Dietary flavonoid actions on senescence, aging, and applications for health

The Journal of Nutritional Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109862 - 109862

Published: Feb. 1, 2025

Language: Английский

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Drying as a Preservation Strategy for Medicinal Plants: Physicochemical and Functional Outcomes for Food and Human Health

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100762 - 100762

Published: Feb. 1, 2025

Language: Английский

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Melatonin Pre-harvest Treatments Leads to Maintenance of Sweet Cherry Quality During Storage by Increasing Antioxidant Systems

Frontiers in Plant Science, Journal Year: 2022, Volume and Issue: 13

Published: April 11, 2022

Melatonin has been reported to have an important role in fruit ripening, although the effect of pre-harvest melatonin treatment on sweet cherry quality properties during storage is still unknown. In present experiments, effects (0.1, 0.3, and 0.5 Mm) by foliar spray treatments 'Prime Giant' 'Sweet Heart' trees traits antioxidants systems was evaluated. Results showed that these reduced weight losses storage, as well firmness titratable acidity. addition, changes colour total soluble solid content were also delayed from treated with respect controls. Moreover, general, phenolic anthocyanin concentrations higher than those control ones, either at harvest or whole period. Finally, activity antioxidant enzymes catalase, ascorbate peroxidase enhanced a consequence treatment. Overall results show post-harvest ripening process fruit, leading maintenance their optimum levels for consumption 2 weeks more trees. Antioxidant systems, both enzymatic non-enzymatic treatments, which would account delay storage.

Language: Английский

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Structured Long-Chain Omega-3 Fatty Acids for Improvement of Cognitive Function during Aging

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(7), P. 3472 - 3472

Published: March 23, 2022

Although the human lifespan has increased in past century owing to advances medicine and lifestyle, healthspan not kept up same pace, especially brain aging. Consequently, role of preventive health interventions become a crucial strategy, particular, identification nutritional compounds that could alleviate deleterious effects Among nutrients cope with aging special cognitive decline, long-chain omega-3 polyunsaturated fatty acids (ω-3 LCPUFAs) docosahexaenoic acid (DHA) eicosapentaenoic (EPA), have emerged as very promising ones. Due their neuroinflammatory resolving effects, an status DHA EPA elderly been linked better function lower risk dementia. However, results from clinical studies do show consistent evidence intake recommendations for old adults are lacking. Recently, supplementation structured forms DHA, which can be derived natural or targeted structures, proven enhanced bioavailability powerful benefits. This review summarizes present future perspectives new structures ω-3 LCPUFAs "omic" technologies combined use high-throughput vivo models shed light on relationships underlying mechanisms between healthy

Language: Английский

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Anti-aging effects and mechanisms of anthocyanins and their intestinal microflora metabolites

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 64(8), P. 2358 - 2374

Published: Sept. 21, 2022

Aging, a natural and inevitable physiological process, is the primary risk factor for all age-related diseases; it severely threatens health of individuals places heavy burden on public health-care system. Thus, strategies to extend lifespan prevent treat diseases have been gaining increasing scientific interest. Anthocyanins (ACNs) are subclass flavonoids widely distributed in fruits vegetables. Growing evidence suggests that ACNs delay aging relieve diseases. However, owing low bioavailability ACNs, their gut metabolites proposed play critical role mediating benefits. In this review, we introduce biological fate after consumption highlight (phenolic acids) from intestinal microorganisms. Additionally, exhibit outstanding anti-aging ability Caenorhabditis elegans, Drosophila melanogaster, mouse models, probably associated with antioxidation, anti-inflammation, protein homeostasis, antiglycation, mitochondrial function, inhibition insulin/IGF-1 signaling (IIS). great application prospects as functional foods drugs manage Further investigation should focus interaction between microbiota, including clarifying complex metabolic pathway maximizing effects ACNs.

Language: Английский

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The Molecular Mechanism of Polyphenols in the Regulation of Ageing Hallmarks

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5508 - 5508

Published: March 14, 2023

Ageing is a complex process characterized mainly by decline in the function of cells, tissues, and organs, resulting an increased risk mortality. This involves several changes, described as hallmarks ageing, which include genomic instability, telomere attrition, epigenetic loss proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell depletion, altered intracellular communication. The determining role that environmental factors such diet lifestyle play on health, life expectancy, susceptibility to diseases, including cancer neurodegenerative wellestablished. In view growing interest beneficial effects phytochemicals prevention chronic studies have been conducted, they strongly suggest intake dietary polyphenols may bring numerous benefits due their antioxidant anti-inflammatory properties, has associated with impaired ageing humans. Polyphenol shown be effective ameliorating age-related phenotypes, oxidative stress, inflammatory processes, among other features, contribute ageing-associated diseases. review aims address, general way, main findings literature about each well regulatory mechanisms responsible for observed antiageing effects.

Language: Английский

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The entrancing role of dietary polyphenols against the most frequent aging‐associated diseases

Medicinal Research Reviews, Journal Year: 2023, Volume and Issue: 44(1), P. 235 - 274

Published: July 24, 2023

Aging, a fundamental physiological process influenced by innumerable biological and genetic pathways, is an important driving factor for several aging-associated disorders like diabetes mellitus, osteoporosis, cancer, neurodegenerative diseases including Alzheimer's Parkinson's diseases. In the modern era, mechanisms associated with aging have been deeply studied. Treatment therapeutics age-related also made considerable advances; however, effective long-lasting treatment, nutritional therapy particularly dietary polyphenols from natural origin are endorsed. These (e.g., apigenin, baicalin, curcumin, epigallocatechin gallate, kaempferol, quercetin, resveratrol, theaflavin), many other phytochemicals target certain molecular, mechanisms. The most common pathways of age-associated mitogen-activated protein kinase, reactive oxygen species production, nuclear kappa light chain enhancer activated B cells signaling metal chelation, c-Jun N-terminal inflammation. Polyphenols slow down course help in combatting age-linked disorders. This exemplified form clinical trials on specific various With this context mind, review reveals new insights to process, consequently reduce some classic age such as aforementioned, targeting activities origin.

Language: Английский

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The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial

BMC Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 25, 2023

Epigenetic age is an estimator of biological based on DNA methylation; its discrepancy from chronologic warrants further investigation. We recently reported that greater polyphenol intake benefitted ectopic fats, brain function, and gut microbiota profile, corresponding with elevated urine polyphenols. The effect polyphenol-rich dietary interventions aging yet to be determined.We calculated different epigenetic clocks generations (Horvath2013, Hannum2013, Li2018, Horvath skin blood2018, PhenoAge2018, PCGrimAge2022), their intrinsic accelerations, DunedinPACE, all methylation (Illumina EPIC array; pre-specified secondary outcome) for 256 participants abdominal obesity or dyslipidemia, before after the 18-month DIRECT PLUS randomized controlled trial. Three were assigned: healthy guidelines, a Mediterranean (MED) diet, polyphenol-rich, low-red/processed meat Green-MED diet. Both MED groups consumed 28 g walnuts/day (+ 440 mg/day polyphenols). group green tea (3-4 cups/day) Mankai (Wolffia globosa strain) 500-ml shake 800 Adherence diet was assessed by questionnaire polyphenols metabolomics (high-performance liquid chromatography quadrupole time flight).Baseline chronological (51.3 ± 10.6 years) significantly correlated (mAge) correlations ranging 0.83 0.95; p < 2.2e - 16 all. While did not differ in terms changes between mAge clocks, Green-Med adherence associated lower relative change (i.e., attenuation) Li Hannum (beta = 0.41, 0.004 beta 0.38, 0.03, respectively; multivariate models). Greater attenuation (multivariate models adjusted age, sex, baseline mAge, weight loss) mostly affected higher 1.8; 0.061) 1.57; 0.0016) corresponded polyphenols: hydroxytyrosol, tyrosol, urolithin C (p 0.05 all) A 0.08), highly common plants. Overall, undergoing either MED-style had ~ 8.9 months favorable difference observed expected at end intervention 0.02).This study showed green-MED diets increased intake, such as Mankai, are inversely aging. To best our knowledge, this first clinical trial indicate potential link polyphenols, aging.ClinicalTrials.gov, NCT03020186.

Language: Английский

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Tea polyphenols: extraction techniques and its potency as a nutraceutical

Frontiers in Sustainable Food Systems, Journal Year: 2023, Volume and Issue: 7

Published: May 24, 2023

Usually, polyphenols help address numerous health issues caused by oxidative stress. Tea is a popular beverage (rich in polyphenols) with abundant promoting and disease prevention great health-promoting disease-prevention attributes, originating from the delicate, dried leaves of Camellia sinensis plant. has been proven to have health-boosting impacts like anti-inflammatory, anti-cancerous, anti-diabetic, aids weight loss. Cognitive impairment, also known as cognitive decline aging or other neurological disorders, become an emerging concern. polyphenols, especially phenolic acids, havegained enormous attention due their link improved function preventing decline. This review summarizes recent studies on benefits tea. Additionally, effective traditional modern techniques extract effects various diseases described.

Language: Английский

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Cell Survival, Death, and Proliferation in Senescent and Cancer Cells: the Role of (Poly)phenols

Advances in Nutrition, Journal Year: 2023, Volume and Issue: 14(5), P. 1111 - 1130

Published: June 2, 2023

Cellular senescence has long been considered a permanent state of cell cycle arrest occurring in proliferating cells subject to different stressors, used as cellular defense mechanism from acquiring potentially harmful genetic faults. However, recent studies highlight that senescent might also alter the local tissue environment and concur chronic inflammation cancer risk by secreting inflammatory matrix remodeling factors, senescence-associated secretory phenotype (SASP). Indeed, during aging age-related diseases, amass mammalian tissues, likely contributing inevitable loss function we age. thus become one potential target tackle age-associated diseases well development. One important aspect characterizing is their telomere length. Telomeres shorten consequence multiple replications, gradually leading arrest, known replicative senescence. Interestingly, large majority cells, escape strategy length maintained telomerase, favoring initiation tumor survival. There growing evidence showing how (poly)phenols can impact maintenance through molecular mechanisms depending on dose phenotypes. Although normally, maintain support telomerase activity, this activity negatively modulated, accelerating attrition promoting death. Some have shown exert senolytic suggesting both antiaging (directly eliminating cells) anticancer (indirectly, via SASP inhibition) potentials. In review, analyze selective (poly)phenol discriminate between vitro vivo human applications considering bioavailability, influence gut microbiota, dose-response effects.

Language: Английский

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