total 15 studies 1640 participants included, comparisons conducted DKD, diabetes mellitus (DM), non-diabetic (NDKD), healthy controls. There no significant α-diversity DM, NDKD, lower richness was found Different compositions subjects. The phylum Actinobacteria be enriched At genus level, we enrichment Hungatella, Bilophila, Escherichia showed abundances Faecalibacterium those NDKD. genera Butyricicoccus, Faecalibacterium, Lachnospira depleted controls, whereas Escherichia, lactobacillus significantly enriched. Ruminococcus torques group demonstrated inversely correlated glomerular filtration rate DKD.Gut characterized Hungatella depletion butyrate-producing bacteria, which might associated occurrence development Further are still needed validate these findings, due substantial heterogeneity.https://www.crd.york.ac.uk/prospero/, identifier CRD42022340870.
Language: Английский
Citations
27
Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14
Published: April 21, 2023
Diabetic kidney disease (DKD) is a common complication in patients with diabetes mellitus (DM). Increasing evidence suggested that the gut microbiota participates progression of DKD, which involved insulin resistance, renin-angiotensin system (RAS) activation, oxidative stress, inflammation and immunity. Gut microbiota-targeted therapies including dietary fiber, supplementation probiotics or prebiotics, fecal transplantation diabetic agents modulate microbiota, such as metformin, glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose transporter-2 (SGLT-2) inhibitors. In this review, we summarize most important findings about role pathogenesis DKD application therapies.
Language: Английский
Citations
15
Life Sciences, Journal Year: 2023, Volume and Issue: 316, P. 121414 - 121414
Published: Jan. 19, 2023
Language: Английский
Citations
14
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: April 10, 2024
Diabetes mellitus (DM) refers to a group of chronic diseases with global prevalence, characterized by persistent hyperglycemia resulting from various etiologies. DM can harm organ systems and lead acute or complications, which severely endanger human well-being. Traditional treatment mainly involves controlling blood sugar levels through replacement therapy drugs insulin; however, some patients still find satisfactory curative effect difficult achieve. Extensive research has demonstrated close correlation between enteric dysbacteriosis the pathogenesis types DM, paving way for novel therapeutic approaches targeting gut microbiota manage DM. Fecal transplantation (FMT), method re-establishing intestinal microbiome balance, offers new possibilities treating diabetes. This article provides comprehensive review microbiota, as well current advancements in FMT using an illustrative example. study aims offer perspectives establish theoretical foundation clinical diagnosis management
Language: Английский
Citations
5
Liver Research, Journal Year: 2023, Volume and Issue: 7(3), P. 207 - 215
Published: July 13, 2023
Coronavirus disease 2019 (COVID-19) has been associated with various liver injury cases worldwide. To date, the prevalence, mechanism, clinical manifestations, diagnosis, and outcomes of COVID-19-induced in at-risk groups are not well defined. Liver may arise prevention treatment COVID-19 from direct causes such as viral infection indirect systemic inflammation, hypoxic changes, drugs that exacerbate any pre-existing disease. Studies have found patients underlying at higher risk injury. Certain condition cardiopulmonary metabolic diseases vulnerable stages lifespan also involve development This review summarized studies different regarding their characteristics, parameters, correlations severity these indicators signs potential suggestions, to increase attention physiological pathological conditions continue function monitoring they can help strengthening early supportive reducing incidence adverse outcomes.
Language: Английский
Citations
11
Acta Diabetologica, Journal Year: 2024, Volume and Issue: 61(6), P. 705 - 714
Published: Feb. 24, 2024
Abstract Aims Several studies have reported dietary microorganisms’ beneficial effects on human health. We aimed to detect the potential association between live microbe intake and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM) through a cross-sectional analysis of National Health Nutrition Examination Survey from 1999 2018. Methods According Sanders classification system microbes, study participants were divided into three groups: low, medium, high groups. In T2DM, DKD was assessed by glomerular filtration rate (< 60 mL/min/1.73 m using Chronic Kidney Disease Epidemiology Collaboration algorithm), proteinuria (urinary albumin creatinine ratio ≥ 30 mg/g), or both. Weighted univariate multivariate logistic regression subgroup analyses conducted investigate independent DKD. Results The included 3836 participants, whom 1467 (38.24%) had for diagnosis. Our demonstrated that group more likely be older, female, non-Hispanic White, higher education levels, lower prevalence smoking, poverty-income ratio, energy intake, haemoglobin (HbA1c) serum risk progression. After adjustment covariates, low DKD, whereas no significant found medium No statistically interaction observed all except HbA1c ( p < 0.05). Conclusions results indicate associated prevalence.
Language: Английский
Citations
4
Aging Medicine, Journal Year: 2025, Volume and Issue: 8(1)
Published: Feb. 1, 2025
ABSTRACT Objectives Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, and its pathogenesis remains incompletely understood. Emerging evidence suggests potential link between gut microbiota DN. This study aimed to explore the causal relationship DN using two‐sample Mendelian randomization (MR) approach. Methods Gut data were obtained from MiBioGen consortium, which provides most comprehensive genome‐wide association studies (GWAS) on microbiota. Summary‐level genetic for sourced publicly available GWAS provided by FinnGen consortium. The primary analysis was conducted inverse variance–weighted (IVW) method, complemented sensitivity analyses evaluate pleiotropy heterogeneity. Results Fourteen species demonstrated significant associations with in MR analysis, including five negatively nine positively associated species, as determined IVW method. No or heterogeneity observed, ensuring robustness findings. Conclusions novel insight into role pathogenesis, uncovering specific microbial that may contribute disease progression. These findings offer promising avenue future research therapeutic development targeting
Language: Английский
Citations
0