d-glutamate and Gut Microbiota in Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(8), P. 2676 - 2676

Published: April 11, 2020

An increasing number of studies have shown that the brain-gut-microbiota axis may significantly contribute to Alzheimer's disease (AD) pathogenesis. Moreover, impaired memory and learning involve dysfunction neurotransmission glutamate, agonist N-methyl-d-aspartate receptor a major excitatory neurotransmitter in brain. This systematic review aimed summarize current cutting-edge research on gut microbiota glutamate alterations associated with dementia.PubMed, Cochrane Collaboration Central Register Controlled Clinical Trials, Systematic Reviews were reviewed for all dementia published up until Feb 2020.Several pilot reported metabolites AD patients other forms dementia. Gut including Bacteroides vulgatus Campylobacter jejuni affect metabolism decrease metabolite 2-keto-glutaramic acid. Meanwhile, bacteria racemase Corynebacterium glutamicum, Brevibacterium lactofermentum, avium can convert l-glutamate d-glutamate. (NMDAR)-enhancing agents been found potentially improve cognition or Parkinson's patients. These findings suggest d-glutamate (d-form glutamate) metabolized by influence NMDAR cognitive function patients.Gut are potential novel interventions be developed Exploring comprehensive functions animal human trials glutamate-related enhancers warranted examine signaling efficacy neurodegenerative dementias.

Language: Английский

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The intestinal barrier in disorders of the central nervous system

˜The œLancet. Gastroenterology & hepatology, Journal Year: 2022, Volume and Issue: 8(1), P. 66 - 80

Published: Nov. 2, 2022

Language: Английский

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The microbiota–gut–brain axis and neurodevelopmental disorders

Protein & Cell, Journal Year: 2023, Volume and Issue: 14(10), P. 762 - 775

Published: May 11, 2023

Abstract The gut microbiota has been found to interact with the brain through microbiota–gut–brain axis, regulating various physiological processes. In recent years, impacts of on neurodevelopment this axis have increasingly appreciated. is commonly considered regulate three pathways, immune pathway, neuronal and endocrine/systemic overlaps crosstalks in between. Accumulating studies identified role neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity Rett Syndrome. Numerous researchers examined pathophysiological mechanisms influenced by (NDDs). This review aims provide a comprehensive overview advancements research pertaining microbiota-gut-brain NDDs. Furthermore, we analyzed both current state progress discuss future perspectives field.

Language: Английский

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Microbiota’s role in health and diseases

Environmental Science and Pollution Research, Journal Year: 2021, Volume and Issue: 28(28), P. 36967 - 36983

Published: May 27, 2021

Language: Английский

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Oral Administration of Resveratrol-Selenium-Peptide Nanocomposites Alleviates Alzheimer’s Disease-like Pathogenesis by Inhibiting Aβ Aggregation and Regulating Gut Microbiota

ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(39), P. 46406 - 46420

Published: Sept. 27, 2021

Alzheimer's disease (AD) is a neurodegenerative associated with amyloid-β (Aβ) deposition, leading to neurotoxicity (oxidative stress and neuroinflammation) gut microbiota imbalance. Resveratrol (Res) has neuroprotective properties, but its bioavailability

Language: Английский

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Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota

Neurobiology of Stress, Journal Year: 2021, Volume and Issue: 14, P. 100294 - 100294

Published: Jan. 14, 2021

Stress has been shown to disturb the balance of human intestinal microbiota and subsequently causes mental health problems like anxiety depression. Our previous study showed that ingesting probiotic strain, Lactobacillus (L.) plantarum P-8, for 12 weeks could alleviate stress stressed adults. The current was a follow-up work aiming investigate functional role gut metagenomes in observed beneficial effects. fecal (n = 43) placebo 36) receivers were analyzed depth. microbiomes group at 0 significantly greater Aitchison distance (P < 0.001) compared with group. Meanwhile, Shannon diversity index 0.05) but not decreased week 12. Additionally, more species-level genome bins (SGBs) Bifidobacterium adolescentis, longum, Fecalibacterium prausnitzii 0.01) identified group, while abundances SGBs representing species Roseburia faecis Fusicatenibacter saccharivorans 0.05). Furthermore, 12-week supplementation enhanced neurotransmitter-synthesizing/consuming levels some predicted microbial neuroactive metabolites (e.g., short-chain fatty acids, gamma-aminobutyric acid, arachidonic sphingomyelin). results potential link between probiotic-induced modulation stress/anxiety alleviation adults, supporting gut-brain axis involved relieving stress-related symptoms. effect relied only on changes importantly metagenome modulations SGB gene levels.

Language: Английский

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A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders

Communications Biology, Journal Year: 2022, Volume and Issue: 5(1)

Published: July 18, 2022

Consistent with the concept of gut-brain phenomenon, observational studies suggest a relationship between Alzheimer's disease (AD) and gastrointestinal tract (GIT) disorders; however, their underlying mechanisms remain unclear. Here, we analyse several genome-wide association (GWAS) summary statistics (N = 34,652-456,327), to assess AD GIT disorders. Findings reveal positive significant genetic overlap correlation gastroesophageal reflux (GERD), peptic ulcer (PUD), gastritis-duodenitis, irritable bowel syndrome diverticulosis, but not inflammatory disease. Cross-trait meta-analysis identifies loci (Pmeta-analysis < 5 × 10-8) shared by disorders (GERD PUD) including PDE4B, BRINP3, ATG16L1, SEMA3F, HLA-DRA, SCARA3, MTSS2, PHB, TOMM40. Colocalization gene-based analyses reinforce these loci. Pathway-based demonstrate enrichment lipid metabolism, autoimmunity, lipase inhibitors, PD-1 signalling, statin mechanisms, among others, for traits. Our findings provide insights into relationship, implicating non-causal susceptibility AD's risk. Genes biological pathways identified are potential targets further investigation in AD, disorders, comorbidity.

Language: Английский

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Recent advances in the epithelial barrier theory

International Immunology, Journal Year: 2024, Volume and Issue: 36(5), P. 211 - 222

Published: Jan. 16, 2024

Abstract The epithelial barrier theory links the recent rise in chronic non-communicable diseases, notably autoimmune and allergic disorders, to environmental agents disrupting barrier. Global pollution toxic agent exposure have worsened over six decades because of uncontrolled growth, modernization, industrialization, affecting human health. Introducing new chemicals without any reasonable control their health effects through these years has led documented adverse effects, especially on skin mucosal barriers. These substances, such as particulate matter, detergents, surfactants, food emulsifiers, micro- nano-plastics, diesel exhaust, cigarette smoke, ozone, been shown compromise integrity. This disruption is linked opening tight-junction barriers, inflammation, cell death, oxidative stress, metabolic regulation. Consideration must be given interplay underlying inflammatory medications, affected tissues. review article discusses detrimental effect barrier-damaging compounds involves cellular molecular mechanisms.

Language: Английский

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The communication mechanism of the gut-brain axis and its effect on central nervous system diseases: A systematic review

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117207 - 117207

Published: July 26, 2024

Language: Английский

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Microbiota-gut brain axis involvement in neuropsychiatric disorders

Expert Review of Neurotherapeutics, Journal Year: 2019, Volume and Issue: 19(10), P. 1037 - 1050

Published: July 1, 2019

Introduction: The microbiota-gut brain (MGB) axis is the bidirectional communication between intestinal microbiota and brain. An increasing body of preclinical clinical evidence has revealed that gut microbial ecosystem can affect neuropsychiatric health. However, there still a need further studies to elucidate complex gene-environment interactions role MGB in diseases, with aim identifying biomarkers new therapeutic targets, allow early diagnosis improving treatments. Areas covered: To review disorders, prediction prevention disease through exploitation, integration, combination data from existing microbiome/microbiota projects appropriate other International '-Omics' studies. authors also evaluated technological advances investigate modulate, nutritional interventions, microbiota. Expert opinion: have documented an association alterations composition and/or function, whereas support for impacting behaviors which are relevance psychiatry central nervous system (CNS) disorders. Targeting could be additional approach treating CNS disorders all conditions involved.

Language: Английский

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