Comparative Study of Sonodynamic and Photoactivated Cancer Therapies with Re(I)-Tricarbonyl Complexes Comprising Phenanthroline Ligands

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(8), P. 6537 - 6548

Published: April 11, 2024

Herein, we have compared the effectivity of light-based photoactivated cancer therapy and ultrasound-based sonodynamic with Re(I)-tricarbonyl complexes (Re1–Re3) against cells. The observed photophysical TD-DFT calculations indicated potential Re1–Re3 to act as good anticancer agents under visible light/ultrasound exposure. Re1 did not display any dark- or light- ultrasound-triggered activity. However, Re2 Re3 displayed concentration-dependent activity upon light ultrasound Interestingly, produced 1O2 OH• on Moreover, induced NADH photo-oxidation in PBS H2O2. To best our knowledge, has been achieved here Re(I) complex for first time PBS. Additionally, released CO cell death mechanism revealed that an apoptotic response HeLa cells via ROS generation. showed slightly better exposure

Language: Английский

---

Visible-Light-Responsive Novel Ru(II)-Metallo-Antibiotics with Potential Antibiofilm and Antibacterial Activity

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(22), P. 28118 - 28133

Published: May 24, 2024

Growing challenges with antibiotic resistance pose immense in combating microbial infections and biofilm prevention on medical devices. Lately, antibacterial photodynamic therapy (aPDT) is now emerging as an alternative to overcome this problem. Herein, we synthesized characterized four Ru(II)-complexes, viz., [Ru(ph-tpy)(bpy)Cl]PF6 (Ru1), [Ru(ph-tpy)(dpq)Cl]PF6 (Ru2), [Ru(ph-tpy)(dppz)Cl]PF6 (Ru3), [Ru(ph-tpy)(dppn)Cl]PF6 (Ru4) (where 4′-phenyl-2,2′:6′,2″-terpyridine = ph-tpy; 2,2′-bipyridine bpy; dipyrido[3,2-f:2′,3′-h]quinoxaline dpq; dipyrido[3,2-a:2′,3′-c]phenazine dppz; Benzo[I]dipyrido[3,2-a:2′,3′-c]phenazine dppn), among which Ru2–Ru4 are novel. Octahedral geometry of the complexes a RuN5Cl core was evident from crystal structure Ru2. Ru1–Ru4 showed MLCT absorption band 450–600 nm region, useful for aPDT performances. Further, optimum triplet excited state energy excellent photostability made them good photosensitizers aPDT. demonstrated enhanced antimicrobial activity visible-light exposure (400–700 nm, 10 J cm–2), confirmed using different assays. Mechanistic studies revealed that inhibition bacterial growth due generation oxidative stress (via NADH oxidation ROS generation) upon treatment Ru2–Ru4, resulting destruction wall. Ru2 performed best killing performance against both Gram-negative (Escherichia coli) Gram-positive (Bacillus subtilis) bacteria when exposed light. coated polydimethylsiloxane (PDMS) disk, long-term reusability durable antibiofilm properties. Molecular docking efficient interaction FabH (regulates fatty acid biosynthesis E. PgaB (gives structural stability helps formation coli), probable downregulation. In vivo healthy Wistar rats biocompatibility This study shows these lead (Ru2–Ru4) can be used potent agents low concentrations toward eradication (PDT).

Language: Английский

---

A NIR‐Light‐Activated and Lysosomal‐Targeted Pt(II) Metallacycle for Highly Potent Evoking of Immunogenic Cell Death that Potentiates Cancer Immunotherapy of Deep‐Seated Tumors

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(37)

Published: May 22, 2024

Though platinum (Pt)-based complexes have been recently exploited as immunogenic cell death (ICD) inducers for activating immunotherapy, the effective activation of sufficient immune responses with minimal side effects in deep-seated tumors remains a formidable challenge. Herein, we propose first example near-infrared (NIR) light-activated and lysosomal targeted Pt(II) metallacycle (1) supramolecular ICD inducer. 1 synergistically potentiates immunomodulatory response via multiple-regulated approaches, involving NIR light excitation, boosted reactive oxygen species (ROS) generation, good selectivity between normal tumor cells, enhanced penetration/retention capabilities. Specifically, has excellent depth-activated ROS production (~7 mm), accompanied by strong anti-diffusion anti-ROS quenching ability. In vitro experiments demonstrate that exhibits significant cellular uptake generation cells well respective multicellular spheroids. Based on these advantages, induces more efficient an ultralow dose (i.e., 5 μM) compared clinical inducer-oxaliplatin (300 μM). vivo, vaccination further serves potent inducer through eliciting CD8

Language: Английский

---

Carboxylesterase Activatable Molecular Probe for Personalized Treatment Guidance by Analyte‐Induced Molecular Transformation

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(31)

Published: May 10, 2024

Abstract Accurate visualization of tumor microenvironment is great significance for personalized medicine. Here, we develop a near‐infrared (NIR) fluorescence/photoacoustic (FL/PA) dual‐mode molecular probe (denoted as NIR−CE) distinguishing tumors based on carboxylesterase (CE) level by an analyte‐induced transformation (AIMT) strategy. The recognition moiety CE activity the acetyl unit NIR−CE, generating pre‐product, NIR−CE−OH, which undergoes spontaneous hydrogen atom exchange between nitrogen atoms in indole group and phenol hydroxyl group, eventually transforming into NIR−CE−H. In cellular experiments vivo blind studies, human hepatoma cells with high were successfully distinguished both NIR FL PA imaging. Our findings provide new imaging strategy treatment guidance.

Language: Английский

---

Advances and perspectives in phototherapy-based combination therapy for cancer treatment

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(26), P. 6285 - 6304

Published: Jan. 1, 2024

Phototherapy, including photothermal therapy (PTT) and photodynamic (PDT), has the advantages of spatiotemporal selectivity, non-invasiveness, negligible drug resistance. Phototherapy been approved for treating superficial epidermal tumors. However, its therapeutic efficacy is limited by hypoxic tumor microenvironment highly expressed heat shock protein. Moreover, poor tissue penetration focused irradiation laser region in phototherapy make deep tissues metastatic tumors challenging. Combination strategies, which integrate each treatment overcome their disadvantages, can significantly improve efficacy. Recently, many combination strategies have reported. Our study summarizes used combining with other cancer treatments such as chemotherapy, immunotherapy, sonodynamic therapy, gas starvation chemodynamic therapy. Some research cases were selected to analyze effect, delivery platform feature, synergetic anticancer mechanisms. additional are summarized tables. This review provides strong evidence that phototherapy-based enhance effect compared alone. Additionally, challenges future perspectives associated these combinational therapies discussed.

Language: Английский

---

Facile synthesis of a hydrazone-based zinc(ii) complex for ferroptosis-augmented sonodynamic therapy

Chemical Science, Journal Year: 2024, Volume and Issue: 15(26), P. 10027 - 10035

Published: Jan. 1, 2024

This work reports a facilely synthesized zinc( ii ) complex based on hydrazone ligand for ferroptosis-augmented sonodynamic therapy.

Language: Английский

---

Metal–organic framework (MOF)-based materials for pyroptosis-mediated cancer therapy

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(51), P. 6476 - 6487

Published: Jan. 1, 2024

This manuscript summarized the recent progress of MOF-based pyroptosis inducers in immunotherapy.

Language: Английский

---

Catalytic Biomaterials‐Activated In Situ Chemical Reactions: Strategic Modulation and Enhanced Disease Treatment

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract Chemical reactions underpin biological processes, and imbalances in critical biochemical pathways within organisms can lead to the onset of severe diseases. Within this context, emerging field “Nanocatalytic Medicine” leverages nanomaterials as catalysts modulate fundamental chemical specific microenvironments This approach is designed facilitate targeted synthesis localized accumulation therapeutic agents, thus enhancing treatment efficacy precision while simultaneously reducing systemic side effects. The effectiveness these nanocatalytic strategies critically hinges on a profound understanding kinetics intricate interplay particular pathological ensure effective catalytic actions. review methodically explores situ their associated biomaterials, emphasizing regulatory that control responses. Furthermore, discussion encapsulates crucial elements‐reactants, catalysts, reaction conditions/environments‐necessary for optimizing thermodynamics reactions, rigorously addressing both biophysical dimensions disease enhance outcomes. It seeks clarify mechanisms underpinning biomaterials evaluate potential revolutionize across various conditions.

Language: Английский

---

Acid‐Responsive Nanoregulators Elicit Hydrogen Sulfide‐Mediated Tumor Oxygenation and Selective Sonosensitization for Hypoxic Tumors

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Oxygen (O 2 ) tension within a tumor is considered hallmark of sonodynamic therapy (SDT). Herein, multifunctional nanoregulators, CMCS‐Au‐SrS (CAS), are reported, which assembled by carboxymethyl chitosan(CMCS) tethered gold nanoclusters (Au NCs) as sonosensitizers and sulfurate donors strontium sulfide nanoparticles (SrS NPs), to evoke selective SDT in hypoxic tumors. CAS possess tumor‐acidity responsiveness form large‐size aggregated Au NCs with shortened bandgap so that effectively induce powerful reactive oxygen species generation. On the other hand, acidity triggers degradation SrS NPs release hydrogen (H S), evoking oxygenation overcome hypoxia. This junction accelerated sonosensiting ability boosts amplified efficacy. More importantly, specific glycolysis induced acidification leads selectively accumulated cancer cells, further guaranteeing execution advanced therapeutic manners. Additionally, doping Nd 3+ endows second near‐infrared fluorescence facilitate vivo tracing property good tissue penetration (up 6 mm). strategy may play pioneering role develop theranostic reagents improved enrichment capacity enhanced hypoxia

Language: Английский

---

Recent advances and challenges in metal-based antimicrobial materials: a review of strategies to combat antibiotic resistance

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 9, 2025

Despite the availability of a series classical antibiotic drugs, bacterial infections continue to represent significant and urgent threat global human health. The emergence drug-resistant bacteria slow pace development have rendered current treatment methods inadequate in meeting clinical demands infections. Consequently, there is an increasingly vital need for safe, efficient, alternative novel antimicrobial agents medical healthcare field. Over past five years, has been notable expansion field nanomedicine with regard prevention control infectious diseases. objective this article provide comprehensive review latest research developments metal nanomaterials therapy. We begin by delineating gravity infection crisis, subsequently undertaking examination potential mechanisms through which nanoparticles may combat specific applications these diverse In conclusion, we eagerly anticipate future directions believe that continuous technological advancements innovations, will make even more outstanding contributions safeguarding health well-being.

Language: Английский

---